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Neonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female rats
dc.creator | Leposavić, Gordana | |
dc.creator | Perišić, Milica | |
dc.creator | Kosec, Duško | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Radojević, Katarina | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Pilipović, Ivan | |
dc.date.accessioned | 2021-02-18T10:34:42Z | |
dc.date.available | 2021-02-18T10:34:42Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0889-1591 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/289 | |
dc.description.abstract | Exposure of female rodents to testosterone in the critical neonatal period produces defeminization/masculinization of the hypothalamo-pituitary-gonadal (HPG) axis, i.e. neonatal androgenization and postpones axis maturation. To address the hypothesis that HPG axis signaling is involved in the programming of thymic maturation/involution and sexual differentiation we studied the impact of neonatal androgenization on thymic cellularity, development of effector and regulatory T cells, and phenotypic characteristics of peripheral blood T lymphocytes in adult rats. A single injection of testosterome on postnatal day 2 postponed thymic maturation/involution as revealed by organ hypercellularity, increased cellularity of the most mature (CD4+CD8- and CD4-CD8+) TCR alpha beta(high) thymocyte and both recent thymic emigrant (RTE) subsets and caused phenotypic efeminization/masculinization of thymic (decreased CD4+CD8-TCR alpha beta(high)/CD4-CD8+TCR alpha beta(high) cell ratio) and peripheral blood T-cell compartments (decreased CD4+RTE/CD8+RTE and CD4+/CD8+ cell ratio). In addition, neonatal androgenization increased the relative and absolute numbers of both CD4+CD25+Foxp3+ and natural killer (NK) regulatory T cells in peripheral blood. These findings, in conjunction with thymocyte overexpression of Thy-1 that is assumed to reduce negative selection affecting self-reactive cell generation, suggest a new relationship between self-reactive and regulatory T cells. In conclusion, our study provides additional evidence for a role of HPG signals (i.e. sex steroids and gonadotropins) in programming the kinetics of thymic maturation/involution and in establishing immunological sexual dimorphism. (C) 2008 Elsevier Inc. All rights reserved. | en |
dc.publisher | Academic Press Inc Elsevier Science, San Diego | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Brain Behavior and Immunity | |
dc.subject | Neonatal androgenization | en |
dc.subject | T-cell differentiation | en |
dc.subject | Peripheral blood T lymphocytes | en |
dc.subject | Recent thymic emigrants | en |
dc.title | Neonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 304 | |
dc.citation.issue | 2 | |
dc.citation.other | 23(2): 294-304 | |
dc.citation.rank | M21 | |
dc.citation.spage | 294 | |
dc.citation.volume | 23 | |
dc.identifier.doi | 10.1016/j.bbi.2008.11.002 | |
dc.identifier.pmid | 19028560 | |
dc.identifier.scopus | 2-s2.0-58749102933 | |
dc.identifier.wos | 000263134100019 | |
dc.type.version | publishedVersion |