Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target
Abstract
We are most thankful to Prof. Yehuda Shoenfeld, head of Autoimmunity Center, Sheba Hospital at Tel Aviv, University in Israel, for critical and constructive comments on the manuscript. Thanks to Prof. B. Reljin and N. Stepanic, School of Informational Technology, Universirty of Belgrade for contribution in molecular images and computing analysis. Authors gratefully acknowledge the repeated gifts of the magnetic beads for magnetic brain stimulation of rats presented by Institute for Nuclear Physics, Vincha, Belgrade. Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted... upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.
Keywords:
adhesion / choroids plexus / EAE induction / magnetic stimulation / ratsSource:
International Journal of Neuroscience, 2009, 119, 9, 1399-1418Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
DOI: 10.1080/00207450802324564
ISSN: 0020-7454
PubMed: 19922364
WoS: 000270737200011
Scopus: 2-s2.0-70350455923
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Institution/Community
TorlakTY - JOUR AU - Jovanova-Nešić, Katica AU - Jovičić, S. AU - Sovilj, M. AU - Spector, Novera Herbert PY - 2009 UR - http://intor.torlakinstitut.com/handle/123456789/280 AB - We are most thankful to Prof. Yehuda Shoenfeld, head of Autoimmunity Center, Sheba Hospital at Tel Aviv, University in Israel, for critical and constructive comments on the manuscript. Thanks to Prof. B. Reljin and N. Stepanic, School of Informational Technology, Universirty of Belgrade for contribution in molecular images and computing analysis. Authors gratefully acknowledge the repeated gifts of the magnetic beads for magnetic brain stimulation of rats presented by Institute for Nuclear Physics, Vincha, Belgrade. Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target EP - 1418 IS - 9 SP - 1399 VL - 119 DO - 10.1080/00207450802324564 ER -
@article{ author = "Jovanova-Nešić, Katica and Jovičić, S. and Sovilj, M. and Spector, Novera Herbert", year = "2009", abstract = "We are most thankful to Prof. Yehuda Shoenfeld, head of Autoimmunity Center, Sheba Hospital at Tel Aviv, University in Israel, for critical and constructive comments on the manuscript. Thanks to Prof. B. Reljin and N. Stepanic, School of Informational Technology, Universirty of Belgrade for contribution in molecular images and computing analysis. Authors gratefully acknowledge the repeated gifts of the magnetic beads for magnetic brain stimulation of rats presented by Institute for Nuclear Physics, Vincha, Belgrade. Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target", pages = "1418-1399", number = "9", volume = "119", doi = "10.1080/00207450802324564" }
Jovanova-Nešić, K., Jovičić, S., Sovilj, M.,& Spector, N. H.. (2009). Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 119(9), 1399-1418. https://doi.org/10.1080/00207450802324564
Jovanova-Nešić K, Jovičić S, Sovilj M, Spector NH. Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. in International Journal of Neuroscience. 2009;119(9):1399-1418. doi:10.1080/00207450802324564 .
Jovanova-Nešić, Katica, Jovičić, S., Sovilj, M., Spector, Novera Herbert, "Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target" in International Journal of Neuroscience, 119, no. 9 (2009):1399-1418, https://doi.org/10.1080/00207450802324564 . .