Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium
Апстракт
Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-(3)). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41 +/- 3.66) mu g L-1, C group (5.60 +/- 0.86) mu g L-1, p lt 0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59 +/- 81.27) mu molL(-1), C group (105.21 +/- 49.62) mu mol L-1, p lt 0.0011 and antioxiclative enzyme activity reduced for glucos...o-6-phosphatedehydrogenase [Al group (5.05 +/- 1.70) IU g(-1) Hb, C group (12.53 +/- 4.12) IU g(-1) Hb, p lt 0.001], glutathione reductase [Al group (1.41 +/- 0.56) IU g(-1) Hb, C group (1.89 +/- 0.57) IU g(-1) Hb, p lt 0.001], glutathione peroxidase [Al group (12.37 +/- 5.76) IU g(-1) Hb, C group (15.54 +/- 4.85) IU g(-1) Hb, p lt 0.001], catalase [Al group (116.76 +/- 26.60) IU g(-1) Hb, C group (158.81 +/- 71.85) IU g(-1) Hb, p lt 0.001] and superoxide dismutase [Al group (1175.8 +/- 149.9) IU mg(-1) Hb, C group (1377.9 +/- 207.5) IU mg(-1) Hb, p lt 0.001].
Кључне речи:
catalase / glucoso-6-phosphate-dehydrogenase / glutathione peroxidase / glutathione reductase / malondialdehyde / occupational exposure / superoxide dismutaseИзвор:
Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology, 2008, 59, 2, 81-87Издавач:
- Inst Medical Research & Occupational Health, Zagreb
DOI: 10.2478/10004-1254-59-2008-1853
ISSN: 0004-1254
PubMed: 18573744
WoS: 000257403700002
Scopus: 2-s2.0-47349084104
Институција/група
TorlakTY - JOUR AU - Bulat, Petar AU - Potkonjak, Bijana AU - Dujić, Ivana PY - 2008 UR - http://intor.torlakinstitut.com/handle/123456789/266 AB - Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-(3)). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41 +/- 3.66) mu g L-1, C group (5.60 +/- 0.86) mu g L-1, p lt 0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59 +/- 81.27) mu molL(-1), C group (105.21 +/- 49.62) mu mol L-1, p lt 0.0011 and antioxiclative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05 +/- 1.70) IU g(-1) Hb, C group (12.53 +/- 4.12) IU g(-1) Hb, p lt 0.001], glutathione reductase [Al group (1.41 +/- 0.56) IU g(-1) Hb, C group (1.89 +/- 0.57) IU g(-1) Hb, p lt 0.001], glutathione peroxidase [Al group (12.37 +/- 5.76) IU g(-1) Hb, C group (15.54 +/- 4.85) IU g(-1) Hb, p lt 0.001], catalase [Al group (116.76 +/- 26.60) IU g(-1) Hb, C group (158.81 +/- 71.85) IU g(-1) Hb, p lt 0.001] and superoxide dismutase [Al group (1175.8 +/- 149.9) IU mg(-1) Hb, C group (1377.9 +/- 207.5) IU mg(-1) Hb, p lt 0.001]. PB - Inst Medical Research & Occupational Health, Zagreb T2 - Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology T1 - Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium EP - 87 IS - 2 SP - 81 VL - 59 DO - 10.2478/10004-1254-59-2008-1853 ER -
@article{ author = "Bulat, Petar and Potkonjak, Bijana and Dujić, Ivana", year = "2008", abstract = "Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-(3)). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41 +/- 3.66) mu g L-1, C group (5.60 +/- 0.86) mu g L-1, p lt 0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59 +/- 81.27) mu molL(-1), C group (105.21 +/- 49.62) mu mol L-1, p lt 0.0011 and antioxiclative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05 +/- 1.70) IU g(-1) Hb, C group (12.53 +/- 4.12) IU g(-1) Hb, p lt 0.001], glutathione reductase [Al group (1.41 +/- 0.56) IU g(-1) Hb, C group (1.89 +/- 0.57) IU g(-1) Hb, p lt 0.001], glutathione peroxidase [Al group (12.37 +/- 5.76) IU g(-1) Hb, C group (15.54 +/- 4.85) IU g(-1) Hb, p lt 0.001], catalase [Al group (116.76 +/- 26.60) IU g(-1) Hb, C group (158.81 +/- 71.85) IU g(-1) Hb, p lt 0.001] and superoxide dismutase [Al group (1175.8 +/- 149.9) IU mg(-1) Hb, C group (1377.9 +/- 207.5) IU mg(-1) Hb, p lt 0.001].", publisher = "Inst Medical Research & Occupational Health, Zagreb", journal = "Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology", title = "Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium", pages = "87-81", number = "2", volume = "59", doi = "10.2478/10004-1254-59-2008-1853" }
Bulat, P., Potkonjak, B.,& Dujić, I.. (2008). Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium. in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology Inst Medical Research & Occupational Health, Zagreb., 59(2), 81-87. https://doi.org/10.2478/10004-1254-59-2008-1853
Bulat P, Potkonjak B, Dujić I. Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium. in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology. 2008;59(2):81-87. doi:10.2478/10004-1254-59-2008-1853 .
Bulat, Petar, Potkonjak, Bijana, Dujić, Ivana, "Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium" in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology, 59, no. 2 (2008):81-87, https://doi.org/10.2478/10004-1254-59-2008-1853 . .