Somatostatin modulates T cells development in adult rat thymus
Само за регистроване кориснике
2007
Аутори
Petrović-Đergović, Danica M.Rakin, Ana
Kuštrimović, Nataša
Ristovski, Jasmina S.
Dimitrijević, Ljiljana
Mićić, Mileva
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha be...ta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved.
Кључне речи:
rodent / thymus / T cells development / somatostatinИзвор:
Regulatory Peptides, 2007, 142, 3, 101-110Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
DOI: 10.1016/j.regpep.2007.02.003
ISSN: 0167-0115
PubMed: 17391781
WoS: 000248091400005
Scopus: 2-s2.0-34250210744
Институција/група
TorlakTY - JOUR AU - Petrović-Đergović, Danica M. AU - Rakin, Ana AU - Kuštrimović, Nataša AU - Ristovski, Jasmina S. AU - Dimitrijević, Ljiljana AU - Mićić, Mileva PY - 2007 UR - http://intor.torlakinstitut.com/handle/123456789/233 AB - It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha beta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved. PB - Elsevier Science Bv, Amsterdam T2 - Regulatory Peptides T1 - Somatostatin modulates T cells development in adult rat thymus EP - 110 IS - 3 SP - 101 VL - 142 DO - 10.1016/j.regpep.2007.02.003 ER -
@article{ author = "Petrović-Đergović, Danica M. and Rakin, Ana and Kuštrimović, Nataša and Ristovski, Jasmina S. and Dimitrijević, Ljiljana and Mićić, Mileva", year = "2007", abstract = "It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha beta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Regulatory Peptides", title = "Somatostatin modulates T cells development in adult rat thymus", pages = "110-101", number = "3", volume = "142", doi = "10.1016/j.regpep.2007.02.003" }
Petrović-Đergović, D. M., Rakin, A., Kuštrimović, N., Ristovski, J. S., Dimitrijević, L.,& Mićić, M.. (2007). Somatostatin modulates T cells development in adult rat thymus. in Regulatory Peptides Elsevier Science Bv, Amsterdam., 142(3), 101-110. https://doi.org/10.1016/j.regpep.2007.02.003
Petrović-Đergović DM, Rakin A, Kuštrimović N, Ristovski JS, Dimitrijević L, Mićić M. Somatostatin modulates T cells development in adult rat thymus. in Regulatory Peptides. 2007;142(3):101-110. doi:10.1016/j.regpep.2007.02.003 .
Petrović-Đergović, Danica M., Rakin, Ana, Kuštrimović, Nataša, Ristovski, Jasmina S., Dimitrijević, Ljiljana, Mićić, Mileva, "Somatostatin modulates T cells development in adult rat thymus" in Regulatory Peptides, 142, no. 3 (2007):101-110, https://doi.org/10.1016/j.regpep.2007.02.003 . .