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dc.creatorLeposavić, Gordana
dc.creatorRadojević, Katarina
dc.creatorVidić-Danković, Biljana
dc.creatorKosec, Duško
dc.creatorPilipović, Ivan
dc.creatorPerišić, Milica
dc.date.accessioned2021-02-18T10:30:13Z
dc.date.available2021-02-18T10:30:13Z
dc.date.issued2007
dc.identifier.issn0165-5728
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/226
dc.description.abstractThe interactions among the nervous, endocrine and immune system were studied by examining: i) thymic and thymocyte catecholamine levels in adult rats castrated (Cx) at postnatal day 3 and ii) effects of 14-day-long propranolol (P) treatment on main thymocyte differentiational molecule expression in adult non-Cx and Cx rat. The results demonstrated that castration in early postnatal period lowers levels of both neurally- and thymocyte-derived noradrenaline in adult rats, and thereby diminishes beta-adrenoceptor-mediated fine tuning of the T-cell differentiation/maturation. In non-Cx rats P affected TCR alpha beta-dependent stages of thymocyte differentiation/maturation decreasing frequency of CD4+8+ double positive (DP) TCR alpha beta(low) low cells entering selection processes and increasing relative number of positively selected DP TCR alpha beta(high) (most likely due to an increased thymocyte surface density of Thy-1 that is involved in negative control of TCR alpha beta-mediated signaling/selection thresholds) and the most mature CD4+8- TCR alpha beta(high) cells (including CD4+25+ regulatory cells). However, in Cx rats P failed to produce any significant changes in thymocyte subset composition. (c) 2006 Published by Elsevier B.V.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectnoradrenaline levelen
dc.subjectthymusen
dc.subjectthymopoiesisen
dc.subjectbeta-adrenoceptor blockadeen
dc.subjectcastrationen
dc.titleEarly postnatal castration affects thymic and thymocyte noradrenaline levels and beta-adrenoceptor-mediated influence on the thymopoiesis in adult ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage115
dc.citation.issue1-2
dc.citation.other182(1-2): 100-115
dc.citation.rankM22
dc.citation.spage100
dc.citation.volume182
dc.identifier.doi10.1016/j.jneuroim.2006.10.004
dc.identifier.pmid17141332
dc.identifier.rcubconv_188
dc.identifier.scopus2-s2.0-33845958656
dc.identifier.wos000243962200012
dc.type.versionpublishedVersion


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