Приказ основних података о документу

dc.creatorStanojević, Stanislava
dc.creatorVujić, Vesna
dc.creatorKovačević-Jovanović, Vesna
dc.creatorMitić, Katarina
dc.creatorKosec, Duško
dc.creatorvon Hoersten, Stephan
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:29:09Z
dc.date.available2021-02-18T10:29:09Z
dc.date.issued2006
dc.identifier.issn0531-5565
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/211
dc.description.abstractIt is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged rats. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceExperimental Gerontology
dc.subjectinflammationen
dc.subjectmacrophagesen
dc.subjectpeptide YY (PYY)en
dc.subjectY1 receptoren
dc.subjectAlbino Oxford ratsen
dc.titleAge-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cellsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage799
dc.citation.issue8
dc.citation.other41(8): 793-799
dc.citation.rankM21
dc.citation.spage793
dc.citation.volume41
dc.identifier.doi10.1016/j.exger.2006.05.012
dc.identifier.pmid16809015
dc.identifier.scopus2-s2.0-33747094756
dc.identifier.wos000240372700011
dc.type.versionpublishedVersion


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Приказ основних података о документу