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dc.creatorLeposavić, Gordana
dc.creatorArsenović-Ranin, Nevena
dc.creatorRadojević, Katarina
dc.creatorKosec, Duško
dc.creatorPešić, Vesna
dc.creatorVidić-Danković, Biljana
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPilipović, Ivan
dc.date.accessioned2021-02-18T10:28:57Z
dc.date.available2021-02-18T10:28:57Z
dc.date.issued2006
dc.identifier.issn0300-8177
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/208
dc.description.abstractAdult male Wistar rats were subjected to propranolol (P, 0.40 mg/100 g/day) or saline (S) administration (controls) over 14 days. The expression of major differentiation molecules on thymocytes and Thy-1 (CD90) molecules, which are shown to adjust thymocyte sensitivity to TCR alpha beta signaling, was studied. In addition, the sensitivity of thymocytes to induction of apoptosis and concanavalin A (Con A) signaling was estimated. The thymocytes from P-treated (PT) rats exhibited an increased sensitivity to induction of apoptosis, as well as to Con A stimulation. Furthermore, P treatment produced changes in the distribution of thymocyte subsets suggesting that more cells passed positive selection and further differentiated into mature CD4+ or CD8+ single positive (SP) TCR alpha beta(high) cells. These changes may, at least partly, be related to the markedly increased density of Thy-1 surface expression on TCR alpha beta(low) thymocytes from these rats. The increased frequency of cells expressing the CD4+25+ phenotype, which has been shown to be characteristic for regulatory cells in the thymus, may also indicate alterations in thymocyte selection following P treatment. Inasmuch as positive and negative selections play an important role in continuously reshaping the T-cell repertoire and maintaining tolerance, the hereby presented study suggests that pharmacological manipulations with beta-AR signaling, or chemically evoked alterations in catecholamine release, may interfere with the regulation of thymocyte selection, and consequently with the immune response.en
dc.publisherSpringer, Dordrecht
dc.rightsrestrictedAccess
dc.sourceMolecular and Cellular Biochemistry
dc.subjectbeta-adrenoceptor blockadeen
dc.subjectCD90 expressionen
dc.subjectCon Aen
dc.subjectT-cell differentiationen
dc.subjectthymocyte apoptosisen
dc.subjectthymocyte proliferationen
dc.titleCharacterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage99
dc.citation.issue1-2
dc.citation.other285(1-2): 87-99
dc.citation.rankM23
dc.citation.spage87
dc.citation.volume285
dc.identifier.doi10.1007/s11010-005-9059-5
dc.identifier.pmid16477376
dc.identifier.rcubconv_179
dc.identifier.scopus2-s2.0-33646152757
dc.identifier.wos000238521100009
dc.type.versionpublishedVersion


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