Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats

Abstract

This article reports here on the influence of the static magnetic fields ( MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis ( NBM) by intracerebral injection of 5 mu l, 1% AlCl3 into the nucleus. Two AKMA micromagnets ( M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with "N" polarity facing down to the cranial bones in the vicinity of the pineal gland ( PG), immediately after the lesioning of NBM, during the same operation procedure. Ten days after the lesions of NBM, Na, K-ATPase activity on the erythrocyte membranes in the peripheral blood, measured spectrophotometrically, was completely inhibited. Magnetic stimulation ( 60 mT) of the brain during the 10 days significantly increased Na, K-ATPase activity on the erythrocyte membranes of rats with lesioned NBM. This results suggests that altered by lesions Na, K-ATPase activity in an experimental model of Alzheimer's disease might be ameliorated by magnetic stimulation of the brain.