The effects of chronic stress on thymus innervation in the adult rat
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Various stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indic...ate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved.
Кључне речи:
rat / thymus / chronic stress / morphometry / noradrenergic nerve fibers / AChE-positive nerve fibersИзвор:
Acta Histochemica, 2005, 106, 6, 449-458Издавач:
- Elsevier Gmbh, Munich
DOI: 10.1016/j.acthis.2004.11.002
ISSN: 0065-1281
PubMed: 15707654
WoS: 000227722700006
Scopus: 2-s2.0-13644263265
Институција/група
TorlakTY - JOUR AU - Živković, Irena AU - Rakin, Ana AU - Petrović-Đergović, Danica M. AU - Miljković, B. AU - Micić, M. PY - 2005 UR - http://intor.torlakinstitut.com/handle/123456789/195 AB - Various stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indicate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved. PB - Elsevier Gmbh, Munich T2 - Acta Histochemica T1 - The effects of chronic stress on thymus innervation in the adult rat EP - 458 IS - 6 SP - 449 VL - 106 DO - 10.1016/j.acthis.2004.11.002 ER -
@article{ author = "Živković, Irena and Rakin, Ana and Petrović-Đergović, Danica M. and Miljković, B. and Micić, M.", year = "2005", abstract = "Various stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indicate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved.", publisher = "Elsevier Gmbh, Munich", journal = "Acta Histochemica", title = "The effects of chronic stress on thymus innervation in the adult rat", pages = "458-449", number = "6", volume = "106", doi = "10.1016/j.acthis.2004.11.002" }
Živković, I., Rakin, A., Petrović-Đergović, D. M., Miljković, B.,& Micić, M.. (2005). The effects of chronic stress on thymus innervation in the adult rat. in Acta Histochemica Elsevier Gmbh, Munich., 106(6), 449-458. https://doi.org/10.1016/j.acthis.2004.11.002
Živković I, Rakin A, Petrović-Đergović DM, Miljković B, Micić M. The effects of chronic stress on thymus innervation in the adult rat. in Acta Histochemica. 2005;106(6):449-458. doi:10.1016/j.acthis.2004.11.002 .
Živković, Irena, Rakin, Ana, Petrović-Đergović, Danica M., Miljković, B., Micić, M., "The effects of chronic stress on thymus innervation in the adult rat" in Acta Histochemica, 106, no. 6 (2005):449-458, https://doi.org/10.1016/j.acthis.2004.11.002 . .