Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.
Кључне речи:
stress / morphometry / thymocyte subpopulations / apoptosis / corticosterone / thymusИзвор:
Journal of Neuroimmunology, 2005, 160, 1-2, 77-86Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/j.jneuroim.2004.11.002
ISSN: 0165-5728
PubMed: 15710460
WoS: 000227633500010
Scopus: 2-s2.0-13844265652
Институција/група
TorlakTY - JOUR AU - Živković, Irena AU - Rakin, Ana AU - Petrović-Đergović, Danica M. AU - Kosec, Duško AU - Mićić, Mileva PY - 2005 UR - http://intor.torlakinstitut.com/handle/123456789/194 AB - The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus EP - 86 IS - 1-2 SP - 77 VL - 160 DO - 10.1016/j.jneuroim.2004.11.002 ER -
@article{ author = "Živković, Irena and Rakin, Ana and Petrović-Đergović, Danica M. and Kosec, Duško and Mićić, Mileva", year = "2005", abstract = "The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus", pages = "86-77", number = "1-2", volume = "160", doi = "10.1016/j.jneuroim.2004.11.002" }
Živković, I., Rakin, A., Petrović-Đergović, D. M., Kosec, D.,& Mićić, M.. (2005). Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus. in Journal of Neuroimmunology Elsevier, Amsterdam., 160(1-2), 77-86. https://doi.org/10.1016/j.jneuroim.2004.11.002
Živković I, Rakin A, Petrović-Đergović DM, Kosec D, Mićić M. Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus. in Journal of Neuroimmunology. 2005;160(1-2):77-86. doi:10.1016/j.jneuroim.2004.11.002 .
Živković, Irena, Rakin, Ana, Petrović-Đergović, Danica M., Kosec, Duško, Mićić, Mileva, "Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus" in Journal of Neuroimmunology, 160, no. 1-2 (2005):77-86, https://doi.org/10.1016/j.jneuroim.2004.11.002 . .