Prikaz osnovnih podataka o dokumentu
Gonadotropin-releasing hormone agonist administration affects the thymopoiesis in adult female rats independently on gonadal hormone production
dc.creator | Leposavić, Gordana | |
dc.creator | Pekić, S. | |
dc.creator | Kosec, Duško | |
dc.date.accessioned | 2021-02-18T10:27:52Z | |
dc.date.available | 2021-02-18T10:27:52Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 1046-7408 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/192 | |
dc.description.abstract | PROBLEM: In addition to having an indirect effect on the T-cell development by controlling the production of ovarian steroids, an accumulating body of evidence suggest that GnRH analogue (GnRH-A) administration may exert a thymopoietic regulatory effect that is not mediated by ovarian hormones. METHOD OF STUDY: In non-ovariectomized (non-OVX) and OVX adult female AO rats treated s.c. with GnRH-A or saline (controls), over 14 days, were estimated the thymic cellularity and thymocyte expression of CD4/CD8/TCRalphabeta by stereological analysis and three-color flow cytometry, respectively. RESULTS: GnRH-A in both groups of rats diminished the thymic cellularity. In non-OVX rats GnRH-A increased the relative numbers of immature cells (CD4-8-TCRalphabeta(-), CD4-8-TCRalphabeta(low) and CD4+8-TCRalphabeta(low)), and reduced those of positively selected CD4+8+TCRalphabeta(high) and mature (CD4-8+TCRalphabeta(high), CD4+8-TCRalphabeta(high)) cells, suggesting decelerated expression of TCRalphabeta followed by less efficient positive selection and further maturation of the selected cells. Differently, in OVX rats GnRH-A decreased the percentage of immature (CD4-8-TCRalphabeta(-), CD4+8+ TCRalphabeta(-)) cells and increased those of all TCRalphabeta(high) subsets, suggesting an increased rate of early thymocyte differentiation, more efficient positive selection and further maturation of the selected cells. CONCLUSIONS: The effect of GnRH-A administration is affected by the presence of ovarian steroids. | en |
dc.publisher | Wiley, Hoboken | |
dc.rights | restrictedAccess | |
dc.source | American Journal of Reproductive Immunology | |
dc.subject | distribution of thymocyte subsets | en |
dc.subject | GnRH agonist chronic treatment | en |
dc.subject | thymic cellularity | en |
dc.title | Gonadotropin-releasing hormone agonist administration affects the thymopoiesis in adult female rats independently on gonadal hormone production | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 41 | |
dc.citation.issue | 1 | |
dc.citation.other | 53(1): 30-41 | |
dc.citation.rank | M23 | |
dc.citation.spage | 30 | |
dc.citation.volume | 53 | |
dc.identifier.doi | 10.1111/j.1600-0897.2004.00244.x | |
dc.identifier.pmid | 15667523 | |
dc.identifier.scopus | 2-s2.0-13844266205 | |
dc.identifier.wos | 000226513500004 | |
dc.type.version | publishedVersion |