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dc.creatorNave, H.
dc.creatorBedoui, Sammy
dc.creatorMoenter, F.
dc.creatorSteffens, J.
dc.creatorFelies, M.
dc.creatorGebhardt, Thomas
dc.creatorStraub, RH
dc.creatorPabst, R.
dc.creatorDimitrijević, Mirjana
dc.creatorStanojević, Stanislava
dc.creatorvon Hoersten, Stephan
dc.date.accessioned2021-02-18T10:26:39Z
dc.date.available2021-02-18T10:26:39Z
dc.date.issued2004
dc.identifier.issn0165-5728
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/175
dc.description.abstractNeuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectmonocytes/macrophagesen
dc.subjectrodenten
dc.subjectendotoxic shocken
dc.subjectcell traffickingen
dc.subjectlungen
dc.titleReduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage12
dc.citation.issue1-2
dc.citation.other155(1-2): 1-12
dc.citation.rankM22
dc.citation.spage1
dc.citation.volume155
dc.identifier.doi10.1016/j.jneuroim.2004.05.009
dc.identifier.pmid15342191
dc.identifier.scopus2-s2.0-4444240980
dc.identifier.wos000224003900001
dc.type.versionpublishedVersion


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