Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation
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2004
Authors
Nave, H.Bedoui, Sammy
Moenter, F.
Steffens, J.
Felies, M.
Gebhardt, Thomas
Straub, RH
Pabst, R.
Dimitrijević, Mirjana
Stanojević, Stanislava
von Hoersten, Stephan
Article (Published version)
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Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.
Keywords:
monocytes/macrophages / rodent / endotoxic shock / cell trafficking / lungSource:
Journal of Neuroimmunology, 2004, 155, 1-2, 1-12Publisher:
- Elsevier, Amsterdam
DOI: 10.1016/j.jneuroim.2004.05.009
ISSN: 0165-5728
PubMed: 15342191
WoS: 000224003900001
Scopus: 2-s2.0-4444240980
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TorlakTY - JOUR AU - Nave, H. AU - Bedoui, Sammy AU - Moenter, F. AU - Steffens, J. AU - Felies, M. AU - Gebhardt, Thomas AU - Straub, RH AU - Pabst, R. AU - Dimitrijević, Mirjana AU - Stanojević, Stanislava AU - von Hoersten, Stephan PY - 2004 UR - http://intor.torlakinstitut.com/handle/123456789/175 AB - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation EP - 12 IS - 1-2 SP - 1 VL - 155 DO - 10.1016/j.jneuroim.2004.05.009 ER -
@article{ author = "Nave, H. and Bedoui, Sammy and Moenter, F. and Steffens, J. and Felies, M. and Gebhardt, Thomas and Straub, RH and Pabst, R. and Dimitrijević, Mirjana and Stanojević, Stanislava and von Hoersten, Stephan", year = "2004", abstract = "Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation", pages = "12-1", number = "1-2", volume = "155", doi = "10.1016/j.jneuroim.2004.05.009" }
Nave, H., Bedoui, S., Moenter, F., Steffens, J., Felies, M., Gebhardt, T., Straub, R., Pabst, R., Dimitrijević, M., Stanojević, S.,& von Hoersten, S.. (2004). Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology Elsevier, Amsterdam., 155(1-2), 1-12. https://doi.org/10.1016/j.jneuroim.2004.05.009
Nave H, Bedoui S, Moenter F, Steffens J, Felies M, Gebhardt T, Straub R, Pabst R, Dimitrijević M, Stanojević S, von Hoersten S. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology. 2004;155(1-2):1-12. doi:10.1016/j.jneuroim.2004.05.009 .
Nave, H., Bedoui, Sammy, Moenter, F., Steffens, J., Felies, M., Gebhardt, Thomas, Straub, RH, Pabst, R., Dimitrijević, Mirjana, Stanojević, Stanislava, von Hoersten, Stephan, "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation" in Journal of Neuroimmunology, 155, no. 1-2 (2004):1-12, https://doi.org/10.1016/j.jneuroim.2004.05.009 . .