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dc.creatorTodorović, C.
dc.creatorDimitrijević, Mirjana
dc.creatorStanojević, Stanislava
dc.creatorKovačević-Jovanović, Vesna
dc.creatorMiletić, Tatjana
dc.creatorLaban, Olgica
dc.creatorRadulović, Jelena
dc.date.accessioned2021-02-18T10:25:32Z
dc.date.available2021-02-18T10:25:32Z
dc.date.issued2003
dc.identifier.issn0020-7454
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/160
dc.description.abstractWe investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectanalgesiaen
dc.subjectforced-swim testen
dc.subjectmacrophagesen
dc.subjectopen fielden
dc.subjectplaque forming cell responseen
dc.subjectraten
dc.titleCorrelation between age-related changes in open field behavior and plaque forming cell response in DA female ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1273
dc.citation.issue9
dc.citation.other113(9): 1259-1273
dc.citation.rankM23
dc.citation.spage1259
dc.citation.volume113
dc.identifier.doi10.1080/00207450390212492
dc.identifier.pmid12959743
dc.identifier.scopus2-s2.0-0141996941
dc.identifier.wos000185728700007
dc.type.versionpublishedVersion


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