We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a comm...on neuroimmune regulatory mechanism.
Keywords:
analgesia / forced-swim test / macrophages / open field / plaque forming cell response / rat
Source:
International Journal of Neuroscience, 2003, 113, 9, 1259-1273
TY - JOUR
AU - Todorović, C.
AU - Dimitrijević, Mirjana
AU - Stanojević, Stanislava
AU - Kovačević-Jovanović, Vesna
AU - Miletić, Tatjana
AU - Laban, Olgica
AU - Radulović, Jelena
PY - 2003
UR - http://intor.torlakinstitut.com/handle/123456789/160
AB - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
PB - Taylor & Francis Ltd, Abingdon
T2 - International Journal of Neuroscience
T1 - Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats
EP - 1273
IS - 9
SP - 1259
VL - 113
DO - 10.1080/00207450390212492
UR - conv_140
ER -
@article{
author = "Todorović, C. and Dimitrijević, Mirjana and Stanojević, Stanislava and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Laban, Olgica and Radulović, Jelena",
year = "2003",
abstract = "We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats",
pages = "1273-1259",
number = "9",
volume = "113",
doi = "10.1080/00207450390212492",
url = "conv_140"
}
Todorović, C., Dimitrijević, M., Stanojević, S., Kovačević-Jovanović, V., Miletić, T., Laban, O.,& Radulović, J.. (2003). Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 113(9), 1259-1273.
https://doi.org/10.1080/00207450390212492
conv_140
Todorović C, Dimitrijević M, Stanojević S, Kovačević-Jovanović V, Miletić T, Laban O, Radulović J. Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience. 2003;113(9):1259-1273.
doi:10.1080/00207450390212492
conv_140 .
Todorović, C., Dimitrijević, Mirjana, Stanojević, Stanislava, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Laban, Olgica, Radulović, Jelena, "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats" in International Journal of Neuroscience, 113, no. 9 (2003):1259-1273,
https://doi.org/10.1080/00207450390212492 .,
conv_140 .
