Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
Само за регистроване кориснике
2002
Аутори
Popović, N.Popović, M.
Jovanova-Nešić, Katica
Bokonjić, D.
Kostić, V.S.
Šternić, N.
Rakić, L.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p lt .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p lt .001) increase in the number of shocks delive...red before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
Кључне речи:
learned helplessness / neural transplantation / nucleus basalis / magnocellularis / ratИзвор:
International Journal of Neuroscience, 2002, 112, 1, 105-115Издавач:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/00207450212017
ISSN: 0020-7454
PubMed: 12152402
WoS: 000175942100008
Scopus: 2-s2.0-0035991040
Институција/група
TorlakTY - JOUR AU - Popović, N. AU - Popović, M. AU - Jovanova-Nešić, Katica AU - Bokonjić, D. AU - Kostić, V.S. AU - Šternić, N. AU - Rakić, L. PY - 2002 UR - http://intor.torlakinstitut.com/handle/123456789/136 AB - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p lt .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p lt .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis EP - 115 IS - 1 SP - 105 VL - 112 DO - 10.1080/00207450212017 ER -
@article{ author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.", year = "2002", abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p lt .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p lt .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis", pages = "115-105", number = "1", volume = "112", doi = "10.1080/00207450212017" }
Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 112(1), 105-115. https://doi.org/10.1080/00207450212017
Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115. doi:10.1080/00207450212017 .
Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115, https://doi.org/10.1080/00207450212017 . .