Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen
Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena
Abstract
Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova.
Keywords:
experimental allergic encephalomyelitis / DA rats / anti-myelin basic protein antibodiesSource:
Acta veterinaria - Beograd, 2000, 50, 5-6, 289-296Publisher:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Collections
Institution/Community
TorlakTY - JOUR AU - Dimitrijević, Mirjana AU - Laban, Olgica AU - Stanojević, Stanislava AU - Radulović, Jelena PY - 2000 UR - http://intor.torlakinstitut.com/handle/123456789/117 AB - Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats. AB - U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta veterinaria - Beograd T1 - Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen T1 - Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena EP - 296 IS - 5-6 SP - 289 VL - 50 UR - https://hdl.handle.net/21.15107/rcub_intor_117 ER -
@article{ author = "Dimitrijević, Mirjana and Laban, Olgica and Stanojević, Stanislava and Radulović, Jelena", year = "2000", abstract = "Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats., U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta veterinaria - Beograd", title = "Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen, Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena", pages = "296-289", number = "5-6", volume = "50", url = "https://hdl.handle.net/21.15107/rcub_intor_117" }
Dimitrijević, M., Laban, O., Stanojević, S.,& Radulović, J.. (2000). Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen. in Acta veterinaria - Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 50(5-6), 289-296. https://hdl.handle.net/21.15107/rcub_intor_117
Dimitrijević M, Laban O, Stanojević S, Radulović J. Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen. in Acta veterinaria - Beograd. 2000;50(5-6):289-296. https://hdl.handle.net/21.15107/rcub_intor_117 .
Dimitrijević, Mirjana, Laban, Olgica, Stanojević, Stanislava, Radulović, Jelena, "Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen" in Acta veterinaria - Beograd, 50, no. 5-6 (2000):289-296, https://hdl.handle.net/21.15107/rcub_intor_117 .