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Infection-induced autoantibodies and pregnancy related pathology: an animal model

Petrušić, Vladimir; Živković, Irena; Muhandes, Lina; Dimitrijević, Rajna; Stojanović, Marijana; Dimitrijević, Ljiljana

(Csiro Publishing, Clayton, 2014)

TY  - JOUR
AU  - Petrušić, Vladimir
AU  - Živković, Irena
AU  - Muhandes, Lina
AU  - Dimitrijević, Rajna
AU  - Stojanović, Marijana
AU  - Dimitrijević, Ljiljana
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/399
AB  - In addition to being the main cause of mortality worldwide, bacterial and viral infections can be the cause of autoimmune and pregnancy disorders as well. The production of autoantibodies during infection can be explained by various mechanisms, including molecular mimicry, bystander cell activation and epitope spreading. Conversely, bacterial and viral infections during pregnancy are especially dangerous for the fetus. It is documented that infection-induced inflammatory processes mediated by Toll-like receptors (TLR) represent the main cause of preterm labour. We used two crucial bacterial components and TLR ligands, namely peptidoglycan and lipopolysaccharide, to stimulate BALB/c mice before immunisation with tetanus toxoid. Tetanus toxoid is an inactive form of the toxin produced by bacterium Clostridium tetani and shares structural similarity with plasma protein beta(2)-glycoprotein I. Treatment with peptidoglycan and lipopolysaccharide in combination with tetanus toxoid induced the production of pathological autoantibodies, different fluctuations in natural autoantibodies and different types of reproductive pathology in treated animals, with peptidoglycan treatment being more deleterious. We propose that the production of pathological autoantibodies, TLR activation and changes in natural autoantibodies play crucial roles in infection-induced reproductive pathology in our animal model.
PB  - Csiro Publishing, Clayton
T2  - Reproduction Fertility and Development
T1  - Infection-induced autoantibodies and pregnancy related pathology: an animal model
EP  - 586
IS  - 4
SP  - 578
VL  - 26
DO  - 10.1071/RD13057
UR  - conv_337
ER  - 
@article{
author = "Petrušić, Vladimir and Živković, Irena and Muhandes, Lina and Dimitrijević, Rajna and Stojanović, Marijana and Dimitrijević, Ljiljana",
year = "2014",
abstract = "In addition to being the main cause of mortality worldwide, bacterial and viral infections can be the cause of autoimmune and pregnancy disorders as well. The production of autoantibodies during infection can be explained by various mechanisms, including molecular mimicry, bystander cell activation and epitope spreading. Conversely, bacterial and viral infections during pregnancy are especially dangerous for the fetus. It is documented that infection-induced inflammatory processes mediated by Toll-like receptors (TLR) represent the main cause of preterm labour. We used two crucial bacterial components and TLR ligands, namely peptidoglycan and lipopolysaccharide, to stimulate BALB/c mice before immunisation with tetanus toxoid. Tetanus toxoid is an inactive form of the toxin produced by bacterium Clostridium tetani and shares structural similarity with plasma protein beta(2)-glycoprotein I. Treatment with peptidoglycan and lipopolysaccharide in combination with tetanus toxoid induced the production of pathological autoantibodies, different fluctuations in natural autoantibodies and different types of reproductive pathology in treated animals, with peptidoglycan treatment being more deleterious. We propose that the production of pathological autoantibodies, TLR activation and changes in natural autoantibodies play crucial roles in infection-induced reproductive pathology in our animal model.",
publisher = "Csiro Publishing, Clayton",
journal = "Reproduction Fertility and Development",
title = "Infection-induced autoantibodies and pregnancy related pathology: an animal model",
pages = "586-578",
number = "4",
volume = "26",
doi = "10.1071/RD13057",
url = "conv_337"
}
Petrušić, V., Živković, I., Muhandes, L., Dimitrijević, R., Stojanović, M.,& Dimitrijević, L.. (2014). Infection-induced autoantibodies and pregnancy related pathology: an animal model. in Reproduction Fertility and Development
Csiro Publishing, Clayton., 26(4), 578-586.
https://doi.org/10.1071/RD13057
conv_337
Petrušić V, Živković I, Muhandes L, Dimitrijević R, Stojanović M, Dimitrijević L. Infection-induced autoantibodies and pregnancy related pathology: an animal model. in Reproduction Fertility and Development. 2014;26(4):578-586.
doi:10.1071/RD13057
conv_337 .
Petrušić, Vladimir, Živković, Irena, Muhandes, Lina, Dimitrijević, Rajna, Stojanović, Marijana, Dimitrijević, Ljiljana, "Infection-induced autoantibodies and pregnancy related pathology: an animal model" in Reproduction Fertility and Development, 26, no. 4 (2014):578-586,
https://doi.org/10.1071/RD13057 .,
conv_337 .
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Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice

Živković, Irena; Petrušić, Vladimir; Dimitrijević, Rajna; Stojanović, Marijana; Dimitrijević, Ljiljana

(Humana Press Inc, Totowa, 2013)

TY  - JOUR
AU  - Živković, Irena
AU  - Petrušić, Vladimir
AU  - Dimitrijević, Rajna
AU  - Stojanović, Marijana
AU  - Dimitrijević, Ljiljana
PY  - 2013
UR  - http://intor.torlakinstitut.com/handle/123456789/394
AB  - One of the established animal models for autoimmune disease antiphospholipid syndrome (APS) is TTd hyperimmunization of mice. Tetanus toxoid (TTd) and plasma protein beta(2)GPI share structural homology so that immunization with TTd induces appearance of cross-reactive antibodies. In this paper, we have investigated the presence and dynamic of fluctuation of specific (anti-TTd) and auto (anti-beta(2)GPI) antibodies induced in BALB/c mice during secondary immune response after TTd immunization with alhydrogel or glycerol as adjuvants. In addition, we followed the induced reproductive pathology as a sign of autoimmune outcome. We show undoubtedly adjuvant dependance of (1) level of induced anti-TTd IgG antibodies, (2) changes in levels of low-affinity anti-beta(2)GPI IgG antibodies, and (3) change in fecundity and fertility during secondary immune response. These findings once more indicate the importance of chosen adjuvants used for successful immunization and eventual autoantibody outcome, this time associated with the processes involving low affinity, natural antibodies.
PB  - Humana Press Inc, Totowa
T2  - Immunologic Research
T1  - Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice
EP  - 149
IS  - 1
SP  - 143
VL  - 56
DO  - 10.1007/s12026-012-8378-3
UR  - conv_305
ER  - 
@article{
author = "Živković, Irena and Petrušić, Vladimir and Dimitrijević, Rajna and Stojanović, Marijana and Dimitrijević, Ljiljana",
year = "2013",
abstract = "One of the established animal models for autoimmune disease antiphospholipid syndrome (APS) is TTd hyperimmunization of mice. Tetanus toxoid (TTd) and plasma protein beta(2)GPI share structural homology so that immunization with TTd induces appearance of cross-reactive antibodies. In this paper, we have investigated the presence and dynamic of fluctuation of specific (anti-TTd) and auto (anti-beta(2)GPI) antibodies induced in BALB/c mice during secondary immune response after TTd immunization with alhydrogel or glycerol as adjuvants. In addition, we followed the induced reproductive pathology as a sign of autoimmune outcome. We show undoubtedly adjuvant dependance of (1) level of induced anti-TTd IgG antibodies, (2) changes in levels of low-affinity anti-beta(2)GPI IgG antibodies, and (3) change in fecundity and fertility during secondary immune response. These findings once more indicate the importance of chosen adjuvants used for successful immunization and eventual autoantibody outcome, this time associated with the processes involving low affinity, natural antibodies.",
publisher = "Humana Press Inc, Totowa",
journal = "Immunologic Research",
title = "Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice",
pages = "149-143",
number = "1",
volume = "56",
doi = "10.1007/s12026-012-8378-3",
url = "conv_305"
}
Živković, I., Petrušić, V., Dimitrijević, R., Stojanović, M.,& Dimitrijević, L.. (2013). Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice. in Immunologic Research
Humana Press Inc, Totowa., 56(1), 143-149.
https://doi.org/10.1007/s12026-012-8378-3
conv_305
Živković I, Petrušić V, Dimitrijević R, Stojanović M, Dimitrijević L. Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice. in Immunologic Research. 2013;56(1):143-149.
doi:10.1007/s12026-012-8378-3
conv_305 .
Živković, Irena, Petrušić, Vladimir, Dimitrijević, Rajna, Stojanović, Marijana, Dimitrijević, Ljiljana, "Adjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c mice" in Immunologic Research, 56, no. 1 (2013):143-149,
https://doi.org/10.1007/s12026-012-8378-3 .,
conv_305 .
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