TY  - JOUR
AU  - Nave, H.
AU  - Bedoui, Sammy
AU  - Moenter, F.
AU  - Steffens, J.
AU  - Felies, M.
AU  - Gebhardt, Thomas
AU  - Straub, RH
AU  - Pabst, R.
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - von Hoersten, Stephan
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/175
AB  - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation
EP  - 12
IS  - 1-2
SP  - 1
VL  - 155
DO  - 10.1016/j.jneuroim.2004.05.009
ER  - 

@article{
author = "Nave, H. and Bedoui, Sammy and Moenter, F. and Steffens, J. and Felies, M. and Gebhardt, Thomas and Straub, RH and Pabst, R. and Dimitrijević, Mirjana and Stanojević, Stanislava and von Hoersten, Stephan",
year = "2004",
abstract = "Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation",
pages = "12-1",
number = "1-2",
volume = "155",
doi = "10.1016/j.jneuroim.2004.05.009"
}

Nave, H., Bedoui, S., Moenter, F., Steffens, J., Felies, M., Gebhardt, T., Straub, R., Pabst, R., Dimitrijević, M., Stanojević, S.,& von Hoersten, S.. (2004). Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology
Elsevier, Amsterdam., 155(1-2), 1-12.
https://doi.org/10.1016/j.jneuroim.2004.05.009

Nave H, Bedoui S, Moenter F, Steffens J, Felies M, Gebhardt T, Straub R, Pabst R, Dimitrijević M, Stanojević S, von Hoersten S. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology. 2004;155(1-2):1-12.
doi:10.1016/j.jneuroim.2004.05.009 .

Nave, H., Bedoui, Sammy, Moenter, F., Steffens, J., Felies, M., Gebhardt, Thomas, Straub, RH, Pabst, R., Dimitrijević, Mirjana, Stanojević, Stanislava, von Hoersten, Stephan, "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation" in Journal of Neuroimmunology, 155, no. 1-2 (2004):1-12,
https://doi.org/10.1016/j.jneuroim.2004.05.009 . .