TY  - JOUR
AU  - Todorović, C.
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Kovačević-Jovanović, Vesna
AU  - Miletić, Tatjana
AU  - Laban, Olgica
AU  - Radulović, Jelena
PY  - 2003
UR  - http://intor.torlakinstitut.com/handle/123456789/160
AB  - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats
EP  - 1273
IS  - 9
SP  - 1259
VL  - 113
DO  - 10.1080/00207450390212492
ER  - 

@article{
author = "Todorović, C. and Dimitrijević, Mirjana and Stanojević, Stanislava and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Laban, Olgica and Radulović, Jelena",
year = "2003",
abstract = "We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats",
pages = "1273-1259",
number = "9",
volume = "113",
doi = "10.1080/00207450390212492"
}

Todorović, C., Dimitrijević, M., Stanojević, S., Kovačević-Jovanović, V., Miletić, T., Laban, O.,& Radulović, J.. (2003). Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 113(9), 1259-1273.
https://doi.org/10.1080/00207450390212492

Todorović C, Dimitrijević M, Stanojević S, Kovačević-Jovanović V, Miletić T, Laban O, Radulović J. Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience. 2003;113(9):1259-1273.
doi:10.1080/00207450390212492 .

Todorović, C., Dimitrijević, Mirjana, Stanojević, Stanislava, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Laban, Olgica, Radulović, Jelena, "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats" in International Journal of Neuroscience, 113, no. 9 (2003):1259-1273,
https://doi.org/10.1080/00207450390212492 . .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Laban, Olgica
AU  - Đurić, V.J.
AU  - Stanojević, Stanislava
AU  - Miletić, Tatjana
AU  - Kovačević-Jovanović, Vesna
AU  - Todorović, C.
AU  - Radulović, Jelena
PY  - 2001
UR  - http://intor.torlakinstitut.com/handle/123456789/128
AB  - Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.
PB  - Academic Press Inc, San Diego
T2  - Brain Behavior and Immunity
T1  - Behavior and severity of adjuvant arthritis in four rat strains
EP  - 265
IS  - 3
SP  - 255
VL  - 15
DO  - 10.1006/brbi.2000.0599
ER  - 

@article{
author = "Dimitrijević, Mirjana and Laban, Olgica and Đurić, V.J. and Stanojević, Stanislava and Miletić, Tatjana and Kovačević-Jovanović, Vesna and Todorović, C. and Radulović, Jelena",
year = "2001",
abstract = "Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.",
publisher = "Academic Press Inc, San Diego",
journal = "Brain Behavior and Immunity",
title = "Behavior and severity of adjuvant arthritis in four rat strains",
pages = "265-255",
number = "3",
volume = "15",
doi = "10.1006/brbi.2000.0599"
}

Dimitrijević, M., Laban, O., Đurić, V.J., Stanojević, S., Miletić, T., Kovačević-Jovanović, V., Todorović, C.,& Radulović, J.. (2001). Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity
Academic Press Inc, San Diego., 15(3), 255-265.
https://doi.org/10.1006/brbi.2000.0599

Dimitrijević M, Laban O, Đurić V, Stanojević S, Miletić T, Kovačević-Jovanović V, Todorović C, Radulović J. Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity. 2001;15(3):255-265.
doi:10.1006/brbi.2000.0599 .

Dimitrijević, Mirjana, Laban, Olgica, Đurić, V.J., Stanojević, Stanislava, Miletić, Tatjana, Kovačević-Jovanović, Vesna, Todorović, C., Radulović, Jelena, "Behavior and severity of adjuvant arthritis in four rat strains" in Brain Behavior and Immunity, 15, no. 3 (2001):255-265,
https://doi.org/10.1006/brbi.2000.0599 . .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Laban, Olgica
AU  - Stanojević, Stanislava
AU  - Radulović, Jelena
PY  - 2000
UR  - http://intor.torlakinstitut.com/handle/123456789/117
AB  - Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
AB  - U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria - Beograd
T1  - Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen
T1  - Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena
EP  - 296
IS  - 5-6
SP  - 289
VL  - 50
UR  - https://hdl.handle.net/21.15107/rcub_intor_117
ER  - 

@article{
author = "Dimitrijević, Mirjana and Laban, Olgica and Stanojević, Stanislava and Radulović, Jelena",
year = "2000",
abstract = "Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats., U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria - Beograd",
title = "Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen, Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena",
pages = "296-289",
number = "5-6",
volume = "50",
url = "https://hdl.handle.net/21.15107/rcub_intor_117"
}

Dimitrijević, M., Laban, O., Stanojević, S.,& Radulović, J.. (2000). Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen. in Acta veterinaria - Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 50(5-6), 289-296.
https://hdl.handle.net/21.15107/rcub_intor_117

Dimitrijević M, Laban O, Stanojević S, Radulović J. Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen. in Acta veterinaria - Beograd. 2000;50(5-6):289-296.
https://hdl.handle.net/21.15107/rcub_intor_117 .

Dimitrijević, Mirjana, Laban, Olgica, Stanojević, Stanislava, Radulović, Jelena, "Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen" in Acta veterinaria - Beograd, 50, no. 5-6 (2000):289-296,
https://hdl.handle.net/21.15107/rcub_intor_117 .

TY  - JOUR
AU  - Kovačević-Jovanović, Vesna
AU  - Laban, Olgica
AU  - Stanojević, Stanislava
AU  - Miletić, Tatjana
AU  - Dimitrijević, Mirjana
AU  - Radulović, Jelena
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/72
AB  - The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
PB  - Karger, Basel
T2  - Neuroimmunomodulation
T1  - Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat
EP  - 187
IS  - 4
SP  - 181
VL  - 4
DO  - 10.1159/000097336
ER  - 

@article{
author = "Kovačević-Jovanović, Vesna and Laban, Olgica and Stanojević, Stanislava and Miletić, Tatjana and Dimitrijević, Mirjana and Radulović, Jelena",
year = "1997",
abstract = "The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.",
publisher = "Karger, Basel",
journal = "Neuroimmunomodulation",
title = "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat",
pages = "187-181",
number = "4",
volume = "4",
doi = "10.1159/000097336"
}

Kovačević-Jovanović, V., Laban, O., Stanojević, S., Miletić, T., Dimitrijević, M.,& Radulović, J.. (1997). Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation
Karger, Basel., 4(4), 181-187.
https://doi.org/10.1159/000097336

Kovačević-Jovanović V, Laban O, Stanojević S, Miletić T, Dimitrijević M, Radulović J. Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation. 1997;4(4):181-187.
doi:10.1159/000097336 .

Kovačević-Jovanović, Vesna, Laban, Olgica, Stanojević, Stanislava, Miletić, Tatjana, Dimitrijević, Mirjana, Radulović, Jelena, "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat" in Neuroimmunomodulation, 4, no. 4 (1997):181-187,
https://doi.org/10.1159/000097336 . .

TY  - JOUR
AU  - Radulović, Jelena
AU  - Dimitrijević, Mirjana
AU  - Laban, Olgica
AU  - Stanojević, Stanislava
AU  - Vasiljević, T.
AU  - Kovačević-Jovanović, Vesna
AU  - Marković, B.M.
PY  - 1995
UR  - http://intor.torlakinstitut.com/handle/123456789/59
AB  - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.
T2  - Peptides
T1  - Effect of Met-enkephalin and opioid antagonists on rat macrophages
EP  - 1213
IS  - 7
SP  - 1209
VL  - 16
DO  - 10.1016/0196-9781(95)02003-F
ER  - 

@article{
author = "Radulović, Jelena and Dimitrijević, Mirjana and Laban, Olgica and Stanojević, Stanislava and Vasiljević, T. and Kovačević-Jovanović, Vesna and Marković, B.M.",
year = "1995",
abstract = "Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.",
journal = "Peptides",
title = "Effect of Met-enkephalin and opioid antagonists on rat macrophages",
pages = "1213-1209",
number = "7",
volume = "16",
doi = "10.1016/0196-9781(95)02003-F"
}

Radulović, J., Dimitrijević, M., Laban, O., Stanojević, S., Vasiljević, T., Kovačević-Jovanović, V.,& Marković, B.M.. (1995). Effect of Met-enkephalin and opioid antagonists on rat macrophages. in Peptides, 16(7), 1209-1213.
https://doi.org/10.1016/0196-9781(95)02003-F

Radulović J, Dimitrijević M, Laban O, Stanojević S, Vasiljević T, Kovačević-Jovanović V, Marković B. Effect of Met-enkephalin and opioid antagonists on rat macrophages. in Peptides. 1995;16(7):1209-1213.
doi:10.1016/0196-9781(95)02003-F .

Radulović, Jelena, Dimitrijević, Mirjana, Laban, Olgica, Stanojević, Stanislava, Vasiljević, T., Kovačević-Jovanović, Vesna, Marković, B.M., "Effect of Met-enkephalin and opioid antagonists on rat macrophages" in Peptides, 16, no. 7 (1995):1209-1213,
https://doi.org/10.1016/0196-9781(95)02003-F . .