TY  - JOUR
AU  - Todorović, C.
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Kovačević-Jovanović, Vesna
AU  - Miletić, Tatjana
AU  - Laban, Olgica
AU  - Radulović, Jelena
PY  - 2003
UR  - http://intor.torlakinstitut.com/handle/123456789/160
AB  - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats
EP  - 1273
IS  - 9
SP  - 1259
VL  - 113
DO  - 10.1080/00207450390212492
ER  - 

@article{
author = "Todorović, C. and Dimitrijević, Mirjana and Stanojević, Stanislava and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Laban, Olgica and Radulović, Jelena",
year = "2003",
abstract = "We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats",
pages = "1273-1259",
number = "9",
volume = "113",
doi = "10.1080/00207450390212492"
}

Todorović, C., Dimitrijević, M., Stanojević, S., Kovačević-Jovanović, V., Miletić, T., Laban, O.,& Radulović, J.. (2003). Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 113(9), 1259-1273.
https://doi.org/10.1080/00207450390212492

Todorović C, Dimitrijević M, Stanojević S, Kovačević-Jovanović V, Miletić T, Laban O, Radulović J. Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience. 2003;113(9):1259-1273.
doi:10.1080/00207450390212492 .

Todorović, C., Dimitrijević, Mirjana, Stanojević, Stanislava, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Laban, Olgica, Radulović, Jelena, "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats" in International Journal of Neuroscience, 113, no. 9 (2003):1259-1273,
https://doi.org/10.1080/00207450390212492 . .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Laban, Olgica
AU  - Đurić, V.J.
AU  - Stanojević, Stanislava
AU  - Miletić, Tatjana
AU  - Kovačević-Jovanović, Vesna
AU  - Todorović, C.
AU  - Radulović, Jelena
PY  - 2001
UR  - http://intor.torlakinstitut.com/handle/123456789/128
AB  - Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.
PB  - Academic Press Inc, San Diego
T2  - Brain Behavior and Immunity
T1  - Behavior and severity of adjuvant arthritis in four rat strains
EP  - 265
IS  - 3
SP  - 255
VL  - 15
DO  - 10.1006/brbi.2000.0599
ER  - 

@article{
author = "Dimitrijević, Mirjana and Laban, Olgica and Đurić, V.J. and Stanojević, Stanislava and Miletić, Tatjana and Kovačević-Jovanović, Vesna and Todorović, C. and Radulović, Jelena",
year = "2001",
abstract = "Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.",
publisher = "Academic Press Inc, San Diego",
journal = "Brain Behavior and Immunity",
title = "Behavior and severity of adjuvant arthritis in four rat strains",
pages = "265-255",
number = "3",
volume = "15",
doi = "10.1006/brbi.2000.0599"
}

Dimitrijević, M., Laban, O., Đurić, V.J., Stanojević, S., Miletić, T., Kovačević-Jovanović, V., Todorović, C.,& Radulović, J.. (2001). Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity
Academic Press Inc, San Diego., 15(3), 255-265.
https://doi.org/10.1006/brbi.2000.0599

Dimitrijević M, Laban O, Đurić V, Stanojević S, Miletić T, Kovačević-Jovanović V, Todorović C, Radulović J. Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity. 2001;15(3):255-265.
doi:10.1006/brbi.2000.0599 .

Dimitrijević, Mirjana, Laban, Olgica, Đurić, V.J., Stanojević, Stanislava, Miletić, Tatjana, Kovačević-Jovanović, Vesna, Todorović, C., Radulović, Jelena, "Behavior and severity of adjuvant arthritis in four rat strains" in Brain Behavior and Immunity, 15, no. 3 (2001):255-265,
https://doi.org/10.1006/brbi.2000.0599 . .