TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Aleksić, Iva
AU  - Vujić, Vesna
AU  - Stanojević, Stanislava
AU  - Pilipović, Ivan
AU  - von Hoersten, Stephan
AU  - Leposavić, Gordana
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/397
AB  - In humans, usual aging, differently from successful aging, is associated with deregulation of proinflammatory/anti-inflammatory cytokine balance. The corresponding data from rat studies are limited. Therefore, we examined (i) cytokine messenger RNA (mRNA) profile of fresh peritoneal cells from 6-(adult), 24-(old), and 31-month-old (long-lived) AO rats and (ii) proinflammatory (IL-1 beta and IL-6) and antiinflammatory (IL-10) cytokine, NO, and urea production in their LPS-stimulated cultures. Comparing with adult rats, cells from old ones expressed lower amount of TNF-alpha and IL-6 mRNAs, but greater amount of IL-1 beta mRNA. On the other hand, cells fromlong-lived rats exhibited a dramatic increase in IL-10 mRNA expression followed by diminished TNF-alpha and IL-6 mRNA expression, and comparable expression of IL-1 beta mRNA relative to adult rats. Consequently, IL-10/IL-1 beta mRNA ratio was greater in cells from long-lived rats than in adult and old rats. In LPS-stimulated peritoneal cell cultures (contained = 95 % macrophages) from old rats, concentration of common proinflammatory cytokines was higher than in those from adult rats. Comparing with adult and old rats, in LPS-stimulated macrophage cultures from long-lived rats, TNF-alpha and IL-6 concentrations were lower; IL-1 beta concentration was comparable or greater (in respect to adult rats), whereas that of IL-10 was strikingly higher. Consistently, in macrophage cultures from long-lived rats, NO (iNOS activity marker)/urea (arginase activity marker) ratio was less and not different from that in old and adult rats, respectively. The study suggests that macrophages from longlived rats, differently from those of old ones, have substantial ability to limit proinflammatory mediator production, which may contribute to their longevity.
PB  - Springer, Dordrecht
T2  - AGE
T1  - Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1 beta expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro
IS  - 4
VL  - 36
DO  - 10.1007/s11357-014-9696-2
ER  - 

@article{
author = "Dimitrijević, Mirjana and Aleksić, Iva and Vujić, Vesna and Stanojević, Stanislava and Pilipović, Ivan and von Hoersten, Stephan and Leposavić, Gordana",
year = "2014",
abstract = "In humans, usual aging, differently from successful aging, is associated with deregulation of proinflammatory/anti-inflammatory cytokine balance. The corresponding data from rat studies are limited. Therefore, we examined (i) cytokine messenger RNA (mRNA) profile of fresh peritoneal cells from 6-(adult), 24-(old), and 31-month-old (long-lived) AO rats and (ii) proinflammatory (IL-1 beta and IL-6) and antiinflammatory (IL-10) cytokine, NO, and urea production in their LPS-stimulated cultures. Comparing with adult rats, cells from old ones expressed lower amount of TNF-alpha and IL-6 mRNAs, but greater amount of IL-1 beta mRNA. On the other hand, cells fromlong-lived rats exhibited a dramatic increase in IL-10 mRNA expression followed by diminished TNF-alpha and IL-6 mRNA expression, and comparable expression of IL-1 beta mRNA relative to adult rats. Consequently, IL-10/IL-1 beta mRNA ratio was greater in cells from long-lived rats than in adult and old rats. In LPS-stimulated peritoneal cell cultures (contained = 95 % macrophages) from old rats, concentration of common proinflammatory cytokines was higher than in those from adult rats. Comparing with adult and old rats, in LPS-stimulated macrophage cultures from long-lived rats, TNF-alpha and IL-6 concentrations were lower; IL-1 beta concentration was comparable or greater (in respect to adult rats), whereas that of IL-10 was strikingly higher. Consistently, in macrophage cultures from long-lived rats, NO (iNOS activity marker)/urea (arginase activity marker) ratio was less and not different from that in old and adult rats, respectively. The study suggests that macrophages from longlived rats, differently from those of old ones, have substantial ability to limit proinflammatory mediator production, which may contribute to their longevity.",
publisher = "Springer, Dordrecht",
journal = "AGE",
title = "Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1 beta expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro",
number = "4",
volume = "36",
doi = "10.1007/s11357-014-9696-2"
}

Dimitrijević, M., Aleksić, I., Vujić, V., Stanojević, S., Pilipović, I., von Hoersten, S.,& Leposavić, G.. (2014). Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1 beta expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro. in AGE
Springer, Dordrecht., 36(4).
https://doi.org/10.1007/s11357-014-9696-2

Dimitrijević M, Aleksić I, Vujić V, Stanojević S, Pilipović I, von Hoersten S, Leposavić G. Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1 beta expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro. in AGE. 2014;36(4).
doi:10.1007/s11357-014-9696-2 .

Dimitrijević, Mirjana, Aleksić, Iva, Vujić, Vesna, Stanojević, Stanislava, Pilipović, Ivan, von Hoersten, Stephan, Leposavić, Gordana, "Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1 beta expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro" in AGE, 36, no. 4 (2014),
https://doi.org/10.1007/s11357-014-9696-2 . .

TY  - JOUR
AU  - Bedoui, Sammy
AU  - Kromer, Andreas
AU  - Gebhardt, Thomas
AU  - Jacobs, Roland
AU  - Raber, Kerstin
AU  - Dimitrijević, Mirjana
AU  - Heine, Joern
AU  - von Hoersten, Stephan
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/252
AB  - Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species. (C) 2008 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Neuropeptide Y receptor-specifically modulates human neutrophil function
EP  - 95
IS  - 1-2
SP  - 88
VL  - 195
DO  - 10.1016/j.jneuroim.2008.01.012
ER  - 

@article{
author = "Bedoui, Sammy and Kromer, Andreas and Gebhardt, Thomas and Jacobs, Roland and Raber, Kerstin and Dimitrijević, Mirjana and Heine, Joern and von Hoersten, Stephan",
year = "2008",
abstract = "Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species. (C) 2008 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Neuropeptide Y receptor-specifically modulates human neutrophil function",
pages = "95-88",
number = "1-2",
volume = "195",
doi = "10.1016/j.jneuroim.2008.01.012"
}

Bedoui, S., Kromer, A., Gebhardt, T., Jacobs, R., Raber, K., Dimitrijević, M., Heine, J.,& von Hoersten, S.. (2008). Neuropeptide Y receptor-specifically modulates human neutrophil function. in Journal of Neuroimmunology
Elsevier Science Bv, Amsterdam., 195(1-2), 88-95.
https://doi.org/10.1016/j.jneuroim.2008.01.012

Bedoui S, Kromer A, Gebhardt T, Jacobs R, Raber K, Dimitrijević M, Heine J, von Hoersten S. Neuropeptide Y receptor-specifically modulates human neutrophil function. in Journal of Neuroimmunology. 2008;195(1-2):88-95.
doi:10.1016/j.jneuroim.2008.01.012 .

Bedoui, Sammy, Kromer, Andreas, Gebhardt, Thomas, Jacobs, Roland, Raber, Kerstin, Dimitrijević, Mirjana, Heine, Joern, von Hoersten, Stephan, "Neuropeptide Y receptor-specifically modulates human neutrophil function" in Journal of Neuroimmunology, 195, no. 1-2 (2008):88-95,
https://doi.org/10.1016/j.jneuroim.2008.01.012 . .

TY  - CONF
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Mitić, Katarina
AU  - Kosec, Duško
AU  - von Hoersten, Stephan
AU  - Dimitrijević, Mirjana
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/222
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Age-related effect of peptide YY(PYY) on paw edema in rat: The function of Y1 receptors on inflammatory
T1  - Efekat peptida YY(PYY) na edem šape pacova u starenju - uloga Y1 receptora na inflamatornim ćelijama
EP  - 401
IS  - 4
SP  - 400
VL  - 56
UR  - https://hdl.handle.net/21.15107/rcub_intor_222
ER  - 

@conference{
author = "Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and Kosec, Duško and von Hoersten, Stephan and Dimitrijević, Mirjana",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Age-related effect of peptide YY(PYY) on paw edema in rat: The function of Y1 receptors on inflammatory, Efekat peptida YY(PYY) na edem šape pacova u starenju - uloga Y1 receptora na inflamatornim ćelijama",
pages = "401-400",
number = "4",
volume = "56",
url = "https://hdl.handle.net/21.15107/rcub_intor_222"
}

Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., Kosec, D., von Hoersten, S.,& Dimitrijević, M.. (2006). Age-related effect of peptide YY(PYY) on paw edema in rat: The function of Y1 receptors on inflammatory. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 400-401.
https://hdl.handle.net/21.15107/rcub_intor_222

Stanojević S, Vujić V, Kovačević-Jovanović V, Mitić K, Kosec D, von Hoersten S, Dimitrijević M. Age-related effect of peptide YY(PYY) on paw edema in rat: The function of Y1 receptors on inflammatory. in Arhiv za farmaciju. 2006;56(4):400-401.
https://hdl.handle.net/21.15107/rcub_intor_222 .

Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, Kosec, Duško, von Hoersten, Stephan, Dimitrijević, Mirjana, "Age-related effect of peptide YY(PYY) on paw edema in rat: The function of Y1 receptors on inflammatory" in Arhiv za farmaciju, 56, no. 4 (2006):400-401,
https://hdl.handle.net/21.15107/rcub_intor_222 .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Micić, Stana
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Mitić, Katarina
AU  - von Hoersten, Stephan
AU  - Kosec, Duško
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/218
AB  - We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Peptides
T1  - Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch
EP  - 3215
IS  - 12
SP  - 3208
VL  - 27
DO  - 10.1016/j.peptides.2006.08.018
ER  - 

@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Micić, Stana and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and von Hoersten, Stephan and Kosec, Duško",
year = "2006",
abstract = "We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch",
pages = "3215-3208",
number = "12",
volume = "27",
doi = "10.1016/j.peptides.2006.08.018"
}

Dimitrijević, M., Stanojević, S., Micić, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., von Hoersten, S.,& Kosec, D.. (2006). Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides
Elsevier Science Inc, New York., 27(12), 3208-3215.
https://doi.org/10.1016/j.peptides.2006.08.018

Dimitrijević M, Stanojević S, Micić S, Vujić V, Kovačević-Jovanović V, Mitić K, von Hoersten S, Kosec D. Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides. 2006;27(12):3208-3215.
doi:10.1016/j.peptides.2006.08.018 .

Dimitrijević, Mirjana, Stanojević, Stanislava, Micić, Stana, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, von Hoersten, Stephan, Kosec, Duško, "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch" in Peptides, 27, no. 12 (2006):3208-3215,
https://doi.org/10.1016/j.peptides.2006.08.018 . .

TY  - JOUR
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Mitić, Katarina
AU  - Kosec, Duško
AU  - von Hoersten, Stephan
AU  - Dimitrijević, Mirjana
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/211
AB  - It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged rats. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Experimental Gerontology
T1  - Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells
EP  - 799
IS  - 8
SP  - 793
VL  - 41
DO  - 10.1016/j.exger.2006.05.012
ER  - 

@article{
author = "Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and Kosec, Duško and von Hoersten, Stephan and Dimitrijević, Mirjana",
year = "2006",
abstract = "It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged rats. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Experimental Gerontology",
title = "Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells",
pages = "799-793",
number = "8",
volume = "41",
doi = "10.1016/j.exger.2006.05.012"
}

Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., Kosec, D., von Hoersten, S.,& Dimitrijević, M.. (2006). Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells. in Experimental Gerontology
Pergamon-Elsevier Science Ltd, Oxford., 41(8), 793-799.
https://doi.org/10.1016/j.exger.2006.05.012

Stanojević S, Vujić V, Kovačević-Jovanović V, Mitić K, Kosec D, von Hoersten S, Dimitrijević M. Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells. in Experimental Gerontology. 2006;41(8):793-799.
doi:10.1016/j.exger.2006.05.012 .

Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, Kosec, Duško, von Hoersten, Stephan, Dimitrijević, Mirjana, "Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells" in Experimental Gerontology, 41, no. 8 (2006):793-799,
https://doi.org/10.1016/j.exger.2006.05.012 . .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Beck-Sickinger, A.
AU  - von Hoersten, Stephan
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/200
AB  - It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Regulatory Peptides
T1  - Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors
EP  - 172
IS  - 1-3
SP  - 163
VL  - 124
DO  - 10.1016/j.regpep.2004.07.012
ER  - 

@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Beck-Sickinger, A. and von Hoersten, Stephan",
year = "2005",
abstract = "It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Regulatory Peptides",
title = "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors",
pages = "172-163",
number = "1-3",
volume = "124",
doi = "10.1016/j.regpep.2004.07.012"
}

Dimitrijević, M., Stanojević, S., Vujić, V., Beck-Sickinger, A.,& von Hoersten, S.. (2005). Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides
Elsevier, Amsterdam., 124(1-3), 163-172.
https://doi.org/10.1016/j.regpep.2004.07.012

Dimitrijević M, Stanojević S, Vujić V, Beck-Sickinger A, von Hoersten S. Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides. 2005;124(1-3):163-172.
doi:10.1016/j.regpep.2004.07.012 .

Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Beck-Sickinger, A., von Hoersten, Stephan, "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors" in Regulatory Peptides, 124, no. 1-3 (2005):163-172,
https://doi.org/10.1016/j.regpep.2004.07.012 . .

TY  - JOUR
AU  - Nave, H.
AU  - Bedoui, Sammy
AU  - Moenter, F.
AU  - Steffens, J.
AU  - Felies, M.
AU  - Gebhardt, Thomas
AU  - Straub, RH
AU  - Pabst, R.
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - von Hoersten, Stephan
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/175
AB  - Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation
EP  - 12
IS  - 1-2
SP  - 1
VL  - 155
DO  - 10.1016/j.jneuroim.2004.05.009
ER  - 

@article{
author = "Nave, H. and Bedoui, Sammy and Moenter, F. and Steffens, J. and Felies, M. and Gebhardt, Thomas and Straub, RH and Pabst, R. and Dimitrijević, Mirjana and Stanojević, Stanislava and von Hoersten, Stephan",
year = "2004",
abstract = "Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation",
pages = "12-1",
number = "1-2",
volume = "155",
doi = "10.1016/j.jneuroim.2004.05.009"
}

Nave, H., Bedoui, S., Moenter, F., Steffens, J., Felies, M., Gebhardt, T., Straub, R., Pabst, R., Dimitrijević, M., Stanojević, S.,& von Hoersten, S.. (2004). Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology
Elsevier, Amsterdam., 155(1-2), 1-12.
https://doi.org/10.1016/j.jneuroim.2004.05.009

Nave H, Bedoui S, Moenter F, Steffens J, Felies M, Gebhardt T, Straub R, Pabst R, Dimitrijević M, Stanojević S, von Hoersten S. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. in Journal of Neuroimmunology. 2004;155(1-2):1-12.
doi:10.1016/j.jneuroim.2004.05.009 .

Nave, H., Bedoui, Sammy, Moenter, F., Steffens, J., Felies, M., Gebhardt, Thomas, Straub, RH, Pabst, R., Dimitrijević, Mirjana, Stanojević, Stanislava, von Hoersten, Stephan, "Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation" in Journal of Neuroimmunology, 155, no. 1-2 (2004):1-12,
https://doi.org/10.1016/j.jneuroim.2004.05.009 . .

TY  - CONF
AU  - Micić, S.
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - von Hoersten, Stephan
AU  - Dimitrijević, Mirjana
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/167
PB  - Elsevier, Amsterdam
C3  - Journal of Neuroimmunology
T1  - Neuropeptide Y modulates oxidative burst and NO production in carrageenan-elicited granulocytes from rat air pouch
EP  - 129
IS  - 1-2
SP  - 129
VL  - 154
UR  - https://hdl.handle.net/21.15107/rcub_intor_167
ER  - 

@conference{
author = "Micić, S. and Stanojević, Stanislava and Vujić, Vesna and von Hoersten, Stephan and Dimitrijević, Mirjana",
year = "2004",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Neuropeptide Y modulates oxidative burst and NO production in carrageenan-elicited granulocytes from rat air pouch",
pages = "129-129",
number = "1-2",
volume = "154",
url = "https://hdl.handle.net/21.15107/rcub_intor_167"
}

Micić, S., Stanojević, S., Vujić, V., von Hoersten, S.,& Dimitrijević, M.. (2004). Neuropeptide Y modulates oxidative burst and NO production in carrageenan-elicited granulocytes from rat air pouch. in Journal of Neuroimmunology
Elsevier, Amsterdam., 154(1-2), 129-129.
https://hdl.handle.net/21.15107/rcub_intor_167

Micić S, Stanojević S, Vujić V, von Hoersten S, Dimitrijević M. Neuropeptide Y modulates oxidative burst and NO production in carrageenan-elicited granulocytes from rat air pouch. in Journal of Neuroimmunology. 2004;154(1-2):129-129.
https://hdl.handle.net/21.15107/rcub_intor_167 .

Micić, S., Stanojević, Stanislava, Vujić, Vesna, von Hoersten, Stephan, Dimitrijević, Mirjana, "Neuropeptide Y modulates oxidative burst and NO production in carrageenan-elicited granulocytes from rat air pouch" in Journal of Neuroimmunology, 154, no. 1-2 (2004):129-129,
https://hdl.handle.net/21.15107/rcub_intor_167 .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Beck-Sickinger, A.
AU  - Demuth, H.U.
AU  - von Hoersten, Stephan
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/153
AB  - Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)
EP  - 42
IS  - 1-2
SP  - 35
VL  - 129
DO  - 10.1016/S0165-5728(02)00173-X
ER  - 

@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Beck-Sickinger, A. and Demuth, H.U. and von Hoersten, Stephan",
year = "2002",
abstract = "Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)",
pages = "42-35",
number = "1-2",
volume = "129",
doi = "10.1016/S0165-5728(02)00173-X"
}

Dimitrijević, M., Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Beck-Sickinger, A., Demuth, H.U.,& von Hoersten, S.. (2002). Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology
Elsevier, Amsterdam., 129(1-2), 35-42.
https://doi.org/10.1016/S0165-5728(02)00173-X

Dimitrijević M, Stanojević S, Vujić V, Kovačević-Jovanović V, Beck-Sickinger A, Demuth H, von Hoersten S. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology. 2002;129(1-2):35-42.
doi:10.1016/S0165-5728(02)00173-X .

Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Beck-Sickinger, A., Demuth, H.U., von Hoersten, Stephan, "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)" in Journal of Neuroimmunology, 129, no. 1-2 (2002):35-42,
https://doi.org/10.1016/S0165-5728(02)00173-X . .