TY  - JOUR
AU  - Maslovarić, Irina
AU  - Stojković, Aleksandra
AU  - Kosanović, Dejana
AU  - Marković, Dragana
AU  - Ilić, Vesna
AU  - Jovanova-Nešić, Katica
PY  - 2018
UR  - http://intor.torlakinstitut.com/handle/123456789/509
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Vaccination and autoimmunity: Influenza vaccination and association with multiple sclerosis
T1  - Vakcinacija i autoimunost - vakcina protiv gripa i povezanost sa multiplom sklerozom
EP  - 729
IS  - 7
SP  - 721
VL  - 75
DO  - 10.2298/VSP160620002M
ER  - 

@article{
author = "Maslovarić, Irina and Stojković, Aleksandra and Kosanović, Dejana and Marković, Dragana and Ilić, Vesna and Jovanova-Nešić, Katica",
year = "2018",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Vaccination and autoimmunity: Influenza vaccination and association with multiple sclerosis, Vakcinacija i autoimunost - vakcina protiv gripa i povezanost sa multiplom sklerozom",
pages = "729-721",
number = "7",
volume = "75",
doi = "10.2298/VSP160620002M"
}

Maslovarić, I., Stojković, A., Kosanović, D., Marković, D., Ilić, V.,& Jovanova-Nešić, K.. (2018). Vaccination and autoimmunity: Influenza vaccination and association with multiple sclerosis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(7), 721-729.
https://doi.org/10.2298/VSP160620002M

Maslovarić I, Stojković A, Kosanović D, Marković D, Ilić V, Jovanova-Nešić K. Vaccination and autoimmunity: Influenza vaccination and association with multiple sclerosis. in Vojnosanitetski pregled. 2018;75(7):721-729.
doi:10.2298/VSP160620002M .

Maslovarić, Irina, Stojković, Aleksandra, Kosanović, Dejana, Marković, Dragana, Ilić, Vesna, Jovanova-Nešić, Katica, "Vaccination and autoimmunity: Influenza vaccination and association with multiple sclerosis" in Vojnosanitetski pregled, 75, no. 7 (2018):721-729,
https://doi.org/10.2298/VSP160620002M . .

TY  - JOUR
AU  - Maslovarić, Irina
AU  - Stojković, A.
AU  - Kosanović, Dejana
AU  - Marković, D.
AU  - Ilić, Vesna
AU  - Jovanova-Nešić, Katica
PY  - 2017
UR  - http://intor.torlakinstitut.com/handle/123456789/499
AB  - The names of the authors were indicated incorrectly (wrong using of diacritical marks). The names of the authors should be written and read as follows: I. Maslovarić, A. Stojković, D. Kosanović, D. Marković, V. Ilić, and K. Jovanova-Nešić.
PB  - Springer New York LLC
T2  - Neurophysiology
T1  - Correction to: Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus (Neurophysiology, (2017), 49, 4, (276-282), 10.1007/s11062-017-9682-2)
IS  - 5
SP  - 393
VL  - 49
DO  - 10.1007/s11062-018-9699-1
ER  - 

@article{
author = "Maslovarić, Irina and Stojković, A. and Kosanović, Dejana and Marković, D. and Ilić, Vesna and Jovanova-Nešić, Katica",
year = "2017",
abstract = "The names of the authors were indicated incorrectly (wrong using of diacritical marks). The names of the authors should be written and read as follows: I. Maslovarić, A. Stojković, D. Kosanović, D. Marković, V. Ilić, and K. Jovanova-Nešić.",
publisher = "Springer New York LLC",
journal = "Neurophysiology",
title = "Correction to: Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus (Neurophysiology, (2017), 49, 4, (276-282), 10.1007/s11062-017-9682-2)",
number = "5",
pages = "393",
volume = "49",
doi = "10.1007/s11062-018-9699-1"
}

Maslovarić, I., Stojković, A., Kosanović, D., Marković, D., Ilić, V.,& Jovanova-Nešić, K.. (2017). Correction to: Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus (Neurophysiology, (2017), 49, 4, (276-282), 10.1007/s11062-017-9682-2). in Neurophysiology
Springer New York LLC., 49(5), 393.
https://doi.org/10.1007/s11062-018-9699-1

Maslovarić I, Stojković A, Kosanović D, Marković D, Ilić V, Jovanova-Nešić K. Correction to: Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus (Neurophysiology, (2017), 49, 4, (276-282), 10.1007/s11062-017-9682-2). in Neurophysiology. 2017;49(5):393.
doi:10.1007/s11062-018-9699-1 .

Maslovarić, Irina, Stojković, A., Kosanović, Dejana, Marković, D., Ilić, Vesna, Jovanova-Nešić, Katica, "Correction to: Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus (Neurophysiology, (2017), 49, 4, (276-282), 10.1007/s11062-017-9682-2)" in Neurophysiology, 49, no. 5 (2017):393,
https://doi.org/10.1007/s11062-018-9699-1 . .

TY  - JOUR
AU  - Grubor, Nikica M.
AU  - Jovanova-Nešić, Katica
AU  - Shoenfeld, Yehuda
PY  - 2017
UR  - http://intor.torlakinstitut.com/handle/123456789/480
AB  - Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus (E. granulosus). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity. In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of E. granulosus infection in man. The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect E. granulosus from elimination and to minimize host severe pathology. Understanding the immune mechanisms of E. granulosus infection in an intermediate human host will provide, we believe, a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections. Besides that, the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides. More studies for the better understanding of the mechanisms of parasite immune evasion is necessary. It will enable a novel approach in protection, detection and improving of the host inflammatory responses. In contrast, according to the "hygiene hypothesis", clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergic and autoimmune diseases. Thus, an understanding of the immune mechanisms of E. granulosus infection is extremely important.
PB  - Baishideng Publishing Group Inc, Pleasanton
T2  - World Journal of Hepatology
T1  - Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review
EP  - 1189
IS  - 30
SP  - 1176
VL  - 9
DO  - 10.4254/wjh.v9.i30.1176
ER  - 

@article{
author = "Grubor, Nikica M. and Jovanova-Nešić, Katica and Shoenfeld, Yehuda",
year = "2017",
abstract = "Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus (E. granulosus). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity. In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of E. granulosus infection in man. The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect E. granulosus from elimination and to minimize host severe pathology. Understanding the immune mechanisms of E. granulosus infection in an intermediate human host will provide, we believe, a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections. Besides that, the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides. More studies for the better understanding of the mechanisms of parasite immune evasion is necessary. It will enable a novel approach in protection, detection and improving of the host inflammatory responses. In contrast, according to the "hygiene hypothesis", clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergic and autoimmune diseases. Thus, an understanding of the immune mechanisms of E. granulosus infection is extremely important.",
publisher = "Baishideng Publishing Group Inc, Pleasanton",
journal = "World Journal of Hepatology",
title = "Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review",
pages = "1189-1176",
number = "30",
volume = "9",
doi = "10.4254/wjh.v9.i30.1176"
}

Grubor, N. M., Jovanova-Nešić, K.,& Shoenfeld, Y.. (2017). Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review. in World Journal of Hepatology
Baishideng Publishing Group Inc, Pleasanton., 9(30), 1176-1189.
https://doi.org/10.4254/wjh.v9.i30.1176

Grubor NM, Jovanova-Nešić K, Shoenfeld Y. Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review. in World Journal of Hepatology. 2017;9(30):1176-1189.
doi:10.4254/wjh.v9.i30.1176 .

Grubor, Nikica M., Jovanova-Nešić, Katica, Shoenfeld, Yehuda, "Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review" in World Journal of Hepatology, 9, no. 30 (2017):1176-1189,
https://doi.org/10.4254/wjh.v9.i30.1176 . .

TY  - JOUR
AU  - Maslovarić, Irina
AU  - Stojković, A.
AU  - Kosanović, Dejana
AU  - Marković, D.
AU  - Ilić, Vesna
AU  - Jovanova-Nešić, Katica
PY  - 2017
UR  - http://intor.torlakinstitut.com/handle/123456789/488
AB  - We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of the CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization.
PB  - Springer, New York
T2  - Neurophysiology
T1  - Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus
EP  - 282
IS  - 4
SP  - 276
VL  - 49
DO  - 10.1007/s11062-017-9682-2
ER  - 

@article{
author = "Maslovarić, Irina and Stojković, A. and Kosanović, Dejana and Marković, D. and Ilić, Vesna and Jovanova-Nešić, Katica",
year = "2017",
abstract = "We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of the CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization.",
publisher = "Springer, New York",
journal = "Neurophysiology",
title = "Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus",
pages = "282-276",
number = "4",
volume = "49",
doi = "10.1007/s11062-017-9682-2"
}

Maslovarić, I., Stojković, A., Kosanović, D., Marković, D., Ilić, V.,& Jovanova-Nešić, K.. (2017). Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus. in Neurophysiology
Springer, New York., 49(4), 276-282.
https://doi.org/10.1007/s11062-017-9682-2

Maslovarić I, Stojković A, Kosanović D, Marković D, Ilić V, Jovanova-Nešić K. Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus. in Neurophysiology. 2017;49(4):276-282.
doi:10.1007/s11062-017-9682-2 .

Maslovarić, Irina, Stojković, A., Kosanović, Dejana, Marković, D., Ilić, Vesna, Jovanova-Nešić, Katica, "Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus" in Neurophysiology, 49, no. 4 (2017):276-282,
https://doi.org/10.1007/s11062-017-9682-2 . .

TY  - JOUR
AU  - Stojković, Aleksandra
AU  - Kosanović, Dejana
AU  - Maslovarić, Irina
AU  - Jovanova-Nešić, Katica
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/419
AB  - Experimental autoimmune encephalomyelitis (EAE) is characterized by appearance of anti-myelin autoantibodies in the blood and with the increased expression of MHC (major histocompatibility complex) class I and II antigens in the brain tissue. Although there is an evidence of possible linkage between influenza vaccination and development of autoimmune processes, the precise mechanisms of action of this vaccine on EAE-induction is still unclear. In this study, effects of influenza vaccine on clinical sign, antimyelin antibody titer in the blood by ELISA test and expression of MHC class I and II molecules immunohistochemistry were examined in the brain of C57BL mice with EAE. EAE was induced by MOG(35-55) protein in 16 of 32 mice. Influenza split vaccine was administered to eight MOG-induced EAE mice and to eight previously nontreated mice. A significant increase of anti-influenza antibody was detected in vaccinated mice compared to nontreated mice. Also, significant increase of antimyelin antibodies was detected in mice with EAE compared to vaccinated group without EAE and control group, respectively. In EAE-influenza vaccinated mice, a mild but not significant increase of antimyelin antibodies was detected, compared to EAE mice. High expression of MHC-II and mild expression of MHC-I were detected in the brain of mice with EAE. No expressions were detected in vaccinated and normal intact brains. Similar staining was found between EAE-vaccinated and EAE group in both MHC-I and MHC-II expression. The results obtained show that influenza vaccine has no significant influence on EAE induction and severity of autoimmune processes.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Role of inactivated influenza vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis
EP  - 147
IS  - 2
SP  - 139
VL  - 124
DO  - 10.3109/00207454.2013.826658
ER  - 

@article{
author = "Stojković, Aleksandra and Kosanović, Dejana and Maslovarić, Irina and Jovanova-Nešić, Katica",
year = "2014",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is characterized by appearance of anti-myelin autoantibodies in the blood and with the increased expression of MHC (major histocompatibility complex) class I and II antigens in the brain tissue. Although there is an evidence of possible linkage between influenza vaccination and development of autoimmune processes, the precise mechanisms of action of this vaccine on EAE-induction is still unclear. In this study, effects of influenza vaccine on clinical sign, antimyelin antibody titer in the blood by ELISA test and expression of MHC class I and II molecules immunohistochemistry were examined in the brain of C57BL mice with EAE. EAE was induced by MOG(35-55) protein in 16 of 32 mice. Influenza split vaccine was administered to eight MOG-induced EAE mice and to eight previously nontreated mice. A significant increase of anti-influenza antibody was detected in vaccinated mice compared to nontreated mice. Also, significant increase of antimyelin antibodies was detected in mice with EAE compared to vaccinated group without EAE and control group, respectively. In EAE-influenza vaccinated mice, a mild but not significant increase of antimyelin antibodies was detected, compared to EAE mice. High expression of MHC-II and mild expression of MHC-I were detected in the brain of mice with EAE. No expressions were detected in vaccinated and normal intact brains. Similar staining was found between EAE-vaccinated and EAE group in both MHC-I and MHC-II expression. The results obtained show that influenza vaccine has no significant influence on EAE induction and severity of autoimmune processes.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Role of inactivated influenza vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis",
pages = "147-139",
number = "2",
volume = "124",
doi = "10.3109/00207454.2013.826658"
}

Stojković, A., Kosanović, D., Maslovarić, I.,& Jovanova-Nešić, K.. (2014). Role of inactivated influenza vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 124(2), 139-147.
https://doi.org/10.3109/00207454.2013.826658

Stojković A, Kosanović D, Maslovarić I, Jovanova-Nešić K. Role of inactivated influenza vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis. in International Journal of Neuroscience. 2014;124(2):139-147.
doi:10.3109/00207454.2013.826658 .

Stojković, Aleksandra, Kosanović, Dejana, Maslovarić, Irina, Jovanova-Nešić, Katica, "Role of inactivated influenza vaccine in regulation of autoimmune processes in experimental autoimmune encephalomyelitis" in International Journal of Neuroscience, 124, no. 2 (2014):139-147,
https://doi.org/10.3109/00207454.2013.826658 . .

TY  - JOUR
AU  - Kosanović, Dejana
AU  - Stojković, Aleksandra
AU  - Maslovarić, Irina
AU  - Vukov, Natasa
AU  - Jovanova-Nešić, Katica
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/410
AB  - Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P  lt  0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.
PB  - Versita, Warsaw
T2  - Central European Journal of Biology
T1  - Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis
EP  - 248
IS  - 3
SP  - 242
VL  - 9
DO  - 10.2478/s11535-013-0270-1
ER  - 

@article{
author = "Kosanović, Dejana and Stojković, Aleksandra and Maslovarić, Irina and Vukov, Natasa and Jovanova-Nešić, Katica",
year = "2014",
abstract = "Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P  lt  0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Biology",
title = "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis",
pages = "248-242",
number = "3",
volume = "9",
doi = "10.2478/s11535-013-0270-1"
}

Kosanović, D., Stojković, A., Maslovarić, I., Vukov, N.,& Jovanova-Nešić, K.. (2014). Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology
Versita, Warsaw., 9(3), 242-248.
https://doi.org/10.2478/s11535-013-0270-1

Kosanović D, Stojković A, Maslovarić I, Vukov N, Jovanova-Nešić K. Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology. 2014;9(3):242-248.
doi:10.2478/s11535-013-0270-1 .

Kosanović, Dejana, Stojković, Aleksandra, Maslovarić, Irina, Vukov, Natasa, Jovanova-Nešić, Katica, "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis" in Central European Journal of Biology, 9, no. 3 (2014):242-248,
https://doi.org/10.2478/s11535-013-0270-1 . .

TY  - JOUR
AU  - Maslovarić, Irina
AU  - Vukov, Nataša
AU  - Stojković, Aleksandra
AU  - Kosanović, Dejana
AU  - Jovanova-Nešić, Katica
PY  - 2013
UR  - http://intor.torlakinstitut.com/handle/123456789/368
AB  - Myelin oligodendrocyte glycoprotein (MOG) is a protein widely used in the induction of experimental autoimmune encephalomyelitis (EAE) for studying human multiple sclerosis (MS). In C57BL/6 female mice aged eight weeks, we administered subcutaneously MOG35-55 peptide in CFA (complete Freund's adjuvant) along with pertussis vaccine injected intraperitoneally. We observed the sign of flaccid tail as early as thirteen days post-immunization in five of twelve animals. Hematoxylin and eosin staining of paraffin-embedded sections of lymph nodes and spleen revealed the presence of germinal centers in the immunized animals. In the control group of animals, lymphoid follicles without germinal centers were observed. Immunohistochemical staining of spleen sections revealed an expression of MHC II molecules in the EAE-induced group. We would like to point out that even though the clinical signs are mild, the morphological changes are apparent in the lymph nodes and spleen of MOG35-55-immunized mice.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic
EP  - 1322
IS  - 4
SP  - 1317
VL  - 65
DO  - 10.2298/ABS1304317M
ER  - 

@article{
author = "Maslovarić, Irina and Vukov, Nataša and Stojković, Aleksandra and Kosanović, Dejana and Jovanova-Nešić, Katica",
year = "2013",
abstract = "Myelin oligodendrocyte glycoprotein (MOG) is a protein widely used in the induction of experimental autoimmune encephalomyelitis (EAE) for studying human multiple sclerosis (MS). In C57BL/6 female mice aged eight weeks, we administered subcutaneously MOG35-55 peptide in CFA (complete Freund's adjuvant) along with pertussis vaccine injected intraperitoneally. We observed the sign of flaccid tail as early as thirteen days post-immunization in five of twelve animals. Hematoxylin and eosin staining of paraffin-embedded sections of lymph nodes and spleen revealed the presence of germinal centers in the immunized animals. In the control group of animals, lymphoid follicles without germinal centers were observed. Immunohistochemical staining of spleen sections revealed an expression of MHC II molecules in the EAE-induced group. We would like to point out that even though the clinical signs are mild, the morphological changes are apparent in the lymph nodes and spleen of MOG35-55-immunized mice.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic",
pages = "1322-1317",
number = "4",
volume = "65",
doi = "10.2298/ABS1304317M"
}

Maslovarić, I., Vukov, N., Stojković, A., Kosanović, D.,& Jovanova-Nešić, K.. (2013). Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(4), 1317-1322.
https://doi.org/10.2298/ABS1304317M

Maslovarić I, Vukov N, Stojković A, Kosanović D, Jovanova-Nešić K. Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic. in Archives of Biological Sciences. 2013;65(4):1317-1322.
doi:10.2298/ABS1304317M .

Maslovarić, Irina, Vukov, Nataša, Stojković, Aleksandra, Kosanović, Dejana, Jovanova-Nešić, Katica, "Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic" in Archives of Biological Sciences, 65, no. 4 (2013):1317-1322,
https://doi.org/10.2298/ABS1304317M . .

TY  - JOUR
AU  - Spector, Novera Herbert
AU  - Jovanova-Nešić, Katica
AU  - Gertz, A.M.
PY  - 2013
UR  - http://intor.torlakinstitut.com/handle/123456789/379
AB  - First, the latest scientific and clinical reports will be evaluated to separate the wheat from the chaff, that is, good data versus merely anecdotal evidence. Thus, the famous (infamous) Stromboli Cocktail will be brought up to date. Second, longevity statistics will be reviewed: Why do the most scientifically advanced countries have such low (comparatively) life expectancies? Scientific knowledge expands exponentially each decade, whereas there have been no significant advances in our knowledge, government, economics, politics, anti-corruption, and so forth since the dawn of history. What can we expect in the future? Will the human species outlive the cockroach? Can we expect to get closer to that theoretical asymptote of 120 years of human life? Will this ceiling ever be lifted? Finally, we offer two vital challenges to scientists of today.
T2  - Current Aging Science
T1  - Aging, cancer, and longevity: The uncertain road
EP  - 91
IS  - 1
SP  - 86
VL  - 6
DO  - 10.2174/1874609811306010011
ER  - 

@article{
author = "Spector, Novera Herbert and Jovanova-Nešić, Katica and Gertz, A.M.",
year = "2013",
abstract = "First, the latest scientific and clinical reports will be evaluated to separate the wheat from the chaff, that is, good data versus merely anecdotal evidence. Thus, the famous (infamous) Stromboli Cocktail will be brought up to date. Second, longevity statistics will be reviewed: Why do the most scientifically advanced countries have such low (comparatively) life expectancies? Scientific knowledge expands exponentially each decade, whereas there have been no significant advances in our knowledge, government, economics, politics, anti-corruption, and so forth since the dawn of history. What can we expect in the future? Will the human species outlive the cockroach? Can we expect to get closer to that theoretical asymptote of 120 years of human life? Will this ceiling ever be lifted? Finally, we offer two vital challenges to scientists of today.",
journal = "Current Aging Science",
title = "Aging, cancer, and longevity: The uncertain road",
pages = "91-86",
number = "1",
volume = "6",
doi = "10.2174/1874609811306010011"
}

Spector, N. H., Jovanova-Nešić, K.,& Gertz, A.M.. (2013). Aging, cancer, and longevity: The uncertain road. in Current Aging Science, 6(1), 86-91.
https://doi.org/10.2174/1874609811306010011

Spector NH, Jovanova-Nešić K, Gertz A. Aging, cancer, and longevity: The uncertain road. in Current Aging Science. 2013;6(1):86-91.
doi:10.2174/1874609811306010011 .

Spector, Novera Herbert, Jovanova-Nešić, Katica, Gertz, A.M., "Aging, cancer, and longevity: The uncertain road" in Current Aging Science, 6, no. 1 (2013):86-91,
https://doi.org/10.2174/1874609811306010011 . .

TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Shoenfeld, Yehuda
AU  - Spector, Novera Herbert
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/345
AB  - In the central nervous system (CNS) microglia are crucial for the defense of the brain against invading microorganisms, formation of tumors, and damage following trauma [1]. However, uncontrolled activation of these cells may have deleterious outcomes [2] through activation of Fcγ and the complement 3 receptors and the induction of an adaptive immune reaction [3]. Proteins contributing to this reaction are the intercellular adhesion molecule-1 (ICAM-1) [3] and CD3 molecules, among others. Both can be expressed on the glia cells before cytokine release and may facilitate an autoimmune inflammatory reaction in the brain. Round microglial cells among the pyramidal cells of the hippocampus with increased expression of CD32+ (FcγIIa) and near the site of injection of aluminum were detected immunohistochemically and indicate microglial activation at the site of aluminum injury. ICAM-1+ immunoreactivity significantly increased in the hippocampus and in the choroids plexus, indicating increased inflammation in the brain as well as increased CD3ε+ expression in the hippocampus and non-MHC-restricted T cytotoxicity after aluminum injection. The pattern of expression of CD32+ (FcγIIa receptor) near the site of aluminum injection indicates that microglia may play a phagocytic role at the site of aluminum-induced excitotoxicity in the brain. Significant expression of ICAM-1+ and CD3ε + immunoreactive cells with the clusters of ICAM-1+ in the choroid plexus suggests a consequently neurotoxic autoimmune reaction induced by microglial hyperactivation in the injured brain.
T2  - Current Aging Science
T1  - Aluminum excytotoxicity and neuroautotoimmunity: The role of the brain expression of CD32+ (FcγRIIa), ICAM-1+ and CD3ε in aging
EP  - 217
IS  - 3
SP  - 209
VL  - 5
DO  - 10.2174/1874609811205030007
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Shoenfeld, Yehuda and Spector, Novera Herbert",
year = "2012",
abstract = "In the central nervous system (CNS) microglia are crucial for the defense of the brain against invading microorganisms, formation of tumors, and damage following trauma [1]. However, uncontrolled activation of these cells may have deleterious outcomes [2] through activation of Fcγ and the complement 3 receptors and the induction of an adaptive immune reaction [3]. Proteins contributing to this reaction are the intercellular adhesion molecule-1 (ICAM-1) [3] and CD3 molecules, among others. Both can be expressed on the glia cells before cytokine release and may facilitate an autoimmune inflammatory reaction in the brain. Round microglial cells among the pyramidal cells of the hippocampus with increased expression of CD32+ (FcγIIa) and near the site of injection of aluminum were detected immunohistochemically and indicate microglial activation at the site of aluminum injury. ICAM-1+ immunoreactivity significantly increased in the hippocampus and in the choroids plexus, indicating increased inflammation in the brain as well as increased CD3ε+ expression in the hippocampus and non-MHC-restricted T cytotoxicity after aluminum injection. The pattern of expression of CD32+ (FcγIIa receptor) near the site of aluminum injection indicates that microglia may play a phagocytic role at the site of aluminum-induced excitotoxicity in the brain. Significant expression of ICAM-1+ and CD3ε + immunoreactive cells with the clusters of ICAM-1+ in the choroid plexus suggests a consequently neurotoxic autoimmune reaction induced by microglial hyperactivation in the injured brain.",
journal = "Current Aging Science",
title = "Aluminum excytotoxicity and neuroautotoimmunity: The role of the brain expression of CD32+ (FcγRIIa), ICAM-1+ and CD3ε in aging",
pages = "217-209",
number = "3",
volume = "5",
doi = "10.2174/1874609811205030007"
}

Jovanova-Nešić, K., Shoenfeld, Y.,& Spector, N. H.. (2012). Aluminum excytotoxicity and neuroautotoimmunity: The role of the brain expression of CD32+ (FcγRIIa), ICAM-1+ and CD3ε in aging. in Current Aging Science, 5(3), 209-217.
https://doi.org/10.2174/1874609811205030007

Jovanova-Nešić K, Shoenfeld Y, Spector NH. Aluminum excytotoxicity and neuroautotoimmunity: The role of the brain expression of CD32+ (FcγRIIa), ICAM-1+ and CD3ε in aging. in Current Aging Science. 2012;5(3):209-217.
doi:10.2174/1874609811205030007 .

Jovanova-Nešić, Katica, Shoenfeld, Yehuda, Spector, Novera Herbert, "Aluminum excytotoxicity and neuroautotoimmunity: The role of the brain expression of CD32+ (FcγRIIa), ICAM-1+ and CD3ε in aging" in Current Aging Science, 5, no. 3 (2012):209-217,
https://doi.org/10.2174/1874609811205030007 . .

TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Koruga, D.
AU  - Kojić, D.
AU  - Kostić, V.
AU  - Rakić, L.
AU  - Shoenfeld, Yehuda
PY  - 2009
UR  - http://intor.torlakinstitut.com/handle/123456789/291
AB  - Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.
PB  - Wiley-Blackwell, Malden
T2  - Contemporary Challenges in Autoimmunity
T1  - Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE
EP  - 82
SP  - 75
VL  - 1173
DO  - 10.1111/j.1749-6632.2009.04658.x
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Koruga, D. and Kojić, D. and Kostić, V. and Rakić, L. and Shoenfeld, Yehuda",
year = "2009",
abstract = "Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.",
publisher = "Wiley-Blackwell, Malden",
journal = "Contemporary Challenges in Autoimmunity",
title = "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE",
pages = "82-75",
volume = "1173",
doi = "10.1111/j.1749-6632.2009.04658.x"
}

Jovanova-Nešić, K., Koruga, D., Kojić, D., Kostić, V., Rakić, L.,& Shoenfeld, Y.. (2009). Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity
Wiley-Blackwell, Malden., 1173, 75-82.
https://doi.org/10.1111/j.1749-6632.2009.04658.x

Jovanova-Nešić K, Koruga D, Kojić D, Kostić V, Rakić L, Shoenfeld Y. Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity. 2009;1173:75-82.
doi:10.1111/j.1749-6632.2009.04658.x .

Jovanova-Nešić, Katica, Koruga, D., Kojić, D., Kostić, V., Rakić, L., Shoenfeld, Yehuda, "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE" in Contemporary Challenges in Autoimmunity, 1173 (2009):75-82,
https://doi.org/10.1111/j.1749-6632.2009.04658.x . .

TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Jovičić, S.
AU  - Sovilj, M.
AU  - Spector, Novera Herbert
PY  - 2009
UR  - http://intor.torlakinstitut.com/handle/123456789/280
AB  - We are most thankful to Prof. Yehuda Shoenfeld, head of Autoimmunity Center, Sheba Hospital at Tel Aviv, University in Israel, for critical and constructive comments on the manuscript. Thanks to Prof. B. Reljin and N. Stepanic, School of Informational Technology, Universirty of Belgrade for contribution in molecular images and computing analysis. Authors gratefully acknowledge the repeated gifts of the magnetic beads for magnetic brain stimulation of rats presented by Institute for Nuclear Physics, Vincha, Belgrade. Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target
EP  - 1418
IS  - 9
SP  - 1399
VL  - 119
DO  - 10.1080/00207450802324564
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Jovičić, S. and Sovilj, M. and Spector, Novera Herbert",
year = "2009",
abstract = "We are most thankful to Prof. Yehuda Shoenfeld, head of Autoimmunity Center, Sheba Hospital at Tel Aviv, University in Israel, for critical and constructive comments on the manuscript. Thanks to Prof. B. Reljin and N. Stepanic, School of Informational Technology, Universirty of Belgrade for contribution in molecular images and computing analysis. Authors gratefully acknowledge the repeated gifts of the magnetic beads for magnetic brain stimulation of rats presented by Institute for Nuclear Physics, Vincha, Belgrade. Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target",
pages = "1418-1399",
number = "9",
volume = "119",
doi = "10.1080/00207450802324564"
}

Jovanova-Nešić, K., Jovičić, S., Sovilj, M.,& Spector, N. H.. (2009). Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 119(9), 1399-1418.
https://doi.org/10.1080/00207450802324564

Jovanova-Nešić K, Jovičić S, Sovilj M, Spector NH. Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. in International Journal of Neuroscience. 2009;119(9):1399-1418.
doi:10.1080/00207450802324564 .

Jovanova-Nešić, Katica, Jovičić, S., Sovilj, M., Spector, Novera Herbert, "Magnetic brain stimulation upregulates adhesion and prevents EAE: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target" in International Journal of Neuroscience, 119, no. 9 (2009):1399-1418,
https://doi.org/10.1080/00207450802324564 . .

TY  - JOUR
AU  - Erić-Jovičić, Milena
AU  - Popović, Miroljub
AU  - Jovanova-Nešić, Katica
AU  - Popović, Natalija
AU  - Jovičić-Pavlović, Svetlana
AU  - Rakić, Ljubisav
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/247
AB  - Several studies suggested that the activity of erythrocyte Na, K-ATPase declines with aging. Here, it is postulated that alterations in the substrate kinetics of the erythrocyte membrane Na, K-ATPase could be more aggravated in conditions of brain cholinergic dysfunction seen in Alzheimer's disease than in normal aging. To test this hypothesis, we compared the Na, K-ATPase activity (Vmax/Km parameters) in aged rats with those in young rats with brain cholinergic dysfunction induced by electrolytic-, kainic acid-lesioned nucleus basalis magnocellularis (NBM) or by intracerebroventricular AlCl3 administration. In the above mentioned groups, Vmax values were significantly lower in comparison to the control animals. Furthermore, Km values were significantly higher in animals with electrolytic-induced NBM lesions, AlCl3 treated rats and aged animals. However, Km was significantly lower in kainic acid-induced NBM lesions compared to the control group. The Na, K-ATPase catalytic efficiency, estimated by the ratio Vm/Km, decreased as followed: young animals  gt  aged animals  gt  kainic acid lesion  gt  electrolityc lesion  gt  AlCl3. Our data suggest that neurodegenerative processes similar to those seen in Alzheimer's disease affect the sodium/potassium pump functionality which might be detected in peripheral blood erythrocyte membranes.
PB  - IOS Press, Amsterdam
T2  - Journal of Alzheimer's Disease
T1  - Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat
EP  - 93
IS  - 1
SP  - 85
VL  - 14
DO  - 10.3233/JAD-2008-14108
ER  - 

@article{
author = "Erić-Jovičić, Milena and Popović, Miroljub and Jovanova-Nešić, Katica and Popović, Natalija and Jovičić-Pavlović, Svetlana and Rakić, Ljubisav",
year = "2008",
abstract = "Several studies suggested that the activity of erythrocyte Na, K-ATPase declines with aging. Here, it is postulated that alterations in the substrate kinetics of the erythrocyte membrane Na, K-ATPase could be more aggravated in conditions of brain cholinergic dysfunction seen in Alzheimer's disease than in normal aging. To test this hypothesis, we compared the Na, K-ATPase activity (Vmax/Km parameters) in aged rats with those in young rats with brain cholinergic dysfunction induced by electrolytic-, kainic acid-lesioned nucleus basalis magnocellularis (NBM) or by intracerebroventricular AlCl3 administration. In the above mentioned groups, Vmax values were significantly lower in comparison to the control animals. Furthermore, Km values were significantly higher in animals with electrolytic-induced NBM lesions, AlCl3 treated rats and aged animals. However, Km was significantly lower in kainic acid-induced NBM lesions compared to the control group. The Na, K-ATPase catalytic efficiency, estimated by the ratio Vm/Km, decreased as followed: young animals  gt  aged animals  gt  kainic acid lesion  gt  electrolityc lesion  gt  AlCl3. Our data suggest that neurodegenerative processes similar to those seen in Alzheimer's disease affect the sodium/potassium pump functionality which might be detected in peripheral blood erythrocyte membranes.",
publisher = "IOS Press, Amsterdam",
journal = "Journal of Alzheimer's Disease",
title = "Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat",
pages = "93-85",
number = "1",
volume = "14",
doi = "10.3233/JAD-2008-14108"
}

Erić-Jovičić, M., Popović, M., Jovanova-Nešić, K., Popović, N., Jovičić-Pavlović, S.,& Rakić, L.. (2008). Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat. in Journal of Alzheimer's Disease
IOS Press, Amsterdam., 14(1), 85-93.
https://doi.org/10.3233/JAD-2008-14108

Erić-Jovičić M, Popović M, Jovanova-Nešić K, Popović N, Jovičić-Pavlović S, Rakić L. Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat. in Journal of Alzheimer's Disease. 2008;14(1):85-93.
doi:10.3233/JAD-2008-14108 .

Erić-Jovičić, Milena, Popović, Miroljub, Jovanova-Nešić, Katica, Popović, Natalija, Jovičić-Pavlović, Svetlana, Rakić, Ljubisav, "Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat" in Journal of Alzheimer's Disease, 14, no. 1 (2008):85-93,
https://doi.org/10.3233/JAD-2008-14108 . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Shoenfeld, Yehuda
PY  - 2007
UR  - http://intor.torlakinstitut.com/handle/123456789/237
AB  - The aim of the study is to explore the relationship between leakage of the blood-brain barrier and inflammation, the reason why demyelination occurs - seemingly in the absence of an antigen-specific immune response that requires explanation if a coherent account of an inflammatory-mediated demyelination is to be achieved. In this study the cellular biology of the glial cells important for the synthesis and maintenance of central nervous system (CNS) myelin and their inter-relations with other environmental cells (neuronal, microglial, olygodendroglial, astrocytes, endothelial, epithelial, T lymphocytes, B lymphocytes, monocytes, and macrophages) and with the compound of the extracellular matrix (ECM) during the development of an autoimmune inflammatory and demyelinating processes in the brain was analyzed. Upon activation in the peripheral tissue, immune cells reach their target organ via bloodstream and interacting with blood vessels wall components in the absence of exogenous stimulus mount an attack against the local milleu, which is the starting point of a pathogenic inflammatory reaction. Each of these contacts may trigger profuse secretion of cytokines, chemokines, and other soluble inflammatory mediators, which in the CNS by activating of local glial cells and by attracting and stimulating blood-borne monocyte/macrophages can act directly on neural cells and will cause their demyelination.
PB  - Blackwell Publishing Inc.
C3  - Annals of the New York Academy of Sciences
T1  - Autoimmunity in the brain: The pathogenesis insight from cell biology
EP  - 154
SP  - 142
VL  - 1107
DO  - 10.1196/annals.1381.016
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Shoenfeld, Yehuda",
year = "2007",
abstract = "The aim of the study is to explore the relationship between leakage of the blood-brain barrier and inflammation, the reason why demyelination occurs - seemingly in the absence of an antigen-specific immune response that requires explanation if a coherent account of an inflammatory-mediated demyelination is to be achieved. In this study the cellular biology of the glial cells important for the synthesis and maintenance of central nervous system (CNS) myelin and their inter-relations with other environmental cells (neuronal, microglial, olygodendroglial, astrocytes, endothelial, epithelial, T lymphocytes, B lymphocytes, monocytes, and macrophages) and with the compound of the extracellular matrix (ECM) during the development of an autoimmune inflammatory and demyelinating processes in the brain was analyzed. Upon activation in the peripheral tissue, immune cells reach their target organ via bloodstream and interacting with blood vessels wall components in the absence of exogenous stimulus mount an attack against the local milleu, which is the starting point of a pathogenic inflammatory reaction. Each of these contacts may trigger profuse secretion of cytokines, chemokines, and other soluble inflammatory mediators, which in the CNS by activating of local glial cells and by attracting and stimulating blood-borne monocyte/macrophages can act directly on neural cells and will cause their demyelination.",
publisher = "Blackwell Publishing Inc.",
journal = "Annals of the New York Academy of Sciences",
title = "Autoimmunity in the brain: The pathogenesis insight from cell biology",
pages = "154-142",
volume = "1107",
doi = "10.1196/annals.1381.016"
}

Jovanova-Nešić, K.,& Shoenfeld, Y.. (2007). Autoimmunity in the brain: The pathogenesis insight from cell biology. in Annals of the New York Academy of Sciences
Blackwell Publishing Inc.., 1107, 142-154.
https://doi.org/10.1196/annals.1381.016

Jovanova-Nešić K, Shoenfeld Y. Autoimmunity in the brain: The pathogenesis insight from cell biology. in Annals of the New York Academy of Sciences. 2007;1107:142-154.
doi:10.1196/annals.1381.016 .

Jovanova-Nešić, Katica, Shoenfeld, Yehuda, "Autoimmunity in the brain: The pathogenesis insight from cell biology" in Annals of the New York Academy of Sciences, 1107 (2007):142-154,
https://doi.org/10.1196/annals.1381.016 . .

TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Erić-Jovičić, Milena
AU  - Spector, Novera Herbert
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/207
AB  - This article reports here on the influence of the static magnetic fields ( MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis ( NBM) by intracerebral injection of 5 mu l, 1% AlCl3 into the nucleus. Two AKMA micromagnets ( M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with "N" polarity facing down to the cranial bones in the vicinity of the pineal gland ( PG), immediately after the lesioning of NBM, during the same operation procedure. Ten days after the lesions of NBM, Na, K-ATPase activity on the erythrocyte membranes in the peripheral blood, measured spectrophotometrically, was completely inhibited. Magnetic stimulation ( 60 mT) of the brain during the 10 days significantly increased Na, K-ATPase activity on the erythrocyte membranes of rats with lesioned NBM. This results suggests that altered by lesions Na, K-ATPase activity in an experimental model of Alzheimer's disease might be ameliorated by magnetic stimulation of the brain.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats
EP  - 695
IS  - 6
SP  - 681
VL  - 116
DO  - 10.1080/00207450600674830
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Erić-Jovičić, Milena and Spector, Novera Herbert",
year = "2006",
abstract = "This article reports here on the influence of the static magnetic fields ( MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis ( NBM) by intracerebral injection of 5 mu l, 1% AlCl3 into the nucleus. Two AKMA micromagnets ( M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with "N" polarity facing down to the cranial bones in the vicinity of the pineal gland ( PG), immediately after the lesioning of NBM, during the same operation procedure. Ten days after the lesions of NBM, Na, K-ATPase activity on the erythrocyte membranes in the peripheral blood, measured spectrophotometrically, was completely inhibited. Magnetic stimulation ( 60 mT) of the brain during the 10 days significantly increased Na, K-ATPase activity on the erythrocyte membranes of rats with lesioned NBM. This results suggests that altered by lesions Na, K-ATPase activity in an experimental model of Alzheimer's disease might be ameliorated by magnetic stimulation of the brain.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats",
pages = "695-681",
number = "6",
volume = "116",
doi = "10.1080/00207450600674830"
}

Jovanova-Nešić, K., Erić-Jovičić, M.,& Spector, N. H.. (2006). Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 116(6), 681-695.
https://doi.org/10.1080/00207450600674830

Jovanova-Nešić K, Erić-Jovičić M, Spector NH. Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats. in International Journal of Neuroscience. 2006;116(6):681-695.
doi:10.1080/00207450600674830 .

Jovanova-Nešić, Katica, Erić-Jovičić, Milena, Spector, Novera Herbert, "Magnetic stimulation of the brain increase Na+, K+-atpase activity decreased by injection of alcl(3) into nucleus basalis magnocellularis of rats" in International Journal of Neuroscience, 116, no. 6 (2006):681-695,
https://doi.org/10.1080/00207450600674830 . .

TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Janković, B.D.
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/202
AB  - The ultimate goal of this report is to learn how to manipulate the level of memory T cells for more effective treatment of such neurological diseases as multiple sclerosis (MS), where certain T cell subsets recognize self-antigens as opposed to pathogen antigens, and Alzheimer's disease (AD). Brain lesions (electrolitically, by kainic acid, with AlCl, and with 6-OHDA); stimulations (electrical, magnetic, or pharmacological); or restoration of some neurological functions (thermoregulatory and behavioral) by fetal graft allotransplantations in bilaterally lesioned anterior hypothalamic area (AHA-immune regulation) and nucleus basalis magnocellularis (NBM-experimental AD) in our studies were designed to reproduce immune and cognitive deficits induced by lesions of these brain structures. To localize memory traces in the immune system and in the brain we used ethanol and drugs such as kainic acid and 6-OHDA, which have been used very effectively to produce temporary lesions in the brain. Rats showed no learning and memory ability as well as inhibition of immune reactions.
PB  - New York Acad Sciences, New York
T2  - Reversal of Aging: Resetting the Pineal Clock
T1  - The neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of information
EP  - 295
SP  - 279
VL  - 1057
DO  - 10.1196/annals.1356.022
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Janković, B.D.",
year = "2005",
abstract = "The ultimate goal of this report is to learn how to manipulate the level of memory T cells for more effective treatment of such neurological diseases as multiple sclerosis (MS), where certain T cell subsets recognize self-antigens as opposed to pathogen antigens, and Alzheimer's disease (AD). Brain lesions (electrolitically, by kainic acid, with AlCl, and with 6-OHDA); stimulations (electrical, magnetic, or pharmacological); or restoration of some neurological functions (thermoregulatory and behavioral) by fetal graft allotransplantations in bilaterally lesioned anterior hypothalamic area (AHA-immune regulation) and nucleus basalis magnocellularis (NBM-experimental AD) in our studies were designed to reproduce immune and cognitive deficits induced by lesions of these brain structures. To localize memory traces in the immune system and in the brain we used ethanol and drugs such as kainic acid and 6-OHDA, which have been used very effectively to produce temporary lesions in the brain. Rats showed no learning and memory ability as well as inhibition of immune reactions.",
publisher = "New York Acad Sciences, New York",
journal = "Reversal of Aging: Resetting the Pineal Clock",
title = "The neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of information",
pages = "295-279",
volume = "1057",
doi = "10.1196/annals.1356.022"
}

Jovanova-Nešić, K.,& Janković, B.D.. (2005). The neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of information. in Reversal of Aging: Resetting the Pineal Clock
New York Acad Sciences, New York., 1057, 279-295.
https://doi.org/10.1196/annals.1356.022

Jovanova-Nešić K, Janković B. The neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of information. in Reversal of Aging: Resetting the Pineal Clock. 2005;1057:279-295.
doi:10.1196/annals.1356.022 .

Jovanova-Nešić, Katica, Janković, B.D., "The neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of information" in Reversal of Aging: Resetting the Pineal Clock, 1057 (2005):279-295,
https://doi.org/10.1196/annals.1356.022 . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Rakić, L.
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/172
AB  - The objective of this study is to investigate whether chronic ethanol consumption include brain damage expressed as; an increase of antibody titer to S-100 and synaptic membrane proteins, additioning of lateral ventricles volume and increasing within the brain cortex in the rats. After six months of ethanol consumption rats wer tested for antibody titer to S-100, neuron specific enolase (NSE), 14-3-2 and synaptic membrane proteins. In this rat's diameter of anterior, medial and posterior cortical areas and diameter of lateral ventricles were measured after histological examination. Ethanol consumption significantly increases antibody titer to V-100 and synaptic membranes, decrease antibody titer to 14-3-2 protein and do not affect antibody to NSE in peripheral blood of these animals. Additional volume of lateral right and left ventricles indicate that brain atrophy appears after six months of ethanol consumption. Increased diameter of anterior cortical area but not medial and posterior cortical area indicate morphological changes in the brain cortical tissue in prefrontal, and frontal cortical areas that art, responsible for attention memory and associative long-term memory in this part of the brain. Of course, all of these morpho-functional changes in the cortex find some depth structures of the brain might disturb the function of neural networks for abovementioned types of memory in the brain.
PB  - IEEE, New York
C3  - 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL
T1  - Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory
EP  - 170
SP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_intor_172
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Rakić, L.",
year = "2004",
abstract = "The objective of this study is to investigate whether chronic ethanol consumption include brain damage expressed as; an increase of antibody titer to S-100 and synaptic membrane proteins, additioning of lateral ventricles volume and increasing within the brain cortex in the rats. After six months of ethanol consumption rats wer tested for antibody titer to S-100, neuron specific enolase (NSE), 14-3-2 and synaptic membrane proteins. In this rat's diameter of anterior, medial and posterior cortical areas and diameter of lateral ventricles were measured after histological examination. Ethanol consumption significantly increases antibody titer to V-100 and synaptic membranes, decrease antibody titer to 14-3-2 protein and do not affect antibody to NSE in peripheral blood of these animals. Additional volume of lateral right and left ventricles indicate that brain atrophy appears after six months of ethanol consumption. Increased diameter of anterior cortical area but not medial and posterior cortical area indicate morphological changes in the brain cortical tissue in prefrontal, and frontal cortical areas that art, responsible for attention memory and associative long-term memory in this part of the brain. Of course, all of these morpho-functional changes in the cortex find some depth structures of the brain might disturb the function of neural networks for abovementioned types of memory in the brain.",
publisher = "IEEE, New York",
journal = "2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL",
title = "Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory",
pages = "170-165",
url = "https://hdl.handle.net/21.15107/rcub_intor_172"
}

Jovanova-Nešić, K.,& Rakić, L.. (2004). Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory. in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL
IEEE, New York., 165-170.
https://hdl.handle.net/21.15107/rcub_intor_172

Jovanova-Nešić K, Rakić L. Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory. in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL. 2004;:165-170.
https://hdl.handle.net/21.15107/rcub_intor_172 .

Jovanova-Nešić, Katica, Rakić, L., "Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory" in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL (2004):165-170,
https://hdl.handle.net/21.15107/rcub_intor_172 .

TY  - JOUR
AU  - Popović, N.
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Kostić, V.S.
AU  - Šternić, N.
AU  - Rakić, L.
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/136
AB  - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 115
IS  - 1
SP  - 105
VL  - 112
DO  - 10.1080/00207450212017
ER  - 

@article{
author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.",
year = "2002",
abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "115-105",
number = "1",
volume = "112",
doi = "10.1080/00207450212017"
}

Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 112(1), 105-115.
https://doi.org/10.1080/00207450212017

Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115.
doi:10.1080/00207450212017 .

Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115,
https://doi.org/10.1080/00207450212017 . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Erić-Jovičić, Milena
AU  - Popović, M.
AU  - Popović, N.
AU  - Rakić, L.
AU  - Spector, Novera Herbert
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/149
AB  - In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.
PB  - IEEE, New York
C3  - 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
T1  - Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease
EP  - 170
SP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_intor_149
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Erić-Jovičić, Milena and Popović, M. and Popović, N. and Rakić, L. and Spector, Novera Herbert",
year = "2002",
abstract = "In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.",
publisher = "IEEE, New York",
journal = "2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings",
title = "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease",
pages = "170-165",
url = "https://hdl.handle.net/21.15107/rcub_intor_149"
}

Jovanova-Nešić, K., Erić-Jovičić, M., Popović, M., Popović, N., Rakić, L.,& Spector, N. H.. (2002). Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
IEEE, New York., 165-170.
https://hdl.handle.net/21.15107/rcub_intor_149

Jovanova-Nešić K, Erić-Jovičić M, Popović M, Popović N, Rakić L, Spector NH. Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings. 2002;:165-170.
https://hdl.handle.net/21.15107/rcub_intor_149 .

Jovanova-Nešić, Katica, Erić-Jovičić, Milena, Popović, M., Popović, N., Rakić, L., Spector, Novera Herbert, "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease" in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings (2002):165-170,
https://hdl.handle.net/21.15107/rcub_intor_149 .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Erić-Jovičić, Milena
AU  - Jovanova-Nešić, Katica
PY  - 2000
UR  - http://intor.torlakinstitut.com/handle/123456789/122
AB  - The present study was designed to establish the influence of chronic social isolation stress on humoral and cellular immunity in nucleus basalis magnocellularis (NBM)-lesioned rats. Therefore, ten days after bilateral electrolytic lesions of NBM, adult male Wistar rats were immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) and placed individually or in groups of five rats during 21 days. On days 10 and 21 after immunization, the Arthus and delayed hypersensitivity skin reactions to BSA as well as anti-BSA antibody production were determined. On day 10, the diameter and intensity of delayed hypersensitivity skin reaction to BSA were significantly higher in social-isolated rats in comparison with the group-reared ones. On day 21, the diameter and intensity of the Arthus skin reaction were significantly higher in social-isolated rats compared to group-reared rats. Between days 10 and 21, the diameter and intensity of the Arthus skin reaction significantly increased in social-isolated rats, while the diameter of delayed hypersensitivity skin reaction significantly decreased. In contrast to social-isolated rats, there were no significant differences in Arthus and delayed hypersensitivity skin reactions in group-reared rats, between days 10 and 21. Also there were no significant differences in the production of anti-BSA antibody between social-isolated and group-reared rats. The relative spleen weight was significantly lower in social-isolated rats. These data suggest that chronic isolation stress modify humoral and cellular immunity in NBM-lesioned rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress
EP  - 131
IS  - 1-4
SP  - 125
VL  - 100
DO  - 10.3109/00207450008999683
ER  - 

@article{
author = "Popović, M. and Popović, N. and Erić-Jovičić, Milena and Jovanova-Nešić, Katica",
year = "2000",
abstract = "The present study was designed to establish the influence of chronic social isolation stress on humoral and cellular immunity in nucleus basalis magnocellularis (NBM)-lesioned rats. Therefore, ten days after bilateral electrolytic lesions of NBM, adult male Wistar rats were immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) and placed individually or in groups of five rats during 21 days. On days 10 and 21 after immunization, the Arthus and delayed hypersensitivity skin reactions to BSA as well as anti-BSA antibody production were determined. On day 10, the diameter and intensity of delayed hypersensitivity skin reaction to BSA were significantly higher in social-isolated rats in comparison with the group-reared ones. On day 21, the diameter and intensity of the Arthus skin reaction were significantly higher in social-isolated rats compared to group-reared rats. Between days 10 and 21, the diameter and intensity of the Arthus skin reaction significantly increased in social-isolated rats, while the diameter of delayed hypersensitivity skin reaction significantly decreased. In contrast to social-isolated rats, there were no significant differences in Arthus and delayed hypersensitivity skin reactions in group-reared rats, between days 10 and 21. Also there were no significant differences in the production of anti-BSA antibody between social-isolated and group-reared rats. The relative spleen weight was significantly lower in social-isolated rats. These data suggest that chronic isolation stress modify humoral and cellular immunity in NBM-lesioned rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress",
pages = "131-125",
number = "1-4",
volume = "100",
doi = "10.3109/00207450008999683"
}

Popović, M., Popović, N., Erić-Jovičić, M.,& Jovanova-Nešić, K.. (2000). Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 100(1-4), 125-131.
https://doi.org/10.3109/00207450008999683

Popović M, Popović N, Erić-Jovičić M, Jovanova-Nešić K. Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress. in International Journal of Neuroscience. 2000;100(1-4):125-131.
doi:10.3109/00207450008999683 .

Popović, M., Popović, N., Erić-Jovičić, Milena, Jovanova-Nešić, Katica, "Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress" in International Journal of Neuroscience, 100, no. 1-4 (2000):125-131,
https://doi.org/10.3109/00207450008999683 . .

TY  - CONF
AU  - Jovičić, M.M.
AU  - Popović, M.D.
AU  - Popović, N.D.
AU  - Jovičić, S.M.
AU  - Jovanova-Nešić, Katica
PY  - 2000
UR  - http://intor.torlakinstitut.com/handle/123456789/118
PB  - Wiley, Hoboken
C3  - European Journal of Neuroscience
T1  - The effect of verapamil on Na/K-ATPase in the experimental model of the Alzheimer's disease
EP  - 213
SP  - 213
VL  - 12
UR  - https://hdl.handle.net/21.15107/rcub_intor_118
ER  - 

@conference{
author = "Jovičić, M.M. and Popović, M.D. and Popović, N.D. and Jovičić, S.M. and Jovanova-Nešić, Katica",
year = "2000",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neuroscience",
title = "The effect of verapamil on Na/K-ATPase in the experimental model of the Alzheimer's disease",
pages = "213-213",
volume = "12",
url = "https://hdl.handle.net/21.15107/rcub_intor_118"
}

Jovičić, M.M., Popović, M.D., Popović, N.D., Jovičić, S.M.,& Jovanova-Nešić, K.. (2000). The effect of verapamil on Na/K-ATPase in the experimental model of the Alzheimer's disease. in European Journal of Neuroscience
Wiley, Hoboken., 12, 213-213.
https://hdl.handle.net/21.15107/rcub_intor_118

Jovičić M, Popović M, Popović N, Jovičić S, Jovanova-Nešić K. The effect of verapamil on Na/K-ATPase in the experimental model of the Alzheimer's disease. in European Journal of Neuroscience. 2000;12:213-213.
https://hdl.handle.net/21.15107/rcub_intor_118 .

Jovičić, M.M., Popović, M.D., Popović, N.D., Jovičić, S.M., Jovanova-Nešić, Katica, "The effect of verapamil on Na/K-ATPase in the experimental model of the Alzheimer's disease" in European Journal of Neuroscience, 12 (2000):213-213,
https://hdl.handle.net/21.15107/rcub_intor_118 .

TY  - JOUR
AU  - Radojević, Katarina
AU  - Velikinac, S.
AU  - Rauški, Aleksandra
AU  - Vidić, Biljana
AU  - Jovanova-Nešić, Katica
PY  - 1999
UR  - http://intor.torlakinstitut.com/handle/123456789/106
AB  - In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls. Two weeks after the operation, the animals were immunized with sheep red blood cells or bovine serum albumin for determination of plaque forming cell-response and Arthus and delayed hypersensitivity skin reactions, respectively. Unilateral and bilateral lesions of CP considerably suppressed PFC-response and Arthus and delayed the hypersensitivity reactions in comparison to control rats, while no differences were observed between unilaterally and bilaterally lesioned animals. (C) 1999 Elsevier Science Ltd. All rights reserved.
PB  - Elsevier Sci Ltd, Oxford
T2  - Parkinsonism & Related Disorders
T1  - Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat
EP  - 82
IS  - 1-2
SP  - 77
VL  - 5
DO  - 10.1016/S1353-8020(99)00014-0
ER  - 

@article{
author = "Radojević, Katarina and Velikinac, S. and Rauški, Aleksandra and Vidić, Biljana and Jovanova-Nešić, Katica",
year = "1999",
abstract = "In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls. Two weeks after the operation, the animals were immunized with sheep red blood cells or bovine serum albumin for determination of plaque forming cell-response and Arthus and delayed hypersensitivity skin reactions, respectively. Unilateral and bilateral lesions of CP considerably suppressed PFC-response and Arthus and delayed the hypersensitivity reactions in comparison to control rats, while no differences were observed between unilaterally and bilaterally lesioned animals. (C) 1999 Elsevier Science Ltd. All rights reserved.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Parkinsonism & Related Disorders",
title = "Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat",
pages = "82-77",
number = "1-2",
volume = "5",
doi = "10.1016/S1353-8020(99)00014-0"
}

Radojević, K., Velikinac, S., Rauški, A., Vidić, B.,& Jovanova-Nešić, K.. (1999). Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat. in Parkinsonism & Related Disorders
Elsevier Sci Ltd, Oxford., 5(1-2), 77-82.
https://doi.org/10.1016/S1353-8020(99)00014-0

Radojević K, Velikinac S, Rauški A, Vidić B, Jovanova-Nešić K. Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat. in Parkinsonism & Related Disorders. 1999;5(1-2):77-82.
doi:10.1016/S1353-8020(99)00014-0 .

Radojević, Katarina, Velikinac, S., Rauški, Aleksandra, Vidić, Biljana, Jovanova-Nešić, Katica, "Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat" in Parkinsonism & Related Disorders, 5, no. 1-2 (1999):77-82,
https://doi.org/10.1016/S1353-8020(99)00014-0 . .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Ugrešić, Nenad
AU  - Kostić, V.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/81
AB  - The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
EP  - 176
IS  - 3-4
SP  - 165
VL  - 89
DO  - 10.3109/00207459708988472
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Ugrešić, Nenad and Kostić, V. and Rakić, L.",
year = "1997",
abstract = "The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat",
pages = "176-165",
number = "3-4",
volume = "89",
doi = "10.3109/00207459708988472"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Ugrešić, N., Kostić, V.,& Rakić, L.. (1997). Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 89(3-4), 165-176.
https://doi.org/10.3109/00207459708988472

Popović M, Jovanova-Nešić K, Popović N, Ugrešić N, Kostić V, Rakić L. Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience. 1997;89(3-4):165-176.
doi:10.3109/00207459708988472 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Ugrešić, Nenad, Kostić, V., Rakić, L., "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat" in International Journal of Neuroscience, 89, no. 3-4 (1997):165-176,
https://doi.org/10.3109/00207459708988472 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/77
AB  - The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil
EP  - 188
IS  - 3-4
SP  - 181
VL  - 91
DO  - 10.3109/00207459708986375
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Rosić, N.",
year = "1997",
abstract = "The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil",
pages = "188-181",
number = "3-4",
volume = "91",
doi = "10.3109/00207459708986375"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S.,& Rosić, N.. (1997). Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(3-4), 181-188.
https://doi.org/10.3109/00207459708986375

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Rosić N. Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience. 1997;91(3-4):181-188.
doi:10.3109/00207459708986375 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Rosić, N., "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil" in International Journal of Neuroscience, 91, no. 3-4 (1997):181-188,
https://doi.org/10.3109/00207459708986375 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Kostić, V.S.
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/76
AB  - The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease
EP  - 97
IS  - 1-2
SP  - 87
VL  - 90
DO  - 10.3109/00207459709000628
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Kostić, V.S. and Rosić, N.",
year = "1997",
abstract = "The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease",
pages = "97-87",
number = "1-2",
volume = "90",
doi = "10.3109/00207459709000628"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S., Kostić, V.S.,& Rosić, N.. (1997). Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 90(1-2), 87-97.
https://doi.org/10.3109/00207459709000628

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Kostić V, Rosić N. Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1997;90(1-2):87-97.
doi:10.3109/00207459709000628 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Kostić, V.S., Rosić, N., "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 90, no. 1-2 (1997):87-97,
https://doi.org/10.3109/00207459709000628 . .

TY  - JOUR
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Popović, M.
AU  - Bokonjić, D.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/75
AB  - The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex
EP  - +
IS  - 1-2
SP  - 11
VL  - 91
DO  - 10.3109/00207459708986362
ER  - 

@article{
author = "Popović, N. and Jovanova-Nešić, Katica and Popović, M. and Bokonjić, D. and Rakić, L.",
year = "1997",
abstract = "The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex",
pages = "+-11",
number = "1-2",
volume = "91",
doi = "10.3109/00207459708986362"
}

Popović, N., Jovanova-Nešić, K., Popović, M., Bokonjić, D.,& Rakić, L.. (1997). Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(1-2), 11-+.
https://doi.org/10.3109/00207459708986362

Popović N, Jovanova-Nešić K, Popović M, Bokonjić D, Rakić L. Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience. 1997;91(1-2):11-+.
doi:10.3109/00207459708986362 .

Popović, N., Jovanova-Nešić, Katica, Popović, M., Bokonjić, D., Rakić, L., "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex" in International Journal of Neuroscience, 91, no. 1-2 (1997):11-+,
https://doi.org/10.3109/00207459708986362 . .