TY  - JOUR
AU  - Jovanova-Nešić, Katica
AU  - Koruga, D.
AU  - Kojić, D.
AU  - Kostić, V.
AU  - Rakić, L.
AU  - Shoenfeld, Yehuda
PY  - 2009
UR  - http://intor.torlakinstitut.com/handle/123456789/291
AB  - Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.
PB  - Wiley-Blackwell, Malden
T2  - Contemporary Challenges in Autoimmunity
T1  - Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE
EP  - 82
SP  - 75
VL  - 1173
DO  - 10.1111/j.1749-6632.2009.04658.x
ER  - 

@article{
author = "Jovanova-Nešić, Katica and Koruga, D. and Kojić, D. and Kostić, V. and Rakić, L. and Shoenfeld, Yehuda",
year = "2009",
abstract = "Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.",
publisher = "Wiley-Blackwell, Malden",
journal = "Contemporary Challenges in Autoimmunity",
title = "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE",
pages = "82-75",
volume = "1173",
doi = "10.1111/j.1749-6632.2009.04658.x"
}

Jovanova-Nešić, K., Koruga, D., Kojić, D., Kostić, V., Rakić, L.,& Shoenfeld, Y.. (2009). Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity
Wiley-Blackwell, Malden., 1173, 75-82.
https://doi.org/10.1111/j.1749-6632.2009.04658.x

Jovanova-Nešić K, Koruga D, Kojić D, Kostić V, Rakić L, Shoenfeld Y. Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity. 2009;1173:75-82.
doi:10.1111/j.1749-6632.2009.04658.x .

Jovanova-Nešić, Katica, Koruga, D., Kojić, D., Kostić, V., Rakić, L., Shoenfeld, Yehuda, "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE" in Contemporary Challenges in Autoimmunity, 1173 (2009):75-82,
https://doi.org/10.1111/j.1749-6632.2009.04658.x . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Rakić, L.
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/172
AB  - The objective of this study is to investigate whether chronic ethanol consumption include brain damage expressed as; an increase of antibody titer to S-100 and synaptic membrane proteins, additioning of lateral ventricles volume and increasing within the brain cortex in the rats. After six months of ethanol consumption rats wer tested for antibody titer to S-100, neuron specific enolase (NSE), 14-3-2 and synaptic membrane proteins. In this rat's diameter of anterior, medial and posterior cortical areas and diameter of lateral ventricles were measured after histological examination. Ethanol consumption significantly increases antibody titer to V-100 and synaptic membranes, decrease antibody titer to 14-3-2 protein and do not affect antibody to NSE in peripheral blood of these animals. Additional volume of lateral right and left ventricles indicate that brain atrophy appears after six months of ethanol consumption. Increased diameter of anterior cortical area but not medial and posterior cortical area indicate morphological changes in the brain cortical tissue in prefrontal, and frontal cortical areas that art, responsible for attention memory and associative long-term memory in this part of the brain. Of course, all of these morpho-functional changes in the cortex find some depth structures of the brain might disturb the function of neural networks for abovementioned types of memory in the brain.
PB  - IEEE, New York
C3  - 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL
T1  - Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory
EP  - 170
SP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_intor_172
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Rakić, L.",
year = "2004",
abstract = "The objective of this study is to investigate whether chronic ethanol consumption include brain damage expressed as; an increase of antibody titer to S-100 and synaptic membrane proteins, additioning of lateral ventricles volume and increasing within the brain cortex in the rats. After six months of ethanol consumption rats wer tested for antibody titer to S-100, neuron specific enolase (NSE), 14-3-2 and synaptic membrane proteins. In this rat's diameter of anterior, medial and posterior cortical areas and diameter of lateral ventricles were measured after histological examination. Ethanol consumption significantly increases antibody titer to V-100 and synaptic membranes, decrease antibody titer to 14-3-2 protein and do not affect antibody to NSE in peripheral blood of these animals. Additional volume of lateral right and left ventricles indicate that brain atrophy appears after six months of ethanol consumption. Increased diameter of anterior cortical area but not medial and posterior cortical area indicate morphological changes in the brain cortical tissue in prefrontal, and frontal cortical areas that art, responsible for attention memory and associative long-term memory in this part of the brain. Of course, all of these morpho-functional changes in the cortex find some depth structures of the brain might disturb the function of neural networks for abovementioned types of memory in the brain.",
publisher = "IEEE, New York",
journal = "2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL",
title = "Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory",
pages = "170-165",
url = "https://hdl.handle.net/21.15107/rcub_intor_172"
}

Jovanova-Nešić, K.,& Rakić, L.. (2004). Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory. in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL
IEEE, New York., 165-170.
https://hdl.handle.net/21.15107/rcub_intor_172

Jovanova-Nešić K, Rakić L. Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory. in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL. 2004;:165-170.
https://hdl.handle.net/21.15107/rcub_intor_172 .

Jovanova-Nešić, Katica, Rakić, L., "Ethanol consumption affecting some brain proteins and cortical plasticity might disturb the neural networks of long-term memory" in 2004 Seventh Seminar on Neural Network Applications in Electrical Engineering - Proceedings, NEUREL (2004):165-170,
https://hdl.handle.net/21.15107/rcub_intor_172 .

TY  - JOUR
AU  - Popović, N.
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Kostić, V.S.
AU  - Šternić, N.
AU  - Rakić, L.
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/136
AB  - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 115
IS  - 1
SP  - 105
VL  - 112
DO  - 10.1080/00207450212017
ER  - 

@article{
author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.",
year = "2002",
abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "115-105",
number = "1",
volume = "112",
doi = "10.1080/00207450212017"
}

Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 112(1), 105-115.
https://doi.org/10.1080/00207450212017

Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115.
doi:10.1080/00207450212017 .

Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115,
https://doi.org/10.1080/00207450212017 . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Erić-Jovičić, Milena
AU  - Popović, M.
AU  - Popović, N.
AU  - Rakić, L.
AU  - Spector, Novera Herbert
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/149
AB  - In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.
PB  - IEEE, New York
C3  - 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
T1  - Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease
EP  - 170
SP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_intor_149
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Erić-Jovičić, Milena and Popović, M. and Popović, N. and Rakić, L. and Spector, Novera Herbert",
year = "2002",
abstract = "In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.",
publisher = "IEEE, New York",
journal = "2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings",
title = "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease",
pages = "170-165",
url = "https://hdl.handle.net/21.15107/rcub_intor_149"
}

Jovanova-Nešić, K., Erić-Jovičić, M., Popović, M., Popović, N., Rakić, L.,& Spector, N. H.. (2002). Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
IEEE, New York., 165-170.
https://hdl.handle.net/21.15107/rcub_intor_149

Jovanova-Nešić K, Erić-Jovičić M, Popović M, Popović N, Rakić L, Spector NH. Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings. 2002;:165-170.
https://hdl.handle.net/21.15107/rcub_intor_149 .

Jovanova-Nešić, Katica, Erić-Jovičić, Milena, Popović, M., Popović, N., Rakić, L., Spector, Novera Herbert, "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease" in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings (2002):165-170,
https://hdl.handle.net/21.15107/rcub_intor_149 .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Ugrešić, Nenad
AU  - Kostić, V.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/81
AB  - The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
EP  - 176
IS  - 3-4
SP  - 165
VL  - 89
DO  - 10.3109/00207459708988472
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Ugrešić, Nenad and Kostić, V. and Rakić, L.",
year = "1997",
abstract = "The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat",
pages = "176-165",
number = "3-4",
volume = "89",
doi = "10.3109/00207459708988472"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Ugrešić, N., Kostić, V.,& Rakić, L.. (1997). Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 89(3-4), 165-176.
https://doi.org/10.3109/00207459708988472

Popović M, Jovanova-Nešić K, Popović N, Ugrešić N, Kostić V, Rakić L. Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience. 1997;89(3-4):165-176.
doi:10.3109/00207459708988472 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Ugrešić, Nenad, Kostić, V., Rakić, L., "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat" in International Journal of Neuroscience, 89, no. 3-4 (1997):165-176,
https://doi.org/10.3109/00207459708988472 . .

TY  - JOUR
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Popović, M.
AU  - Bokonjić, D.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/75
AB  - The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex
EP  - +
IS  - 1-2
SP  - 11
VL  - 91
DO  - 10.3109/00207459708986362
ER  - 

@article{
author = "Popović, N. and Jovanova-Nešić, Katica and Popović, M. and Bokonjić, D. and Rakić, L.",
year = "1997",
abstract = "The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex",
pages = "+-11",
number = "1-2",
volume = "91",
doi = "10.3109/00207459708986362"
}

Popović, N., Jovanova-Nešić, K., Popović, M., Bokonjić, D.,& Rakić, L.. (1997). Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(1-2), 11-+.
https://doi.org/10.3109/00207459708986362

Popović N, Jovanova-Nešić K, Popović M, Bokonjić D, Rakić L. Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience. 1997;91(1-2):11-+.
doi:10.3109/00207459708986362 .

Popović, N., Jovanova-Nešić, Katica, Popović, M., Bokonjić, D., Rakić, L., "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex" in International Journal of Neuroscience, 91, no. 1-2 (1997):11-+,
https://doi.org/10.3109/00207459708986362 . .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
AU  - Rakić, L.
PY  - 1996
UR  - http://intor.torlakinstitut.com/handle/123456789/66
AB  - Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats
EP  - 299
IS  - 3-4
SP  - 281
VL  - 86
DO  - 10.3109/00207459608986719
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Bokonjić, D. and Dobrić, Silva and Rosić, N. and Rakić, L.",
year = "1996",
abstract = "Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats",
pages = "299-281",
number = "3-4",
volume = "86",
doi = "10.3109/00207459608986719"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Bokonjić, D., Dobrić, S., Rosić, N.,& Rakić, L.. (1996). Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 86(3-4), 281-299.
https://doi.org/10.3109/00207459608986719

Popović M, Jovanova-Nešić K, Popović N, Bokonjić D, Dobrić S, Rosić N, Rakić L. Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience. 1996;86(3-4):281-299.
doi:10.3109/00207459608986719 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Bokonjić, D., Dobrić, Silva, Rosić, N., Rakić, L., "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats" in International Journal of Neuroscience, 86, no. 3-4 (1996):281-299,
https://doi.org/10.3109/00207459608986719 . .