TY  - JOUR
AU  - Ristanović, Elizabeta
AU  - Kokoskov, Nenad S.
AU  - Crozier, Ian
AU  - Kuhn, Jens H.
AU  - Gligić, Ana
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/570
AB  - In 1967, several workers involved in poliomyelitis vaccine development and production fell ill at three different locations in Europe with a severe and often lethal novel disease associated with grivets (Chlorocebus aethiops) imported from Uganda. This disease was named Marburg virus disease (MVD) after the West German town of Marburg an der Lahn, where most human infections and deaths had been recorded. Consequently, the Marburg episode received the most scientific and media attention. Cases that occurred in Frankfurt am Main, West Germany, were also described in commonly accessible scientific literature, although they were less frequently cited than those pertaining to the Marburg infections. However, two infections occurring in a third location, in Belgrade, Yugoslavia, have seemingly been all but forgotten. Due in part to their absence in commonly used databases and in part to the fact that they were written in languages other than English, the important articles describing this part of the outbreak are very rarely cited. Here, we summarize this literature and correct published inaccuracies to remind a younger generation of scientists focusing on Marburg virus and its closest filoviral relatives of this important historical context. Importantly, and unfortunately, the three episodes of infection of 1967 still represent the best in-depth clinical look at MVD in general and in the context of "modern" medicine (fully resourced versus less-resourced capacity) in particular. Hence, each individual case of these episodes holds crucial information for health care providers who may be confronted with MVD today.
PB  - Amer Soc Microbiology, Washington
T2  - Microbiology and Molecular Biology Reviews
T1  - A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967
IS  - 2
VL  - 84
DO  - 10.1128/MMBR.00095-19
ER  - 

@article{
author = "Ristanović, Elizabeta and Kokoskov, Nenad S. and Crozier, Ian and Kuhn, Jens H. and Gligić, Ana",
year = "2020",
abstract = "In 1967, several workers involved in poliomyelitis vaccine development and production fell ill at three different locations in Europe with a severe and often lethal novel disease associated with grivets (Chlorocebus aethiops) imported from Uganda. This disease was named Marburg virus disease (MVD) after the West German town of Marburg an der Lahn, where most human infections and deaths had been recorded. Consequently, the Marburg episode received the most scientific and media attention. Cases that occurred in Frankfurt am Main, West Germany, were also described in commonly accessible scientific literature, although they were less frequently cited than those pertaining to the Marburg infections. However, two infections occurring in a third location, in Belgrade, Yugoslavia, have seemingly been all but forgotten. Due in part to their absence in commonly used databases and in part to the fact that they were written in languages other than English, the important articles describing this part of the outbreak are very rarely cited. Here, we summarize this literature and correct published inaccuracies to remind a younger generation of scientists focusing on Marburg virus and its closest filoviral relatives of this important historical context. Importantly, and unfortunately, the three episodes of infection of 1967 still represent the best in-depth clinical look at MVD in general and in the context of "modern" medicine (fully resourced versus less-resourced capacity) in particular. Hence, each individual case of these episodes holds crucial information for health care providers who may be confronted with MVD today.",
publisher = "Amer Soc Microbiology, Washington",
journal = "Microbiology and Molecular Biology Reviews",
title = "A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967",
number = "2",
volume = "84",
doi = "10.1128/MMBR.00095-19"
}

Ristanović, E., Kokoskov, N. S., Crozier, I., Kuhn, J. H.,& Gligić, A.. (2020). A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967. in Microbiology and Molecular Biology Reviews
Amer Soc Microbiology, Washington., 84(2).
https://doi.org/10.1128/MMBR.00095-19

Ristanović E, Kokoskov NS, Crozier I, Kuhn JH, Gligić A. A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967. in Microbiology and Molecular Biology Reviews. 2020;84(2).
doi:10.1128/MMBR.00095-19 .

Ristanović, Elizabeta, Kokoskov, Nenad S., Crozier, Ian, Kuhn, Jens H., Gligić, Ana, "A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967" in Microbiology and Molecular Biology Reviews, 84, no. 2 (2020),
https://doi.org/10.1128/MMBR.00095-19 . .

TY  - JOUR
AU  - Ristanović, Elizabeta
AU  - Gligić, Ana
AU  - Atanasievska, Sonja
AU  - Protić-Đokić, Vesna
AU  - Jovanović, Dragutin
AU  - Radunović, Miodrag
PY  - 2016
UR  - http://intor.torlakinstitut.com/handle/123456789/463
AB  - Variola (smallpox) virus is classified as class A of potential biological weapons, due to its microbiological, genetic, antigenic and epidemiological characteristics. The potential danger is more real because vaccination against smallpox has stopped since disease eradication in 1979. That is why we want to share our unique, rich experience and acquired knowledge in the fight against this highly contagious and deadly disease during the smallpox outbreak in ex-Yugoslavia in 1972. It was the largest postwar outbreak in Europe when there were officially registered 175 ill patients, 35 of them with lethal outcome. This outbreak was specific by the time of its occurrence, the affected territory, dimensions and some epidemiological characteristics, but also by the well-organized, synchronized and efficient reaction of the competent state services in the fight against it.
PB  - Editrice Kurtis S R L, Milan
T2  - Annali Dell Istituto Superiore di Sanita
T1  - Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972
EP  - 597
IS  - 4
SP  - 587
VL  - 52
DO  - 10.4415/ANN_16_04_21
ER  - 

@article{
author = "Ristanović, Elizabeta and Gligić, Ana and Atanasievska, Sonja and Protić-Đokić, Vesna and Jovanović, Dragutin and Radunović, Miodrag",
year = "2016",
abstract = "Variola (smallpox) virus is classified as class A of potential biological weapons, due to its microbiological, genetic, antigenic and epidemiological characteristics. The potential danger is more real because vaccination against smallpox has stopped since disease eradication in 1979. That is why we want to share our unique, rich experience and acquired knowledge in the fight against this highly contagious and deadly disease during the smallpox outbreak in ex-Yugoslavia in 1972. It was the largest postwar outbreak in Europe when there were officially registered 175 ill patients, 35 of them with lethal outcome. This outbreak was specific by the time of its occurrence, the affected territory, dimensions and some epidemiological characteristics, but also by the well-organized, synchronized and efficient reaction of the competent state services in the fight against it.",
publisher = "Editrice Kurtis S R L, Milan",
journal = "Annali Dell Istituto Superiore di Sanita",
title = "Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972",
pages = "597-587",
number = "4",
volume = "52",
doi = "10.4415/ANN_16_04_21"
}

Ristanović, E., Gligić, A., Atanasievska, S., Protić-Đokić, V., Jovanović, D.,& Radunović, M.. (2016). Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972. in Annali Dell Istituto Superiore di Sanita
Editrice Kurtis S R L, Milan., 52(4), 587-597.
https://doi.org/10.4415/ANN_16_04_21

Ristanović E, Gligić A, Atanasievska S, Protić-Đokić V, Jovanović D, Radunović M. Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972. in Annali Dell Istituto Superiore di Sanita. 2016;52(4):587-597.
doi:10.4415/ANN_16_04_21 .

Ristanović, Elizabeta, Gligić, Ana, Atanasievska, Sonja, Protić-Đokić, Vesna, Jovanović, Dragutin, Radunović, Miodrag, "Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972" in Annali Dell Istituto Superiore di Sanita, 52, no. 4 (2016):587-597,
https://doi.org/10.4415/ANN_16_04_21 . .

TY  - JOUR
AU  - Arsić, Bogdan
AU  - Gligić, Ana
AU  - Ristanović, Elizabeta
AU  - Lako, Branislav
AU  - Potkonjak, Aleksandar
AU  - Peruničić, Milan
AU  - Pavlović, Momčilo
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/403
AB  - Introduction Ehrlichiosis is a bacterial zoonosis transmitted by hematophagous arthropods - ticks. In humans, it occurs as monocytic, granulocytic, and ewingii ehrlichiosis. Pathological process is based on parasitic presence of Ehrlichia organisms within peripheral blood cells - monocytes and granulocytes. Case Outline Fifty-two year old patient was admitted to hospital due to high fever of over 40°C that lasted two days, accompanied with chills, muscle aches, malaise, loss of appetite, headache, confusion, breathing difficulties, and mild dry cough. The history suggested tick bite that occurred seven days before the onset of disease. Doxycycline was introduced and administered for 14 days, causing the disease to subside. Indirect immunofluorescence assay was used to analyze three serum samples obtained from this patient for Ehrlichia chaffeensis antibodies, and peripheral blood smear was evaluated for the presence of Ehrlichia and Ehrlichia aggregation into morulae. Conclusion Ehrlichiosis should be considered in each case where there is a history of tick bite together with the clinical picture (high fever, chills, muscle aches, headache, generalized weakness and malaise, and possible maculopapular rash). The presence of Ehrlichia chaffeensis antibodies was confirmed in a patient with the history of tick bite, appropriate clinical picture and indirect immunofluorescence assay. This confirmed the presence of human monocytotropic ehrlichiosis, a disease that is uncommonly identified in our country.
AB  - Uvod Erlihioza je bakterijska zoonoza koja se prenosi hematofagnim artropodama - krpeljima. Kod ljudi se javlja kao monocitna, granulocitna i ewingii erlihioza. Patološki proces je posledica unutar ćelijskog parazitiranja erlihije u monocitima i granulocitima periferne krvi. Prikaz bolesnika Bolesnik star 52 godine primljen je na odeljenje zbog visoke dvodnevne febrilnosti (preko 40°C) koja je praćena drhtavicom, bolovima u mišićima, malaksalošću, gubitkom apetita, glavoboljom, konfuznošću, otežanim disanjem i oskudnim suvim kašljem. U anamnezi je dobijen podatak o ujedu krpelja sedam dana pre prijema. Laboratorijski nalazi su ukazali na trombocitopeniju, leukopeniju, anemiju i povećanje aktivnosti transaminaza u serumu. Bolesnik je lečen doksiciklinom 14 dana, nakon čega su se tegobe povukle. Metodom indirektne imunofluorescencije analizirana su tri uzorka seruma ovog bolesnika na prisustvo antitela na bakteriju Ehrlichia chaffeensis i pregledan je uzorak razmaza periferne krvi na prisustvo erlihija i konglomerata erlihije u morule, koje predstavljaju citoplazmatske vakuole. Zaključak Kod bolesnika s podatkom o ubodu krpelja, odgovarajućom kliničkom slikom i serološkim testom indirektne imunofluorescencije dokazana su antitela za bakteriju Ehrlichia chaffeensis, što ukazuje na humanu monocitotropnu erlihiozu, bolest koja se kod nas retko dokazuje. Na erlihiozu treba misliti kada uz kliničku sliku (visoka febrilnost, groznica, bolovi u mišićima, glavobolja, opšta slabost i malaksalost, eventualno makulopapulozna ospa) postoji podatak o ubodu krpelja.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - A case of human monocytic ehrlichiosis in Serbia
T1  - Slučaj humane monocitne erlihioze u Srbiji
EP  - 82
IS  - 1-2
SP  - 79
VL  - 142
DO  - 10.2298/SARH1402079A
ER  - 

@article{
author = "Arsić, Bogdan and Gligić, Ana and Ristanović, Elizabeta and Lako, Branislav and Potkonjak, Aleksandar and Peruničić, Milan and Pavlović, Momčilo",
year = "2014",
abstract = "Introduction Ehrlichiosis is a bacterial zoonosis transmitted by hematophagous arthropods - ticks. In humans, it occurs as monocytic, granulocytic, and ewingii ehrlichiosis. Pathological process is based on parasitic presence of Ehrlichia organisms within peripheral blood cells - monocytes and granulocytes. Case Outline Fifty-two year old patient was admitted to hospital due to high fever of over 40°C that lasted two days, accompanied with chills, muscle aches, malaise, loss of appetite, headache, confusion, breathing difficulties, and mild dry cough. The history suggested tick bite that occurred seven days before the onset of disease. Doxycycline was introduced and administered for 14 days, causing the disease to subside. Indirect immunofluorescence assay was used to analyze three serum samples obtained from this patient for Ehrlichia chaffeensis antibodies, and peripheral blood smear was evaluated for the presence of Ehrlichia and Ehrlichia aggregation into morulae. Conclusion Ehrlichiosis should be considered in each case where there is a history of tick bite together with the clinical picture (high fever, chills, muscle aches, headache, generalized weakness and malaise, and possible maculopapular rash). The presence of Ehrlichia chaffeensis antibodies was confirmed in a patient with the history of tick bite, appropriate clinical picture and indirect immunofluorescence assay. This confirmed the presence of human monocytotropic ehrlichiosis, a disease that is uncommonly identified in our country., Uvod Erlihioza je bakterijska zoonoza koja se prenosi hematofagnim artropodama - krpeljima. Kod ljudi se javlja kao monocitna, granulocitna i ewingii erlihioza. Patološki proces je posledica unutar ćelijskog parazitiranja erlihije u monocitima i granulocitima periferne krvi. Prikaz bolesnika Bolesnik star 52 godine primljen je na odeljenje zbog visoke dvodnevne febrilnosti (preko 40°C) koja je praćena drhtavicom, bolovima u mišićima, malaksalošću, gubitkom apetita, glavoboljom, konfuznošću, otežanim disanjem i oskudnim suvim kašljem. U anamnezi je dobijen podatak o ujedu krpelja sedam dana pre prijema. Laboratorijski nalazi su ukazali na trombocitopeniju, leukopeniju, anemiju i povećanje aktivnosti transaminaza u serumu. Bolesnik je lečen doksiciklinom 14 dana, nakon čega su se tegobe povukle. Metodom indirektne imunofluorescencije analizirana su tri uzorka seruma ovog bolesnika na prisustvo antitela na bakteriju Ehrlichia chaffeensis i pregledan je uzorak razmaza periferne krvi na prisustvo erlihija i konglomerata erlihije u morule, koje predstavljaju citoplazmatske vakuole. Zaključak Kod bolesnika s podatkom o ubodu krpelja, odgovarajućom kliničkom slikom i serološkim testom indirektne imunofluorescencije dokazana su antitela za bakteriju Ehrlichia chaffeensis, što ukazuje na humanu monocitotropnu erlihiozu, bolest koja se kod nas retko dokazuje. Na erlihiozu treba misliti kada uz kliničku sliku (visoka febrilnost, groznica, bolovi u mišićima, glavobolja, opšta slabost i malaksalost, eventualno makulopapulozna ospa) postoji podatak o ubodu krpelja.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "A case of human monocytic ehrlichiosis in Serbia, Slučaj humane monocitne erlihioze u Srbiji",
pages = "82-79",
number = "1-2",
volume = "142",
doi = "10.2298/SARH1402079A"
}

Arsić, B., Gligić, A., Ristanović, E., Lako, B., Potkonjak, A., Peruničić, M.,& Pavlović, M.. (2014). A case of human monocytic ehrlichiosis in Serbia. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(1-2), 79-82.
https://doi.org/10.2298/SARH1402079A

Arsić B, Gligić A, Ristanović E, Lako B, Potkonjak A, Peruničić M, Pavlović M. A case of human monocytic ehrlichiosis in Serbia. in Srpski arhiv za celokupno lekarstvo. 2014;142(1-2):79-82.
doi:10.2298/SARH1402079A .

Arsić, Bogdan, Gligić, Ana, Ristanović, Elizabeta, Lako, Branislav, Potkonjak, Aleksandar, Peruničić, Milan, Pavlović, Momčilo, "A case of human monocytic ehrlichiosis in Serbia" in Srpski arhiv za celokupno lekarstvo, 142, no. 1-2 (2014):79-82,
https://doi.org/10.2298/SARH1402079A . .

TY  - JOUR
AU  - Samardžić, Svetomir
AU  - Marinković, Tatjana
AU  - Marinković, Dragan
AU  - Đuricić, Bosiljka
AU  - Ristanović, Elizabeta
AU  - Simović, Tatjana
AU  - Lako, Branislav
AU  - Vukov, Biljana
AU  - Božović, Bojana
AU  - Gligić, Ana
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/258
AB  - We assayed the presence of antibodies specific for Rickettsia typhi, R. akari, and R. conorii in sera of persons from several localities in Serbia with different geographic, climatic, and lifestyle characteristics. Sera from 140 patients with unclear clinical symptoms and 273 healthy persons were tested for the presence of rickettsiae-specific antibodies by indirect immunofluorescence assay. In this study, for the first time we detected the presence of rickettsiae from the spotted fever group in Serbia. We detected the presence of antibodies against R. conorii in the samples from all tested localities. The proportion of positive cases was low in the plain agricultural areas but reached up to 23% in the mountain areas. We also observed a significant number of cases positive for antibodies against R. akari. Antibodies specific for the antigens of R. typhi were detected in only 2 samples from the municipality of Pec (Kosovo region). These findings contribute to the prevalence of Rickettsia species in Southeast Europe. Our study also revealed a dramatic lack of awareness of rickettsioses among medical personnel and pointed to the need for urgent measures that would help improve the current situation in the region.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Vector-Borne and Zoonotic Diseases
T1  - Prevalence of antibodies to Rickettsiae in different regions of Serbia
EP  - 224
IS  - 2
SP  - 219
VL  - 8
DO  - 10.1089/vbz.2007.0122
ER  - 

@article{
author = "Samardžić, Svetomir and Marinković, Tatjana and Marinković, Dragan and Đuricić, Bosiljka and Ristanović, Elizabeta and Simović, Tatjana and Lako, Branislav and Vukov, Biljana and Božović, Bojana and Gligić, Ana",
year = "2008",
abstract = "We assayed the presence of antibodies specific for Rickettsia typhi, R. akari, and R. conorii in sera of persons from several localities in Serbia with different geographic, climatic, and lifestyle characteristics. Sera from 140 patients with unclear clinical symptoms and 273 healthy persons were tested for the presence of rickettsiae-specific antibodies by indirect immunofluorescence assay. In this study, for the first time we detected the presence of rickettsiae from the spotted fever group in Serbia. We detected the presence of antibodies against R. conorii in the samples from all tested localities. The proportion of positive cases was low in the plain agricultural areas but reached up to 23% in the mountain areas. We also observed a significant number of cases positive for antibodies against R. akari. Antibodies specific for the antigens of R. typhi were detected in only 2 samples from the municipality of Pec (Kosovo region). These findings contribute to the prevalence of Rickettsia species in Southeast Europe. Our study also revealed a dramatic lack of awareness of rickettsioses among medical personnel and pointed to the need for urgent measures that would help improve the current situation in the region.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Vector-Borne and Zoonotic Diseases",
title = "Prevalence of antibodies to Rickettsiae in different regions of Serbia",
pages = "224-219",
number = "2",
volume = "8",
doi = "10.1089/vbz.2007.0122"
}

Samardžić, S., Marinković, T., Marinković, D., Đuricić, B., Ristanović, E., Simović, T., Lako, B., Vukov, B., Božović, B.,& Gligić, A.. (2008). Prevalence of antibodies to Rickettsiae in different regions of Serbia. in Vector-Borne and Zoonotic Diseases
Mary Ann Liebert, Inc, New Rochelle., 8(2), 219-224.
https://doi.org/10.1089/vbz.2007.0122

Samardžić S, Marinković T, Marinković D, Đuricić B, Ristanović E, Simović T, Lako B, Vukov B, Božović B, Gligić A. Prevalence of antibodies to Rickettsiae in different regions of Serbia. in Vector-Borne and Zoonotic Diseases. 2008;8(2):219-224.
doi:10.1089/vbz.2007.0122 .

Samardžić, Svetomir, Marinković, Tatjana, Marinković, Dragan, Đuricić, Bosiljka, Ristanović, Elizabeta, Simović, Tatjana, Lako, Branislav, Vukov, Biljana, Božović, Bojana, Gligić, Ana, "Prevalence of antibodies to Rickettsiae in different regions of Serbia" in Vector-Borne and Zoonotic Diseases, 8, no. 2 (2008):219-224,
https://doi.org/10.1089/vbz.2007.0122 . .