TY  - JOUR
AU  - Stojanović, Marijana
AU  - Inić-Kanada, Aleksandra
AU  - Popović, Zoran
AU  - Živković, Irena
AU  - Dimitrijević, Ljiljana
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/170
AB  - Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Immunology Letters
T1  - Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment
EP  - 133
IS  - 1-2
SP  - 123
VL  - 94
DO  - 10.1016/j.imlet.2004.04.011
ER  - 

@article{
author = "Stojanović, Marijana and Inić-Kanada, Aleksandra and Popović, Zoran and Živković, Irena and Dimitrijević, Ljiljana",
year = "2004",
abstract = "Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Immunology Letters",
title = "Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment",
pages = "133-123",
number = "1-2",
volume = "94",
doi = "10.1016/j.imlet.2004.04.011"
}

Stojanović, M., Inić-Kanada, A., Popović, Z., Živković, I.,& Dimitrijević, L.. (2004). Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment. in Immunology Letters
Elsevier, Amsterdam., 94(1-2), 123-133.
https://doi.org/10.1016/j.imlet.2004.04.011

Stojanović M, Inić-Kanada A, Popović Z, Živković I, Dimitrijević L. Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment. in Immunology Letters. 2004;94(1-2):123-133.
doi:10.1016/j.imlet.2004.04.011 .

Stojanović, Marijana, Inić-Kanada, Aleksandra, Popović, Zoran, Živković, Irena, Dimitrijević, Ljiljana, "Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment" in Immunology Letters, 94, no. 1-2 (2004):123-133,
https://doi.org/10.1016/j.imlet.2004.04.011 . .

TY  - JOUR
AU  - Dimitrijević, Ljiljana
AU  - Stojanović, M.
AU  - Cirić, B.
AU  - Radulović, M.
AU  - Stojanović, R.
AU  - Popović, Zoran
AU  - Inić-Kanada, Aleksandra
AU  - Živković, Irena
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/178
AB  - In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to V(H)3/V(L)2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7(+) human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infections of the lower urinary tract. Antigen binding repertoire and properties of Y7(+) monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Immunological Investigations
T1  - Expression of Y7 cross-reactive idiotope on human IgM molecules
EP  - 14
IS  - 1
SP  - 1
VL  - 33
DO  - 10.1081/IMM-120027680
ER  - 

@article{
author = "Dimitrijević, Ljiljana and Stojanović, M. and Cirić, B. and Radulović, M. and Stojanović, R. and Popović, Zoran and Inić-Kanada, Aleksandra and Živković, Irena",
year = "2004",
abstract = "In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to V(H)3/V(L)2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7(+) human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infections of the lower urinary tract. Antigen binding repertoire and properties of Y7(+) monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Immunological Investigations",
title = "Expression of Y7 cross-reactive idiotope on human IgM molecules",
pages = "14-1",
number = "1",
volume = "33",
doi = "10.1081/IMM-120027680"
}

Dimitrijević, L., Stojanović, M., Cirić, B., Radulović, M., Stojanović, R., Popović, Z., Inić-Kanada, A.,& Živković, I.. (2004). Expression of Y7 cross-reactive idiotope on human IgM molecules. in Immunological Investigations
Taylor & Francis Inc, Philadelphia., 33(1), 1-14.
https://doi.org/10.1081/IMM-120027680

Dimitrijević L, Stojanović M, Cirić B, Radulović M, Stojanović R, Popović Z, Inić-Kanada A, Živković I. Expression of Y7 cross-reactive idiotope on human IgM molecules. in Immunological Investigations. 2004;33(1):1-14.
doi:10.1081/IMM-120027680 .

Dimitrijević, Ljiljana, Stojanović, M., Cirić, B., Radulović, M., Stojanović, R., Popović, Zoran, Inić-Kanada, Aleksandra, Živković, Irena, "Expression of Y7 cross-reactive idiotope on human IgM molecules" in Immunological Investigations, 33, no. 1 (2004):1-14,
https://doi.org/10.1081/IMM-120027680 . .