TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gavrović-Jankulović, Marija
AU  - Janković, Srđa
AU  - Blagojević, Gordan
AU  - Ćirković-Veličković, Tanja
AU  - Milojević, Irina
AU  - Simić, Dušica
AU  - Nestorovic, Branimir
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/342
AB  - Introduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT) was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule.
AB  - Uvod. Uprkos širokoj primeni kortikosteroida u lečenju od različitih bolesti, oni ponekad mogu izazvati ranu alergijsku reakciju. Prikaz bolesnika. Kod dvanaestogodišnjeg dečaka došlo je do rane alergijske reakcije izazvane intravenskom primenom metilprednizolona neposredno pre hirurške intervencije, tačnije, korekcije kontrakture šake koja se javila kao komplikacija opekotine. Mesec dana pre pojave alergijske reakcije dete je primalo metilprednizolon i dobro ga podnosilo. Šest nedelja posle operacije ponovo se javila anafilaktička reakcija tokom kožnog testiranja metilprednizolonom. Primenjen je i test aktivacije bazofila (BAT) ovim lekom, čiji je nalaz bio pozitivan. Zaključak. Ovo je prvi prikaz dve vrste anafilaktičke reakcije izazvane metilprednizolonom kod iste osobe. Klinička slika, pozitivni nalaz BAT i pozitivne kožne probe na metilprednizolon pokazuju da se kod deteta razvio prvi tip hipersenzitivne reakcije. Nedostatak unakrsne reaktivnosti s ostalim kortikosteroidima ukazuje na to da je alergijska reakcija izazvana steroidnim molekulom.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids
T1  - Rana alergijska reakcija na metilprednizolon sa tolerancijom drugih kortikosteroida
EP  - 235
IS  - 3-4
SP  - 233
VL  - 140
DO  - 10.2298/SARH1204233A
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gavrović-Jankulović, Marija and Janković, Srđa and Blagojević, Gordan and Ćirković-Veličković, Tanja and Milojević, Irina and Simić, Dušica and Nestorovic, Branimir",
year = "2012",
abstract = "Introduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT) was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule., Uvod. Uprkos širokoj primeni kortikosteroida u lečenju od različitih bolesti, oni ponekad mogu izazvati ranu alergijsku reakciju. Prikaz bolesnika. Kod dvanaestogodišnjeg dečaka došlo je do rane alergijske reakcije izazvane intravenskom primenom metilprednizolona neposredno pre hirurške intervencije, tačnije, korekcije kontrakture šake koja se javila kao komplikacija opekotine. Mesec dana pre pojave alergijske reakcije dete je primalo metilprednizolon i dobro ga podnosilo. Šest nedelja posle operacije ponovo se javila anafilaktička reakcija tokom kožnog testiranja metilprednizolonom. Primenjen je i test aktivacije bazofila (BAT) ovim lekom, čiji je nalaz bio pozitivan. Zaključak. Ovo je prvi prikaz dve vrste anafilaktičke reakcije izazvane metilprednizolonom kod iste osobe. Klinička slika, pozitivni nalaz BAT i pozitivne kožne probe na metilprednizolon pokazuju da se kod deteta razvio prvi tip hipersenzitivne reakcije. Nedostatak unakrsne reaktivnosti s ostalim kortikosteroidima ukazuje na to da je alergijska reakcija izazvana steroidnim molekulom.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids, Rana alergijska reakcija na metilprednizolon sa tolerancijom drugih kortikosteroida",
pages = "235-233",
number = "3-4",
volume = "140",
doi = "10.2298/SARH1204233A"
}

Atanasković-Marković, M., Gavrović-Jankulović, M., Janković, S., Blagojević, G., Ćirković-Veličković, T., Milojević, I., Simić, D.,& Nestorovic, B.. (2012). Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(3-4), 233-235.
https://doi.org/10.2298/SARH1204233A

Atanasković-Marković M, Gavrović-Jankulović M, Janković S, Blagojević G, Ćirković-Veličković T, Milojević I, Simić D, Nestorovic B. Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids. in Srpski arhiv za celokupno lekarstvo. 2012;140(3-4):233-235.
doi:10.2298/SARH1204233A .

Atanasković-Marković, Marina, Gavrović-Jankulović, Marija, Janković, Srđa, Blagojević, Gordan, Ćirković-Veličković, Tanja, Milojević, Irina, Simić, Dušica, Nestorovic, Branimir, "Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids" in Srpski arhiv za celokupno lekarstvo, 140, no. 3-4 (2012):233-235,
https://doi.org/10.2298/SARH1204233A . .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gavrović-Jankulović, Marija
AU  - Veličković, Tanja
AU  - Vučković, Olga
AU  - Ivanovski, P.
AU  - Nestorovic, Branimir
AU  - Čuturilo, G.
AU  - Simić, D.
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/264
AB  - Natural rubber latex is the second most implicated agent in intraoperative anaphylactic reactions. This report describes a case of intraoperative anaphylaxis occurring in a non-atopic fourteen-year-old girl undergoing multiple surgical procedures, but without spina bifida, in which latex surgical gloves were the main culprit for the anaphylactic reactions. Clinical manifestations of an anaphylactic reaction were also experienced during the examination of the possible cause of intraoperative anaphylaxis by skin prick testing with a latex allergen extract. Skin tests with anesthetics were negative. Specific IgE to latex was positive at 92.9 kUA/L (class 5). The molecular basis for the reported intraoperative anaphylaxis was ascribed to three low-molecular mass latex allergens (10-15 kD) detected in the brand of latex surgical gloves used during the operation. Given the potential of a dramatic outcome, latex allergy testing as a regular preoperative measure may contribute to the reduction of anaphylactic reactions during surgical interventions.
T2  - Iranian Journal of Allergy, Asthma and Immunology
T1  - Intraoperative anaphylactic shock in a child with no history of type I hypersensitivity
EP  - 99
IS  - 2
SP  - 97
VL  - 7
UR  - https://hdl.handle.net/21.15107/rcub_intor_264
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gavrović-Jankulović, Marija and Veličković, Tanja and Vučković, Olga and Ivanovski, P. and Nestorovic, Branimir and Čuturilo, G. and Simić, D.",
year = "2008",
abstract = "Natural rubber latex is the second most implicated agent in intraoperative anaphylactic reactions. This report describes a case of intraoperative anaphylaxis occurring in a non-atopic fourteen-year-old girl undergoing multiple surgical procedures, but without spina bifida, in which latex surgical gloves were the main culprit for the anaphylactic reactions. Clinical manifestations of an anaphylactic reaction were also experienced during the examination of the possible cause of intraoperative anaphylaxis by skin prick testing with a latex allergen extract. Skin tests with anesthetics were negative. Specific IgE to latex was positive at 92.9 kUA/L (class 5). The molecular basis for the reported intraoperative anaphylaxis was ascribed to three low-molecular mass latex allergens (10-15 kD) detected in the brand of latex surgical gloves used during the operation. Given the potential of a dramatic outcome, latex allergy testing as a regular preoperative measure may contribute to the reduction of anaphylactic reactions during surgical interventions.",
journal = "Iranian Journal of Allergy, Asthma and Immunology",
title = "Intraoperative anaphylactic shock in a child with no history of type I hypersensitivity",
pages = "99-97",
number = "2",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_intor_264"
}

Atanasković-Marković, M., Gavrović-Jankulović, M., Veličković, T., Vučković, O., Ivanovski, P., Nestorovic, B., Čuturilo, G.,& Simić, D.. (2008). Intraoperative anaphylactic shock in a child with no history of type I hypersensitivity. in Iranian Journal of Allergy, Asthma and Immunology, 7(2), 97-99.
https://hdl.handle.net/21.15107/rcub_intor_264

Atanasković-Marković M, Gavrović-Jankulović M, Veličković T, Vučković O, Ivanovski P, Nestorovic B, Čuturilo G, Simić D. Intraoperative anaphylactic shock in a child with no history of type I hypersensitivity. in Iranian Journal of Allergy, Asthma and Immunology. 2008;7(2):97-99.
https://hdl.handle.net/21.15107/rcub_intor_264 .

Atanasković-Marković, Marina, Gavrović-Jankulović, Marija, Veličković, Tanja, Vučković, Olga, Ivanovski, P., Nestorovic, Branimir, Čuturilo, G., Simić, D., "Intraoperative anaphylactic shock in a child with no history of type I hypersensitivity" in Iranian Journal of Allergy, Asthma and Immunology, 7, no. 2 (2008):97-99,
https://hdl.handle.net/21.15107/rcub_intor_264 .

TY  - CONF
AU  - Atanasković-Marković, Marina
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Međo, B.
AU  - Kukolj, D.
AU  - Nestorovic, Branimir
AU  - Vučković, Olga
PY  - 2007
UR  - http://intor.torlakinstitut.com/handle/123456789/235
PB  - Blackwell Publishing, Oxford
C3  - Allergy
T1  - Intraoperative anaphylactic shock in a child with undiagnosed latex allergy
EP  - 80
SP  - 80
VL  - 62
UR  - https://hdl.handle.net/21.15107/rcub_intor_235
ER  - 

@conference{
author = "Atanasković-Marković, Marina and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Međo, B. and Kukolj, D. and Nestorovic, Branimir and Vučković, Olga",
year = "2007",
publisher = "Blackwell Publishing, Oxford",
journal = "Allergy",
title = "Intraoperative anaphylactic shock in a child with undiagnosed latex allergy",
pages = "80-80",
volume = "62",
url = "https://hdl.handle.net/21.15107/rcub_intor_235"
}

Atanasković-Marković, M., Gavrović-Jankulović, M., Ćirković-Veličković, T., Međo, B., Kukolj, D., Nestorovic, B.,& Vučković, O.. (2007). Intraoperative anaphylactic shock in a child with undiagnosed latex allergy. in Allergy
Blackwell Publishing, Oxford., 62, 80-80.
https://hdl.handle.net/21.15107/rcub_intor_235

Atanasković-Marković M, Gavrović-Jankulović M, Ćirković-Veličković T, Međo B, Kukolj D, Nestorovic B, Vučković O. Intraoperative anaphylactic shock in a child with undiagnosed latex allergy. in Allergy. 2007;62:80-80.
https://hdl.handle.net/21.15107/rcub_intor_235 .

Atanasković-Marković, Marina, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Međo, B., Kukolj, D., Nestorovic, Branimir, Vučković, Olga, "Intraoperative anaphylactic shock in a child with undiagnosed latex allergy" in Allergy, 62 (2007):80-80,
https://hdl.handle.net/21.15107/rcub_intor_235 .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Ćirković-Veličković, Tanja
AU  - Gavrović-Jankulović, Marija
AU  - Vučković, Olga
AU  - Nestorovic, Branimir
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/214
PB  - Blackwell Munksgaard
T2  - Pediatric Allergy and Immunology
T1  - Authors reply to beta-lactam allergy in children
EP  - 640
IS  - 8
SP  - 639
VL  - 17
DO  - 10.1111/j.1399-3038.2006.00462.x
ER  - 

@article{
author = "Atanasković-Marković, Marina and Ćirković-Veličković, Tanja and Gavrović-Jankulović, Marija and Vučković, Olga and Nestorovic, Branimir",
year = "2006",
publisher = "Blackwell Munksgaard",
journal = "Pediatric Allergy and Immunology",
title = "Authors reply to beta-lactam allergy in children",
pages = "640-639",
number = "8",
volume = "17",
doi = "10.1111/j.1399-3038.2006.00462.x"
}

Atanasković-Marković, M., Ćirković-Veličković, T., Gavrović-Jankulović, M., Vučković, O.,& Nestorovic, B.. (2006). Authors reply to beta-lactam allergy in children. in Pediatric Allergy and Immunology
Blackwell Munksgaard., 17(8), 639-640.
https://doi.org/10.1111/j.1399-3038.2006.00462.x

Atanasković-Marković M, Ćirković-Veličković T, Gavrović-Jankulović M, Vučković O, Nestorovic B. Authors reply to beta-lactam allergy in children. in Pediatric Allergy and Immunology. 2006;17(8):639-640.
doi:10.1111/j.1399-3038.2006.00462.x .

Atanasković-Marković, Marina, Ćirković-Veličković, Tanja, Gavrović-Jankulović, Marija, Vučković, Olga, Nestorovic, Branimir, "Authors reply to beta-lactam allergy in children" in Pediatric Allergy and Immunology, 17, no. 8 (2006):639-640,
https://doi.org/10.1111/j.1399-3038.2006.00462.x . .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Veličković, Tanja
AU  - Gavrović-Jankulović, Marija
AU  - Vučković, Olga
AU  - Nestorovic, Branimir
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/203
AB  - Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins.
PB  - Blackwell Munksgaard
T2  - Pediatric Allergy and Immunology
T1  - Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children
EP  - 347
IS  - 4
SP  - 341
VL  - 16
DO  - 10.1111/j.1399-3038.2005.00280.x
ER  - 

@article{
author = "Atanasković-Marković, Marina and Veličković, Tanja and Gavrović-Jankulović, Marija and Vučković, Olga and Nestorovic, Branimir",
year = "2005",
abstract = "Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins.",
publisher = "Blackwell Munksgaard",
journal = "Pediatric Allergy and Immunology",
title = "Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children",
pages = "347-341",
number = "4",
volume = "16",
doi = "10.1111/j.1399-3038.2005.00280.x"
}

Atanasković-Marković, M., Veličković, T., Gavrović-Jankulović, M., Vučković, O.,& Nestorovic, B.. (2005). Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. in Pediatric Allergy and Immunology
Blackwell Munksgaard., 16(4), 341-347.
https://doi.org/10.1111/j.1399-3038.2005.00280.x

Atanasković-Marković M, Veličković T, Gavrović-Jankulović M, Vučković O, Nestorovic B. Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. in Pediatric Allergy and Immunology. 2005;16(4):341-347.
doi:10.1111/j.1399-3038.2005.00280.x .

Atanasković-Marković, Marina, Veličković, Tanja, Gavrović-Jankulović, Marija, Vučković, Olga, Nestorovic, Branimir, "Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children" in Pediatric Allergy and Immunology, 16, no. 4 (2005):341-347,
https://doi.org/10.1111/j.1399-3038.2005.00280.x . .