TY  - JOUR
AU  - Obradović, Ana
AU  - Matić, Miloš
AU  - Ognjanović, Branka
AU  - Đurđević, Predrag
AU  - Marinković, Emilija
AU  - Ušćumlić, Gordana
AU  - Božić, Bojan
AU  - Božić-Nedeljković, Biljana
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/566
AB  - In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives were examined on human breast cancer cell line MDA-MB-231. The cells were treated with different concentrations of compounds (from 0.01 mu M to 100 mu M) during 24 h and 72 h. The proliferation index, nitric oxide production, apoptosis rate, and migration capacity were measured. The cell invasion potential was examined by measuring the level of MMP-9 and COX-2 gene expression. All tested compounds expressed antiproliferative activity and induced dose- and time-dependent increase in the level of nitrites. The investigated molecules significantly decreased cell survival rate, migration capacity and the expression levels of genes included in the process of tumor invasion. Obtained data suggest that the tested hydantoin derivatives express considerable antitumor activity by reducing cell division rate, elevating apoptosis level, and inhibiting the motility and invasiveness of breast cancer cells. The results obtained in this study indicate that investigated compounds express potential as a novel chemotherapeutic agents against breast cancer growth and progression. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
PB  - Elsevier, Amsterdam
T2  - Saudi Pharmaceutical Journal
T1  - Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cells
EP  - 254
IS  - 3
SP  - 246
VL  - 28
DO  - 10.1016/j.jsps.2020.01.003
ER  - 

@article{
author = "Obradović, Ana and Matić, Miloš and Ognjanović, Branka and Đurđević, Predrag and Marinković, Emilija and Ušćumlić, Gordana and Božić, Bojan and Božić-Nedeljković, Biljana",
year = "2020",
abstract = "In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives were examined on human breast cancer cell line MDA-MB-231. The cells were treated with different concentrations of compounds (from 0.01 mu M to 100 mu M) during 24 h and 72 h. The proliferation index, nitric oxide production, apoptosis rate, and migration capacity were measured. The cell invasion potential was examined by measuring the level of MMP-9 and COX-2 gene expression. All tested compounds expressed antiproliferative activity and induced dose- and time-dependent increase in the level of nitrites. The investigated molecules significantly decreased cell survival rate, migration capacity and the expression levels of genes included in the process of tumor invasion. Obtained data suggest that the tested hydantoin derivatives express considerable antitumor activity by reducing cell division rate, elevating apoptosis level, and inhibiting the motility and invasiveness of breast cancer cells. The results obtained in this study indicate that investigated compounds express potential as a novel chemotherapeutic agents against breast cancer growth and progression. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.",
publisher = "Elsevier, Amsterdam",
journal = "Saudi Pharmaceutical Journal",
title = "Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cells",
pages = "254-246",
number = "3",
volume = "28",
doi = "10.1016/j.jsps.2020.01.003"
}

Obradović, A., Matić, M., Ognjanović, B., Đurđević, P., Marinković, E., Ušćumlić, G., Božić, B.,& Božić-Nedeljković, B.. (2020). Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cells. in Saudi Pharmaceutical Journal
Elsevier, Amsterdam., 28(3), 246-254.
https://doi.org/10.1016/j.jsps.2020.01.003

Obradović A, Matić M, Ognjanović B, Đurđević P, Marinković E, Ušćumlić G, Božić B, Božić-Nedeljković B. Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cells. in Saudi Pharmaceutical Journal. 2020;28(3):246-254.
doi:10.1016/j.jsps.2020.01.003 .

Obradović, Ana, Matić, Miloš, Ognjanović, Branka, Đurđević, Predrag, Marinković, Emilija, Ušćumlić, Gordana, Božić, Bojan, Božić-Nedeljković, Biljana, "Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cells" in Saudi Pharmaceutical Journal, 28, no. 3 (2020):246-254,
https://doi.org/10.1016/j.jsps.2020.01.003 . .