TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/77
AB  - The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil
EP  - 188
IS  - 3-4
SP  - 181
VL  - 91
DO  - 10.3109/00207459708986375
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Rosić, N.",
year = "1997",
abstract = "The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil",
pages = "188-181",
number = "3-4",
volume = "91",
doi = "10.3109/00207459708986375"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S.,& Rosić, N.. (1997). Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(3-4), 181-188.
https://doi.org/10.3109/00207459708986375

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Rosić N. Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience. 1997;91(3-4):181-188.
doi:10.3109/00207459708986375 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Rosić, N., "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil" in International Journal of Neuroscience, 91, no. 3-4 (1997):181-188,
https://doi.org/10.3109/00207459708986375 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Kostić, V.S.
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/76
AB  - The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease
EP  - 97
IS  - 1-2
SP  - 87
VL  - 90
DO  - 10.3109/00207459709000628
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Kostić, V.S. and Rosić, N.",
year = "1997",
abstract = "The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease",
pages = "97-87",
number = "1-2",
volume = "90",
doi = "10.3109/00207459709000628"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S., Kostić, V.S.,& Rosić, N.. (1997). Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 90(1-2), 87-97.
https://doi.org/10.3109/00207459709000628

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Kostić V, Rosić N. Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1997;90(1-2):87-97.
doi:10.3109/00207459709000628 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Kostić, V.S., Rosić, N., "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 90, no. 1-2 (1997):87-97,
https://doi.org/10.3109/00207459709000628 . .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
AU  - Rakić, L.
PY  - 1996
UR  - http://intor.torlakinstitut.com/handle/123456789/66
AB  - Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats
EP  - 299
IS  - 3-4
SP  - 281
VL  - 86
DO  - 10.3109/00207459608986719
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Bokonjić, D. and Dobrić, Silva and Rosić, N. and Rakić, L.",
year = "1996",
abstract = "Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats",
pages = "299-281",
number = "3-4",
volume = "86",
doi = "10.3109/00207459608986719"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Bokonjić, D., Dobrić, S., Rosić, N.,& Rakić, L.. (1996). Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 86(3-4), 281-299.
https://doi.org/10.3109/00207459608986719

Popović M, Jovanova-Nešić K, Popović N, Bokonjić D, Dobrić S, Rosić N, Rakić L. Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience. 1996;86(3-4):281-299.
doi:10.3109/00207459608986719 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Bokonjić, D., Dobrić, Silva, Rosić, N., Rakić, L., "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats" in International Journal of Neuroscience, 86, no. 3-4 (1996):281-299,
https://doi.org/10.3109/00207459608986719 . .