TY  - JOUR
AU  - Tomić-Spirić, Vesna
AU  - Dizdarević, Denisa
AU  - Janković, Slavenka
AU  - Burazer, Lidija
AU  - Barac, Aleksandra
AU  - Bolpacić, Jasna
AU  - Đurić, Vojislav
AU  - Perić-Popadić, Aleksandra
AU  - Aleksić, Aleksandra
AU  - Bogić, Mirjana
PY  - 2016
UR  - http://intor.torlakinstitut.com/handle/123456789/474
AB  - Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt  0.001) and MS (54.3%, p lt  0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p lt  0.001 and p lt  0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt  0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients.
PB  - Tehran Univ Medical Sciences, Tehran
T2  - Iranian Journal of Allergy, Asthma and Immunology
T1  - Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study
EP  - 121
IS  - 2
SP  - 112
VL  - 15
UR  - https://hdl.handle.net/21.15107/rcub_intor_474
ER  - 

@article{
author = "Tomić-Spirić, Vesna and Dizdarević, Denisa and Janković, Slavenka and Burazer, Lidija and Barac, Aleksandra and Bolpacić, Jasna and Đurić, Vojislav and Perić-Popadić, Aleksandra and Aleksić, Aleksandra and Bogić, Mirjana",
year = "2016",
abstract = "Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt  0.001) and MS (54.3%, p lt  0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p lt  0.001 and p lt  0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt  0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients.",
publisher = "Tehran Univ Medical Sciences, Tehran",
journal = "Iranian Journal of Allergy, Asthma and Immunology",
title = "Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study",
pages = "121-112",
number = "2",
volume = "15",
url = "https://hdl.handle.net/21.15107/rcub_intor_474"
}

Tomić-Spirić, V., Dizdarević, D., Janković, S., Burazer, L., Barac, A., Bolpacić, J., Đurić, V., Perić-Popadić, A., Aleksić, A.,& Bogić, M.. (2016). Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study. in Iranian Journal of Allergy, Asthma and Immunology
Tehran Univ Medical Sciences, Tehran., 15(2), 112-121.
https://hdl.handle.net/21.15107/rcub_intor_474

Tomić-Spirić V, Dizdarević D, Janković S, Burazer L, Barac A, Bolpacić J, Đurić V, Perić-Popadić A, Aleksić A, Bogić M. Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study. in Iranian Journal of Allergy, Asthma and Immunology. 2016;15(2):112-121.
https://hdl.handle.net/21.15107/rcub_intor_474 .

Tomić-Spirić, Vesna, Dizdarević, Denisa, Janković, Slavenka, Burazer, Lidija, Barac, Aleksandra, Bolpacić, Jasna, Đurić, Vojislav, Perić-Popadić, Aleksandra, Aleksić, Aleksandra, Bogić, Mirjana, "Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study" in Iranian Journal of Allergy, Asthma and Immunology, 15, no. 2 (2016):112-121,
https://hdl.handle.net/21.15107/rcub_intor_474 .