TY  - JOUR
AU  - Zivkovic, Irena
AU  - Muhandes, Lina
AU  - Petrusic, Vladimir
AU  - Minić, Rajna
AU  - Dimitrijevic, Ljiljana
PY  - 2021
UR  - http://intor.torlakinstitut.com/handle/123456789/612
AB  - Natural, polyreactive, low-affinity antibodies are known to play an important role not only
in the immediate defense against pathogens, but also in shaping the acquired immune response.
On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural
antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur
in the IgM and IgG pool of natural antibodies after immunization with split or whole virion
influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were
divided, according to the vaccination status, into those who had been immunized with the
influenza vaccine in previous years and those who had been immunized for the first time. The
analysis indicated that the pool of natural antibodies was not impaired by the immunization,
evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced
in order to maintain the homeostasis of the immune system.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - The effect of influenza vaccine immunization on natural antibodies
EP  - 223
SP  - 207
VL  - 71
DO  - 10.5937/arhfarm71‐31544
ER  - 

@article{
author = "Zivkovic, Irena and Muhandes, Lina and Petrusic, Vladimir and Minić, Rajna and Dimitrijevic, Ljiljana",
year = "2021",
abstract = "Natural, polyreactive, low-affinity antibodies are known to play an important role not only
in the immediate defense against pathogens, but also in shaping the acquired immune response.
On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural
antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur
in the IgM and IgG pool of natural antibodies after immunization with split or whole virion
influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were
divided, according to the vaccination status, into those who had been immunized with the
influenza vaccine in previous years and those who had been immunized for the first time. The
analysis indicated that the pool of natural antibodies was not impaired by the immunization,
evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced
in order to maintain the homeostasis of the immune system.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "The effect of influenza vaccine immunization on natural antibodies",
pages = "223-207",
volume = "71",
doi = "10.5937/arhfarm71‐31544"
}

Zivkovic, I., Muhandes, L., Petrusic, V., Minić, R.,& Dimitrijevic, L.. (2021). The effect of influenza vaccine immunization on natural antibodies. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 71, 207-223.
https://doi.org/10.5937/arhfarm71‐31544

Zivkovic I, Muhandes L, Petrusic V, Minić R, Dimitrijevic L. The effect of influenza vaccine immunization on natural antibodies. in Arhiv za farmaciju. 2021;71:207-223.
doi:10.5937/arhfarm71‐31544 .

Zivkovic, Irena, Muhandes, Lina, Petrusic, Vladimir, Minić, Rajna, Dimitrijevic, Ljiljana, "The effect of influenza vaccine immunization on natural antibodies" in Arhiv za farmaciju, 71 (2021):207-223,
https://doi.org/10.5937/arhfarm71‐31544 . .