TY  - JOUR
AU  - Kosanović, Dejana
AU  - Stojković, Aleksandra
AU  - Maslovarić, Irina
AU  - Vukov, Natasa
AU  - Jovanova-Nešić, Katica
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/410
AB  - Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P  lt  0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.
PB  - Versita, Warsaw
T2  - Central European Journal of Biology
T1  - Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis
EP  - 248
IS  - 3
SP  - 242
VL  - 9
DO  - 10.2478/s11535-013-0270-1
ER  - 

@article{
author = "Kosanović, Dejana and Stojković, Aleksandra and Maslovarić, Irina and Vukov, Natasa and Jovanova-Nešić, Katica",
year = "2014",
abstract = "Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P  lt  0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Biology",
title = "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis",
pages = "248-242",
number = "3",
volume = "9",
doi = "10.2478/s11535-013-0270-1"
}

Kosanović, D., Stojković, A., Maslovarić, I., Vukov, N.,& Jovanova-Nešić, K.. (2014). Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology
Versita, Warsaw., 9(3), 242-248.
https://doi.org/10.2478/s11535-013-0270-1

Kosanović D, Stojković A, Maslovarić I, Vukov N, Jovanova-Nešić K. Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology. 2014;9(3):242-248.
doi:10.2478/s11535-013-0270-1 .

Kosanović, Dejana, Stojković, Aleksandra, Maslovarić, Irina, Vukov, Natasa, Jovanova-Nešić, Katica, "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis" in Central European Journal of Biology, 9, no. 3 (2014):242-248,
https://doi.org/10.2478/s11535-013-0270-1 . .