TY  - JOUR
AU  - Vrndić, Olgica
AU  - Živančević-Simonović, Snežana
AU  - Dimitrijević, Ljiljana
AU  - Đukić, Aleksandar
AU  - Arsenijević, Nebojša
PY  - 2010
UR  - http://intor.torlakinstitut.com/handle/123456789/307
AB  - Introduction. Thyroid peroxidase-specific autoantibodies (TPO Abs) are mostly measured in patients with autoimmune thyroid diseases. The aim of this study was to compare TPO Ab concentrations measured by two radioimmunoassays. Material and methods. Our investigation included 38 patients. Sera concentrations of TPO Abs were measured by using Cis biointernational (France) and Immunotech (Czech Republic) assays. Results. Concentrations obtained by two assays were extensively different. The values measured by Cis biointernational assay were higher than ones obtained by Immunotech assay. The statistical arrangement of results showed the direct correlation between the two assays, with the coefficient of agreement R=0.6239 (p lt 0.001). The analysis of relative values (ratio of measured and upper limit values given by the manufacturer) demonstrated the statistically significant difference (p=0.003) between values measured by Cis biointernational (18.94±37.22) and by Immunotech assay (4.22±8.22) concerning the distinction between normal and raised concentrations of TPO Abs. The agreement of results (enhanced or normal TPO Ab concentrations in both tests) was shown in 30 sera samples (78.95%), but in residual 8 sera (21.05%) normal TPO Ab concentrations were obtained by Immunotech, and enchanced by Cis biointernational assay. There is no difference in capability of distinction between normal and pathological results between the two tests (χ2=3.484, p gt 0.05). The highest concentration of TPO Ab measured by Cis biointernational assay was not the highest one in Immunotech assay, which might be a reflection of different specificity of antibodies used in two diagnostic tests. Conclusion. TPO Ab concentrations obtained by Cis biointernational and Immunotech assays are very different. In several sera samples, normal concentrations of TPO autoantibodies were obtained by Immunotech assay and enhanced by Cis biointernational assay. The highest value obtained by one is not the highest value measured by another assay we used.
AB  - Autontitela specifična za tiroidnu peroksidazu autoantitela specifičnih za tiroidnu peroksidazu prevashodno se određuju radi dijagnoze autoimunih bolesti štitaste žlezde. Cilj rada bio je da se uporede koncentracije autoantitela specifičnih za tiroidnu peroksidazu dobijene korišćenjem dva testa: Cis bionternational (Francuska) i Immunotech (Češka Republika). Ispitivanjem je obuhvaćeno 38 ispitanika. Iako su se koncentracije autoantitela specifičnih za tiroidnu peroksidazu u ispitivanim serumima znatno razlikovale i u apsolutnim i u relativnim vrednostima, statističkom obradom rezultata pokazana je direktna korelacija rezultata merenja ova dva testa, sa koeficijentom R=0,6239 (p lt 0,001). Na osnovu analize relativnih vrednosti. pokazana je statistički značajna razlika (p=0,003) između srednjih vrednosti rezultata izmerenih testovima Cis (18,94±37,22) i Immunotech (4,22±8,22). Slaganje rezultata pokazano je u 78,95% seruma, dok je u 21,05% seruma testom Immunotech dobijena normalna, a testom Cis biointernational granična ili povećana koncentracija antitela. Statistički podaci su pokazali da se testovi ne razlikuju po razdvajanju patoloških od normalnih vrednosti (χ2=3,484, p gt 0,05). Iako koncentracije autoantitela specifičnih za tiroidnu peroksidazu izmerene pomoću testova Cis biointernational i testom Immunotech pokazuju značajan stepen korelacije, njihove i apsolutne i relativne vrednosti znatno se razlikuju.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Medicinski pregled
T1  - Correlation of sera concentra tions of thyroperoxidase a utoantibodies measured by two radioimmunoassays
T1  - Korelacija koncentracija autoantitela specifičnih za tiroidnu peroksidazu određenih korišćenjem dva radioimunološka testa
EP  - 108
IS  - 1-2
SP  - 104
VL  - 63
DO  - 10.2298/MPNS1002104V
ER  - 

@article{
author = "Vrndić, Olgica and Živančević-Simonović, Snežana and Dimitrijević, Ljiljana and Đukić, Aleksandar and Arsenijević, Nebojša",
year = "2010",
abstract = "Introduction. Thyroid peroxidase-specific autoantibodies (TPO Abs) are mostly measured in patients with autoimmune thyroid diseases. The aim of this study was to compare TPO Ab concentrations measured by two radioimmunoassays. Material and methods. Our investigation included 38 patients. Sera concentrations of TPO Abs were measured by using Cis biointernational (France) and Immunotech (Czech Republic) assays. Results. Concentrations obtained by two assays were extensively different. The values measured by Cis biointernational assay were higher than ones obtained by Immunotech assay. The statistical arrangement of results showed the direct correlation between the two assays, with the coefficient of agreement R=0.6239 (p lt 0.001). The analysis of relative values (ratio of measured and upper limit values given by the manufacturer) demonstrated the statistically significant difference (p=0.003) between values measured by Cis biointernational (18.94±37.22) and by Immunotech assay (4.22±8.22) concerning the distinction between normal and raised concentrations of TPO Abs. The agreement of results (enhanced or normal TPO Ab concentrations in both tests) was shown in 30 sera samples (78.95%), but in residual 8 sera (21.05%) normal TPO Ab concentrations were obtained by Immunotech, and enchanced by Cis biointernational assay. There is no difference in capability of distinction between normal and pathological results between the two tests (χ2=3.484, p gt 0.05). The highest concentration of TPO Ab measured by Cis biointernational assay was not the highest one in Immunotech assay, which might be a reflection of different specificity of antibodies used in two diagnostic tests. Conclusion. TPO Ab concentrations obtained by Cis biointernational and Immunotech assays are very different. In several sera samples, normal concentrations of TPO autoantibodies were obtained by Immunotech assay and enhanced by Cis biointernational assay. The highest value obtained by one is not the highest value measured by another assay we used., Autontitela specifična za tiroidnu peroksidazu autoantitela specifičnih za tiroidnu peroksidazu prevashodno se određuju radi dijagnoze autoimunih bolesti štitaste žlezde. Cilj rada bio je da se uporede koncentracije autoantitela specifičnih za tiroidnu peroksidazu dobijene korišćenjem dva testa: Cis bionternational (Francuska) i Immunotech (Češka Republika). Ispitivanjem je obuhvaćeno 38 ispitanika. Iako su se koncentracije autoantitela specifičnih za tiroidnu peroksidazu u ispitivanim serumima znatno razlikovale i u apsolutnim i u relativnim vrednostima, statističkom obradom rezultata pokazana je direktna korelacija rezultata merenja ova dva testa, sa koeficijentom R=0,6239 (p lt 0,001). Na osnovu analize relativnih vrednosti. pokazana je statistički značajna razlika (p=0,003) između srednjih vrednosti rezultata izmerenih testovima Cis (18,94±37,22) i Immunotech (4,22±8,22). Slaganje rezultata pokazano je u 78,95% seruma, dok je u 21,05% seruma testom Immunotech dobijena normalna, a testom Cis biointernational granična ili povećana koncentracija antitela. Statistički podaci su pokazali da se testovi ne razlikuju po razdvajanju patoloških od normalnih vrednosti (χ2=3,484, p gt 0,05). Iako koncentracije autoantitela specifičnih za tiroidnu peroksidazu izmerene pomoću testova Cis biointernational i testom Immunotech pokazuju značajan stepen korelacije, njihove i apsolutne i relativne vrednosti znatno se razlikuju.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Medicinski pregled",
title = "Correlation of sera concentra tions of thyroperoxidase a utoantibodies measured by two radioimmunoassays, Korelacija koncentracija autoantitela specifičnih za tiroidnu peroksidazu određenih korišćenjem dva radioimunološka testa",
pages = "108-104",
number = "1-2",
volume = "63",
doi = "10.2298/MPNS1002104V"
}

Vrndić, O., Živančević-Simonović, S., Dimitrijević, L., Đukić, A.,& Arsenijević, N.. (2010). Correlation of sera concentra tions of thyroperoxidase a utoantibodies measured by two radioimmunoassays. in Medicinski pregled
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 63(1-2), 104-108.
https://doi.org/10.2298/MPNS1002104V

Vrndić O, Živančević-Simonović S, Dimitrijević L, Đukić A, Arsenijević N. Correlation of sera concentra tions of thyroperoxidase a utoantibodies measured by two radioimmunoassays. in Medicinski pregled. 2010;63(1-2):104-108.
doi:10.2298/MPNS1002104V .

Vrndić, Olgica, Živančević-Simonović, Snežana, Dimitrijević, Ljiljana, Đukić, Aleksandar, Arsenijević, Nebojša, "Correlation of sera concentra tions of thyroperoxidase a utoantibodies measured by two radioimmunoassays" in Medicinski pregled, 63, no. 1-2 (2010):104-108,
https://doi.org/10.2298/MPNS1002104V . .

TY  - JOUR
AU  - Živančević-Simonović, Snežana
AU  - Đukić, Aleksandar
AU  - Inić-Kanada, Aleksandra
AU  - Dimitrijević, Ljiljana
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/182
AB  - Free radicals are generated as the byproducts of many physiological cellular reactions or accidentally. Biologically, the most relevant free radicals are highly reactive oxygen and nitric molecules. These molecules can establish chain reactions causing damage of cell membranes, proteins and nucleic acids. Numerous antioxidative mechanisms exist in order to control their effects and maintain redox homeostasis. The situation in which the cellular redox homoeostasis is altered, i.e. the balance between pro-oxidants and antioxidants, is known as the "oxidative stress". An oxidative stress maybe induced by the activation of endogenous generating systems or by conditions generated by environmental factors. The response to increased levels of ROS is known as "oxidative stress response". In cases of persistently high ROS levels the loss of homeostasis might be developed which could result m pathological conditions. In this study, we review the main mechanisms that generate free radicals and lead to oxidative stress conditions included in aging and pathogenesis of many different disorders. Because of the involvement of the immune system m many of these diseases, a particular attention was focused on oxidative stress influence on both natural and acquired immunity, with the special emphasis on free radical influence on T cell activation and survival.
AB  - Slobodni radikali se stvaraju kao uzgredni produkti mnogih fizioloških procesa u ćelijama ili zadesno. Najveći biološki značaj imaju reaktivni oblici kiseonika i azota. Ti molekuli mogu izazvati lančane reakcije koje prouzrokuju oštećenje ćelijskih membrana, proteina i nukleinskih kiselina. Da bi se kontrolisali njihovi efekti i održala redox homeostaza, postoje brojni zaštitni antioksidativni mehanizmi. "Oksidativni stres" predstavlja stanje u kome je narušena redoks homeostaza, odnosno balans između pro-oksidativnih i antioksidativnih supstanci. Oksidativni stres može biti prouzrokovan aktivacijom endogenih mehanizama stvaranja slobodnih radikala ili dejstvom egzogenih faktora. Ćelijske reakcije na povećanje koncentracije reaktivnih oblika kiseonika predstavljaju "odgovor na Oksidativni stres". Ako se povećana koncentracija reaktivnih obuka kiseonika održava uprkos aktivaciji antioksidativnih mehanizama, narušava se redox homeostaza i može doći do pojave bolesti. U ovom radu su prikazani glavni mehanizmi stvaranja slobodnih radikala koji vode nastanku oksidativnog stresa uključenog u proces starenja i nastanak mnogobrojnih i raznovrsnih bolesti. S obzirom na ulogu imunskog sistema u njihovoj patogenezi, posebno je prikazan uticaj oksidativnog stresa na urođene i stečene imunske mehanizme, kao i uticaj slobodnih radikala na aktivaciju i preživljavanje T linfocita.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Medicus
T1  - Role of the oxidative stress in pathophysiology of immune system
T1  - Uloga oksidativnog stresa u patofiziologiji imunskog sistema
EP  - 16
IS  - 2
SP  - 11
VL  - 5
UR  - https://hdl.handle.net/21.15107/rcub_intor_182
ER  - 

@article{
author = "Živančević-Simonović, Snežana and Đukić, Aleksandar and Inić-Kanada, Aleksandra and Dimitrijević, Ljiljana",
year = "2004",
abstract = "Free radicals are generated as the byproducts of many physiological cellular reactions or accidentally. Biologically, the most relevant free radicals are highly reactive oxygen and nitric molecules. These molecules can establish chain reactions causing damage of cell membranes, proteins and nucleic acids. Numerous antioxidative mechanisms exist in order to control their effects and maintain redox homeostasis. The situation in which the cellular redox homoeostasis is altered, i.e. the balance between pro-oxidants and antioxidants, is known as the "oxidative stress". An oxidative stress maybe induced by the activation of endogenous generating systems or by conditions generated by environmental factors. The response to increased levels of ROS is known as "oxidative stress response". In cases of persistently high ROS levels the loss of homeostasis might be developed which could result m pathological conditions. In this study, we review the main mechanisms that generate free radicals and lead to oxidative stress conditions included in aging and pathogenesis of many different disorders. Because of the involvement of the immune system m many of these diseases, a particular attention was focused on oxidative stress influence on both natural and acquired immunity, with the special emphasis on free radical influence on T cell activation and survival., Slobodni radikali se stvaraju kao uzgredni produkti mnogih fizioloških procesa u ćelijama ili zadesno. Najveći biološki značaj imaju reaktivni oblici kiseonika i azota. Ti molekuli mogu izazvati lančane reakcije koje prouzrokuju oštećenje ćelijskih membrana, proteina i nukleinskih kiselina. Da bi se kontrolisali njihovi efekti i održala redox homeostaza, postoje brojni zaštitni antioksidativni mehanizmi. "Oksidativni stres" predstavlja stanje u kome je narušena redoks homeostaza, odnosno balans između pro-oksidativnih i antioksidativnih supstanci. Oksidativni stres može biti prouzrokovan aktivacijom endogenih mehanizama stvaranja slobodnih radikala ili dejstvom egzogenih faktora. Ćelijske reakcije na povećanje koncentracije reaktivnih oblika kiseonika predstavljaju "odgovor na Oksidativni stres". Ako se povećana koncentracija reaktivnih obuka kiseonika održava uprkos aktivaciji antioksidativnih mehanizama, narušava se redox homeostaza i može doći do pojave bolesti. U ovom radu su prikazani glavni mehanizmi stvaranja slobodnih radikala koji vode nastanku oksidativnog stresa uključenog u proces starenja i nastanak mnogobrojnih i raznovrsnih bolesti. S obzirom na ulogu imunskog sistema u njihovoj patogenezi, posebno je prikazan uticaj oksidativnog stresa na urođene i stečene imunske mehanizme, kao i uticaj slobodnih radikala na aktivaciju i preživljavanje T linfocita.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Medicus",
title = "Role of the oxidative stress in pathophysiology of immune system, Uloga oksidativnog stresa u patofiziologiji imunskog sistema",
pages = "16-11",
number = "2",
volume = "5",
url = "https://hdl.handle.net/21.15107/rcub_intor_182"
}

Živančević-Simonović, S., Đukić, A., Inić-Kanada, A.,& Dimitrijević, L.. (2004). Role of the oxidative stress in pathophysiology of immune system. in Medicus
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 5(2), 11-16.
https://hdl.handle.net/21.15107/rcub_intor_182

Živančević-Simonović S, Đukić A, Inić-Kanada A, Dimitrijević L. Role of the oxidative stress in pathophysiology of immune system. in Medicus. 2004;5(2):11-16.
https://hdl.handle.net/21.15107/rcub_intor_182 .

Živančević-Simonović, Snežana, Đukić, Aleksandar, Inić-Kanada, Aleksandra, Dimitrijević, Ljiljana, "Role of the oxidative stress in pathophysiology of immune system" in Medicus, 5, no. 2 (2004):11-16,
https://hdl.handle.net/21.15107/rcub_intor_182 .

TY  - JOUR
AU  - Živančević-Simonović, Snežana
AU  - Đukić, Aleksandar
AU  - Matović, Milovan D.
AU  - Dimitrijević, Ljiljana
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/185
AB  - Autoimmune thyroid disease, Graves disease and Hashimoto thyroiditis, cause changing in morphology and function of the thyroid tissue. Graves disease is characterized by an increased synthesis and release of thyroid hormones (hyperthyrosis). Hashimoto fhyroiditis is characterized by the destruction and regeneration of thyroid follicles, which are clinically expressed by symptoms of hypothyrosis. Less frequently, Hashimoto fhyroiditis is expressed by transient thyrotoxicosis (if the destruction of the thyroid gland tissue is extremely emphasized). In order to examine thyroid morphology and function, there are numerous in iga diagnostic methods. Ultrasono graphy enables the examination of the fine structure and vasculanzation of the thyroid gland, and nuclear medicine methods reflect the function of the thyroid tissue. Radioactive iodine uptake is useful in assessment of the ability of thyrocytes to uptake iodide, and scmtigraphy gives the morpho-functional picture of the thyroid gland. Scintigraphy of orbital tissue gives the insight of orbital accumulation of the activated leucocytes. Although modem imaging methods (positron emission tomography, computed tomography and magnetic resonance imaging) are very useful in assessment of nodular changes in the thyroid gland and retrostemal goiter, these techniques are not widely applied in diagnostic procedures of autoimmune thyroid diseases. In this study we reviewed in vivo diagnostic methods used in the examination of Graves disease and Hashimoto thyroiditis, we considered their significance in the investigation of pathological process in the thyroid gland and we noticed the factors which could influence the results of morphological and functional investigations of the thyroid gland.
AB  - Autoimunske bolesti štitaste žlezde, Gravesova bolest i Hashimoto tireoiditis, prouzrokuju promenu strukture i funkcije tireoidnog tkiva. Gravesovu bolest karakteriše povećana sinteza i oslobađanje tireoidnih hormona (hipemreoza), a Hashimoto tireoiditis destrukcija i regeneracija tireoidnih folikula, koje se klinički ispoljavaju simptomima hipotireoze, a ako je destrukcija tkiva štitaste žlezde veoma izražena, privremeno mogu da se jave i simptomi tireotoksikoze. Da bi se ispitala struktura i funkcija tireoidnog tkiva primenjuju se brojne in vivo dijagnostičke metode. Ultrasonografija daje uvid u finu strukturu i vaskularizaciju štitaste žlezde, a metode nuklearne medicine odslikavaju funkciju tireoidnog tkiva. Testom fiksacije radioaktivnog joda procenjuje se sposobnost tireocita da preuzmu jodid, a scintigrafijom se dobija morfofunkcijska slika štitaste žlezde. Scintigrafijom orbite kod obolelih od Gravesove bolesti ispituje se stepen infiltracije orbitalnog tkiva aktivisanim leukocitima. Iako su savremene imaging metode (pozitronska emisiona tomografija, kompjuterizovana tomografija i magnetna rezonanca) veoma korisne u ispitivanju nodoznih promena u štitastoj žlezdi i substemame strume, te metode nisu značajnije zastupljene u dijagnostici autoimunskih tireoidnih bolesti. U ovom radu su prikazane in vivo dijagnostičke metode koje se koriste u dijagnostici Gravesove bolesti i Hashimoto tireoiditisa, njihov značaj u ispitivanju patološkog procesa u štitastoj žlezdi i faktori koji svojim dejstvom mogu da utiču na rezultate ispitivanja.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Medicus
T1  - Autoimmune thyroid diseases: In vivo diagnostics
T1  - Autoimunske bolesti štitaste žlezde - in vivo dijagnostika
EP  - 33
IS  - 1
SP  - 27
VL  - 5
UR  - https://hdl.handle.net/21.15107/rcub_intor_185
ER  - 

@article{
author = "Živančević-Simonović, Snežana and Đukić, Aleksandar and Matović, Milovan D. and Dimitrijević, Ljiljana",
year = "2004",
abstract = "Autoimmune thyroid disease, Graves disease and Hashimoto thyroiditis, cause changing in morphology and function of the thyroid tissue. Graves disease is characterized by an increased synthesis and release of thyroid hormones (hyperthyrosis). Hashimoto fhyroiditis is characterized by the destruction and regeneration of thyroid follicles, which are clinically expressed by symptoms of hypothyrosis. Less frequently, Hashimoto fhyroiditis is expressed by transient thyrotoxicosis (if the destruction of the thyroid gland tissue is extremely emphasized). In order to examine thyroid morphology and function, there are numerous in iga diagnostic methods. Ultrasono graphy enables the examination of the fine structure and vasculanzation of the thyroid gland, and nuclear medicine methods reflect the function of the thyroid tissue. Radioactive iodine uptake is useful in assessment of the ability of thyrocytes to uptake iodide, and scmtigraphy gives the morpho-functional picture of the thyroid gland. Scintigraphy of orbital tissue gives the insight of orbital accumulation of the activated leucocytes. Although modem imaging methods (positron emission tomography, computed tomography and magnetic resonance imaging) are very useful in assessment of nodular changes in the thyroid gland and retrostemal goiter, these techniques are not widely applied in diagnostic procedures of autoimmune thyroid diseases. In this study we reviewed in vivo diagnostic methods used in the examination of Graves disease and Hashimoto thyroiditis, we considered their significance in the investigation of pathological process in the thyroid gland and we noticed the factors which could influence the results of morphological and functional investigations of the thyroid gland., Autoimunske bolesti štitaste žlezde, Gravesova bolest i Hashimoto tireoiditis, prouzrokuju promenu strukture i funkcije tireoidnog tkiva. Gravesovu bolest karakteriše povećana sinteza i oslobađanje tireoidnih hormona (hipemreoza), a Hashimoto tireoiditis destrukcija i regeneracija tireoidnih folikula, koje se klinički ispoljavaju simptomima hipotireoze, a ako je destrukcija tkiva štitaste žlezde veoma izražena, privremeno mogu da se jave i simptomi tireotoksikoze. Da bi se ispitala struktura i funkcija tireoidnog tkiva primenjuju se brojne in vivo dijagnostičke metode. Ultrasonografija daje uvid u finu strukturu i vaskularizaciju štitaste žlezde, a metode nuklearne medicine odslikavaju funkciju tireoidnog tkiva. Testom fiksacije radioaktivnog joda procenjuje se sposobnost tireocita da preuzmu jodid, a scintigrafijom se dobija morfofunkcijska slika štitaste žlezde. Scintigrafijom orbite kod obolelih od Gravesove bolesti ispituje se stepen infiltracije orbitalnog tkiva aktivisanim leukocitima. Iako su savremene imaging metode (pozitronska emisiona tomografija, kompjuterizovana tomografija i magnetna rezonanca) veoma korisne u ispitivanju nodoznih promena u štitastoj žlezdi i substemame strume, te metode nisu značajnije zastupljene u dijagnostici autoimunskih tireoidnih bolesti. U ovom radu su prikazane in vivo dijagnostičke metode koje se koriste u dijagnostici Gravesove bolesti i Hashimoto tireoiditisa, njihov značaj u ispitivanju patološkog procesa u štitastoj žlezdi i faktori koji svojim dejstvom mogu da utiču na rezultate ispitivanja.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Medicus",
title = "Autoimmune thyroid diseases: In vivo diagnostics, Autoimunske bolesti štitaste žlezde - in vivo dijagnostika",
pages = "33-27",
number = "1",
volume = "5",
url = "https://hdl.handle.net/21.15107/rcub_intor_185"
}

Živančević-Simonović, S., Đukić, A., Matović, M. D.,& Dimitrijević, L.. (2004). Autoimmune thyroid diseases: In vivo diagnostics. in Medicus
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 5(1), 27-33.
https://hdl.handle.net/21.15107/rcub_intor_185

Živančević-Simonović S, Đukić A, Matović MD, Dimitrijević L. Autoimmune thyroid diseases: In vivo diagnostics. in Medicus. 2004;5(1):27-33.
https://hdl.handle.net/21.15107/rcub_intor_185 .

Živančević-Simonović, Snežana, Đukić, Aleksandar, Matović, Milovan D., Dimitrijević, Ljiljana, "Autoimmune thyroid diseases: In vivo diagnostics" in Medicus, 5, no. 1 (2004):27-33,
https://hdl.handle.net/21.15107/rcub_intor_185 .

TY  - JOUR
AU  - Živančević-Simonović, Snežana
AU  - Đukić, Aleksandar
AU  - Arsenijević, Nebojša
AU  - Dimitrijević, Ljiljana
PY  - 2003
UR  - http://intor.torlakinstitut.com/handle/123456789/164
AB  - It is generally accepted that autoimmune thyroid disorders, Graves disease and Hashimoto thyroiditis, differ in pathogenesis and clinical implications. In Graves disease the basic pathogenetic mechanism is B lymphocyte activation which produce auto antibodies specific for TSH receptor (TSHR) which binding to thyrocyte membrane causes their long-termed stimulation which gives as a result the occurrence of hyperthyrosis. On the other hand in Hashimoto thyroiditis lymphocyte accumulation occurs and they cause gradual thyrocyte damage and hypothyrosis development. However, it was found that the reisa certain genetic predisposition for both autoimmune thyroid diseases and that they can appear among several members of the same family. Besides in the serum of the patients with Graves disease and Hashimoto thyroiditis the presence of autoantibodi esspecific for dominant thyroid autoantigenes: TSHR, thyroperoxidase (TPO) and thyroglobulin (Tg) can be found as indicators of the auto immune process in thyroid gland. For these reasons both autoimmune diseases of thyroid gland sometimes are marked with the common name: autoimmune thyroid disease. As cell and molecule mechanisms included in initiation of the autoimmune process in thyroid gland that define the type and natural course of disease have not completely been explained, in this review the data from the literature considering pathogenesis of autoimmune diseases of thyroid gland have been shown. After introductory considerations, dominant autoantigenes and autoantibodies (as indicators of autoimmune process in thyroid gland) are shown in details, as well as mechanisms included in effector phase of autoimmune process which cau se the thyroid cell damage. The role of disturbance in regulation of the apoptosis process is especially analyzed as they could effect the development of autoimmune diseases of thyroid gland.
AB  - Prihvaćeno je shvatanje da se autoimunske bolesti štitaste žlezde Graves-ova bolest i Hashimoto tireoiditis razlikuju po patogenezi i kliničkim posledicama. U Graves-ovoj bolesti je osnovni patogenetski mehanizam aktivacija Blimfocita koji produkuju auto antitela specifična za TSH receptor (TSHR), čije vezivanje za membranu tireocita uzrokuje njihovu dugotrajnu stimulaciju, sa posledičnim nastankom hipertireoze. S druge strane, u Hashimoto tireoiditi su nastaje akumulacija limfocita koji prouzrokuju postepeno oštećenje tireocita i nastanak hipotireoze. Međutim utvrđeno je da za obe autoimunske tireoidne bolesti postoji određena genetska predispozicija i da se one mogu javiti kod više članova u istoj porodici. Osim toga, u serumu obolelih od Graves-ove bolesti i Hashimoto tireoiditi sa se može pokazati prisustvo autoantitela specifičnih za dominantne tireoidne autoantigene (receptor za TSH, tireoperoksidazu i tireoglobulin) koji predstavljaju pokazatelje autoimunskog procesa u štitastoj žlezdi. Iz tih razloga se obe autoimunske bolesti štitaste žlezde nekad označavaju zajedničkim nazivom: autoimunska bolest štitaste žlezde. Budući da ćelijski i molekulski mehanizmi koji su uključeni u inicijaciju autoimunskog procesa u štita stoj žlezdi, i opredeljuju vrstu i prirodni tok bolesti, nisu potpuno rasvetljeni, u ovom radu su prikazani podaci iz literature koji se odnose na patogenezu autoimunskih bolesti štitaste žlezde. Nakon uvodnih razmatranja, detaljno su prikazani dominantni autoantigeni i autoantitela (kao pokazatelji autoimunskog procesa u štitastoj žlezdi), kao i mehanizmi uključeni u efektorsku fazu autoimunskog procesa koji uzrokuju oštećenje tireocita. Posebno je analizirana uloga poremećaja u regulaciji procesa apoptoze u nastanku autoimunskih bolesti štitaste žlezde.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Medicus
T1  - Auto immune thyroid disease: The pathogenesis of Graves disease and Hashimoto thyroiditis
T1  - Auto imunska bolest štitaste žlezde - patogeneza Graves-ove bolesti i Hashimoto tireoiditisa
EP  - 26
IS  - 1
SP  - 21
VL  - 4
UR  - https://hdl.handle.net/21.15107/rcub_intor_164
ER  - 

@article{
author = "Živančević-Simonović, Snežana and Đukić, Aleksandar and Arsenijević, Nebojša and Dimitrijević, Ljiljana",
year = "2003",
abstract = "It is generally accepted that autoimmune thyroid disorders, Graves disease and Hashimoto thyroiditis, differ in pathogenesis and clinical implications. In Graves disease the basic pathogenetic mechanism is B lymphocyte activation which produce auto antibodies specific for TSH receptor (TSHR) which binding to thyrocyte membrane causes their long-termed stimulation which gives as a result the occurrence of hyperthyrosis. On the other hand in Hashimoto thyroiditis lymphocyte accumulation occurs and they cause gradual thyrocyte damage and hypothyrosis development. However, it was found that the reisa certain genetic predisposition for both autoimmune thyroid diseases and that they can appear among several members of the same family. Besides in the serum of the patients with Graves disease and Hashimoto thyroiditis the presence of autoantibodi esspecific for dominant thyroid autoantigenes: TSHR, thyroperoxidase (TPO) and thyroglobulin (Tg) can be found as indicators of the auto immune process in thyroid gland. For these reasons both autoimmune diseases of thyroid gland sometimes are marked with the common name: autoimmune thyroid disease. As cell and molecule mechanisms included in initiation of the autoimmune process in thyroid gland that define the type and natural course of disease have not completely been explained, in this review the data from the literature considering pathogenesis of autoimmune diseases of thyroid gland have been shown. After introductory considerations, dominant autoantigenes and autoantibodies (as indicators of autoimmune process in thyroid gland) are shown in details, as well as mechanisms included in effector phase of autoimmune process which cau se the thyroid cell damage. The role of disturbance in regulation of the apoptosis process is especially analyzed as they could effect the development of autoimmune diseases of thyroid gland., Prihvaćeno je shvatanje da se autoimunske bolesti štitaste žlezde Graves-ova bolest i Hashimoto tireoiditis razlikuju po patogenezi i kliničkim posledicama. U Graves-ovoj bolesti je osnovni patogenetski mehanizam aktivacija Blimfocita koji produkuju auto antitela specifična za TSH receptor (TSHR), čije vezivanje za membranu tireocita uzrokuje njihovu dugotrajnu stimulaciju, sa posledičnim nastankom hipertireoze. S druge strane, u Hashimoto tireoiditi su nastaje akumulacija limfocita koji prouzrokuju postepeno oštećenje tireocita i nastanak hipotireoze. Međutim utvrđeno je da za obe autoimunske tireoidne bolesti postoji određena genetska predispozicija i da se one mogu javiti kod više članova u istoj porodici. Osim toga, u serumu obolelih od Graves-ove bolesti i Hashimoto tireoiditi sa se može pokazati prisustvo autoantitela specifičnih za dominantne tireoidne autoantigene (receptor za TSH, tireoperoksidazu i tireoglobulin) koji predstavljaju pokazatelje autoimunskog procesa u štitastoj žlezdi. Iz tih razloga se obe autoimunske bolesti štitaste žlezde nekad označavaju zajedničkim nazivom: autoimunska bolest štitaste žlezde. Budući da ćelijski i molekulski mehanizmi koji su uključeni u inicijaciju autoimunskog procesa u štita stoj žlezdi, i opredeljuju vrstu i prirodni tok bolesti, nisu potpuno rasvetljeni, u ovom radu su prikazani podaci iz literature koji se odnose na patogenezu autoimunskih bolesti štitaste žlezde. Nakon uvodnih razmatranja, detaljno su prikazani dominantni autoantigeni i autoantitela (kao pokazatelji autoimunskog procesa u štitastoj žlezdi), kao i mehanizmi uključeni u efektorsku fazu autoimunskog procesa koji uzrokuju oštećenje tireocita. Posebno je analizirana uloga poremećaja u regulaciji procesa apoptoze u nastanku autoimunskih bolesti štitaste žlezde.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Medicus",
title = "Auto immune thyroid disease: The pathogenesis of Graves disease and Hashimoto thyroiditis, Auto imunska bolest štitaste žlezde - patogeneza Graves-ove bolesti i Hashimoto tireoiditisa",
pages = "26-21",
number = "1",
volume = "4",
url = "https://hdl.handle.net/21.15107/rcub_intor_164"
}

Živančević-Simonović, S., Đukić, A., Arsenijević, N.,& Dimitrijević, L.. (2003). Auto immune thyroid disease: The pathogenesis of Graves disease and Hashimoto thyroiditis. in Medicus
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 4(1), 21-26.
https://hdl.handle.net/21.15107/rcub_intor_164

Živančević-Simonović S, Đukić A, Arsenijević N, Dimitrijević L. Auto immune thyroid disease: The pathogenesis of Graves disease and Hashimoto thyroiditis. in Medicus. 2003;4(1):21-26.
https://hdl.handle.net/21.15107/rcub_intor_164 .

Živančević-Simonović, Snežana, Đukić, Aleksandar, Arsenijević, Nebojša, Dimitrijević, Ljiljana, "Auto immune thyroid disease: The pathogenesis of Graves disease and Hashimoto thyroiditis" in Medicus, 4, no. 1 (2003):21-26,
https://hdl.handle.net/21.15107/rcub_intor_164 .

TY  - JOUR
AU  - Živančević-Simonović, Snežana
AU  - Đukić, Aleksandar
AU  - Matović, Milovan D.
AU  - Dimitrijević, Ljiljana
PY  - 2003
UR  - http://intor.torlakinstitut.com/handle/123456789/158
AB  - In diagnostics of autoimmune thyroid diseases a number of in vitro methods is used to evaluate thyroid function or examine the presence of an tithyroid antibodies which may be included in pathogenesis of the disease or only represent "silent witnesses" of autoimmune processes. During the evaluation of thyroid function serum concentrations of thyroid-stimulating hormone (TSH) and thyroid hormones are determined and due to these concentrations the diagnosis of manifested or subclinical disturbances of thyroid gland is set. Detection of antibodies specific in dominant thyroid auto antigenes represents confirmation of autoimmune pathogenesis of the disease. The concentration of TSH and thyroid hormones in blood may be influenced by some diseases and drugs, so abnormal values can be detected in absence of diseases of thyroid gland. In the serum of a tested person heterophilic antibodies, rheumatoid factors or other antibodies may occur which reduce the number of specific interactions in the assay, causing increased or decreased concentrations of hormones or autoantibodies. A great number of methods used in in vitro diagnostics differs very much by sensitivity which should be considered during the interpretation of laboratory results. This study presents the most important methods used in diagnostics of autoimmune thyroid diseases.
AB  - U dijagnostici autoimunskih bolesti štitaste žlezde koriste se brojne in vitro metode kojima se procenjuje tireoidna funkcija ili ispituje prisustvo antitireoidnih autoantitela koja mogu biti uključena u patogenezu bolesti ili samo predstavljati "neme svedoke" autoimunskog procesa. Pri proceni funkcije štitaste žlezde određuju se serumske koncentracije tireostimulišućeg (TSH) i tireoidnih hormona i na osnovu njihove koncentracije postavlja dijagnoza ispoljenih ili subkliničkih poremećajafunkcije štitaste žlezde (hipertireoze ili hipotireoze). Potvrdu autoimunske patogeneze bolesti predstavlja detekcija antitela specifičnih za dominantne tireoidne autoantigene (receptor za TSH, tireoidnu peroksida zuitireoglobulin). Na koncentraciju TSH i tireoidnih hormona u krvi mogu uticati neka fiziološka stanja, bolesti i lekovi, tako da se abnormalne vrednosti mogu detektovati i u odsustvu bolesti štitaste žlezde. U serumu ispitanika mogu biti prisutna heterofilna anti tela, reumatoidni faktori ili druga auto anti tela koja smanjuju broj specifičnih interakcija u testu prouzrokujući povećanu ili smanjenu koncentraciju hormona ili autoantitela. Veliki broj metoda koje se koriste u in vitro dijagnostici veoma se razlikuju prema osetljivosti, što treba imati u vidu prilikom interpretacije laboratorijskih rezultata. U ovom radu su prikazane najvažnije metode koje se koriste u dijagnostici autoimunskih bolesti štitaste žlezde: Graves-ove bolesti i Hashimoto tireoiditisa.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Medicus
T1  - Autoimmune thyroid diseases: In vitro diagnostics
T1  - Autoimunske bolesti štitaste žlezde - in vitro dijagnostika
EP  - 30
IS  - 2
SP  - 23
VL  - 4
UR  - https://hdl.handle.net/21.15107/rcub_intor_158
ER  - 

@article{
author = "Živančević-Simonović, Snežana and Đukić, Aleksandar and Matović, Milovan D. and Dimitrijević, Ljiljana",
year = "2003",
abstract = "In diagnostics of autoimmune thyroid diseases a number of in vitro methods is used to evaluate thyroid function or examine the presence of an tithyroid antibodies which may be included in pathogenesis of the disease or only represent "silent witnesses" of autoimmune processes. During the evaluation of thyroid function serum concentrations of thyroid-stimulating hormone (TSH) and thyroid hormones are determined and due to these concentrations the diagnosis of manifested or subclinical disturbances of thyroid gland is set. Detection of antibodies specific in dominant thyroid auto antigenes represents confirmation of autoimmune pathogenesis of the disease. The concentration of TSH and thyroid hormones in blood may be influenced by some diseases and drugs, so abnormal values can be detected in absence of diseases of thyroid gland. In the serum of a tested person heterophilic antibodies, rheumatoid factors or other antibodies may occur which reduce the number of specific interactions in the assay, causing increased or decreased concentrations of hormones or autoantibodies. A great number of methods used in in vitro diagnostics differs very much by sensitivity which should be considered during the interpretation of laboratory results. This study presents the most important methods used in diagnostics of autoimmune thyroid diseases., U dijagnostici autoimunskih bolesti štitaste žlezde koriste se brojne in vitro metode kojima se procenjuje tireoidna funkcija ili ispituje prisustvo antitireoidnih autoantitela koja mogu biti uključena u patogenezu bolesti ili samo predstavljati "neme svedoke" autoimunskog procesa. Pri proceni funkcije štitaste žlezde određuju se serumske koncentracije tireostimulišućeg (TSH) i tireoidnih hormona i na osnovu njihove koncentracije postavlja dijagnoza ispoljenih ili subkliničkih poremećajafunkcije štitaste žlezde (hipertireoze ili hipotireoze). Potvrdu autoimunske patogeneze bolesti predstavlja detekcija antitela specifičnih za dominantne tireoidne autoantigene (receptor za TSH, tireoidnu peroksida zuitireoglobulin). Na koncentraciju TSH i tireoidnih hormona u krvi mogu uticati neka fiziološka stanja, bolesti i lekovi, tako da se abnormalne vrednosti mogu detektovati i u odsustvu bolesti štitaste žlezde. U serumu ispitanika mogu biti prisutna heterofilna anti tela, reumatoidni faktori ili druga auto anti tela koja smanjuju broj specifičnih interakcija u testu prouzrokujući povećanu ili smanjenu koncentraciju hormona ili autoantitela. Veliki broj metoda koje se koriste u in vitro dijagnostici veoma se razlikuju prema osetljivosti, što treba imati u vidu prilikom interpretacije laboratorijskih rezultata. U ovom radu su prikazane najvažnije metode koje se koriste u dijagnostici autoimunskih bolesti štitaste žlezde: Graves-ove bolesti i Hashimoto tireoiditisa.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Medicus",
title = "Autoimmune thyroid diseases: In vitro diagnostics, Autoimunske bolesti štitaste žlezde - in vitro dijagnostika",
pages = "30-23",
number = "2",
volume = "4",
url = "https://hdl.handle.net/21.15107/rcub_intor_158"
}

Živančević-Simonović, S., Đukić, A., Matović, M. D.,& Dimitrijević, L.. (2003). Autoimmune thyroid diseases: In vitro diagnostics. in Medicus
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 4(2), 23-30.
https://hdl.handle.net/21.15107/rcub_intor_158

Živančević-Simonović S, Đukić A, Matović MD, Dimitrijević L. Autoimmune thyroid diseases: In vitro diagnostics. in Medicus. 2003;4(2):23-30.
https://hdl.handle.net/21.15107/rcub_intor_158 .

Živančević-Simonović, Snežana, Đukić, Aleksandar, Matović, Milovan D., Dimitrijević, Ljiljana, "Autoimmune thyroid diseases: In vitro diagnostics" in Medicus, 4, no. 2 (2003):23-30,
https://hdl.handle.net/21.15107/rcub_intor_158 .