TY  - JOUR
AU  - Erić-Jovičić, Milena
AU  - Popović, Miroljub
AU  - Jovanova-Nešić, Katica
AU  - Popović, Natalija
AU  - Jovičić-Pavlović, Svetlana
AU  - Rakić, Ljubisav
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/247
AB  - Several studies suggested that the activity of erythrocyte Na, K-ATPase declines with aging. Here, it is postulated that alterations in the substrate kinetics of the erythrocyte membrane Na, K-ATPase could be more aggravated in conditions of brain cholinergic dysfunction seen in Alzheimer's disease than in normal aging. To test this hypothesis, we compared the Na, K-ATPase activity (Vmax/Km parameters) in aged rats with those in young rats with brain cholinergic dysfunction induced by electrolytic-, kainic acid-lesioned nucleus basalis magnocellularis (NBM) or by intracerebroventricular AlCl3 administration. In the above mentioned groups, Vmax values were significantly lower in comparison to the control animals. Furthermore, Km values were significantly higher in animals with electrolytic-induced NBM lesions, AlCl3 treated rats and aged animals. However, Km was significantly lower in kainic acid-induced NBM lesions compared to the control group. The Na, K-ATPase catalytic efficiency, estimated by the ratio Vm/Km, decreased as followed: young animals  gt  aged animals  gt  kainic acid lesion  gt  electrolityc lesion  gt  AlCl3. Our data suggest that neurodegenerative processes similar to those seen in Alzheimer's disease affect the sodium/potassium pump functionality which might be detected in peripheral blood erythrocyte membranes.
PB  - IOS Press, Amsterdam
T2  - Journal of Alzheimer's Disease
T1  - Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat
EP  - 93
IS  - 1
SP  - 85
VL  - 14
DO  - 10.3233/JAD-2008-14108
ER  - 

@article{
author = "Erić-Jovičić, Milena and Popović, Miroljub and Jovanova-Nešić, Katica and Popović, Natalija and Jovičić-Pavlović, Svetlana and Rakić, Ljubisav",
year = "2008",
abstract = "Several studies suggested that the activity of erythrocyte Na, K-ATPase declines with aging. Here, it is postulated that alterations in the substrate kinetics of the erythrocyte membrane Na, K-ATPase could be more aggravated in conditions of brain cholinergic dysfunction seen in Alzheimer's disease than in normal aging. To test this hypothesis, we compared the Na, K-ATPase activity (Vmax/Km parameters) in aged rats with those in young rats with brain cholinergic dysfunction induced by electrolytic-, kainic acid-lesioned nucleus basalis magnocellularis (NBM) or by intracerebroventricular AlCl3 administration. In the above mentioned groups, Vmax values were significantly lower in comparison to the control animals. Furthermore, Km values were significantly higher in animals with electrolytic-induced NBM lesions, AlCl3 treated rats and aged animals. However, Km was significantly lower in kainic acid-induced NBM lesions compared to the control group. The Na, K-ATPase catalytic efficiency, estimated by the ratio Vm/Km, decreased as followed: young animals  gt  aged animals  gt  kainic acid lesion  gt  electrolityc lesion  gt  AlCl3. Our data suggest that neurodegenerative processes similar to those seen in Alzheimer's disease affect the sodium/potassium pump functionality which might be detected in peripheral blood erythrocyte membranes.",
publisher = "IOS Press, Amsterdam",
journal = "Journal of Alzheimer's Disease",
title = "Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat",
pages = "93-85",
number = "1",
volume = "14",
doi = "10.3233/JAD-2008-14108"
}

Erić-Jovičić, M., Popović, M., Jovanova-Nešić, K., Popović, N., Jovičić-Pavlović, S.,& Rakić, L.. (2008). Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat. in Journal of Alzheimer's Disease
IOS Press, Amsterdam., 14(1), 85-93.
https://doi.org/10.3233/JAD-2008-14108

Erić-Jovičić M, Popović M, Jovanova-Nešić K, Popović N, Jovičić-Pavlović S, Rakić L. Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat. in Journal of Alzheimer's Disease. 2008;14(1):85-93.
doi:10.3233/JAD-2008-14108 .

Erić-Jovičić, Milena, Popović, Miroljub, Jovanova-Nešić, Katica, Popović, Natalija, Jovičić-Pavlović, Svetlana, Rakić, Ljubisav, "Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na, K-ATPase in the rat" in Journal of Alzheimer's Disease, 14, no. 1 (2008):85-93,
https://doi.org/10.3233/JAD-2008-14108 . .