TY  - JOUR
AU  - Živković, Irena
AU  - Rakin, Ana
AU  - Petrović-Đergović, Danica M.
AU  - Miljković, B.
AU  - Micić, M.
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/195
AB  - Various stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indicate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved.
PB  - Elsevier Gmbh, Munich
T2  - Acta Histochemica
T1  - The effects of chronic stress on thymus innervation in the adult rat
EP  - 458
IS  - 6
SP  - 449
VL  - 106
DO  - 10.1016/j.acthis.2004.11.002
ER  - 

@article{
author = "Živković, Irena and Rakin, Ana and Petrović-Đergović, Danica M. and Miljković, B. and Micić, M.",
year = "2005",
abstract = "Various stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indicate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved.",
publisher = "Elsevier Gmbh, Munich",
journal = "Acta Histochemica",
title = "The effects of chronic stress on thymus innervation in the adult rat",
pages = "458-449",
number = "6",
volume = "106",
doi = "10.1016/j.acthis.2004.11.002"
}

Živković, I., Rakin, A., Petrović-Đergović, D. M., Miljković, B.,& Micić, M.. (2005). The effects of chronic stress on thymus innervation in the adult rat. in Acta Histochemica
Elsevier Gmbh, Munich., 106(6), 449-458.
https://doi.org/10.1016/j.acthis.2004.11.002

Živković I, Rakin A, Petrović-Đergović DM, Miljković B, Micić M. The effects of chronic stress on thymus innervation in the adult rat. in Acta Histochemica. 2005;106(6):449-458.
doi:10.1016/j.acthis.2004.11.002 .

Živković, Irena, Rakin, Ana, Petrović-Đergović, Danica M., Miljković, B., Micić, M., "The effects of chronic stress on thymus innervation in the adult rat" in Acta Histochemica, 106, no. 6 (2005):449-458,
https://doi.org/10.1016/j.acthis.2004.11.002 . .