TY  - JOUR
AU  - Popović, N.
AU  - Milošević, B.
AU  - Urošević, A.
AU  - Poluga, J.
AU  - Lavadinović, Lidija
AU  - Nedeljković, Jasminka
AU  - Jevtović, Dj.
AU  - Dulović, O.
PY  - 2013
UR  - http://intor.torlakinstitut.com/handle/123456789/369
AB  - We describe the first reported outbreak of West Nile virus (WNV) infection in humans in Serbia in August to October 2012 and examine the association of various variables with encephalitis and fatal outcome. Enzyme-linked immunosorbent assay (ELISA) was used for detection of WNV-specific IgM and IgG antibodies in sera and cerebrospinal fluid. A total of 58 patients (mean age: 61 years; standard deviation: 15) were analysed: 44 were from Belgrade and its suburbs; 52 had neuroinvasive disease, of whom 8 had meningitis, while 44 had encephalitis. Acute flaccid paralysis developed in 13 of the patients with encephalitis. Age over 60 years and immunosuppression (including diabetes) were independently associated with the development of encephalitis in a multivariate analysis: odds ratio (OR): 44.8 (95% confidence interval (CI): 4.93-408.59); p=0.001 (age over 60 years); OR: 10.76 (95% CI: 1.06-109.65); p=0.045 (immunosuppression including diabetes). Respiratory failure requiring mechanical ventilation developed in 13 patients with encephalitis. A total of 35 patients had completely recovered by the time they were discharged; nine patients died. The presence of acute flaccid paralysis, consciousness impairment, respiratory failure and immunosuppression (without diabetes) were found to be associated with death in hospital in a univariate analysis (p lt 0.001, p=0.007, p lt 0.001 and p=0.010, respectively).
PB  - Eur Centre Dis Prevention & Control, Stockholm
T2  - Eurosurveillance
T1  - Outbreak of West Nile virus infection among humans in Serbia, August to October 2012
EP  - 25
IS  - 43
SP  - 18
VL  - 18
DO  - 10.2807/1560-7917.ES2013.18.43.20613
ER  - 

@article{
author = "Popović, N. and Milošević, B. and Urošević, A. and Poluga, J. and Lavadinović, Lidija and Nedeljković, Jasminka and Jevtović, Dj. and Dulović, O.",
year = "2013",
abstract = "We describe the first reported outbreak of West Nile virus (WNV) infection in humans in Serbia in August to October 2012 and examine the association of various variables with encephalitis and fatal outcome. Enzyme-linked immunosorbent assay (ELISA) was used for detection of WNV-specific IgM and IgG antibodies in sera and cerebrospinal fluid. A total of 58 patients (mean age: 61 years; standard deviation: 15) were analysed: 44 were from Belgrade and its suburbs; 52 had neuroinvasive disease, of whom 8 had meningitis, while 44 had encephalitis. Acute flaccid paralysis developed in 13 of the patients with encephalitis. Age over 60 years and immunosuppression (including diabetes) were independently associated with the development of encephalitis in a multivariate analysis: odds ratio (OR): 44.8 (95% confidence interval (CI): 4.93-408.59); p=0.001 (age over 60 years); OR: 10.76 (95% CI: 1.06-109.65); p=0.045 (immunosuppression including diabetes). Respiratory failure requiring mechanical ventilation developed in 13 patients with encephalitis. A total of 35 patients had completely recovered by the time they were discharged; nine patients died. The presence of acute flaccid paralysis, consciousness impairment, respiratory failure and immunosuppression (without diabetes) were found to be associated with death in hospital in a univariate analysis (p lt 0.001, p=0.007, p lt 0.001 and p=0.010, respectively).",
publisher = "Eur Centre Dis Prevention & Control, Stockholm",
journal = "Eurosurveillance",
title = "Outbreak of West Nile virus infection among humans in Serbia, August to October 2012",
pages = "25-18",
number = "43",
volume = "18",
doi = "10.2807/1560-7917.ES2013.18.43.20613"
}

Popović, N., Milošević, B., Urošević, A., Poluga, J., Lavadinović, L., Nedeljković, J., Jevtović, Dj.,& Dulović, O.. (2013). Outbreak of West Nile virus infection among humans in Serbia, August to October 2012. in Eurosurveillance
Eur Centre Dis Prevention & Control, Stockholm., 18(43), 18-25.
https://doi.org/10.2807/1560-7917.ES2013.18.43.20613

Popović N, Milošević B, Urošević A, Poluga J, Lavadinović L, Nedeljković J, Jevtović D, Dulović O. Outbreak of West Nile virus infection among humans in Serbia, August to October 2012. in Eurosurveillance. 2013;18(43):18-25.
doi:10.2807/1560-7917.ES2013.18.43.20613 .

Popović, N., Milošević, B., Urošević, A., Poluga, J., Lavadinović, Lidija, Nedeljković, Jasminka, Jevtović, Dj., Dulović, O., "Outbreak of West Nile virus infection among humans in Serbia, August to October 2012" in Eurosurveillance, 18, no. 43 (2013):18-25,
https://doi.org/10.2807/1560-7917.ES2013.18.43.20613 . .

TY  - JOUR
AU  - Popović, N.
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Kostić, V.S.
AU  - Šternić, N.
AU  - Rakić, L.
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/136
AB  - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 115
IS  - 1
SP  - 105
VL  - 112
DO  - 10.1080/00207450212017
ER  - 

@article{
author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.",
year = "2002",
abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "115-105",
number = "1",
volume = "112",
doi = "10.1080/00207450212017"
}

Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 112(1), 105-115.
https://doi.org/10.1080/00207450212017

Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115.
doi:10.1080/00207450212017 .

Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115,
https://doi.org/10.1080/00207450212017 . .

TY  - CONF
AU  - Jovanova-Nešić, Katica
AU  - Erić-Jovičić, Milena
AU  - Popović, M.
AU  - Popović, N.
AU  - Rakić, L.
AU  - Spector, Novera Herbert
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/149
AB  - In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.
PB  - IEEE, New York
C3  - 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
T1  - Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease
EP  - 170
SP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_intor_149
ER  - 

@conference{
author = "Jovanova-Nešić, Katica and Erić-Jovičić, Milena and Popović, M. and Popović, N. and Rakić, L. and Spector, Novera Herbert",
year = "2002",
abstract = "In a previous paper, the authors have described the effect of Ca2+-antagonist. verapamil on Na,K-ATPase in experimental model of Alzheimer's disease (AD-[38,39]. The present paper is concerned with the effect of magnetic, stimulation of. pineal complex on Na,K-ATPase activity in the same experimental model of AD. Because accumulating data indicate that free radicals mediate injury and death of neurons in AD, and because magnetic fields (MFs) can alter- free radicals. reactions; we tested the hypothesis that stationary MFs mediates ion homeostasis through membrane Na;K-ATPase activity. Results are presented as Vmax/Km - parameters on erythrocyte membranes in peripheral blood of rats with lesioned nucleus basalis magnocellularis. Bilateral electrolytic or by kainic acid induced lesions of NBM induce significant decrease of Vmax/Km activity on erythrocyte membranes obtained by cardiac punction. Stimulation of - pineal complex of the brain more than ten days, by magnetic beards (600-Gauss flux density), fixed on the skull upon pineal gland, significantly increase impaired by lesions of NBM, Na, K-ATPase activity. Results are presented as Vmax/Km parameters. on erythrocyte membranes in peripheral blood of rats with lesioned NBM of the basal forebrain bundle. Chronically magnetic stimulation of the pineal complex significantly increase maximum velocity (Vmax; nmol Pi/mg protein/min) of proteins in both lesioned group, even more than 2-fold in by kainic acid (ka)lesioned animals in comparison of lesioned sham-stimulated and increase Vmax in comparison to both controls (sham-lesioned m-sham-stimulated, and intact controls, and return desturbed by lesions affinity of enzyme to substrate (Km; nM) near to the control values. These results confirm the hypothesis that altered ion homeostasis disturbed by neurodegenerations play an essential role in pathogenesis of experimental Alzheimer's disease (AD) and that magnetic stimulation of the pineal complex might successfully restore disturbed by neuronal death Na, K-ATPase activity.",
publisher = "IEEE, New York",
journal = "2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings",
title = "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease",
pages = "170-165",
url = "https://hdl.handle.net/21.15107/rcub_intor_149"
}

Jovanova-Nešić, K., Erić-Jovičić, M., Popović, M., Popović, N., Rakić, L.,& Spector, N. H.. (2002). Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings
IEEE, New York., 165-170.
https://hdl.handle.net/21.15107/rcub_intor_149

Jovanova-Nešić K, Erić-Jovičić M, Popović M, Popović N, Rakić L, Spector NH. Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease. in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings. 2002;:165-170.
https://hdl.handle.net/21.15107/rcub_intor_149 .

Jovanova-Nešić, Katica, Erić-Jovičić, Milena, Popović, M., Popović, N., Rakić, L., Spector, Novera Herbert, "Effect of magnetic stimulation of pineal complex of the brain on Na,K-ATPase in experimental Alzheimer's Disease" in 2002 6th Seminar on Neural Network Applications in Electrical Engineering, NEUREL 2002 - Proceedings (2002):165-170,
https://hdl.handle.net/21.15107/rcub_intor_149 .

TY  - JOUR
AU  - Ilić, V.
AU  - Lazarević, M.
AU  - Rauški, Aleksandra
AU  - Popović, N.
AU  - Kosec, Duško
PY  - 2001
UR  - http://intor.torlakinstitut.com/handle/123456789/133
AB  - We investigated the influence of an antiparasitic drug, levamisole (2,3,5,6 - tetrahydro - 6- phenyl-imidazo (2,1 - b) thiazole -hydrochloride) with potent immunomodulatory properties on the course and development of experimental autoimmune encepha-lomyelitis (EAE). EAE was induced in female Dark Agouti (DA) rats aged two months by immunization with guinea pig spinal cord in complete Freunds adjuvant. Following immunization animals were subcutaneously treated every other day with 2.2 mg/kg levamisole. The course, development and characteristics of this autoimmune process were monitored as indirect indicators of immune system activity. Our results indicate that in EAE levamisole exerts immunosuppressive effects when administered every other day from the moment of immunization until the end of the disease. This application regime and dose postponed the onset of the first clinical signs, shortened the duration of the disease, abrogated the severity of clinical symptoms and accelerated the recovery of sick animals. In the period of induction and during EAE, levamisole also decreased the severity of changes in the cerebral perivascular spaces. In the peripheral blood of levamisole treated animals with induced EAE, a significant increase of CD4-CD8+ T cells was demonstrated. Furthermore, all rats with induced EAE had decreased numbers of CD4+CD8- T cells in their blood. These changes were in correlation with clinical signs of EAE.
AB  - U ovom radu su prikazani rezultati ispitivanja anthelmintika levamizola (2,3,5,6 tetrahidro - 6 - fenil - imidazo (2,1 - b) tiazol hidrohlorida) sa snažnim imunomodulatornim svojstvima na tok i razvoj eksperimentalnog autoimunog encefalomijelitisa (EAE). EAE je indukovan imunizacijom ženki pacova soja DA (Dark Agouti) starih dva meseca pomoću homogenata kičmene moždine zamorčeta u kompletnom Freundovom adjuvansu. Posle imunizacije, životinje su tretirane subkutanim injekcijama levamizola (2.2 mg/kg) svaki drugi dan a praćeni su tok, razvoj i karakteristike ovog autoimunog oboljenja kao indirektni indikatori aktivnosti imunološkog sistema. Postignuti rezultati ukazuju dalevamizol ispoljava imunosupresivno delovanje u modelu EAE ako se aplikuje svaki drugi dan od momenta imunizacije do kraja bolesti. Primenjena doza i režim aplikacije odložili su momenat pojavljivanja prvih kliničkih simptoma, skratili trajanje bolesti, ublažili ispoljavanje simptoma i ubrzali oporavak bolesnih životinja. U periodu indukcije i tokom EAE-a levamizol je smanjio stepen promena u cerebralnim perivaskularnim prostorima. U ženskoj krvi ženki pacova sa indukovanim EAE i tretiranim levamizolom uočeno je značajno povećanje broja CD4-CD8+ T ćelija. Osim toga, u obe imunizovane grupe životinja zapaženo je smanjenje broja CD4+CD8- ćelija. Ove promene su bile u skladu sa kliničkom slikom bolesti.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria - Beograd
T1  - Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats
T1  - Modulacija eksperimentalnog autoimunog encefalomijelitisa (EAE) DA pacova levamizolom
EP  - 100
IS  - 2-3
SP  - 89
VL  - 51
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_171
ER  - 

@article{
author = "Ilić, V. and Lazarević, M. and Rauški, Aleksandra and Popović, N. and Kosec, Duško",
year = "2001",
abstract = "We investigated the influence of an antiparasitic drug, levamisole (2,3,5,6 - tetrahydro - 6- phenyl-imidazo (2,1 - b) thiazole -hydrochloride) with potent immunomodulatory properties on the course and development of experimental autoimmune encepha-lomyelitis (EAE). EAE was induced in female Dark Agouti (DA) rats aged two months by immunization with guinea pig spinal cord in complete Freunds adjuvant. Following immunization animals were subcutaneously treated every other day with 2.2 mg/kg levamisole. The course, development and characteristics of this autoimmune process were monitored as indirect indicators of immune system activity. Our results indicate that in EAE levamisole exerts immunosuppressive effects when administered every other day from the moment of immunization until the end of the disease. This application regime and dose postponed the onset of the first clinical signs, shortened the duration of the disease, abrogated the severity of clinical symptoms and accelerated the recovery of sick animals. In the period of induction and during EAE, levamisole also decreased the severity of changes in the cerebral perivascular spaces. In the peripheral blood of levamisole treated animals with induced EAE, a significant increase of CD4-CD8+ T cells was demonstrated. Furthermore, all rats with induced EAE had decreased numbers of CD4+CD8- T cells in their blood. These changes were in correlation with clinical signs of EAE., U ovom radu su prikazani rezultati ispitivanja anthelmintika levamizola (2,3,5,6 tetrahidro - 6 - fenil - imidazo (2,1 - b) tiazol hidrohlorida) sa snažnim imunomodulatornim svojstvima na tok i razvoj eksperimentalnog autoimunog encefalomijelitisa (EAE). EAE je indukovan imunizacijom ženki pacova soja DA (Dark Agouti) starih dva meseca pomoću homogenata kičmene moždine zamorčeta u kompletnom Freundovom adjuvansu. Posle imunizacije, životinje su tretirane subkutanim injekcijama levamizola (2.2 mg/kg) svaki drugi dan a praćeni su tok, razvoj i karakteristike ovog autoimunog oboljenja kao indirektni indikatori aktivnosti imunološkog sistema. Postignuti rezultati ukazuju dalevamizol ispoljava imunosupresivno delovanje u modelu EAE ako se aplikuje svaki drugi dan od momenta imunizacije do kraja bolesti. Primenjena doza i režim aplikacije odložili su momenat pojavljivanja prvih kliničkih simptoma, skratili trajanje bolesti, ublažili ispoljavanje simptoma i ubrzali oporavak bolesnih životinja. U periodu indukcije i tokom EAE-a levamizol je smanjio stepen promena u cerebralnim perivaskularnim prostorima. U ženskoj krvi ženki pacova sa indukovanim EAE i tretiranim levamizolom uočeno je značajno povećanje broja CD4-CD8+ T ćelija. Osim toga, u obe imunizovane grupe životinja zapaženo je smanjenje broja CD4+CD8- ćelija. Ove promene su bile u skladu sa kliničkom slikom bolesti.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria - Beograd",
title = "Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats, Modulacija eksperimentalnog autoimunog encefalomijelitisa (EAE) DA pacova levamizolom",
pages = "100-89",
number = "2-3",
volume = "51",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_171"
}

Ilić, V., Lazarević, M., Rauški, A., Popović, N.,& Kosec, D.. (2001). Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats. in Acta veterinaria - Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 51(2-3), 89-100.
https://hdl.handle.net/21.15107/rcub_veterinar_171

Ilić V, Lazarević M, Rauški A, Popović N, Kosec D. Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats. in Acta veterinaria - Beograd. 2001;51(2-3):89-100.
https://hdl.handle.net/21.15107/rcub_veterinar_171 .

Ilić, V., Lazarević, M., Rauški, Aleksandra, Popović, N., Kosec, Duško, "Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats" in Acta veterinaria - Beograd, 51, no. 2-3 (2001):89-100,
https://hdl.handle.net/21.15107/rcub_veterinar_171 .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Erić-Jovičić, Milena
AU  - Jovanova-Nešić, Katica
PY  - 2000
UR  - http://intor.torlakinstitut.com/handle/123456789/122
AB  - The present study was designed to establish the influence of chronic social isolation stress on humoral and cellular immunity in nucleus basalis magnocellularis (NBM)-lesioned rats. Therefore, ten days after bilateral electrolytic lesions of NBM, adult male Wistar rats were immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) and placed individually or in groups of five rats during 21 days. On days 10 and 21 after immunization, the Arthus and delayed hypersensitivity skin reactions to BSA as well as anti-BSA antibody production were determined. On day 10, the diameter and intensity of delayed hypersensitivity skin reaction to BSA were significantly higher in social-isolated rats in comparison with the group-reared ones. On day 21, the diameter and intensity of the Arthus skin reaction were significantly higher in social-isolated rats compared to group-reared rats. Between days 10 and 21, the diameter and intensity of the Arthus skin reaction significantly increased in social-isolated rats, while the diameter of delayed hypersensitivity skin reaction significantly decreased. In contrast to social-isolated rats, there were no significant differences in Arthus and delayed hypersensitivity skin reactions in group-reared rats, between days 10 and 21. Also there were no significant differences in the production of anti-BSA antibody between social-isolated and group-reared rats. The relative spleen weight was significantly lower in social-isolated rats. These data suggest that chronic isolation stress modify humoral and cellular immunity in NBM-lesioned rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress
EP  - 131
IS  - 1-4
SP  - 125
VL  - 100
DO  - 10.3109/00207450008999683
ER  - 

@article{
author = "Popović, M. and Popović, N. and Erić-Jovičić, Milena and Jovanova-Nešić, Katica",
year = "2000",
abstract = "The present study was designed to establish the influence of chronic social isolation stress on humoral and cellular immunity in nucleus basalis magnocellularis (NBM)-lesioned rats. Therefore, ten days after bilateral electrolytic lesions of NBM, adult male Wistar rats were immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) and placed individually or in groups of five rats during 21 days. On days 10 and 21 after immunization, the Arthus and delayed hypersensitivity skin reactions to BSA as well as anti-BSA antibody production were determined. On day 10, the diameter and intensity of delayed hypersensitivity skin reaction to BSA were significantly higher in social-isolated rats in comparison with the group-reared ones. On day 21, the diameter and intensity of the Arthus skin reaction were significantly higher in social-isolated rats compared to group-reared rats. Between days 10 and 21, the diameter and intensity of the Arthus skin reaction significantly increased in social-isolated rats, while the diameter of delayed hypersensitivity skin reaction significantly decreased. In contrast to social-isolated rats, there were no significant differences in Arthus and delayed hypersensitivity skin reactions in group-reared rats, between days 10 and 21. Also there were no significant differences in the production of anti-BSA antibody between social-isolated and group-reared rats. The relative spleen weight was significantly lower in social-isolated rats. These data suggest that chronic isolation stress modify humoral and cellular immunity in NBM-lesioned rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress",
pages = "131-125",
number = "1-4",
volume = "100",
doi = "10.3109/00207450008999683"
}

Popović, M., Popović, N., Erić-Jovičić, M.,& Jovanova-Nešić, K.. (2000). Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 100(1-4), 125-131.
https://doi.org/10.3109/00207450008999683

Popović M, Popović N, Erić-Jovičić M, Jovanova-Nešić K. Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress. in International Journal of Neuroscience. 2000;100(1-4):125-131.
doi:10.3109/00207450008999683 .

Popović, M., Popović, N., Erić-Jovičić, Milena, Jovanova-Nešić, Katica, "Immune responses in nucleus basalis magnocellularis-lesioned rats exposed to chronic isolation stress" in International Journal of Neuroscience, 100, no. 1-4 (2000):125-131,
https://doi.org/10.3109/00207450008999683 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
PY  - 1999
UR  - http://intor.torlakinstitut.com/handle/123456789/103
AB  - The aim of the present study was to analyze the influence of the estrus cycle on the development of cold restraint-induced gastric lesions in single- and group-stressed female rats. Therefore, adult female Wistar rats, in different phases of the estrus cycle (proestrus, estrus, metestrus and diestrus), were restrained individually or in groups (two, three, six or nine rats) and exposed to a temperature of 4 degrees C for 2 h. The comparison between stressed female rats in different phases of the estrus cycle indicated that gastric pathology was significantly higher in estrus phase as compared to the other phases of the estrus cycle. The intensity of stress-induced gastric pathology was either not changed (estrus), moderately decreased (proestrus and metestrus) or highly decreased (diestrus) by increasing the number of concomitantly exposed rats to cold restraint. The vulnerability to cold restraint-induced stress ulcer rose as followed: proestrus  lt  metestrus ( diestrus  lt  estrus. It could be concluded that female rats are more vulnerable to cold restraint-induced stress ulcer in estrus period and that in this phase, social interaction did not made any significant influence on the stress induced gastric lesions. (C) 1999 Elsevier Science B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - International Journal of Psychophysiology
T1  - Estrus cycle and gastric lesions in individual- and group-stressed female rats
EP  - 26
IS  - 1
SP  - 21
VL  - 33
DO  - 10.1016/S0167-8760(99)00023-9
ER  - 

@article{
author = "Popović, M. and Popović, N.",
year = "1999",
abstract = "The aim of the present study was to analyze the influence of the estrus cycle on the development of cold restraint-induced gastric lesions in single- and group-stressed female rats. Therefore, adult female Wistar rats, in different phases of the estrus cycle (proestrus, estrus, metestrus and diestrus), were restrained individually or in groups (two, three, six or nine rats) and exposed to a temperature of 4 degrees C for 2 h. The comparison between stressed female rats in different phases of the estrus cycle indicated that gastric pathology was significantly higher in estrus phase as compared to the other phases of the estrus cycle. The intensity of stress-induced gastric pathology was either not changed (estrus), moderately decreased (proestrus and metestrus) or highly decreased (diestrus) by increasing the number of concomitantly exposed rats to cold restraint. The vulnerability to cold restraint-induced stress ulcer rose as followed: proestrus  lt  metestrus ( diestrus  lt  estrus. It could be concluded that female rats are more vulnerable to cold restraint-induced stress ulcer in estrus period and that in this phase, social interaction did not made any significant influence on the stress induced gastric lesions. (C) 1999 Elsevier Science B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Psychophysiology",
title = "Estrus cycle and gastric lesions in individual- and group-stressed female rats",
pages = "26-21",
number = "1",
volume = "33",
doi = "10.1016/S0167-8760(99)00023-9"
}

Popović, M.,& Popović, N.. (1999). Estrus cycle and gastric lesions in individual- and group-stressed female rats. in International Journal of Psychophysiology
Elsevier, Amsterdam., 33(1), 21-26.
https://doi.org/10.1016/S0167-8760(99)00023-9

Popović M, Popović N. Estrus cycle and gastric lesions in individual- and group-stressed female rats. in International Journal of Psychophysiology. 1999;33(1):21-26.
doi:10.1016/S0167-8760(99)00023-9 .

Popović, M., Popović, N., "Estrus cycle and gastric lesions in individual- and group-stressed female rats" in International Journal of Psychophysiology, 33, no. 1 (1999):21-26,
https://doi.org/10.1016/S0167-8760(99)00023-9 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Caballero-Bleda, M.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/101
AB  - Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease
EP  - 257
IS  - 3-4
SP  - 251
VL  - 94
DO  - 10.3109/00207459808986450
ER  - 

@article{
author = "Popović, M. and Popović, N. and Caballero-Bleda, M.",
year = "1998",
abstract = "Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease",
pages = "257-251",
number = "3-4",
volume = "94",
doi = "10.3109/00207459808986450"
}

Popović, M., Popović, N.,& Caballero-Bleda, M.. (1998). Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 94(3-4), 251-257.
https://doi.org/10.3109/00207459808986450

Popović M, Popović N, Caballero-Bleda M. Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1998;94(3-4):251-257.
doi:10.3109/00207459808986450 .

Popović, M., Popović, N., Caballero-Bleda, M., "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 94, no. 3-4 (1998):251-257,
https://doi.org/10.3109/00207459808986450 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Ugrešić, Nenad
AU  - Kostić, V.S.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/87
AB  - In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.
PB  - Wiley, Hoboken
T2  - Neuroscience Research Communications
T1  - Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 22
IS  - 1
SP  - 13
VL  - 23
DO  - 10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
ER  - 

@article{
author = "Popović, M. and Popović, N. and Bokonjić, D. and Dobrić, Silva and Ugrešić, Nenad and Kostić, V.S.",
year = "1998",
abstract = "In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.",
publisher = "Wiley, Hoboken",
journal = "Neuroscience Research Communications",
title = "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "22-13",
number = "1",
volume = "23",
doi = "10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O"
}

Popović, M., Popović, N., Bokonjić, D., Dobrić, S., Ugrešić, N.,& Kostić, V.S.. (1998). Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications
Wiley, Hoboken., 23(1), 13-22.
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O

Popović M, Popović N, Bokonjić D, Dobrić S, Ugrešić N, Kostić V. Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications. 1998;23(1):13-22.
doi:10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O .

Popović, M., Popović, N., Bokonjić, D., Dobrić, Silva, Ugrešić, Nenad, Kostić, V.S., "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis" in Neuroscience Research Communications, 23, no. 1 (1998):13-22,
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O . .

TY  - JOUR
AU  - Popović, M.
AU  - Caballero-Bleda, M.
AU  - Puelles, L.
AU  - Popović, N.
AU  - Popović, N.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/85
AB  - The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease
EP  - 236
IS  - 3-4
SP  - 203
VL  - 95
DO  - 10.3109/00207459809003341
ER  - 

@article{
author = "Popović, M. and Caballero-Bleda, M. and Puelles, L. and Popović, N. and Popović, N.",
year = "1998",
abstract = "The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease",
pages = "236-203",
number = "3-4",
volume = "95",
doi = "10.3109/00207459809003341"
}

Popović, M., Caballero-Bleda, M., Puelles, L., Popović, N.,& Popović, N.. (1998). Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 95(3-4), 203-236.
https://doi.org/10.3109/00207459809003341

Popović M, Caballero-Bleda M, Puelles L, Popović N, Popović N. Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease. in International Journal of Neuroscience. 1998;95(3-4):203-236.
doi:10.3109/00207459809003341 .

Popović, M., Caballero-Bleda, M., Puelles, L., Popović, N., Popović, N., "Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease" in International Journal of Neuroscience, 95, no. 3-4 (1998):203-236,
https://doi.org/10.3109/00207459809003341 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Caballero-Bleda, M.
AU  - Puelles, L.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/84
AB  - Our recent studies suggest that lesions of the nucleus basalis magnocellularis (nbm) in rats induce a significant decrease of core body temperature in standard laboratory conditions. Considering the importance of calcium homeostasis in thermoregulation, as well as in the pathogenesis of neurodegeneration, the aim of the present study was to investigate the effect of acute verapamil treatment on body temperature in nbm-lesioned rats. The body temperature was registered before and 30 min after verapamil was subcutaneously administered (1.0, 2.5, 5.0 and 10.0 mg/kg). Verapamil did not change body temperature in control animals. However, verapamil in doses of 2.5 and 5.0 mg/kg significantly increased the core body temperature in nbm-lesioned rats nearly up to the temperature of control animals. Findings that verapamil in doses of 1.0 and 10.0 mg/kg did not change body temperature in nbm-lesioned suggest the existence of an inverted U-shape curve in its effect.
PB  - Wiley, Hoboken
T2  - Neuroscience Research Communications
T1  - Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats
EP  - 187
IS  - 3
SP  - 181
VL  - 23
DO  - 10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E
ER  - 

@article{
author = "Popović, M. and Popović, N. and Caballero-Bleda, M. and Puelles, L.",
year = "1998",
abstract = "Our recent studies suggest that lesions of the nucleus basalis magnocellularis (nbm) in rats induce a significant decrease of core body temperature in standard laboratory conditions. Considering the importance of calcium homeostasis in thermoregulation, as well as in the pathogenesis of neurodegeneration, the aim of the present study was to investigate the effect of acute verapamil treatment on body temperature in nbm-lesioned rats. The body temperature was registered before and 30 min after verapamil was subcutaneously administered (1.0, 2.5, 5.0 and 10.0 mg/kg). Verapamil did not change body temperature in control animals. However, verapamil in doses of 2.5 and 5.0 mg/kg significantly increased the core body temperature in nbm-lesioned rats nearly up to the temperature of control animals. Findings that verapamil in doses of 1.0 and 10.0 mg/kg did not change body temperature in nbm-lesioned suggest the existence of an inverted U-shape curve in its effect.",
publisher = "Wiley, Hoboken",
journal = "Neuroscience Research Communications",
title = "Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats",
pages = "187-181",
number = "3",
volume = "23",
doi = "10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E"
}

Popović, M., Popović, N., Caballero-Bleda, M.,& Puelles, L.. (1998). Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats. in Neuroscience Research Communications
Wiley, Hoboken., 23(3), 181-187.
https://doi.org/10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E

Popović M, Popović N, Caballero-Bleda M, Puelles L. Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats. in Neuroscience Research Communications. 1998;23(3):181-187.
doi:10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E .

Popović, M., Popović, N., Caballero-Bleda, M., Puelles, L., "Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats" in Neuroscience Research Communications, 23, no. 3 (1998):181-187,
https://doi.org/10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E . .

TY  - CONF
AU  - Popović, M.
AU  - Popović, N.
AU  - Erić-Jovičić, Milena
AU  - Inić, Aleksandra
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/100
PB  - Wiley, Hoboken
C3  - European Journal of Neuroscience
T1  - Effect of physostigmine on cold restraint-induced gastric lesions in an experimental, model of Alzheimer's disease
EP  - 94
SP  - 94
VL  - 10
UR  - https://hdl.handle.net/21.15107/rcub_intor_100
ER  - 

@conference{
author = "Popović, M. and Popović, N. and Erić-Jovičić, Milena and Inić, Aleksandra",
year = "1998",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neuroscience",
title = "Effect of physostigmine on cold restraint-induced gastric lesions in an experimental, model of Alzheimer's disease",
pages = "94-94",
volume = "10",
url = "https://hdl.handle.net/21.15107/rcub_intor_100"
}

Popović, M., Popović, N., Erić-Jovičić, M.,& Inić, A.. (1998). Effect of physostigmine on cold restraint-induced gastric lesions in an experimental, model of Alzheimer's disease. in European Journal of Neuroscience
Wiley, Hoboken., 10, 94-94.
https://hdl.handle.net/21.15107/rcub_intor_100

Popović M, Popović N, Erić-Jovičić M, Inić A. Effect of physostigmine on cold restraint-induced gastric lesions in an experimental, model of Alzheimer's disease. in European Journal of Neuroscience. 1998;10:94-94.
https://hdl.handle.net/21.15107/rcub_intor_100 .

Popović, M., Popović, N., Erić-Jovičić, Milena, Inić, Aleksandra, "Effect of physostigmine on cold restraint-induced gastric lesions in an experimental, model of Alzheimer's disease" in European Journal of Neuroscience, 10 (1998):94-94,
https://hdl.handle.net/21.15107/rcub_intor_100 .

TY  - CONF
AU  - Popović, N.
AU  - Erić-Jovičić, Milena
AU  - Petrićević, Marijana
AU  - Popović, M.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/99
PB  - Wiley, Hoboken
C3  - European Journal of Neuroscience
T1  - Thermoregulation in an animal model of Alzheimer's disease
EP  - 94
SP  - 94
VL  - 10
UR  - https://hdl.handle.net/21.15107/rcub_intor_99
ER  - 

@conference{
author = "Popović, N. and Erić-Jovičić, Milena and Petrićević, Marijana and Popović, M.",
year = "1998",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neuroscience",
title = "Thermoregulation in an animal model of Alzheimer's disease",
pages = "94-94",
volume = "10",
url = "https://hdl.handle.net/21.15107/rcub_intor_99"
}

Popović, N., Erić-Jovičić, M., Petrićević, M.,& Popović, M.. (1998). Thermoregulation in an animal model of Alzheimer's disease. in European Journal of Neuroscience
Wiley, Hoboken., 10, 94-94.
https://hdl.handle.net/21.15107/rcub_intor_99

Popović N, Erić-Jovičić M, Petrićević M, Popović M. Thermoregulation in an animal model of Alzheimer's disease. in European Journal of Neuroscience. 1998;10:94-94.
https://hdl.handle.net/21.15107/rcub_intor_99 .

Popović, N., Erić-Jovičić, Milena, Petrićević, Marijana, Popović, M., "Thermoregulation in an animal model of Alzheimer's disease" in European Journal of Neuroscience, 10 (1998):94-94,
https://hdl.handle.net/21.15107/rcub_intor_99 .

TY  - CONF
AU  - Popović, N.
AU  - Erić-Jovičić, Milena
AU  - Popović, M.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/90
PB  - Wiley, Hoboken
C3  - European Journal of Neuroscience
T1  - Pharmacological and transplantational approaches to treatment of learning and memory impairment in an animal model of Alzheimer's disease
EP  - 437
SP  - 437
VL  - 10
UR  - https://hdl.handle.net/21.15107/rcub_intor_90
ER  - 

@conference{
author = "Popović, N. and Erić-Jovičić, Milena and Popović, M.",
year = "1998",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neuroscience",
title = "Pharmacological and transplantational approaches to treatment of learning and memory impairment in an animal model of Alzheimer's disease",
pages = "437-437",
volume = "10",
url = "https://hdl.handle.net/21.15107/rcub_intor_90"
}

Popović, N., Erić-Jovičić, M.,& Popović, M.. (1998). Pharmacological and transplantational approaches to treatment of learning and memory impairment in an animal model of Alzheimer's disease. in European Journal of Neuroscience
Wiley, Hoboken., 10, 437-437.
https://hdl.handle.net/21.15107/rcub_intor_90

Popović N, Erić-Jovičić M, Popović M. Pharmacological and transplantational approaches to treatment of learning and memory impairment in an animal model of Alzheimer's disease. in European Journal of Neuroscience. 1998;10:437-437.
https://hdl.handle.net/21.15107/rcub_intor_90 .

Popović, N., Erić-Jovičić, Milena, Popović, M., "Pharmacological and transplantational approaches to treatment of learning and memory impairment in an animal model of Alzheimer's disease" in European Journal of Neuroscience, 10 (1998):437-437,
https://hdl.handle.net/21.15107/rcub_intor_90 .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Ugrešić, Nenad
AU  - Kostić, V.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/81
AB  - The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
EP  - 176
IS  - 3-4
SP  - 165
VL  - 89
DO  - 10.3109/00207459708988472
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Ugrešić, Nenad and Kostić, V. and Rakić, L.",
year = "1997",
abstract = "The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat",
pages = "176-165",
number = "3-4",
volume = "89",
doi = "10.3109/00207459708988472"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Ugrešić, N., Kostić, V.,& Rakić, L.. (1997). Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 89(3-4), 165-176.
https://doi.org/10.3109/00207459708988472

Popović M, Jovanova-Nešić K, Popović N, Ugrešić N, Kostić V, Rakić L. Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience. 1997;89(3-4):165-176.
doi:10.3109/00207459708988472 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Ugrešić, Nenad, Kostić, V., Rakić, L., "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat" in International Journal of Neuroscience, 89, no. 3-4 (1997):165-176,
https://doi.org/10.3109/00207459708988472 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/77
AB  - The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil
EP  - 188
IS  - 3-4
SP  - 181
VL  - 91
DO  - 10.3109/00207459708986375
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Rosić, N.",
year = "1997",
abstract = "The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil",
pages = "188-181",
number = "3-4",
volume = "91",
doi = "10.3109/00207459708986375"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S.,& Rosić, N.. (1997). Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(3-4), 181-188.
https://doi.org/10.3109/00207459708986375

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Rosić N. Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience. 1997;91(3-4):181-188.
doi:10.3109/00207459708986375 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Rosić, N., "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil" in International Journal of Neuroscience, 91, no. 3-4 (1997):181-188,
https://doi.org/10.3109/00207459708986375 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Kostić, V.S.
AU  - Rosić, N.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/76
AB  - The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease
EP  - 97
IS  - 1-2
SP  - 87
VL  - 90
DO  - 10.3109/00207459709000628
ER  - 

@article{
author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Kostić, V.S. and Rosić, N.",
year = "1997",
abstract = "The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease",
pages = "97-87",
number = "1-2",
volume = "90",
doi = "10.3109/00207459709000628"
}

Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S., Kostić, V.S.,& Rosić, N.. (1997). Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 90(1-2), 87-97.
https://doi.org/10.3109/00207459709000628

Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Kostić V, Rosić N. Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1997;90(1-2):87-97.
doi:10.3109/00207459709000628 .

Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Kostić, V.S., Rosić, N., "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 90, no. 1-2 (1997):87-97,
https://doi.org/10.3109/00207459709000628 . .

TY  - JOUR
AU  - Popović, M.
AU  - Caballero-Bleda, M.
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/74
AB  - It is well known that disturbance of calcium homeostasis has a significant role in the development of neurodegenerative disorders, such as Alzheimer's disease (AD). Our recent data suggest that acute treatment with the calcium antagonist verapamil can improve some behavioral deficits in an experimental model of AD. Therefore, the present study was done to establish the effect of chronically administered verapamil on cognitive and noncognitive behavior of rats with bilateral electrolytical lesions of nucleus basalis manocellularis (NBM) - an animal model of AD. The NBM lesions produce a deficit in performance of diverse behavior tests: active avoidance (AA), low level of fear (the open field test) as well as aggressive (the test of foot-shock induced aggression) and depressive (the learned helplessness test) behavior. Verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg i.p.) or saline solution (1 ml/kg i.p.) were injected 24 hr after the lesion of NBM and then repeatedly administered during the next 8 days (twice a day). Performance of the two-way active avoidance test, the open field test, the foot shock-induced aggression test and the learned helplessness test were done on day 4 after the last verapamil or saline treatment (day 13 after the lesion). Verapamil in doses of 2.5 and 5.0 mg/kg significantly ameliorated the deficit in the performance of AA, the open field behavior, and the depression, but not the aggressive behavior. The obtained beneficial effect of chronic administered verapamil suggests that the regulation of calcium homeostasis during the early period after NBM lesions might be a reasonable way to prevent the behavioral deficits in an experimental model of AD.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Neuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in rats
EP  - 93
IS  - 1-2
SP  - 79
VL  - 92
DO  - 10.3109/00207459708986392
ER  - 

@article{
author = "Popović, M. and Caballero-Bleda, M. and Popović, N. and Bokonjić, D. and Dobrić, Silva",
year = "1997",
abstract = "It is well known that disturbance of calcium homeostasis has a significant role in the development of neurodegenerative disorders, such as Alzheimer's disease (AD). Our recent data suggest that acute treatment with the calcium antagonist verapamil can improve some behavioral deficits in an experimental model of AD. Therefore, the present study was done to establish the effect of chronically administered verapamil on cognitive and noncognitive behavior of rats with bilateral electrolytical lesions of nucleus basalis manocellularis (NBM) - an animal model of AD. The NBM lesions produce a deficit in performance of diverse behavior tests: active avoidance (AA), low level of fear (the open field test) as well as aggressive (the test of foot-shock induced aggression) and depressive (the learned helplessness test) behavior. Verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg i.p.) or saline solution (1 ml/kg i.p.) were injected 24 hr after the lesion of NBM and then repeatedly administered during the next 8 days (twice a day). Performance of the two-way active avoidance test, the open field test, the foot shock-induced aggression test and the learned helplessness test were done on day 4 after the last verapamil or saline treatment (day 13 after the lesion). Verapamil in doses of 2.5 and 5.0 mg/kg significantly ameliorated the deficit in the performance of AA, the open field behavior, and the depression, but not the aggressive behavior. The obtained beneficial effect of chronic administered verapamil suggests that the regulation of calcium homeostasis during the early period after NBM lesions might be a reasonable way to prevent the behavioral deficits in an experimental model of AD.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Neuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in rats",
pages = "93-79",
number = "1-2",
volume = "92",
doi = "10.3109/00207459708986392"
}

Popović, M., Caballero-Bleda, M., Popović, N., Bokonjić, D.,& Dobrić, S.. (1997). Neuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 92(1-2), 79-93.
https://doi.org/10.3109/00207459708986392

Popović M, Caballero-Bleda M, Popović N, Bokonjić D, Dobrić S. Neuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in rats. in International Journal of Neuroscience. 1997;92(1-2):79-93.
doi:10.3109/00207459708986392 .

Popović, M., Caballero-Bleda, M., Popović, N., Bokonjić, D., Dobrić, Silva, "Neuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in rats" in International Journal of Neuroscience, 92, no. 1-2 (1997):79-93,
https://doi.org/10.3109/00207459708986392 . .

TY  - JOUR
AU  - Popović, N.
AU  - Jovanova-Nešić, Katica
AU  - Popović, M.
AU  - Bokonjić, D.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/75
AB  - The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex
EP  - +
IS  - 1-2
SP  - 11
VL  - 91
DO  - 10.3109/00207459708986362
ER  - 

@article{
author = "Popović, N. and Jovanova-Nešić, Katica and Popović, M. and Bokonjić, D. and Rakić, L.",
year = "1997",
abstract = "The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex",
pages = "+-11",
number = "1-2",
volume = "91",
doi = "10.3109/00207459708986362"
}

Popović, N., Jovanova-Nešić, K., Popović, M., Bokonjić, D.,& Rakić, L.. (1997). Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(1-2), 11-+.
https://doi.org/10.3109/00207459708986362

Popović N, Jovanova-Nešić K, Popović M, Bokonjić D, Rakić L. Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience. 1997;91(1-2):11-+.
doi:10.3109/00207459708986362 .

Popović, N., Jovanova-Nešić, Katica, Popović, M., Bokonjić, D., Rakić, L., "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex" in International Journal of Neuroscience, 91, no. 1-2 (1997):11-+,
https://doi.org/10.3109/00207459708986362 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/71
AB  - The aim of the present study was to 1) determine the intensity of cold restraint-induced gastric lesions and core body temperature in single-and group-stressed rats, and establish a correlation between them; and 2) determine the influence of visual contact among animals during cold restraint on development of gastric stress ulcer. Therefore, adult male Wistar rats were put into individual or group restraint boxes (composed of two, three, six or nine single boxes) with or without possibility of visual contact and then exposed 2 hr to the cold (4 degrees C). Core body temperature was measured just before and after cold restraint using a digital rectal thermometar. The results showed that: 1) single stressed animals expressed significantly higher ulcer index than those stressed in group of three, six and nine rats; 2) there was no significant difference in degree of hypothermia among rats exposed to various group paradigms; and 3) there was no significant difference in ulcer index among animals stressed in conditions with or without visual contact. An absence of significant difference in ulcer index between single and paired stressed rats implies that three is the lowest number of animals per group at which an influence of group size on behavioral and adaptive mechanisms in rats exposed to cold restraint becomes manifest.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Cold restraint-induced gastric lesions in individual- and group-stressed rats
EP  - 10
IS  - 1-2
SP  - 1
VL  - 91
UR  - https://hdl.handle.net/21.15107/rcub_intor_71
ER  - 

@article{
author = "Popović, M. and Popović, N. and Bokonjić, D. and Dobrić, Silva",
year = "1997",
abstract = "The aim of the present study was to 1) determine the intensity of cold restraint-induced gastric lesions and core body temperature in single-and group-stressed rats, and establish a correlation between them; and 2) determine the influence of visual contact among animals during cold restraint on development of gastric stress ulcer. Therefore, adult male Wistar rats were put into individual or group restraint boxes (composed of two, three, six or nine single boxes) with or without possibility of visual contact and then exposed 2 hr to the cold (4 degrees C). Core body temperature was measured just before and after cold restraint using a digital rectal thermometar. The results showed that: 1) single stressed animals expressed significantly higher ulcer index than those stressed in group of three, six and nine rats; 2) there was no significant difference in degree of hypothermia among rats exposed to various group paradigms; and 3) there was no significant difference in ulcer index among animals stressed in conditions with or without visual contact. An absence of significant difference in ulcer index between single and paired stressed rats implies that three is the lowest number of animals per group at which an influence of group size on behavioral and adaptive mechanisms in rats exposed to cold restraint becomes manifest.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Cold restraint-induced gastric lesions in individual- and group-stressed rats",
pages = "10-1",
number = "1-2",
volume = "91",
url = "https://hdl.handle.net/21.15107/rcub_intor_71"
}

Popović, M., Popović, N., Bokonjić, D.,& Dobrić, S.. (1997). Cold restraint-induced gastric lesions in individual- and group-stressed rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 91(1-2), 1-10.
https://hdl.handle.net/21.15107/rcub_intor_71

Popović M, Popović N, Bokonjić D, Dobrić S. Cold restraint-induced gastric lesions in individual- and group-stressed rats. in International Journal of Neuroscience. 1997;91(1-2):1-10.
https://hdl.handle.net/21.15107/rcub_intor_71 .

Popović, M., Popović, N., Bokonjić, D., Dobrić, Silva, "Cold restraint-induced gastric lesions in individual- and group-stressed rats" in International Journal of Neuroscience, 91, no. 1-2 (1997):1-10,
https://hdl.handle.net/21.15107/rcub_intor_71 .

TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Rosić, N.
AU  - Rakić, L.
PY  - 1996
UR  - http://intor.torlakinstitut.com/handle/123456789/66
AB  - Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats
EP  - 299
IS  - 3-4
SP  - 281
VL  - 86
DO  - 10.3109/00207459608986719
ER  - 

@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Bokonjić, D. and Dobrić, Silva and Rosić, N. and Rakić, L.",
year = "1996",
abstract = "Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats",
pages = "299-281",
number = "3-4",
volume = "86",
doi = "10.3109/00207459608986719"
}

Popović, M., Jovanova-Nešić, K., Popović, N., Bokonjić, D., Dobrić, S., Rosić, N.,& Rakić, L.. (1996). Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 86(3-4), 281-299.
https://doi.org/10.3109/00207459608986719

Popović M, Jovanova-Nešić K, Popović N, Bokonjić D, Dobrić S, Rosić N, Rakić L. Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience. 1996;86(3-4):281-299.
doi:10.3109/00207459608986719 .

Popović, M., Jovanova-Nešić, Katica, Popović, N., Bokonjić, D., Dobrić, Silva, Rosić, N., Rakić, L., "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats" in International Journal of Neuroscience, 86, no. 3-4 (1996):281-299,
https://doi.org/10.3109/00207459608986719 . .