TY  - JOUR
AU  - Popović, N.
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Kostić, V.S.
AU  - Šternić, N.
AU  - Rakić, L.
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/136
AB  - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 115
IS  - 1
SP  - 105
VL  - 112
DO  - 10.1080/00207450212017
ER  - 

@article{
author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.",
year = "2002",
abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "115-105",
number = "1",
volume = "112",
doi = "10.1080/00207450212017"
}

Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 112(1), 105-115.
https://doi.org/10.1080/00207450212017

Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115.
doi:10.1080/00207450212017 .

Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115,
https://doi.org/10.1080/00207450212017 . .

TY  - JOUR
AU  - Popović, M.
AU  - Popović, N.
AU  - Bokonjić, D.
AU  - Dobrić, Silva
AU  - Ugrešić, Nenad
AU  - Kostić, V.S.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/87
AB  - In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.
PB  - Wiley, Hoboken
T2  - Neuroscience Research Communications
T1  - Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 22
IS  - 1
SP  - 13
VL  - 23
DO  - 10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
ER  - 

@article{
author = "Popović, M. and Popović, N. and Bokonjić, D. and Dobrić, Silva and Ugrešić, Nenad and Kostić, V.S.",
year = "1998",
abstract = "In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.",
publisher = "Wiley, Hoboken",
journal = "Neuroscience Research Communications",
title = "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "22-13",
number = "1",
volume = "23",
doi = "10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O"
}

Popović, M., Popović, N., Bokonjić, D., Dobrić, S., Ugrešić, N.,& Kostić, V.S.. (1998). Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications
Wiley, Hoboken., 23(1), 13-22.
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O

Popović M, Popović N, Bokonjić D, Dobrić S, Ugrešić N, Kostić V. Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications. 1998;23(1):13-22.
doi:10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O .

Popović, M., Popović, N., Bokonjić, D., Dobrić, Silva, Ugrešić, Nenad, Kostić, V.S., "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis" in Neuroscience Research Communications, 23, no. 1 (1998):13-22,
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O . .