Živančević-Simonović, Snežana

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  • Živančević-Simonović, Snežana (4)
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Author's Bibliography

Vaccine model of antiphospholipid syndrome induced by tetanus vaccine

Dimitrijević, Ljiljana; Živković, Irena; Stojanović, Marijana; Petrušić, Vladimir; Živančević-Simonović, Snežana

(Sage Publications Ltd, London, 2012)

TY  - JOUR
AU  - Dimitrijević, Ljiljana
AU  - Živković, Irena
AU  - Stojanović, Marijana
AU  - Petrušić, Vladimir
AU  - Živančević-Simonović, Snežana
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/351
AB  - Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, BALB/c and C57BL/6, was achieved by tetanus toxoid (TTd) hyperimmunization using different adjuvants (glycerol or aluminium hydroxide), and different adjuvant pretreatments (glycerol or Complete Freund's Adjuvant (CFA)). APS had different manifestations of reproductive pathology in BALB/c and C57BL/6 mice: fetal resorption (as a consequence of extreme T-cell activation obtained in the course of pretreatment), and lowering of fecundity (as a consequence of polyclonal B-cell stimulation), respectively. In BALB/c mice fetal resorption coincided with glycerol and CFA pretreatments, while in C57BL/6 mice lowering of fecundity was most obvious in CFA-pretreated mice immunized with TTd in aluminium hydroxide. Both molecular mimicry and polyclonal B-cell activation occur in APS induction, with molecular mimicry effects being dominant in BALB/c mice, and polyclonal cell activation being dominant in C57BL/6 mice. Confirmation of molecular mimicry effects, which in the condition of T-cell stimulation generated fetal resorptions in the BALB/c strain, was achieved by passive infusion of monoclonal antibody (MoAb) T-26 specific for TTd and anti-beta(2)-glycoprotein I obtained after TTd hyperimunization. High polyclonal B-cell activation in C57BL/6 mice prevented fetal resorption but induced fecundity lowering, as was the case in passive administration of MoAb T-26 in this mouse strain. Passive infusion of anti-idiotypic MoAb Y7 into C57BL/6 mice induced fetal resorptions and confirmed the above suggestion on the protective role of polyclonal B-cell stimulation in fetal resorptions. Lupus (2012) 21, 195-202.
PB  - Sage Publications Ltd, London
T2  - Lupus
T1  - Vaccine model of antiphospholipid syndrome induced by tetanus vaccine
EP  - 202
IS  - 2
SP  - 195
VL  - 21
DO  - 10.1177/0961203311429816
UR  - conv_280
ER  - 
@article{
author = "Dimitrijević, Ljiljana and Živković, Irena and Stojanović, Marijana and Petrušić, Vladimir and Živančević-Simonović, Snežana",
year = "2012",
abstract = "Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, BALB/c and C57BL/6, was achieved by tetanus toxoid (TTd) hyperimmunization using different adjuvants (glycerol or aluminium hydroxide), and different adjuvant pretreatments (glycerol or Complete Freund's Adjuvant (CFA)). APS had different manifestations of reproductive pathology in BALB/c and C57BL/6 mice: fetal resorption (as a consequence of extreme T-cell activation obtained in the course of pretreatment), and lowering of fecundity (as a consequence of polyclonal B-cell stimulation), respectively. In BALB/c mice fetal resorption coincided with glycerol and CFA pretreatments, while in C57BL/6 mice lowering of fecundity was most obvious in CFA-pretreated mice immunized with TTd in aluminium hydroxide. Both molecular mimicry and polyclonal B-cell activation occur in APS induction, with molecular mimicry effects being dominant in BALB/c mice, and polyclonal cell activation being dominant in C57BL/6 mice. Confirmation of molecular mimicry effects, which in the condition of T-cell stimulation generated fetal resorptions in the BALB/c strain, was achieved by passive infusion of monoclonal antibody (MoAb) T-26 specific for TTd and anti-beta(2)-glycoprotein I obtained after TTd hyperimunization. High polyclonal B-cell activation in C57BL/6 mice prevented fetal resorption but induced fecundity lowering, as was the case in passive administration of MoAb T-26 in this mouse strain. Passive infusion of anti-idiotypic MoAb Y7 into C57BL/6 mice induced fetal resorptions and confirmed the above suggestion on the protective role of polyclonal B-cell stimulation in fetal resorptions. Lupus (2012) 21, 195-202.",
publisher = "Sage Publications Ltd, London",
journal = "Lupus",
title = "Vaccine model of antiphospholipid syndrome induced by tetanus vaccine",
pages = "202-195",
number = "2",
volume = "21",
doi = "10.1177/0961203311429816",
url = "conv_280"
}
Dimitrijević, L., Živković, I., Stojanović, M., Petrušić, V.,& Živančević-Simonović, S.. (2012). Vaccine model of antiphospholipid syndrome induced by tetanus vaccine. in Lupus
Sage Publications Ltd, London., 21(2), 195-202.
https://doi.org/10.1177/0961203311429816
conv_280
Dimitrijević L, Živković I, Stojanović M, Petrušić V, Živančević-Simonović S. Vaccine model of antiphospholipid syndrome induced by tetanus vaccine. in Lupus. 2012;21(2):195-202.
doi:10.1177/0961203311429816
conv_280 .
Dimitrijević, Ljiljana, Živković, Irena, Stojanović, Marijana, Petrušić, Vladimir, Živančević-Simonović, Snežana, "Vaccine model of antiphospholipid syndrome induced by tetanus vaccine" in Lupus, 21, no. 2 (2012):195-202,
https://doi.org/10.1177/0961203311429816 .,
conv_280 .
107
20
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Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry

Inić-Kanada, Aleksandra; Stojanović, Marijana; Živković, Irena; Kosec, Duško; Mićić, Mileva; Petrušić, Vladimir; Živančević-Simonović, Snežana; Dimitrijević, Ljiljana

(Wiley, Hoboken, 2009)

TY  - JOUR
AU  - Inić-Kanada, Aleksandra
AU  - Stojanović, Marijana
AU  - Živković, Irena
AU  - Kosec, Duško
AU  - Mićić, Mileva
AU  - Petrušić, Vladimir
AU  - Živančević-Simonović, Snežana
AU  - Dimitrijević, Ljiljana
PY  - 2009
UR  - http://intor.torlakinstitut.com/handle/123456789/283
AB  - Studies on experimental antiphospholipid syndrome (APS) models proved that molecular mimicry between plasma protein beta(2)-glycoprotein I (beta(2)GPI) and structure within micro-organisms or their products, might be a cause for experimental APS. Considering the heterogeneity of polyclonal antiphospholipid antibodies (aPLs), it is important to define the precise characteristics of pathogenic aPLs. To avoid the influence of polyclonality and to further analyse the connection between molecular mimicry and APS, we produced monoclonal antibodies (MAbs) against tetanus toxoid (TTd) and tested their reactivity against beta(2)GPI. In this report, we analysed the characteristics of MAb26 raised against TTd and cross-reactive with beta(2)GPI: its binding properties in various in vitro immunoassays, its specific interactions with surface epitopes expressed on apoptotic cells and its role in vivo. We have demonstrated that MAb26: (i) binds beta(2)GPI being immobilized on an appropriate surface: irradiated polystyrene plates, non-irradiated plates pre-coated with anionic phospholipids and polyvinylidene fluoride membrane; (ii) binds specifically to apoptotic but not to viable cells and the binding is beta(2)GPI-dependent; and (iii) induces a pathologic pregnancy outcome when passively injected into BALB/c mice. This study concluded that certain subpopulations of antibodies raised against TTd and cross-reactive with beta(2)GPI, because of the molecular mimicry mechanism, could have pathologic potential.
PB  - Wiley, Hoboken
T2  - American Journal of Reproductive Immunology
T1  - Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry
EP  - 51
IS  - 1
SP  - 39
VL  - 61
DO  - 10.1111/j.1600-0897.2008.00660.x
UR  - conv_223
ER  - 
@article{
author = "Inić-Kanada, Aleksandra and Stojanović, Marijana and Živković, Irena and Kosec, Duško and Mićić, Mileva and Petrušić, Vladimir and Živančević-Simonović, Snežana and Dimitrijević, Ljiljana",
year = "2009",
abstract = "Studies on experimental antiphospholipid syndrome (APS) models proved that molecular mimicry between plasma protein beta(2)-glycoprotein I (beta(2)GPI) and structure within micro-organisms or their products, might be a cause for experimental APS. Considering the heterogeneity of polyclonal antiphospholipid antibodies (aPLs), it is important to define the precise characteristics of pathogenic aPLs. To avoid the influence of polyclonality and to further analyse the connection between molecular mimicry and APS, we produced monoclonal antibodies (MAbs) against tetanus toxoid (TTd) and tested their reactivity against beta(2)GPI. In this report, we analysed the characteristics of MAb26 raised against TTd and cross-reactive with beta(2)GPI: its binding properties in various in vitro immunoassays, its specific interactions with surface epitopes expressed on apoptotic cells and its role in vivo. We have demonstrated that MAb26: (i) binds beta(2)GPI being immobilized on an appropriate surface: irradiated polystyrene plates, non-irradiated plates pre-coated with anionic phospholipids and polyvinylidene fluoride membrane; (ii) binds specifically to apoptotic but not to viable cells and the binding is beta(2)GPI-dependent; and (iii) induces a pathologic pregnancy outcome when passively injected into BALB/c mice. This study concluded that certain subpopulations of antibodies raised against TTd and cross-reactive with beta(2)GPI, because of the molecular mimicry mechanism, could have pathologic potential.",
publisher = "Wiley, Hoboken",
journal = "American Journal of Reproductive Immunology",
title = "Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry",
pages = "51-39",
number = "1",
volume = "61",
doi = "10.1111/j.1600-0897.2008.00660.x",
url = "conv_223"
}
Inić-Kanada, A., Stojanović, M., Živković, I., Kosec, D., Mićić, M., Petrušić, V., Živančević-Simonović, S.,& Dimitrijević, L.. (2009). Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry. in American Journal of Reproductive Immunology
Wiley, Hoboken., 61(1), 39-51.
https://doi.org/10.1111/j.1600-0897.2008.00660.x
conv_223
Inić-Kanada A, Stojanović M, Živković I, Kosec D, Mićić M, Petrušić V, Živančević-Simonović S, Dimitrijević L. Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry. in American Journal of Reproductive Immunology. 2009;61(1):39-51.
doi:10.1111/j.1600-0897.2008.00660.x
conv_223 .
Inić-Kanada, Aleksandra, Stojanović, Marijana, Živković, Irena, Kosec, Duško, Mićić, Mileva, Petrušić, Vladimir, Živančević-Simonović, Snežana, Dimitrijević, Ljiljana, "Murine Monoclonal Antibody 26 Raised Against Tetanus Toxoid Cross-Reacts with beta(2)-Glycoprotein I: Its Characteristics and Role in Molecular Mimicry" in American Journal of Reproductive Immunology, 61, no. 1 (2009):39-51,
https://doi.org/10.1111/j.1600-0897.2008.00660.x .,
conv_223 .
22
18
22

A high dose of an idiotype generates high levels of Ab2s

Živančević-Simonović, Snežana; Stojanović, Marijana; Inić-Kanada, Aleksandra; Živković, Irena; Odrljin, Tatjana; Dimitrijević, Ljiljana

(Int Inst Anticancer Research, Athens, 2006)

TY  - JOUR
AU  - Živančević-Simonović, Snežana
AU  - Stojanović, Marijana
AU  - Inić-Kanada, Aleksandra
AU  - Živković, Irena
AU  - Odrljin, Tatjana
AU  - Dimitrijević, Ljiljana
PY  - 2006
UR  - http://intor.torlakinstitut.com/handle/123456789/215
AB  - Background: Network perturbations have been reported in autoimmune processes which could cause polyclonal cell activation. Materials and Methods: Hyper-immunization was achieved by the injection of 3 mg of human monoclonal IgM DJ into BALB/c mice. Indirect ELISA was performed to detect induced antibody specificities. Competitive ELISAs were carried out on sera to detect the idiotypes expressed in first (Ab1) and second (Ab2) antibodies in sequence. Results: In the sera of hyper-immunized mice, the concentrations of Ab1 and Ab2 were respectively five and ten times higher than in the sera of non-noimmunized mice. Polyclonal lymphocyte activation was demonstrated by an increase in antibodies specific for antigens (cytochrome Q not related to the immunizing antigen, elevated levels of IgM antibodies specific for the immunogen and elevated levels of Ab2s of the IgM isotype. Conclusion: These findings are indicative of antigen-dependent network perturbation being a causative factor in polyclonal lymphocyte activation.
PB  - Int Inst Anticancer Research, Athens
T2  - In Vivo
T1  - A high dose of an idiotype generates high levels of Ab2s
EP  - 627
IS  - 5
SP  - 621
VL  - 20
UR  - conv_185
ER  - 
@article{
author = "Živančević-Simonović, Snežana and Stojanović, Marijana and Inić-Kanada, Aleksandra and Živković, Irena and Odrljin, Tatjana and Dimitrijević, Ljiljana",
year = "2006",
abstract = "Background: Network perturbations have been reported in autoimmune processes which could cause polyclonal cell activation. Materials and Methods: Hyper-immunization was achieved by the injection of 3 mg of human monoclonal IgM DJ into BALB/c mice. Indirect ELISA was performed to detect induced antibody specificities. Competitive ELISAs were carried out on sera to detect the idiotypes expressed in first (Ab1) and second (Ab2) antibodies in sequence. Results: In the sera of hyper-immunized mice, the concentrations of Ab1 and Ab2 were respectively five and ten times higher than in the sera of non-noimmunized mice. Polyclonal lymphocyte activation was demonstrated by an increase in antibodies specific for antigens (cytochrome Q not related to the immunizing antigen, elevated levels of IgM antibodies specific for the immunogen and elevated levels of Ab2s of the IgM isotype. Conclusion: These findings are indicative of antigen-dependent network perturbation being a causative factor in polyclonal lymphocyte activation.",
publisher = "Int Inst Anticancer Research, Athens",
journal = "In Vivo",
title = "A high dose of an idiotype generates high levels of Ab2s",
pages = "627-621",
number = "5",
volume = "20",
url = "conv_185"
}
Živančević-Simonović, S., Stojanović, M., Inić-Kanada, A., Živković, I., Odrljin, T.,& Dimitrijević, L.. (2006). A high dose of an idiotype generates high levels of Ab2s. in In Vivo
Int Inst Anticancer Research, Athens., 20(5), 621-627.
conv_185
Živančević-Simonović S, Stojanović M, Inić-Kanada A, Živković I, Odrljin T, Dimitrijević L. A high dose of an idiotype generates high levels of Ab2s. in In Vivo. 2006;20(5):621-627.
conv_185 .
Živančević-Simonović, Snežana, Stojanović, Marijana, Inić-Kanada, Aleksandra, Živković, Irena, Odrljin, Tatjana, Dimitrijević, Ljiljana, "A high dose of an idiotype generates high levels of Ab2s" in In Vivo, 20, no. 5 (2006):621-627,
conv_185 .

The possible role of natural idiotopes in immune memory

Dimitrijević, Ljiljana; Živančević-Simonović, Snežana; Stojanović, Marijana; Inić-Kanada, Aleksandra; Živković, Irena

(Taylor and Francis Ltd., 2004)

TY  - CONF
AU  - Dimitrijević, Ljiljana
AU  - Živančević-Simonović, Snežana
AU  - Stojanović, Marijana
AU  - Inić-Kanada, Aleksandra
AU  - Živković, Irena
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/177
AB  - In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.
PB  - Taylor and Francis Ltd.
C3  - Clinical and Developmental Immunology
T1  - The possible role of natural idiotopes in immune memory
EP  - 285
IS  - 3-4
SP  - 281
VL  - 11
DO  - 10.1080/17402520400001645
UR  - conv_562
ER  - 
@conference{
author = "Dimitrijević, Ljiljana and Živančević-Simonović, Snežana and Stojanović, Marijana and Inić-Kanada, Aleksandra and Živković, Irena",
year = "2004",
abstract = "In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.",
publisher = "Taylor and Francis Ltd.",
journal = "Clinical and Developmental Immunology",
title = "The possible role of natural idiotopes in immune memory",
pages = "285-281",
number = "3-4",
volume = "11",
doi = "10.1080/17402520400001645",
url = "conv_562"
}
Dimitrijević, L., Živančević-Simonović, S., Stojanović, M., Inić-Kanada, A.,& Živković, I.. (2004). The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology
Taylor and Francis Ltd.., 11(3-4), 281-285.
https://doi.org/10.1080/17402520400001645
conv_562
Dimitrijević L, Živančević-Simonović S, Stojanović M, Inić-Kanada A, Živković I. The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology. 2004;11(3-4):281-285.
doi:10.1080/17402520400001645
conv_562 .
Dimitrijević, Ljiljana, Živančević-Simonović, Snežana, Stojanović, Marijana, Inić-Kanada, Aleksandra, Živković, Irena, "The possible role of natural idiotopes in immune memory" in Clinical and Developmental Immunology, 11, no. 3-4 (2004):281-285,
https://doi.org/10.1080/17402520400001645 .,
conv_562 .
4
3