TY  - JOUR
AU  - Sinnathamby, Mary A.
AU  - Meslé, Margaux M. I.
AU  - Mook, Piers
AU  - Pebody, Richard
AU  - Bino, Silvia
AU  - Hasibra, Iris
AU  - Bakunts, Nune
AU  - Abovyan, Romella
AU  - Khachtryan, Evgenia
AU  - Redlberger‐Fritz, Monika
AU  - Mursalova, Nazifa
AU  - Aliyeva, Firuza
AU  - Vysotskaya, Veronika
AU  - Shmialiova, Natallia
AU  - Karaban, Inna
AU  - Bossuyt, Nathalie
AU  - Barbezange, Cyril
AU  - Musa, Sanja
AU  - Vukmir, Nina Rodić
AU  - Ljubović, Amela Dedeić
AU  - Baštinac, Dijana
AU  - Vladimirov, Nadezhda
AU  - Korsun, Neli
AU  - Trifonova, Ivelina
AU  - Tabain, Irena
AU  - Petrović, Goranka
AU  - Karagiannis, Christos
AU  - Haralambous, Christos
AU  - Jirincova, Helena
AU  - Kyncl, Jan
AU  - Trebbien, Ramona
AU  - Vestergaard, Lasse Skafte
AU  - Sadikova, Olga
AU  - Eero, Irina
AU  - Metsoja, Eliisa
AU  - Ikonen, Niina
AU  - Lyytikäinen, Outi
AU  - Nohynek, Hanna
AU  - Fournier, Lucie
AU  - Guerrisi, Caroline
AU  - Valette, Martine
AU  - Machablishvili, Ani
AU  - Buda, Silke
AU  - Dürrwald, Ralf
AU  - Gioula, Georgia
AU  - Mary, Emmanouil
AU  - Mellou, Kassiani
AU  - Rózsa, Mónika
AU  - Molnár, Zsuzsanna
AU  - Armannsdottir, Brynja
AU  - Aspelund, Guðrún
AU  - O’Donnell, Joan
AU  - Domegan, Lisa
AU  - Connell, Jeff
AU  - Mandelboim, Michal
AU  - Glatman‐Freedman, Aharona
AU  - Puzelli, Simona
AU  - Palamara, Anna Teresa
AU  - Maraglino, Francesco
AU  - Smagulova, Smagulova Meiramgul Kanapiyanovna
AU  - Userbayev, Aidar Sharipkhanuly
AU  - Kalaveshi, Ariana
AU  - Jakupi, Xhevat
AU  - Gunga, Zana Kaçaniku
AU  - Otorbaeva, D. S
AU  - Abdyldaeva, S. Zh
AU  - Esengeldiev, G. M
AU  - Vasiļevska, Darja
AU  - Tomašūna, Kate Karolīna
AU  - Savicka, Oksana
AU  - Gargasiene, Greta
AU  - Muralyte, Svajune
AU  - Nguyen, Trung‐Nguyen
AU  - Mossong, Joel
AU  - Abdelrahman, Tamir T.
AU  - Melillo, Tanya
AU  - Zahra, Graziella
AU  - Melillo, Jackie
AU  - Rakocevic, Bozidarka
AU  - Zekovic, Zeljka
AU  - Medenica, Sanja
AU  - de Lange, Marit
AU  - Meijer, Adam
AU  - Kochinski, Dragan
AU  - Boshevska, Golubinka
AU  - Paulsen, Trinehessevik
AU  - Bragstad, Karoline
AU  - Brydak, Lidia B.
AU  - Hallmann, Ewelina
AU  - Szymański, Karol
AU  - Rodrigues, Ana Paula
AU  - Verdasca, Nuno
AU  - Guiomar, Raquel
AU  - Druc, Alina
AU  - Apostol, Mariana
AU  - Popescu, Rodica
AU  - Popovici, Odette
AU  - Lazar, Mihaela
AU  - Komissarov, Andrey B.
AU  - Fadeev, Artem
AU  - Stolyarov, Kirill
AU  - Protic, Jelena
AU  - Avdičová, Mária
AU  - Mečochová, Adriana
AU  - Staroňová, Edita
AU  - Sočan, Maja
AU  - Prosenc, Katarina
AU  - Berginc, Nataša
AU  - Larrauri, Amparo
AU  - Mazagatos, Clara
AU  - Pozo, Francisco
AU  - Appelqvist, Emma
AU  - Carnahan, AnnaSara
AU  - Cabecinhas, Ana Rita Goncalves
AU  - Spedaliero, Tania
AU  - Jafarov, Navaruz
AU  - Safarova, Tamanno
AU  - Barotova, Barno
AU  - Kovalchuk, Tatyana
AU  - Altas, Ayse Basak
AU  - Avci, Emine
AU  - Ozdemir, Betul
AU  - Ovliyakulova, Gurbangul
AU  - Dykhanovska, Tetiana
AU  - Demchyshyna, Iryna
AU  - Koshako, Oksana
AU  - Watson, Conall
AU  - Zambon, Maria
AU  - Lakhani, Anissa
AU  - Shepherd, Samantha
AU  - Bradley, Declan T.
AU  - Curran, Tanya
AU  - Moore, Catherine
AU  - Cottrell, Simon
AU  - Kudasheva, Lyudmila
AU  - Djemileva, Sultan
AU  - Pleshkov, Boris
PY  - 2024
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081882/
UR  - http://intor.torlakinstitut.com/handle/123456789/881
AB  - Background: The emergence of SARS‐CoV‐2 in late 2019 saw the implementation of public health and social measures (PHSM) by countries across Europe to reduce its transmission and impact on populations. Consequently, countries reported changes in influenza circulation and extensive disruptions to routine surveillance systems.MethodsWe describe the epidemiology of influenza in Europe between Weeks 40/2020 and 39/2022 compared to the 2016/17 to 2019/20 seasons, to assess the impact of the COVID‐19 pandemic and PHSM on surveillance systems and influenza circulation.ResultsLow detections of influenza were observed through primary care sentinel sources during seasonal influenza periods (Week 40 to 20); 56 (of 39,457 specimens tested; < 1% positivity) in 2020/21 and 7261 (of 64,153 specimens tested; 11% positivity) detections in 2021/22 were observed, compared to an average of 18,383 (of 50,544 specimens tested; 36% positivity) detections in 2016/17 to 2019/20. Similarly, 11 (of 19,989 specimens tested; < 1% positivity) and 1488 (of 23,636 specimens tested; 6% positivity) detections were reported through SARI surveillance sources in 2020/21 and 2021/22, respectively, compared to an average of 2850 (of 10,389 specimens tested; 27% positivity) detections in 2016/17 to 2019/20. However, the 2021/22 interseasonal period saw unusual increases in influenza detections across surveillance site types when PHSM were easing.ConclusionIn conclusion, findings suggest that the restriction and easing of PHSM measures were associated with variations in influenza detections. Our observations of out‐of‐season influenza activity highlight the importance of an integrated respiratory surveillance strategy to monitor circulating respiratory viruses throughout the year to inform optimal prevention and control strategies.
PB  - Wiley
T2  - Influenza and Other Respiratory Viruses
T1  - Impact of the COVID‐19 Pandemic on Influenza Circulation During the 2020/21 and 2021/22 Seasons, in Europe
IS  - 5
SP  - e13297
VL  - 18
DO  - 10.1111/irv.13297
ER  - 

@article{
author = "Sinnathamby, Mary A. and Meslé, Margaux M. I. and Mook, Piers and Pebody, Richard and Bino, Silvia and Hasibra, Iris and Bakunts, Nune and Abovyan, Romella and Khachtryan, Evgenia and Redlberger‐Fritz, Monika and Mursalova, Nazifa and Aliyeva, Firuza and Vysotskaya, Veronika and Shmialiova, Natallia and Karaban, Inna and Bossuyt, Nathalie and Barbezange, Cyril and Musa, Sanja and Vukmir, Nina Rodić and Ljubović, Amela Dedeić and Baštinac, Dijana and Vladimirov, Nadezhda and Korsun, Neli and Trifonova, Ivelina and Tabain, Irena and Petrović, Goranka and Karagiannis, Christos and Haralambous, Christos and Jirincova, Helena and Kyncl, Jan and Trebbien, Ramona and Vestergaard, Lasse Skafte and Sadikova, Olga and Eero, Irina and Metsoja, Eliisa and Ikonen, Niina and Lyytikäinen, Outi and Nohynek, Hanna and Fournier, Lucie and Guerrisi, Caroline and Valette, Martine and Machablishvili, Ani and Buda, Silke and Dürrwald, Ralf and Gioula, Georgia and Mary, Emmanouil and Mellou, Kassiani and Rózsa, Mónika and Molnár, Zsuzsanna and Armannsdottir, Brynja and Aspelund, Guðrún and O’Donnell, Joan and Domegan, Lisa and Connell, Jeff and Mandelboim, Michal and Glatman‐Freedman, Aharona and Puzelli, Simona and Palamara, Anna Teresa and Maraglino, Francesco and Smagulova, Smagulova Meiramgul Kanapiyanovna and Userbayev, Aidar Sharipkhanuly and Kalaveshi, Ariana and Jakupi, Xhevat and Gunga, Zana Kaçaniku and Otorbaeva, D. S and Abdyldaeva, S. Zh and Esengeldiev, G. M and Vasiļevska, Darja and Tomašūna, Kate Karolīna and Savicka, Oksana and Gargasiene, Greta and Muralyte, Svajune and Nguyen, Trung‐Nguyen and Mossong, Joel and Abdelrahman, Tamir T. and Melillo, Tanya and Zahra, Graziella and Melillo, Jackie and Rakocevic, Bozidarka and Zekovic, Zeljka and Medenica, Sanja and de Lange, Marit and Meijer, Adam and Kochinski, Dragan and Boshevska, Golubinka and Paulsen, Trinehessevik and Bragstad, Karoline and Brydak, Lidia B. and Hallmann, Ewelina and Szymański, Karol and Rodrigues, Ana Paula and Verdasca, Nuno and Guiomar, Raquel and Druc, Alina and Apostol, Mariana and Popescu, Rodica and Popovici, Odette and Lazar, Mihaela and Komissarov, Andrey B. and Fadeev, Artem and Stolyarov, Kirill and Protic, Jelena and Avdičová, Mária and Mečochová, Adriana and Staroňová, Edita and Sočan, Maja and Prosenc, Katarina and Berginc, Nataša and Larrauri, Amparo and Mazagatos, Clara and Pozo, Francisco and Appelqvist, Emma and Carnahan, AnnaSara and Cabecinhas, Ana Rita Goncalves and Spedaliero, Tania and Jafarov, Navaruz and Safarova, Tamanno and Barotova, Barno and Kovalchuk, Tatyana and Altas, Ayse Basak and Avci, Emine and Ozdemir, Betul and Ovliyakulova, Gurbangul and Dykhanovska, Tetiana and Demchyshyna, Iryna and Koshako, Oksana and Watson, Conall and Zambon, Maria and Lakhani, Anissa and Shepherd, Samantha and Bradley, Declan T. and Curran, Tanya and Moore, Catherine and Cottrell, Simon and Kudasheva, Lyudmila and Djemileva, Sultan and Pleshkov, Boris",
year = "2024",
abstract = "Background: The emergence of SARS‐CoV‐2 in late 2019 saw the implementation of public health and social measures (PHSM) by countries across Europe to reduce its transmission and impact on populations. Consequently, countries reported changes in influenza circulation and extensive disruptions to routine surveillance systems.MethodsWe describe the epidemiology of influenza in Europe between Weeks 40/2020 and 39/2022 compared to the 2016/17 to 2019/20 seasons, to assess the impact of the COVID‐19 pandemic and PHSM on surveillance systems and influenza circulation.ResultsLow detections of influenza were observed through primary care sentinel sources during seasonal influenza periods (Week 40 to 20); 56 (of 39,457 specimens tested; < 1% positivity) in 2020/21 and 7261 (of 64,153 specimens tested; 11% positivity) detections in 2021/22 were observed, compared to an average of 18,383 (of 50,544 specimens tested; 36% positivity) detections in 2016/17 to 2019/20. Similarly, 11 (of 19,989 specimens tested; < 1% positivity) and 1488 (of 23,636 specimens tested; 6% positivity) detections were reported through SARI surveillance sources in 2020/21 and 2021/22, respectively, compared to an average of 2850 (of 10,389 specimens tested; 27% positivity) detections in 2016/17 to 2019/20. However, the 2021/22 interseasonal period saw unusual increases in influenza detections across surveillance site types when PHSM were easing.ConclusionIn conclusion, findings suggest that the restriction and easing of PHSM measures were associated with variations in influenza detections. Our observations of out‐of‐season influenza activity highlight the importance of an integrated respiratory surveillance strategy to monitor circulating respiratory viruses throughout the year to inform optimal prevention and control strategies.",
publisher = "Wiley",
journal = "Influenza and Other Respiratory Viruses",
title = "Impact of the COVID‐19 Pandemic on Influenza Circulation During the 2020/21 and 2021/22 Seasons, in Europe",
number = "5",
pages = "e13297",
volume = "18",
doi = "10.1111/irv.13297"
}

Sinnathamby, Mary A., Meslé, Margaux M. I., Mook, P., Pebody, R., Bino, S., Hasibra, I., Bakunts, N., Abovyan, R., Khachtryan, E., Redlberger‐Fritz, M., Mursalova, N., Aliyeva, F., Vysotskaya, V., Shmialiova, N., Karaban, I., Bossuyt, N., Barbezange, C., Musa, S., Vukmir, N. R., Ljubović, A. D., Baštinac, D., Vladimirov, N., Korsun, N., Trifonova, I., Tabain, I., Petrović, G., Karagiannis, C., Haralambous, C., Jirincova, H., Kyncl, J., Trebbien, R., Vestergaard, L. S., Sadikova, O., Eero, I., Metsoja, E., Ikonen, N., Lyytikäinen, O., Nohynek, H., Fournier, L., Guerrisi, C., Valette, M., Machablishvili, A., Buda, S., Dürrwald, R., Gioula, G., Mary, E., Mellou, K., Rózsa, M., Molnár, Z., Armannsdottir, B., Aspelund, G., O’Donnell, J., Domegan, L., Connell, J., Mandelboim, M., Glatman‐Freedman, A., Puzelli, S., Palamara, A. T., Maraglino, F., Smagulova, S. M. K., Userbayev, A. S., Kalaveshi, A., Jakupi, X., Gunga, Z. K., Otorbaeva, D. S., Abdyldaeva, S. Z., Esengeldiev, G. M., Vasiļevska, D., Tomašūna, K. K., Savicka, O., Gargasiene, G., Muralyte, S., Nguyen, T., Mossong, J., Abdelrahman, T. T., Melillo, T., Zahra, G., Melillo, J., Rakocevic, B., Zekovic, Z., Medenica, S., de Lange, M., Meijer, A., Kochinski, D., Boshevska, G., Paulsen, T., Bragstad, K., Brydak, L. B., Hallmann, E., Szymański, K., Rodrigues, A. P., Verdasca, N., Guiomar, R., Druc, A., Apostol, M., Popescu, R., Popovici, O., Lazar, M., Komissarov, A. B., Fadeev, A., Stolyarov, K., Protic, J., Avdičová, M., Mečochová, A., Staroňová, E., Sočan, M., Prosenc, K., Berginc, N., Larrauri, A., Mazagatos, C., Pozo, F., Appelqvist, E., Carnahan, A., Cabecinhas, A. R. G., Spedaliero, T., Jafarov, N., Safarova, T., Barotova, B., Kovalchuk, T., Altas, A. B., Avci, E., Ozdemir, B., Ovliyakulova, G., Dykhanovska, T., Demchyshyna, I., Koshako, O., Watson, C., Zambon, M., Lakhani, A., Shepherd, S., Bradley, D. T., Curran, T., Moore, C., Cottrell, S., Kudasheva, L., Djemileva, S.,& Pleshkov, B.. (2024). Impact of the COVID‐19 Pandemic on Influenza Circulation During the 2020/21 and 2021/22 Seasons, in Europe. in Influenza and Other Respiratory Viruses
Wiley., 18(5), e13297.
https://doi.org/10.1111/irv.13297

Sinnathamby M, Meslé M, Mook P, Pebody R, Bino S, Hasibra I, Bakunts N, Abovyan R, Khachtryan E, Redlberger‐Fritz M, Mursalova N, Aliyeva F, Vysotskaya V, Shmialiova N, Karaban I, Bossuyt N, Barbezange C, Musa S, Vukmir NR, Ljubović AD, Baštinac D, Vladimirov N, Korsun N, Trifonova I, Tabain I, Petrović G, Karagiannis C, Haralambous C, Jirincova H, Kyncl J, Trebbien R, Vestergaard LS, Sadikova O, Eero I, Metsoja E, Ikonen N, Lyytikäinen O, Nohynek H, Fournier L, Guerrisi C, Valette M, Machablishvili A, Buda S, Dürrwald R, Gioula G, Mary E, Mellou K, Rózsa M, Molnár Z, Armannsdottir B, Aspelund G, O’Donnell J, Domegan L, Connell J, Mandelboim M, Glatman‐Freedman A, Puzelli S, Palamara AT, Maraglino F, Smagulova SMK, Userbayev AS, Kalaveshi A, Jakupi X, Gunga ZK, Otorbaeva DS, Abdyldaeva SZ, Esengeldiev GM, Vasiļevska D, Tomašūna KK, Savicka O, Gargasiene G, Muralyte S, Nguyen T, Mossong J, Abdelrahman TT, Melillo T, Zahra G, Melillo J, Rakocevic B, Zekovic Z, Medenica S, de Lange M, Meijer A, Kochinski D, Boshevska G, Paulsen T, Bragstad K, Brydak LB, Hallmann E, Szymański K, Rodrigues AP, Verdasca N, Guiomar R, Druc A, Apostol M, Popescu R, Popovici O, Lazar M, Komissarov AB, Fadeev A, Stolyarov K, Protic J, Avdičová M, Mečochová A, Staroňová E, Sočan M, Prosenc K, Berginc N, Larrauri A, Mazagatos C, Pozo F, Appelqvist E, Carnahan A, Cabecinhas ARG, Spedaliero T, Jafarov N, Safarova T, Barotova B, Kovalchuk T, Altas AB, Avci E, Ozdemir B, Ovliyakulova G, Dykhanovska T, Demchyshyna I, Koshako O, Watson C, Zambon M, Lakhani A, Shepherd S, Bradley DT, Curran T, Moore C, Cottrell S, Kudasheva L, Djemileva S, Pleshkov B. Impact of the COVID‐19 Pandemic on Influenza Circulation During the 2020/21 and 2021/22 Seasons, in Europe. in Influenza and Other Respiratory Viruses. 2024;18(5):e13297.
doi:10.1111/irv.13297 .

Sinnathamby, Mary A., Meslé, Margaux M. I., Mook, Piers, Pebody, Richard, Bino, Silvia, Hasibra, Iris, Bakunts, Nune, Abovyan, Romella, Khachtryan, Evgenia, Redlberger‐Fritz, Monika, Mursalova, Nazifa, Aliyeva, Firuza, Vysotskaya, Veronika, Shmialiova, Natallia, Karaban, Inna, Bossuyt, Nathalie, Barbezange, Cyril, Musa, Sanja, Vukmir, Nina Rodić, Ljubović, Amela Dedeić, Baštinac, Dijana, Vladimirov, Nadezhda, Korsun, Neli, Trifonova, Ivelina, Tabain, Irena, Petrović, Goranka, Karagiannis, Christos, Haralambous, Christos, Jirincova, Helena, Kyncl, Jan, Trebbien, Ramona, Vestergaard, Lasse Skafte, Sadikova, Olga, Eero, Irina, Metsoja, Eliisa, Ikonen, Niina, Lyytikäinen, Outi, Nohynek, Hanna, Fournier, Lucie, Guerrisi, Caroline, Valette, Martine, Machablishvili, Ani, Buda, Silke, Dürrwald, Ralf, Gioula, Georgia, Mary, Emmanouil, Mellou, Kassiani, Rózsa, Mónika, Molnár, Zsuzsanna, Armannsdottir, Brynja, Aspelund, Guðrún, O’Donnell, Joan, Domegan, Lisa, Connell, Jeff, Mandelboim, Michal, Glatman‐Freedman, Aharona, Puzelli, Simona, Palamara, Anna Teresa, Maraglino, Francesco, Smagulova, Smagulova Meiramgul Kanapiyanovna, Userbayev, Aidar Sharipkhanuly, Kalaveshi, Ariana, Jakupi, Xhevat, Gunga, Zana Kaçaniku, Otorbaeva, D. S, Abdyldaeva, S. Zh, Esengeldiev, G. M, Vasiļevska, Darja, Tomašūna, Kate Karolīna, Savicka, Oksana, Gargasiene, Greta, Muralyte, Svajune, Nguyen, Trung‐Nguyen, Mossong, Joel, Abdelrahman, Tamir T., Melillo, Tanya, Zahra, Graziella, Melillo, Jackie, Rakocevic, Bozidarka, Zekovic, Zeljka, Medenica, Sanja, de Lange, Marit, Meijer, Adam, Kochinski, Dragan, Boshevska, Golubinka, Paulsen, Trinehessevik, Bragstad, Karoline, Brydak, Lidia B., Hallmann, Ewelina, Szymański, Karol, Rodrigues, Ana Paula, Verdasca, Nuno, Guiomar, Raquel, Druc, Alina, Apostol, Mariana, Popescu, Rodica, Popovici, Odette, Lazar, Mihaela, Komissarov, Andrey B., Fadeev, Artem, Stolyarov, Kirill, Protic, Jelena, Avdičová, Mária, Mečochová, Adriana, Staroňová, Edita, Sočan, Maja, Prosenc, Katarina, Berginc, Nataša, Larrauri, Amparo, Mazagatos, Clara, Pozo, Francisco, Appelqvist, Emma, Carnahan, AnnaSara, Cabecinhas, Ana Rita Goncalves, Spedaliero, Tania, Jafarov, Navaruz, Safarova, Tamanno, Barotova, Barno, Kovalchuk, Tatyana, Altas, Ayse Basak, Avci, Emine, Ozdemir, Betul, Ovliyakulova, Gurbangul, Dykhanovska, Tetiana, Demchyshyna, Iryna, Koshako, Oksana, Watson, Conall, Zambon, Maria, Lakhani, Anissa, Shepherd, Samantha, Bradley, Declan T., Curran, Tanya, Moore, Catherine, Cottrell, Simon, Kudasheva, Lyudmila, Djemileva, Sultan, Pleshkov, Boris, "Impact of the COVID‐19 Pandemic on Influenza Circulation During the 2020/21 and 2021/22 Seasons, in Europe" in Influenza and Other Respiratory Viruses, 18, no. 5 (2024):e13297,
https://doi.org/10.1111/irv.13297 . .

TY  - JOUR
AU  - Mögling, Ramona
AU  - Reimerink, Johan
AU  - Stanoeva, Kamelia R.
AU  - Keramarou, Maria
AU  - Guiomar, Raquel
AU  - Costa, Inês
AU  - Haveri, Anu
AU  - Holzer, Barbara
AU  - Korukluoğlu, Gülay
AU  - Nguyen, Trung
AU  - Pakarna, Gatis
AU  - Pancer, Katarzyna
AU  - Trilar, Katarina Prosenc
AU  - Protić, Jelena
AU  - Stojanović, Marijana
AU  - De Santis, Riccardo
AU  - Lista, Florigio
AU  - Vremera, Teodora
AU  - Leustean, Mihaela
AU  - Pistol, Adriana
AU  - Zelena, Hana
AU  - Reusken, Chantal
AU  - Broberg, Eeva K.
PY  - 2023
UR  - http://intor.torlakinstitut.com/handle/123456789/805
AB  - One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infections. It is crucial to evaluate the quality of these serological tests and consequently the sero-epidemiological studies that are performed with the respective tests. Here, we describe the set-up and results of a comparative study, in which a laboratory contracted by the European Centre for Disease Prevention and Control offered a centralised service to EU/EEA Member and pre-accession Member States to test representative serum specimens with known serological results, with the gold standard technique (virus neutralisation tests) to determine the presence of neutralising antibodies. Laboratories from 12 European countries shared 719 serum specimens with the contractor laboratory. We found that in-house serological tests detecting neutralising antibodies showed the highest percent agreement, both positive and negative, with the virus neutralisation test results. Despite extensive differences in virus neutralisation protocols neutralisation titres showed a strong correlation. From the commercial assays, the best positive percent agreement was found for SARS-CoV-2 IgG (sCOVG) (Siemens - Atellica IM Analyzer). Despite lower positive percent agreement of LIAISON SARS-CoV-2 TrimericS IgG kit (Diasorin Inc.), the obtained results showed relatively good correlation with neutralisation titres. The set-up of this study allowed for high comparability between laboratories and enabled laboratories that do not have the capacity or capability to perform VNTs themselves. Given the variety of in-house protocols detecting SARS-CoV-2 specific neutralising antibodies, including the virus strain, it could be of interest to select reference isolates for SARS-CoV-2 diagnostic to be made available for interested EU Member States and pre-accession countries.
PB  - Elsevier
T2  - Journal of Virological Methods
T1  - Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021
SP  - 114825
VL  - 322
DO  - 10.1016/j.jviromet.2023.114825
ER  - 

@article{
author = "Mögling, Ramona and Reimerink, Johan and Stanoeva, Kamelia R. and Keramarou, Maria and Guiomar, Raquel and Costa, Inês and Haveri, Anu and Holzer, Barbara and Korukluoğlu, Gülay and Nguyen, Trung and Pakarna, Gatis and Pancer, Katarzyna and Trilar, Katarina Prosenc and Protić, Jelena and Stojanović, Marijana and De Santis, Riccardo and Lista, Florigio and Vremera, Teodora and Leustean, Mihaela and Pistol, Adriana and Zelena, Hana and Reusken, Chantal and Broberg, Eeva K.",
year = "2023",
abstract = "One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infections. It is crucial to evaluate the quality of these serological tests and consequently the sero-epidemiological studies that are performed with the respective tests. Here, we describe the set-up and results of a comparative study, in which a laboratory contracted by the European Centre for Disease Prevention and Control offered a centralised service to EU/EEA Member and pre-accession Member States to test representative serum specimens with known serological results, with the gold standard technique (virus neutralisation tests) to determine the presence of neutralising antibodies. Laboratories from 12 European countries shared 719 serum specimens with the contractor laboratory. We found that in-house serological tests detecting neutralising antibodies showed the highest percent agreement, both positive and negative, with the virus neutralisation test results. Despite extensive differences in virus neutralisation protocols neutralisation titres showed a strong correlation. From the commercial assays, the best positive percent agreement was found for SARS-CoV-2 IgG (sCOVG) (Siemens - Atellica IM Analyzer). Despite lower positive percent agreement of LIAISON SARS-CoV-2 TrimericS IgG kit (Diasorin Inc.), the obtained results showed relatively good correlation with neutralisation titres. The set-up of this study allowed for high comparability between laboratories and enabled laboratories that do not have the capacity or capability to perform VNTs themselves. Given the variety of in-house protocols detecting SARS-CoV-2 specific neutralising antibodies, including the virus strain, it could be of interest to select reference isolates for SARS-CoV-2 diagnostic to be made available for interested EU Member States and pre-accession countries.",
publisher = "Elsevier",
journal = "Journal of Virological Methods",
title = "Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021",
pages = "114825",
volume = "322",
doi = "10.1016/j.jviromet.2023.114825"
}

Mögling, R., Reimerink, J., Stanoeva, K. R., Keramarou, M., Guiomar, R., Costa, I., Haveri, A., Holzer, B., Korukluoğlu, G., Nguyen, T., Pakarna, G., Pancer, K., Trilar, K. P., Protić, J., Stojanović, M., De Santis, R., Lista, F., Vremera, T., Leustean, M., Pistol, A., Zelena, H., Reusken, C.,& Broberg, E. K.. (2023). Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021. in Journal of Virological Methods
Elsevier., 322, 114825.
https://doi.org/10.1016/j.jviromet.2023.114825

Mögling R, Reimerink J, Stanoeva KR, Keramarou M, Guiomar R, Costa I, Haveri A, Holzer B, Korukluoğlu G, Nguyen T, Pakarna G, Pancer K, Trilar KP, Protić J, Stojanović M, De Santis R, Lista F, Vremera T, Leustean M, Pistol A, Zelena H, Reusken C, Broberg EK. Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021. in Journal of Virological Methods. 2023;322:114825.
doi:10.1016/j.jviromet.2023.114825 .

Mögling, Ramona, Reimerink, Johan, Stanoeva, Kamelia R., Keramarou, Maria, Guiomar, Raquel, Costa, Inês, Haveri, Anu, Holzer, Barbara, Korukluoğlu, Gülay, Nguyen, Trung, Pakarna, Gatis, Pancer, Katarzyna, Trilar, Katarina Prosenc, Protić, Jelena, Stojanović, Marijana, De Santis, Riccardo, Lista, Florigio, Vremera, Teodora, Leustean, Mihaela, Pistol, Adriana, Zelena, Hana, Reusken, Chantal, Broberg, Eeva K., "Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021" in Journal of Virological Methods, 322 (2023):114825,
https://doi.org/10.1016/j.jviromet.2023.114825 . .