TY  - JOUR
AU  - Bulat, Petar
AU  - Potkonjak, Bijana
AU  - Dujić, Ivana
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/266
AB  - Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-(3)). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41 +/- 3.66) mu g L-1, C group (5.60 +/- 0.86) mu g L-1, p lt 0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59 +/- 81.27) mu molL(-1), C group (105.21 +/- 49.62) mu mol L-1, p lt 0.0011 and antioxiclative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05 +/- 1.70) IU g(-1) Hb, C group (12.53 +/- 4.12) IU g(-1) Hb, p lt 0.001], glutathione reductase [Al group (1.41 +/- 0.56) IU g(-1) Hb, C group (1.89 +/- 0.57) IU g(-1) Hb, p lt 0.001], glutathione peroxidase [Al group (12.37 +/- 5.76) IU g(-1) Hb, C group (15.54 +/- 4.85) IU g(-1) Hb, p lt 0.001], catalase [Al group (116.76 +/- 26.60) IU g(-1) Hb, C group (158.81 +/- 71.85) IU g(-1) Hb, p lt 0.001] and superoxide dismutase [Al group (1175.8 +/- 149.9) IU mg(-1) Hb, C group (1377.9 +/- 207.5) IU mg(-1) Hb, p lt 0.001].
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology
T1  - Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium
EP  - 87
IS  - 2
SP  - 81
VL  - 59
DO  - 10.2478/10004-1254-59-2008-1853
ER  - 

@article{
author = "Bulat, Petar and Potkonjak, Bijana and Dujić, Ivana",
year = "2008",
abstract = "Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-(3)). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41 +/- 3.66) mu g L-1, C group (5.60 +/- 0.86) mu g L-1, p lt 0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59 +/- 81.27) mu molL(-1), C group (105.21 +/- 49.62) mu mol L-1, p lt 0.0011 and antioxiclative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05 +/- 1.70) IU g(-1) Hb, C group (12.53 +/- 4.12) IU g(-1) Hb, p lt 0.001], glutathione reductase [Al group (1.41 +/- 0.56) IU g(-1) Hb, C group (1.89 +/- 0.57) IU g(-1) Hb, p lt 0.001], glutathione peroxidase [Al group (12.37 +/- 5.76) IU g(-1) Hb, C group (15.54 +/- 4.85) IU g(-1) Hb, p lt 0.001], catalase [Al group (116.76 +/- 26.60) IU g(-1) Hb, C group (158.81 +/- 71.85) IU g(-1) Hb, p lt 0.001] and superoxide dismutase [Al group (1175.8 +/- 149.9) IU mg(-1) Hb, C group (1377.9 +/- 207.5) IU mg(-1) Hb, p lt 0.001].",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology",
title = "Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium",
pages = "87-81",
number = "2",
volume = "59",
doi = "10.2478/10004-1254-59-2008-1853"
}

Bulat, P., Potkonjak, B.,& Dujić, I.. (2008). Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium. in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 59(2), 81-87.
https://doi.org/10.2478/10004-1254-59-2008-1853

Bulat P, Potkonjak B, Dujić I. Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium. in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology. 2008;59(2):81-87.
doi:10.2478/10004-1254-59-2008-1853 .

Bulat, Petar, Potkonjak, Bijana, Dujić, Ivana, "Lipid peroxidation and antioxidative enzyme activity erythrocytes of workers occupationally exposed to aluminium" in Arhiv za higijenu rada i toksikologiju-Archives of Industrial Hygiene and Toxicology, 59, no. 2 (2008):81-87,
https://doi.org/10.2478/10004-1254-59-2008-1853 . .

TY  - JOUR
AU  - Bulat, Petar
AU  - Dujić, I.
AU  - Potkonjak, Bijana
AU  - Vidaković, A.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/86
AB  - According to previous research the lipid peroxidation process has a significant role in mercury toxicity. Since glutathione peroxidase (GPX) and superoxide dismutase (SOD) play a significant role in erythrocyte antioxidative defence, it is very important to determine their activity in occupationally exposed workers. The aim of this study was to assess the activity of antioxidative enzymes in the erythrocytes of workers occupationally exposed to mercury. We compared a group of 42 workers exposed to elemental mercury in a chloralkali plant (Hg group). The control group (C group) consisted of 75 subjects employed in lime production who had never been exposed to mercury or any toxic substance. The GPX activities in erythrocytes were significantly lower in the Hg group than in the control group (Hg group, 9.05 +/- 7.52 IU/gHb; C group 15.54 +/- 4.85 IU/gHb; p  lt  0,001). Also, SOD activity in the erythrocytes of workers occupationally exposed to mercury was significantly lower than in the control group (Hg group, 1280.7 +/- 132.3 IU/gHb; C group, 1377.9 +/- 207.5 IU/gHb; p  lt  0.006). The concentrations of mercury in blood were significantly higher in the Hg group compared to the control group (Hg group, 0.179 +/- 0.040 mu mol/l; C group, 0.023 +/- 0.011 mu mol/l; p  lt  0.001). Urine mercury concentrations were also significantly higher in the Hg group than in the control group (Hg group, 23.2 +/- 11.3 nmol/mmol creatinine; C group, 2.7 +/- 0.6 nmol/mmol creatinine; p  lt  0.001). The concentrations of selenium in erythrocytes were almost equal in both groups examined (Hg group, 62.9 +/- 8.72 mu g/l; C group, 65.8 +/- 10.57 mu g/l) Also, in the Hg group there were increased levels of erythrocyte malondialdehyde (Hg group, 138.58 +/- 33.85 mu mol/l; C group 105.21 +/- 49.62 mu mol/l; p  lt  0.001). On the basis of previous results, it can be concluded that occupational exposure to elemental mercury leads to increased lipid peroxidation in erythrocytes. Also, it can be postulated that this exposure leads to decreased activity of GPX and SOD in erythrocytes.
PB  - Springer, New York
T2  - International Archives of Occupational and Environmental Health
T1  - Activity of glutathione peroxidase and superoxide dismutase in workers occupationally exposed to mercury
EP  - S39
SP  - S37
VL  - 71
UR  - https://hdl.handle.net/21.15107/rcub_intor_86
ER  - 

@article{
author = "Bulat, Petar and Dujić, I. and Potkonjak, Bijana and Vidaković, A.",
year = "1998",
abstract = "According to previous research the lipid peroxidation process has a significant role in mercury toxicity. Since glutathione peroxidase (GPX) and superoxide dismutase (SOD) play a significant role in erythrocyte antioxidative defence, it is very important to determine their activity in occupationally exposed workers. The aim of this study was to assess the activity of antioxidative enzymes in the erythrocytes of workers occupationally exposed to mercury. We compared a group of 42 workers exposed to elemental mercury in a chloralkali plant (Hg group). The control group (C group) consisted of 75 subjects employed in lime production who had never been exposed to mercury or any toxic substance. The GPX activities in erythrocytes were significantly lower in the Hg group than in the control group (Hg group, 9.05 +/- 7.52 IU/gHb; C group 15.54 +/- 4.85 IU/gHb; p  lt  0,001). Also, SOD activity in the erythrocytes of workers occupationally exposed to mercury was significantly lower than in the control group (Hg group, 1280.7 +/- 132.3 IU/gHb; C group, 1377.9 +/- 207.5 IU/gHb; p  lt  0.006). The concentrations of mercury in blood were significantly higher in the Hg group compared to the control group (Hg group, 0.179 +/- 0.040 mu mol/l; C group, 0.023 +/- 0.011 mu mol/l; p  lt  0.001). Urine mercury concentrations were also significantly higher in the Hg group than in the control group (Hg group, 23.2 +/- 11.3 nmol/mmol creatinine; C group, 2.7 +/- 0.6 nmol/mmol creatinine; p  lt  0.001). The concentrations of selenium in erythrocytes were almost equal in both groups examined (Hg group, 62.9 +/- 8.72 mu g/l; C group, 65.8 +/- 10.57 mu g/l) Also, in the Hg group there were increased levels of erythrocyte malondialdehyde (Hg group, 138.58 +/- 33.85 mu mol/l; C group 105.21 +/- 49.62 mu mol/l; p  lt  0.001). On the basis of previous results, it can be concluded that occupational exposure to elemental mercury leads to increased lipid peroxidation in erythrocytes. Also, it can be postulated that this exposure leads to decreased activity of GPX and SOD in erythrocytes.",
publisher = "Springer, New York",
journal = "International Archives of Occupational and Environmental Health",
title = "Activity of glutathione peroxidase and superoxide dismutase in workers occupationally exposed to mercury",
pages = "S39-S37",
volume = "71",
url = "https://hdl.handle.net/21.15107/rcub_intor_86"
}

Bulat, P., Dujić, I., Potkonjak, B.,& Vidaković, A.. (1998). Activity of glutathione peroxidase and superoxide dismutase in workers occupationally exposed to mercury. in International Archives of Occupational and Environmental Health
Springer, New York., 71, S37-S39.
https://hdl.handle.net/21.15107/rcub_intor_86

Bulat P, Dujić I, Potkonjak B, Vidaković A. Activity of glutathione peroxidase and superoxide dismutase in workers occupationally exposed to mercury. in International Archives of Occupational and Environmental Health. 1998;71:S37-S39.
https://hdl.handle.net/21.15107/rcub_intor_86 .

Bulat, Petar, Dujić, I., Potkonjak, Bijana, Vidaković, A., "Activity of glutathione peroxidase and superoxide dismutase in workers occupationally exposed to mercury" in International Archives of Occupational and Environmental Health, 71 (1998):S37-S39,
https://hdl.handle.net/21.15107/rcub_intor_86 .