TY  - JOUR
AU  - Janković, Marko
AU  - Knežević, Aleksandra
AU  - Todorović, Milena
AU  - Đunić, Irena
AU  - Mihaljević, Biljana
AU  - Soldatović, Ivan
AU  - Protić, Jelena
AU  - Miković, Nevenka
AU  - Stoiljković, Vera
AU  - Jovanović, Tanja
PY  - 2022
UR  - http://intor.torlakinstitut.com/handle/123456789/629
AB  - Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical studies suggest its putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients with B-lymphocyte (B-cell) malignancies in a retrospective single-center study and extracted relevant data on CMV prevalences and the incidences of B-cell cancers the world over.
PB  - BMC
T2  - Virology Journal
T1  - Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence
IS  - 1
SP  - 155
VL  - 19
DO  - 10.1186/s12985-022-01884-1
ER  - 

@article{
author = "Janković, Marko and Knežević, Aleksandra and Todorović, Milena and Đunić, Irena and Mihaljević, Biljana and Soldatović, Ivan and Protić, Jelena and Miković, Nevenka and Stoiljković, Vera and Jovanović, Tanja",
year = "2022",
abstract = "Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical studies suggest its putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients with B-lymphocyte (B-cell) malignancies in a retrospective single-center study and extracted relevant data on CMV prevalences and the incidences of B-cell cancers the world over.",
publisher = "BMC",
journal = "Virology Journal",
title = "Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence",
number = "1",
pages = "155",
volume = "19",
doi = "10.1186/s12985-022-01884-1"
}

Janković, M., Knežević, A., Todorović, M., Đunić, I., Mihaljević, B., Soldatović, I., Protić, J., Miković, N., Stoiljković, V.,& Jovanović, T.. (2022). Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence. in Virology Journal
BMC., 19(1), 155.
https://doi.org/10.1186/s12985-022-01884-1

Janković M, Knežević A, Todorović M, Đunić I, Mihaljević B, Soldatović I, Protić J, Miković N, Stoiljković V, Jovanović T. Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence. in Virology Journal. 2022;19(1):155.
doi:10.1186/s12985-022-01884-1 .

Janković, Marko, Knežević, Aleksandra, Todorović, Milena, Đunić, Irena, Mihaljević, Biljana, Soldatović, Ivan, Protić, Jelena, Miković, Nevenka, Stoiljković, Vera, Jovanović, Tanja, "Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence" in Virology Journal, 19, no. 1 (2022):155,
https://doi.org/10.1186/s12985-022-01884-1 . .

TY  - DATA
AU  - Stevanović, Goran
AU  - Obradović, Aleksandar
AU  - Ristić, Snezana
AU  - Petrović, Dragan
AU  - Milenković, Branislava
AU  - Mitrović, Danilo
AU  - Vignjević Filipović, Svetlana
AU  - Ilić, Katarina
AU  - Stoiljković, Vera
AU  - Lavadinović, Lidija
AU  - Pelemis, Mijomir
AU  - Petrović, Svetlana
AU  - Vidmanić, Ana
AU  - Popović, Olga
AU  - Eremić, Natasa
AU  - Sparrow, Erin
AU  - Torelli, Guido
AU  - Socquet, Muriel
AU  - Holt, Renée
AU  - Ilieva-Borisova, Yordanka
AU  - Tang, Yuxiao
AU  - Scorza, Francesco Berlanda
AU  - Flores, Jorge
AU  - Rathi, Niraj
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/637
AB  - Supplementary Table 1: Trial Scheme - Schedule of events for each participant; Supplementary Table 2: Details of Ethics committee/Institutional Review Board Overseeing  the study;
PB  - SAGE Publications
T2  - Therapeutic Advances in Vaccines and Immunotherapy
T1  - Supplementary information for the article: Stevanovic, G.; Obradovic, A.; Ristic, S.; Petrovic, D.; Milenkovic, B.; Mitrovic, D.; Vignjevic, S. F.;  Ilic, K.; Stoiljkovic, V.; Lavadinovic, L.; Pelemis, M.; Petrovic, S.; Vidmanic, A.; Popovic, O.; Eremic,  N.; Sparrow, E.; Torelli, G.; Socquet, M.; Holt, R.; Ilieva-Borisova, Y.; Tang, Y.; Scorza, F. B.; Flores,  J.; Rathi, N. Safety and Immunogenicity of a Seasonal Trivalent Inactivated Split Influenza Vaccine: A  Double Blind, Phase III Randomized Clinical Trial in Healthy Serbian Adults. Therapeutic Advances in Vaccines and Immunotherapy 2020, 8, 2515135520925336.  https://doi.org/10.1177/2515135520925336
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_intor_637
ER  - 

@misc{
author = "Stevanović, Goran and Obradović, Aleksandar and Ristić, Snezana and Petrović, Dragan and Milenković, Branislava and Mitrović, Danilo and Vignjević Filipović, Svetlana and Ilić, Katarina and Stoiljković, Vera and Lavadinović, Lidija and Pelemis, Mijomir and Petrović, Svetlana and Vidmanić, Ana and Popović, Olga and Eremić, Natasa and Sparrow, Erin and Torelli, Guido and Socquet, Muriel and Holt, Renée and Ilieva-Borisova, Yordanka and Tang, Yuxiao and Scorza, Francesco Berlanda and Flores, Jorge and Rathi, Niraj",
year = "2020",
abstract = "Supplementary Table 1: Trial Scheme - Schedule of events for each participant; Supplementary Table 2: Details of Ethics committee/Institutional Review Board Overseeing  the study;",
publisher = "SAGE Publications",
journal = "Therapeutic Advances in Vaccines and Immunotherapy",
title = "Supplementary information for the article: Stevanovic, G.; Obradovic, A.; Ristic, S.; Petrovic, D.; Milenkovic, B.; Mitrovic, D.; Vignjevic, S. F.;  Ilic, K.; Stoiljkovic, V.; Lavadinovic, L.; Pelemis, M.; Petrovic, S.; Vidmanic, A.; Popovic, O.; Eremic,  N.; Sparrow, E.; Torelli, G.; Socquet, M.; Holt, R.; Ilieva-Borisova, Y.; Tang, Y.; Scorza, F. B.; Flores,  J.; Rathi, N. Safety and Immunogenicity of a Seasonal Trivalent Inactivated Split Influenza Vaccine: A  Double Blind, Phase III Randomized Clinical Trial in Healthy Serbian Adults. Therapeutic Advances in Vaccines and Immunotherapy 2020, 8, 2515135520925336.  https://doi.org/10.1177/2515135520925336",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_intor_637"
}

Stevanović, G., Obradović, A., Ristić, S., Petrović, D., Milenković, B., Mitrović, D., Vignjević Filipović, S., Ilić, K., Stoiljković, V., Lavadinović, L., Pelemis, M., Petrović, S., Vidmanić, A., Popović, O., Eremić, N., Sparrow, E., Torelli, G., Socquet, M., Holt, R., Ilieva-Borisova, Y., Tang, Y., Scorza, F. B., Flores, J.,& Rathi, N.. (2020). Supplementary information for the article: Stevanovic, G.; Obradovic, A.; Ristic, S.; Petrovic, D.; Milenkovic, B.; Mitrovic, D.; Vignjevic, S. F.;  Ilic, K.; Stoiljkovic, V.; Lavadinovic, L.; Pelemis, M.; Petrovic, S.; Vidmanic, A.; Popovic, O.; Eremic,  N.; Sparrow, E.; Torelli, G.; Socquet, M.; Holt, R.; Ilieva-Borisova, Y.; Tang, Y.; Scorza, F. B.; Flores,  J.; Rathi, N. Safety and Immunogenicity of a Seasonal Trivalent Inactivated Split Influenza Vaccine: A  Double Blind, Phase III Randomized Clinical Trial in Healthy Serbian Adults. Therapeutic Advances in Vaccines and Immunotherapy 2020, 8, 2515135520925336.  https://doi.org/10.1177/2515135520925336. in Therapeutic Advances in Vaccines and Immunotherapy
SAGE Publications., 8.
https://hdl.handle.net/21.15107/rcub_intor_637

Stevanović G, Obradović A, Ristić S, Petrović D, Milenković B, Mitrović D, Vignjević Filipović S, Ilić K, Stoiljković V, Lavadinović L, Pelemis M, Petrović S, Vidmanić A, Popović O, Eremić N, Sparrow E, Torelli G, Socquet M, Holt R, Ilieva-Borisova Y, Tang Y, Scorza FB, Flores J, Rathi N. Supplementary information for the article: Stevanovic, G.; Obradovic, A.; Ristic, S.; Petrovic, D.; Milenkovic, B.; Mitrovic, D.; Vignjevic, S. F.;  Ilic, K.; Stoiljkovic, V.; Lavadinovic, L.; Pelemis, M.; Petrovic, S.; Vidmanic, A.; Popovic, O.; Eremic,  N.; Sparrow, E.; Torelli, G.; Socquet, M.; Holt, R.; Ilieva-Borisova, Y.; Tang, Y.; Scorza, F. B.; Flores,  J.; Rathi, N. Safety and Immunogenicity of a Seasonal Trivalent Inactivated Split Influenza Vaccine: A  Double Blind, Phase III Randomized Clinical Trial in Healthy Serbian Adults. Therapeutic Advances in Vaccines and Immunotherapy 2020, 8, 2515135520925336.  https://doi.org/10.1177/2515135520925336. in Therapeutic Advances in Vaccines and Immunotherapy. 2020;8.
https://hdl.handle.net/21.15107/rcub_intor_637 .

Stevanović, Goran, Obradović, Aleksandar, Ristić, Snezana, Petrović, Dragan, Milenković, Branislava, Mitrović, Danilo, Vignjević Filipović, Svetlana, Ilić, Katarina, Stoiljković, Vera, Lavadinović, Lidija, Pelemis, Mijomir, Petrović, Svetlana, Vidmanić, Ana, Popović, Olga, Eremić, Natasa, Sparrow, Erin, Torelli, Guido, Socquet, Muriel, Holt, Renée, Ilieva-Borisova, Yordanka, Tang, Yuxiao, Scorza, Francesco Berlanda, Flores, Jorge, Rathi, Niraj, "Supplementary information for the article: Stevanovic, G.; Obradovic, A.; Ristic, S.; Petrovic, D.; Milenkovic, B.; Mitrovic, D.; Vignjevic, S. F.;  Ilic, K.; Stoiljkovic, V.; Lavadinovic, L.; Pelemis, M.; Petrovic, S.; Vidmanic, A.; Popovic, O.; Eremic,  N.; Sparrow, E.; Torelli, G.; Socquet, M.; Holt, R.; Ilieva-Borisova, Y.; Tang, Y.; Scorza, F. B.; Flores,  J.; Rathi, N. Safety and Immunogenicity of a Seasonal Trivalent Inactivated Split Influenza Vaccine: A  Double Blind, Phase III Randomized Clinical Trial in Healthy Serbian Adults. Therapeutic Advances in Vaccines and Immunotherapy 2020, 8, 2515135520925336.  https://doi.org/10.1177/2515135520925336" in Therapeutic Advances in Vaccines and Immunotherapy, 8 (2020),
https://hdl.handle.net/21.15107/rcub_intor_637 .

TY  - JOUR
AU  - Stevanović, Goran
AU  - Obradović, Aleksandar
AU  - Ristić, Snezana
AU  - Petrović, Dragan
AU  - Milenković, Branislava
AU  - Mitrović, Danilo
AU  - Vignjević Filipović, Svetlana
AU  - Ilić, Katarina
AU  - Stoiljković, Vera
AU  - Lavadinović, Lidija
AU  - Pelemis, Mijomir
AU  - Petrović, Svetlana
AU  - Vidmanić, Ana
AU  - Popović, Olga
AU  - Eremić, Natasa
AU  - Sparrow, Erin
AU  - Torelli, Guido
AU  - Socquet, Muriel
AU  - Holt, Renée
AU  - Ilieva-Borisova, Yordanka
AU  - Tang, Yuxiao
AU  - Scorza, Francesco Berlanda
AU  - Flores, Jorge
AU  - Rathi, Niraj
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/616
AB  - This study was a phase III, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a seasonal trivalent split, inactivated influenza vaccine (TIV) in healthy Serbian adults between the ages of 18 and 65 years. This egg-based vaccine was manufactured by the Institute of Virology, Vaccines and Sera, Torlak, Belgrade, Serbia. A total of 480 participants were assigned randomly in a ratio of 2:1 to receive a single intramuscular dose (0.5 ml) of the vaccine (15 µg of hemagglutinin per strain) or placebo (phosphate-buffered saline). Participants were monitored for safety, including solicited and unsolicited adverse events (AEs) and serious adverse events (SAEs). No SAEs related to vaccination were reported. Injection site pain (51.3%), injection site tenderness (40.4%), tiredness (17.0%), and headache (15.1%) were the most commonly reported solicited events in the vaccine group. Incidence of related unsolicited AEs was low (1.3%) among vaccinees. Hemagglutinin inhibition (HAI) titers were measured before and 21 days after vaccination in 151 participants. Overall, HAI seroconversion rates to H1 and H3 were observed in 90.1% and 76.2% of vaccinees, respectively. For B antigen, it was 51.5%, likely due to high pre-vaccination titers. Post-vaccination seroprotection rates were in the range of 78.2–95.0% for the three antigens. Post-vaccination geometric mean titers (GMT) were at least 3.8 times higher than baseline levels for all the three strains among vaccinees. Overall, the study showed that the vaccine was safe and well tolerated, and induced a robust immune response against all three vaccine strains., ClinicalTrials.gov identifier: NCT02935192, October 17, 2016
PB  - SAGE Publications
T2  - Therapeutic Advances in Vaccines and Immunotherapy
T1  - Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults
VL  - 8
DO  - 10.1177/2515135520925336
ER  - 

@article{
author = "Stevanović, Goran and Obradović, Aleksandar and Ristić, Snezana and Petrović, Dragan and Milenković, Branislava and Mitrović, Danilo and Vignjević Filipović, Svetlana and Ilić, Katarina and Stoiljković, Vera and Lavadinović, Lidija and Pelemis, Mijomir and Petrović, Svetlana and Vidmanić, Ana and Popović, Olga and Eremić, Natasa and Sparrow, Erin and Torelli, Guido and Socquet, Muriel and Holt, Renée and Ilieva-Borisova, Yordanka and Tang, Yuxiao and Scorza, Francesco Berlanda and Flores, Jorge and Rathi, Niraj",
year = "2020",
abstract = "This study was a phase III, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a seasonal trivalent split, inactivated influenza vaccine (TIV) in healthy Serbian adults between the ages of 18 and 65 years. This egg-based vaccine was manufactured by the Institute of Virology, Vaccines and Sera, Torlak, Belgrade, Serbia. A total of 480 participants were assigned randomly in a ratio of 2:1 to receive a single intramuscular dose (0.5 ml) of the vaccine (15 µg of hemagglutinin per strain) or placebo (phosphate-buffered saline). Participants were monitored for safety, including solicited and unsolicited adverse events (AEs) and serious adverse events (SAEs). No SAEs related to vaccination were reported. Injection site pain (51.3%), injection site tenderness (40.4%), tiredness (17.0%), and headache (15.1%) were the most commonly reported solicited events in the vaccine group. Incidence of related unsolicited AEs was low (1.3%) among vaccinees. Hemagglutinin inhibition (HAI) titers were measured before and 21 days after vaccination in 151 participants. Overall, HAI seroconversion rates to H1 and H3 were observed in 90.1% and 76.2% of vaccinees, respectively. For B antigen, it was 51.5%, likely due to high pre-vaccination titers. Post-vaccination seroprotection rates were in the range of 78.2–95.0% for the three antigens. Post-vaccination geometric mean titers (GMT) were at least 3.8 times higher than baseline levels for all the three strains among vaccinees. Overall, the study showed that the vaccine was safe and well tolerated, and induced a robust immune response against all three vaccine strains., ClinicalTrials.gov identifier: NCT02935192, October 17, 2016",
publisher = "SAGE Publications",
journal = "Therapeutic Advances in Vaccines and Immunotherapy",
title = "Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults",
volume = "8",
doi = "10.1177/2515135520925336"
}

Stevanović, G., Obradović, A., Ristić, S., Petrović, D., Milenković, B., Mitrović, D., Vignjević Filipović, S., Ilić, K., Stoiljković, V., Lavadinović, L., Pelemis, M., Petrović, S., Vidmanić, A., Popović, O., Eremić, N., Sparrow, E., Torelli, G., Socquet, M., Holt, R., Ilieva-Borisova, Y., Tang, Y., Scorza, F. B., Flores, J.,& Rathi, N.. (2020). Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults. in Therapeutic Advances in Vaccines and Immunotherapy
SAGE Publications., 8.
https://doi.org/10.1177/2515135520925336

Stevanović G, Obradović A, Ristić S, Petrović D, Milenković B, Mitrović D, Vignjević Filipović S, Ilić K, Stoiljković V, Lavadinović L, Pelemis M, Petrović S, Vidmanić A, Popović O, Eremić N, Sparrow E, Torelli G, Socquet M, Holt R, Ilieva-Borisova Y, Tang Y, Scorza FB, Flores J, Rathi N. Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults. in Therapeutic Advances in Vaccines and Immunotherapy. 2020;8.
doi:10.1177/2515135520925336 .

Stevanović, Goran, Obradović, Aleksandar, Ristić, Snezana, Petrović, Dragan, Milenković, Branislava, Mitrović, Danilo, Vignjević Filipović, Svetlana, Ilić, Katarina, Stoiljković, Vera, Lavadinović, Lidija, Pelemis, Mijomir, Petrović, Svetlana, Vidmanić, Ana, Popović, Olga, Eremić, Natasa, Sparrow, Erin, Torelli, Guido, Socquet, Muriel, Holt, Renée, Ilieva-Borisova, Yordanka, Tang, Yuxiao, Scorza, Francesco Berlanda, Flores, Jorge, Rathi, Niraj, "Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults" in Therapeutic Advances in Vaccines and Immunotherapy, 8 (2020),
https://doi.org/10.1177/2515135520925336 . .

TY  - JOUR
AU  - Stoiljković, Vera
AU  - Bichurina, M.A.
AU  - Lavrentieva, I.N.
AU  - Filipović-Vignjević, Svetlana
AU  - Bancević, M.D.
AU  - Zheleznova, N.V.
AU  - Antipova, A.Yu
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/550
AB  - In 2017, the WHO registered 23,927 measles cases in 44 out of 53 countries in the European region. In 2018, measles incidence rate increased up to 82,599 cases registered in 48 countries of the region, with a large number of measles-associated deaths. Overall, 72 measles fatalities were registered in 10 European countries, including Serbia (15 cases). Aim of the study: to characterize 2017-2018 epidemiological upsurge of measles incidence rate observed in the Republic of Serbia (RS) and the Northwestern Federal District (NWFD) of the Russian Federation. Materials and methods. During the 2017-2018 season, 944 serum samples were collected from patients with measles, rubella, or exanthematous diseases in the NWFD and tested in the Laboratory of Virology at the St. Petersburg Regional Centre for Measles Surveillance (SPbRC). In 2017-2018, 2,946 serum samples from the Republic of Serbia were analyzed in the SPbRC by using ELISA with IgM measles test system (Vector-Best, Russia; or Siemens, Germany). Urine and swab samples were examined by RT-PCR and used for isolation and genotyping of measles viruses. Results. From 2017 to 2018, 5,798 measles cases were registered in the RS, among which 2,946 were laboratory-confirmed (serological testing and/or PCR). Unvaccinated subjects or those with unknown vaccination status accounted for majority of the cases. Children under 5 years of age and adults aged 30 years and over dominated among measles patients. During this season, 15 deaths were reported. Several genotypes of measles virus circulated in the RS, e.g. B3 Dublin, D8 Gir Somnath, and D8 Herborn. In 2018, 109 measles cases were recorded in the NWFD, 5 of which were imported from abroad. Among patients, adults comprised 64.2%, wherein 74.3% were covered by unvaccinated subjects or those with unknown vaccination status. Rise in measles incidence rate linked to multiple importations of various measles virus genotypes: B3 Kabul; B3 Dublin; D8 Frankfurt; D8 Cambridge; and D8 Gir Somnath.
PB  - Sankt-Petersburg-Niiem Imeni Pastera, St Petersburg
T2  - Infektsiya I Immunitet
T1  - Rise in 2017-2018 measles morbidity in Serbia and northwest Russia
EP  - 734
IS  - 4
SP  - 729
VL  - 10
DO  - 10.15789/2220-7619-RIM-1342
ER  - 

@article{
author = "Stoiljković, Vera and Bichurina, M.A. and Lavrentieva, I.N. and Filipović-Vignjević, Svetlana and Bancević, M.D. and Zheleznova, N.V. and Antipova, A.Yu",
year = "2020",
abstract = "In 2017, the WHO registered 23,927 measles cases in 44 out of 53 countries in the European region. In 2018, measles incidence rate increased up to 82,599 cases registered in 48 countries of the region, with a large number of measles-associated deaths. Overall, 72 measles fatalities were registered in 10 European countries, including Serbia (15 cases). Aim of the study: to characterize 2017-2018 epidemiological upsurge of measles incidence rate observed in the Republic of Serbia (RS) and the Northwestern Federal District (NWFD) of the Russian Federation. Materials and methods. During the 2017-2018 season, 944 serum samples were collected from patients with measles, rubella, or exanthematous diseases in the NWFD and tested in the Laboratory of Virology at the St. Petersburg Regional Centre for Measles Surveillance (SPbRC). In 2017-2018, 2,946 serum samples from the Republic of Serbia were analyzed in the SPbRC by using ELISA with IgM measles test system (Vector-Best, Russia; or Siemens, Germany). Urine and swab samples were examined by RT-PCR and used for isolation and genotyping of measles viruses. Results. From 2017 to 2018, 5,798 measles cases were registered in the RS, among which 2,946 were laboratory-confirmed (serological testing and/or PCR). Unvaccinated subjects or those with unknown vaccination status accounted for majority of the cases. Children under 5 years of age and adults aged 30 years and over dominated among measles patients. During this season, 15 deaths were reported. Several genotypes of measles virus circulated in the RS, e.g. B3 Dublin, D8 Gir Somnath, and D8 Herborn. In 2018, 109 measles cases were recorded in the NWFD, 5 of which were imported from abroad. Among patients, adults comprised 64.2%, wherein 74.3% were covered by unvaccinated subjects or those with unknown vaccination status. Rise in measles incidence rate linked to multiple importations of various measles virus genotypes: B3 Kabul; B3 Dublin; D8 Frankfurt; D8 Cambridge; and D8 Gir Somnath.",
publisher = "Sankt-Petersburg-Niiem Imeni Pastera, St Petersburg",
journal = "Infektsiya I Immunitet",
title = "Rise in 2017-2018 measles morbidity in Serbia and northwest Russia",
pages = "734-729",
number = "4",
volume = "10",
doi = "10.15789/2220-7619-RIM-1342"
}

Stoiljković, V., Bichurina, M.A., Lavrentieva, I.N., Filipović-Vignjević, S., Bancević, M.D., Zheleznova, N.V.,& Antipova, A.Yu. (2020). Rise in 2017-2018 measles morbidity in Serbia and northwest Russia. in Infektsiya I Immunitet
Sankt-Petersburg-Niiem Imeni Pastera, St Petersburg., 10(4), 729-734.
https://doi.org/10.15789/2220-7619-RIM-1342

Stoiljković V, Bichurina M, Lavrentieva I, Filipović-Vignjević S, Bancević M, Zheleznova N, Antipova A. Rise in 2017-2018 measles morbidity in Serbia and northwest Russia. in Infektsiya I Immunitet. 2020;10(4):729-734.
doi:10.15789/2220-7619-RIM-1342 .

Stoiljković, Vera, Bichurina, M.A., Lavrentieva, I.N., Filipović-Vignjević, Svetlana, Bancević, M.D., Zheleznova, N.V., Antipova, A.Yu, "Rise in 2017-2018 measles morbidity in Serbia and northwest Russia" in Infektsiya I Immunitet, 10, no. 4 (2020):729-734,
https://doi.org/10.15789/2220-7619-RIM-1342 . .

TY  - JOUR
AU  - Bufan, Biljana
AU  - Arsenović-Ranin, Nevena
AU  - Petrović, Raisa
AU  - Živković, Irena
AU  - Stoiljković, Vera
AU  - Leposavić, Gordana
PY  - 2020
UR  - http://intor.torlakinstitut.com/handle/123456789/556
AB  - Considering variability in vaccine responsiveness across human populations, in respect to magnitude and quality, and importance of vaccines in the elderly, the influence of recipient genetic background on the kinetics of age-related changes in the serum IgG antibody responses to seasonal trivalent inactivated split-virus influenza bulk (TIV) was studied in BALB/c and C57BL/6 mice showing quantitative and qualitative differences in this responses in young adult ages. With ageing the total serum IgG response to influenza viruses declined, in a strain-specific manner, so the strain disparity observed in young adult mice (the greater magnitude of IgG response in BALB/c mice) disappeared in aged mice. However, the sexual dimorphisms in this response (more prominent in females of both strains) remained in aged ones. The strain-specific differences in age-related decline in the magnitude of IgG response to TIV correlated with the number of germinal centre (GC) B splenocytes. The agerelated decline in GC B cell number was consistent with the decrease in the proliferation of B cells and CD4 + cells in splenocyte cultures upon restimulation with TIV. Additionally, the age-related decrease in the magnitude of IgG response correlated with the increase in follicular T regulatory (fTreg)/follicular T helper (fTh) and fTreg/GC B splenocyte ratios (reflecting decrease in fTh and GC B numbers without changes in fTreg number), and the frequency of CD4 + splenocytes producing IL-21, a key factor in balancing the B cell and fTreg cell activity. With ageing the avidity of virus influenza-specific antibody increased in females of both strains. Moreover, ageing affected IgG2a/IgG1 and IgG2c/IgG1 ratios (reflecting Thl/Th2 balance) in male BALB/c mice and female C57BL/6 mice, respectively. Consequently, differently from young mice exhibiting the similar ratios in male and female mice, in aged female mice of both strains IgG2a(c)/IgG1 ratios were shifted towards a less effective IgG1 response (stimulated by IL-4 cytokines) compared with males. The age-related alterations in IgG subclass profiles in both strains correlated with those in IFN-gamma/IL-4 production level ratio in splenocyte cultures restimulated with TIV. These findings stimulate further research to formulate sex-specific strategies to improve efficacy of influenza vaccine in the elderly.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Experimental Gerontology
T1  - Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences
VL  - 133
DO  - 10.1016/j.exger.2020.110857
ER  - 

@article{
author = "Bufan, Biljana and Arsenović-Ranin, Nevena and Petrović, Raisa and Živković, Irena and Stoiljković, Vera and Leposavić, Gordana",
year = "2020",
abstract = "Considering variability in vaccine responsiveness across human populations, in respect to magnitude and quality, and importance of vaccines in the elderly, the influence of recipient genetic background on the kinetics of age-related changes in the serum IgG antibody responses to seasonal trivalent inactivated split-virus influenza bulk (TIV) was studied in BALB/c and C57BL/6 mice showing quantitative and qualitative differences in this responses in young adult ages. With ageing the total serum IgG response to influenza viruses declined, in a strain-specific manner, so the strain disparity observed in young adult mice (the greater magnitude of IgG response in BALB/c mice) disappeared in aged mice. However, the sexual dimorphisms in this response (more prominent in females of both strains) remained in aged ones. The strain-specific differences in age-related decline in the magnitude of IgG response to TIV correlated with the number of germinal centre (GC) B splenocytes. The agerelated decline in GC B cell number was consistent with the decrease in the proliferation of B cells and CD4 + cells in splenocyte cultures upon restimulation with TIV. Additionally, the age-related decrease in the magnitude of IgG response correlated with the increase in follicular T regulatory (fTreg)/follicular T helper (fTh) and fTreg/GC B splenocyte ratios (reflecting decrease in fTh and GC B numbers without changes in fTreg number), and the frequency of CD4 + splenocytes producing IL-21, a key factor in balancing the B cell and fTreg cell activity. With ageing the avidity of virus influenza-specific antibody increased in females of both strains. Moreover, ageing affected IgG2a/IgG1 and IgG2c/IgG1 ratios (reflecting Thl/Th2 balance) in male BALB/c mice and female C57BL/6 mice, respectively. Consequently, differently from young mice exhibiting the similar ratios in male and female mice, in aged female mice of both strains IgG2a(c)/IgG1 ratios were shifted towards a less effective IgG1 response (stimulated by IL-4 cytokines) compared with males. The age-related alterations in IgG subclass profiles in both strains correlated with those in IFN-gamma/IL-4 production level ratio in splenocyte cultures restimulated with TIV. These findings stimulate further research to formulate sex-specific strategies to improve efficacy of influenza vaccine in the elderly.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Experimental Gerontology",
title = "Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences",
volume = "133",
doi = "10.1016/j.exger.2020.110857"
}

Bufan, B., Arsenović-Ranin, N., Petrović, R., Živković, I., Stoiljković, V.,& Leposavić, G.. (2020). Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences. in Experimental Gerontology
Pergamon-Elsevier Science Ltd, Oxford., 133.
https://doi.org/10.1016/j.exger.2020.110857

Bufan B, Arsenović-Ranin N, Petrović R, Živković I, Stoiljković V, Leposavić G. Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences. in Experimental Gerontology. 2020;133.
doi:10.1016/j.exger.2020.110857 .

Bufan, Biljana, Arsenović-Ranin, Nevena, Petrović, Raisa, Živković, Irena, Stoiljković, Vera, Leposavić, Gordana, "Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences" in Experimental Gerontology, 133 (2020),
https://doi.org/10.1016/j.exger.2020.110857 . .

TY  - JOUR
AU  - Dente, Maria Grazia
AU  - Riccardo, Flavia
AU  - Bolici, Francesco
AU  - Colella, Nello Augusto
AU  - Jovanović, Verica
AU  - Drakulović, Mitra
AU  - Vasić, Milena
AU  - Mamlouk, Habiba
AU  - Maazaoui, Latifa
AU  - Bejaoui, Mondher
AU  - Zakhashvili, Khatuna
AU  - Kalandadze, Irine
AU  - Imnadze, Paata
AU  - Declich, Silvia
AU  - Knjeginić, Vesna
AU  - Stojković, Borka
AU  - Labus, Tatjana
AU  - Milicević, Vesna
AU  - Veljović, Ljubiša
AU  - Maksimović-Zorić, Jelena
AU  - Stoiljković, Vera
AU  - Filipović-Vignjević, Svetlana
AU  - Protić, Jelena
AU  - Zgomba, Marija
AU  - Petrić, Dusan
AU  - Despot, Dragana
AU  - Pesić, Branislav
AU  - Serović, Katarina
AU  - Aleksić, Ivan
AU  - Đurić, Ivana
AU  - Ilić, Dragan
AU  - Vrga, Svetlana
AU  - Pavlović, Ljiljana
AU  - Plavsa, Dragana
AU  - Grego, Edita
AU  - Harabech, Kaouther
AU  - Ben Alaya, Nissaf
AU  - Bougatef, Souha
AU  - Triki, Henda
AU  - Bouattour, Ali
AU  - Rebhi, Mohamed
AU  - Daaboub, Jabeur
AU  - Somai, Lamia
AU  - Zerlli, Malek
AU  - Zerlli, Malek
AU  - Oukaili, Kaouther
AU  - Ammar, Heni Haj
AU  - Sghaier, Chedia
AU  - Fatnassi, Naouel
AU  - Kalthoum, Sana
AU  - Dhaouadi, Anissa
AU  - Ben Youness, Abdelhak
AU  - Mahale, Issam
AU  - Marzouk, Mongi
AU  - Ben Bdira, Sassi
AU  - Grira, Samia
AU  - Ayadi, Sonia
AU  - Mastouri, Maha
AU  - Faten, Allad
AU  - Abdelkader, Ben
AU  - Chakhunashvili, Giorgi
AU  - Babuadze, Giorgi
AU  - Mamuchishvili, Nana
AU  - Chanturia, Gvantsa
AU  - Adeishvili, Ekaterine
AU  - Avaliani, Lasha
AU  - Ninidze, Lena
AU  - Kartskhia, Natia
AU  - Gulbani, Ana
AU  - Kokhreidze, Maka
AU  - Donduashvili, Marina
AU  - Kekelidze, Anna
PY  - 2019
UR  - http://intor.torlakinstitut.com/handle/123456789/535
AB  - Background In the Mediterranean and Black Sea Region, arbovirus infections are emerging infectious diseases. Their surveillance can benefit from one health inter-sectoral collaboration; however, no standardized methodology exists to study One Health surveillance. Methods We designed a situation analysis study to document how integration of laboratory/clinical human, animal and entomological surveillance of arboviruses was being implemented in the Region. We applied a framework designed to assess three levels of integration: policy/institutional, data collection/data analysis and dissemination. We tested the use of Business Process Modelling Notation (BPMN) to graphically present evidence of inter-sectoral integration. Results Serbia, Tunisia and Georgia participated in the study. West Nile Virus surveillance was analysed in Serbia and Tunisia, Crimea-Congo Haemorrhagic Fever surveillance in Georgia. Our framework enabled a standardized analysis of One Health surveillance integration, and BPMN was easily understandable and conducive to detailed discussions among different actors/institutions. In all countries, we observed integration across sectors and levels except in data collection and data analysis. Data collection was interoperable only in Georgia without integrated analysis. In all countries, surveillance was mainly oriented towards outbreak response, triggered by an index human case. Discussion The three surveillance systems we observed prove that integrated surveillance can be operationalized with a diverse spectrum of options. However, in all countries, the integrated use of data for early warning and inter-sectoral priority setting is pioneeristic. We also noted that early warning before human case occurrence is recurrently not operationally prioritized.
PB  - Wiley, Hoboken
T2  - Zoonoses and Public Health
T1  - Implementation of the One Health approach to fight arbovirus infections in the Mediterranean and Black Sea Region: Assessing integrated surveillance in Serbia, Tunisia and Georgia
EP  - 287
IS  - 3
SP  - 276
VL  - 66
DO  - 10.1111/zph.12562
ER  - 

@article{
author = "Dente, Maria Grazia and Riccardo, Flavia and Bolici, Francesco and Colella, Nello Augusto and Jovanović, Verica and Drakulović, Mitra and Vasić, Milena and Mamlouk, Habiba and Maazaoui, Latifa and Bejaoui, Mondher and Zakhashvili, Khatuna and Kalandadze, Irine and Imnadze, Paata and Declich, Silvia and Knjeginić, Vesna and Stojković, Borka and Labus, Tatjana and Milicević, Vesna and Veljović, Ljubiša and Maksimović-Zorić, Jelena and Stoiljković, Vera and Filipović-Vignjević, Svetlana and Protić, Jelena and Zgomba, Marija and Petrić, Dusan and Despot, Dragana and Pesić, Branislav and Serović, Katarina and Aleksić, Ivan and Đurić, Ivana and Ilić, Dragan and Vrga, Svetlana and Pavlović, Ljiljana and Plavsa, Dragana and Grego, Edita and Harabech, Kaouther and Ben Alaya, Nissaf and Bougatef, Souha and Triki, Henda and Bouattour, Ali and Rebhi, Mohamed and Daaboub, Jabeur and Somai, Lamia and Zerlli, Malek and Zerlli, Malek and Oukaili, Kaouther and Ammar, Heni Haj and Sghaier, Chedia and Fatnassi, Naouel and Kalthoum, Sana and Dhaouadi, Anissa and Ben Youness, Abdelhak and Mahale, Issam and Marzouk, Mongi and Ben Bdira, Sassi and Grira, Samia and Ayadi, Sonia and Mastouri, Maha and Faten, Allad and Abdelkader, Ben and Chakhunashvili, Giorgi and Babuadze, Giorgi and Mamuchishvili, Nana and Chanturia, Gvantsa and Adeishvili, Ekaterine and Avaliani, Lasha and Ninidze, Lena and Kartskhia, Natia and Gulbani, Ana and Kokhreidze, Maka and Donduashvili, Marina and Kekelidze, Anna",
year = "2019",
abstract = "Background In the Mediterranean and Black Sea Region, arbovirus infections are emerging infectious diseases. Their surveillance can benefit from one health inter-sectoral collaboration; however, no standardized methodology exists to study One Health surveillance. Methods We designed a situation analysis study to document how integration of laboratory/clinical human, animal and entomological surveillance of arboviruses was being implemented in the Region. We applied a framework designed to assess three levels of integration: policy/institutional, data collection/data analysis and dissemination. We tested the use of Business Process Modelling Notation (BPMN) to graphically present evidence of inter-sectoral integration. Results Serbia, Tunisia and Georgia participated in the study. West Nile Virus surveillance was analysed in Serbia and Tunisia, Crimea-Congo Haemorrhagic Fever surveillance in Georgia. Our framework enabled a standardized analysis of One Health surveillance integration, and BPMN was easily understandable and conducive to detailed discussions among different actors/institutions. In all countries, we observed integration across sectors and levels except in data collection and data analysis. Data collection was interoperable only in Georgia without integrated analysis. In all countries, surveillance was mainly oriented towards outbreak response, triggered by an index human case. Discussion The three surveillance systems we observed prove that integrated surveillance can be operationalized with a diverse spectrum of options. However, in all countries, the integrated use of data for early warning and inter-sectoral priority setting is pioneeristic. We also noted that early warning before human case occurrence is recurrently not operationally prioritized.",
publisher = "Wiley, Hoboken",
journal = "Zoonoses and Public Health",
title = "Implementation of the One Health approach to fight arbovirus infections in the Mediterranean and Black Sea Region: Assessing integrated surveillance in Serbia, Tunisia and Georgia",
pages = "287-276",
number = "3",
volume = "66",
doi = "10.1111/zph.12562"
}

Dente, M. G., Riccardo, F., Bolici, F., Colella, N. A., Jovanović, V., Drakulović, M., Vasić, M., Mamlouk, H., Maazaoui, L., Bejaoui, M., Zakhashvili, K., Kalandadze, I., Imnadze, P., Declich, S., Knjeginić, V., Stojković, B., Labus, T., Milicević, V., Veljović, L., Maksimović-Zorić, J., Stoiljković, V., Filipović-Vignjević, S., Protić, J., Zgomba, M., Petrić, D., Despot, D., Pesić, B., Serović, K., Aleksić, I., Đurić, I., Ilić, D., Vrga, S., Pavlović, L., Plavsa, D., Grego, E., Harabech, K., Ben Alaya, N., Bougatef, S., Triki, H., Bouattour, A., Rebhi, M., Daaboub, J., Somai, L., Zerlli, M., Zerlli, M., Oukaili, K., Ammar, H. H., Sghaier, C., Fatnassi, N., Kalthoum, S., Dhaouadi, A., Ben Youness, A., Mahale, I., Marzouk, M., Ben Bdira, S., Grira, S., Ayadi, S., Mastouri, M., Faten, A., Abdelkader, B., Chakhunashvili, G., Babuadze, G., Mamuchishvili, N., Chanturia, G., Adeishvili, E., Avaliani, L., Ninidze, L., Kartskhia, N., Gulbani, A., Kokhreidze, M., Donduashvili, M.,& Kekelidze, A.. (2019). Implementation of the One Health approach to fight arbovirus infections in the Mediterranean and Black Sea Region: Assessing integrated surveillance in Serbia, Tunisia and Georgia. in Zoonoses and Public Health
Wiley, Hoboken., 66(3), 276-287.
https://doi.org/10.1111/zph.12562

Dente MG, Riccardo F, Bolici F, Colella NA, Jovanović V, Drakulović M, Vasić M, Mamlouk H, Maazaoui L, Bejaoui M, Zakhashvili K, Kalandadze I, Imnadze P, Declich S, Knjeginić V, Stojković B, Labus T, Milicević V, Veljović L, Maksimović-Zorić J, Stoiljković V, Filipović-Vignjević S, Protić J, Zgomba M, Petrić D, Despot D, Pesić B, Serović K, Aleksić I, Đurić I, Ilić D, Vrga S, Pavlović L, Plavsa D, Grego E, Harabech K, Ben Alaya N, Bougatef S, Triki H, Bouattour A, Rebhi M, Daaboub J, Somai L, Zerlli M, Zerlli M, Oukaili K, Ammar HH, Sghaier C, Fatnassi N, Kalthoum S, Dhaouadi A, Ben Youness A, Mahale I, Marzouk M, Ben Bdira S, Grira S, Ayadi S, Mastouri M, Faten A, Abdelkader B, Chakhunashvili G, Babuadze G, Mamuchishvili N, Chanturia G, Adeishvili E, Avaliani L, Ninidze L, Kartskhia N, Gulbani A, Kokhreidze M, Donduashvili M, Kekelidze A. Implementation of the One Health approach to fight arbovirus infections in the Mediterranean and Black Sea Region: Assessing integrated surveillance in Serbia, Tunisia and Georgia. in Zoonoses and Public Health. 2019;66(3):276-287.
doi:10.1111/zph.12562 .

Dente, Maria Grazia, Riccardo, Flavia, Bolici, Francesco, Colella, Nello Augusto, Jovanović, Verica, Drakulović, Mitra, Vasić, Milena, Mamlouk, Habiba, Maazaoui, Latifa, Bejaoui, Mondher, Zakhashvili, Khatuna, Kalandadze, Irine, Imnadze, Paata, Declich, Silvia, Knjeginić, Vesna, Stojković, Borka, Labus, Tatjana, Milicević, Vesna, Veljović, Ljubiša, Maksimović-Zorić, Jelena, Stoiljković, Vera, Filipović-Vignjević, Svetlana, Protić, Jelena, Zgomba, Marija, Petrić, Dusan, Despot, Dragana, Pesić, Branislav, Serović, Katarina, Aleksić, Ivan, Đurić, Ivana, Ilić, Dragan, Vrga, Svetlana, Pavlović, Ljiljana, Plavsa, Dragana, Grego, Edita, Harabech, Kaouther, Ben Alaya, Nissaf, Bougatef, Souha, Triki, Henda, Bouattour, Ali, Rebhi, Mohamed, Daaboub, Jabeur, Somai, Lamia, Zerlli, Malek, Zerlli, Malek, Oukaili, Kaouther, Ammar, Heni Haj, Sghaier, Chedia, Fatnassi, Naouel, Kalthoum, Sana, Dhaouadi, Anissa, Ben Youness, Abdelhak, Mahale, Issam, Marzouk, Mongi, Ben Bdira, Sassi, Grira, Samia, Ayadi, Sonia, Mastouri, Maha, Faten, Allad, Abdelkader, Ben, Chakhunashvili, Giorgi, Babuadze, Giorgi, Mamuchishvili, Nana, Chanturia, Gvantsa, Adeishvili, Ekaterine, Avaliani, Lasha, Ninidze, Lena, Kartskhia, Natia, Gulbani, Ana, Kokhreidze, Maka, Donduashvili, Marina, Kekelidze, Anna, "Implementation of the One Health approach to fight arbovirus infections in the Mediterranean and Black Sea Region: Assessing integrated surveillance in Serbia, Tunisia and Georgia" in Zoonoses and Public Health, 66, no. 3 (2019):276-287,
https://doi.org/10.1111/zph.12562 . .

TY  - CONF
AU  - Petrović, Raisa
AU  - Arsenović-Ranin, Nevena
AU  - Bufan, Biljana
AU  - Živković, Irena
AU  - Prijić, Ivana
AU  - Stoiljković, Vera
AU  - Leposavić, Gordana
PY  - 2019
UR  - http://intor.torlakinstitut.com/handle/123456789/692
AB  - Efficacy of the immune response to vaccine depends on genetic background, sex and
age of the recipient. However, mechanisms underlying this phenomenon have not been
elucidated, yet. The study investigated influence of sex and age on serum IgG response
to seasonal trivalent inactivated split influenza vaccine (TIV) in BALB/c and C57BL/6
mice, and mechanisms underlying this response. Total serum IgG responses to
influenza virus type A strains declined with aging, in a strain-specific manner.
Consequently, strain differences (greater IgG responses in BALB/c mice) observed in
young mice (three-month-old) were abrogated in old (eighteen-month-old) ones.
However, irrespective of strain and age, females developed stronger influenza type Aspecific IgG responses than males. Despite age-related decrease in influenza B-specific
serum IgG response, it was comparable between old BALB/c and C57BL/6 mice. The
strain/sex-specific differences in age-related changes in the magnitudes of IgG
responses to TIV correlated with those in number of germinal centre (GC) B
splenocytes. These differences were related to those in B splenocyte and CD4+
splenocyte proliferation in culture upon restimulation with influenza viruses from TIV.
The magnitudes of IgG responses also correlated to T follicular regulatory (Tfr)/T
follicular helper and Tfr/GC B splenocyte ratios across all groups of mice. Aging,
irrespective of influenza virus-specificity, affected serum IgG2a(c)/IgG1 ratios
(reflecting IFN-γ/IL-4 production level ratio) in male BALB/c and female C57BL/6
mice, respectively. Thus, although in young mice of both strains these ratios were
comparable between sexes, in old females they were shifted towards IgG1 when
compared with age-matched males. Consistently, the IFN-γ/IL-4 production level ratios
in splenocyte cultures stimulated with influenza viruses from old females of both strains
were shifted towards IL-4 compared with that in age-matched male cultures. The study
stimulates further research to formulate sex-specific strategies to improve efficacy of
influenza vaccine in elderly.
PB  - Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade Immunological Society of Serbia
C3  - Immunology at the confluence of multidisciplinary approaches: Abstract book, Hotel Mona Plaza, Belgrade, December 6th-8th
T1  - Influence of ageing on sex and strain differences in immune response to inactivated influenza vaccine
UR  - https://hdl.handle.net/21.15107/rcub_intor_692
ER  - 

@conference{
author = "Petrović, Raisa and Arsenović-Ranin, Nevena and Bufan, Biljana and Živković, Irena and Prijić, Ivana and Stoiljković, Vera and Leposavić, Gordana",
year = "2019",
abstract = "Efficacy of the immune response to vaccine depends on genetic background, sex and
age of the recipient. However, mechanisms underlying this phenomenon have not been
elucidated, yet. The study investigated influence of sex and age on serum IgG response
to seasonal trivalent inactivated split influenza vaccine (TIV) in BALB/c and C57BL/6
mice, and mechanisms underlying this response. Total serum IgG responses to
influenza virus type A strains declined with aging, in a strain-specific manner.
Consequently, strain differences (greater IgG responses in BALB/c mice) observed in
young mice (three-month-old) were abrogated in old (eighteen-month-old) ones.
However, irrespective of strain and age, females developed stronger influenza type Aspecific IgG responses than males. Despite age-related decrease in influenza B-specific
serum IgG response, it was comparable between old BALB/c and C57BL/6 mice. The
strain/sex-specific differences in age-related changes in the magnitudes of IgG
responses to TIV correlated with those in number of germinal centre (GC) B
splenocytes. These differences were related to those in B splenocyte and CD4+
splenocyte proliferation in culture upon restimulation with influenza viruses from TIV.
The magnitudes of IgG responses also correlated to T follicular regulatory (Tfr)/T
follicular helper and Tfr/GC B splenocyte ratios across all groups of mice. Aging,
irrespective of influenza virus-specificity, affected serum IgG2a(c)/IgG1 ratios
(reflecting IFN-γ/IL-4 production level ratio) in male BALB/c and female C57BL/6
mice, respectively. Thus, although in young mice of both strains these ratios were
comparable between sexes, in old females they were shifted towards IgG1 when
compared with age-matched males. Consistently, the IFN-γ/IL-4 production level ratios
in splenocyte cultures stimulated with influenza viruses from old females of both strains
were shifted towards IL-4 compared with that in age-matched male cultures. The study
stimulates further research to formulate sex-specific strategies to improve efficacy of
influenza vaccine in elderly.",
publisher = "Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade Immunological Society of Serbia",
journal = "Immunology at the confluence of multidisciplinary approaches: Abstract book, Hotel Mona Plaza, Belgrade, December 6th-8th",
title = "Influence of ageing on sex and strain differences in immune response to inactivated influenza vaccine",
url = "https://hdl.handle.net/21.15107/rcub_intor_692"
}

Petrović, R., Arsenović-Ranin, N., Bufan, B., Živković, I., Prijić, I., Stoiljković, V.,& Leposavić, G.. (2019). Influence of ageing on sex and strain differences in immune response to inactivated influenza vaccine. in Immunology at the confluence of multidisciplinary approaches: Abstract book, Hotel Mona Plaza, Belgrade, December 6th-8th
Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade Immunological Society of Serbia..
https://hdl.handle.net/21.15107/rcub_intor_692

Petrović R, Arsenović-Ranin N, Bufan B, Živković I, Prijić I, Stoiljković V, Leposavić G. Influence of ageing on sex and strain differences in immune response to inactivated influenza vaccine. in Immunology at the confluence of multidisciplinary approaches: Abstract book, Hotel Mona Plaza, Belgrade, December 6th-8th. 2019;.
https://hdl.handle.net/21.15107/rcub_intor_692 .

Petrović, Raisa, Arsenović-Ranin, Nevena, Bufan, Biljana, Živković, Irena, Prijić, Ivana, Stoiljković, Vera, Leposavić, Gordana, "Influence of ageing on sex and strain differences in immune response to inactivated influenza vaccine" in Immunology at the confluence of multidisciplinary approaches: Abstract book, Hotel Mona Plaza, Belgrade, December 6th-8th (2019),
https://hdl.handle.net/21.15107/rcub_intor_692 .

TY  - JOUR
AU  - Arsenović-Ranin, Nevena
AU  - Petrović, Raisa
AU  - Živković, Irena
AU  - Bufan, Biljana
AU  - Stoiljković, Vera
AU  - Leposavić, Gordana
PY  - 2019
UR  - http://intor.torlakinstitut.com/handle/123456789/534
AB  - The study examined sex-specificities in age-related changes in BALB/c mice IgG antibody responses to immunisation with trivalent inactivated split-virus influenza bulk. Aging diminished the total serum IgG antibody responses to H1N1 and H3N2 and B influenza virus antigens in mice of both sexes, but they remained greater in aged females. This sex difference in aged mice correlated with the greater post-immunisation increase in the frequency of spleen germinal centre (GC) B cells and more favourable T follicular regulatory (Tfr)/GC B cell ratio, as Tfr cells are suggested to control antibody production through suppression of glycolysis. The greater post-immunisation GC B cell response in aged females compared with males correlated with the greater proliferation of B cells and CD4+ cells in splenocyte cultures from aged females restimulated with inactivated split-virus influenza from the bulk. To support the greater post-immunisation increase in the frequency GC B cell in aged females was more favourable Tfr/T follicular helper (Tfh) cell ratio. Additionally, compared with aged males, in age-matched females the greater avidity of serum IgG antibodies was found. However, in aged females IgG2a/IgG1 antibody ratio, reflecting spleen Th1/Th2 cytokine balance, was shifted towards IgG1 when compared with age-matched male mice. This shift was ascribed to a more prominent decline in the titres of functionally important IgG2a antibodies in females with aging. The study suggest that biological sex should be considered as a variable in designing strategies to manipulate with immune outcome of immunisation in aged animals, and possibly, at very long distance, humans.
PB  - Springer, New York
T2  - Biogerontology
T1  - Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences
EP  - 496
IS  - 4
SP  - 475
VL  - 20
DO  - 10.1007/s10522-019-09811-8
ER  - 

@article{
author = "Arsenović-Ranin, Nevena and Petrović, Raisa and Živković, Irena and Bufan, Biljana and Stoiljković, Vera and Leposavić, Gordana",
year = "2019",
abstract = "The study examined sex-specificities in age-related changes in BALB/c mice IgG antibody responses to immunisation with trivalent inactivated split-virus influenza bulk. Aging diminished the total serum IgG antibody responses to H1N1 and H3N2 and B influenza virus antigens in mice of both sexes, but they remained greater in aged females. This sex difference in aged mice correlated with the greater post-immunisation increase in the frequency of spleen germinal centre (GC) B cells and more favourable T follicular regulatory (Tfr)/GC B cell ratio, as Tfr cells are suggested to control antibody production through suppression of glycolysis. The greater post-immunisation GC B cell response in aged females compared with males correlated with the greater proliferation of B cells and CD4+ cells in splenocyte cultures from aged females restimulated with inactivated split-virus influenza from the bulk. To support the greater post-immunisation increase in the frequency GC B cell in aged females was more favourable Tfr/T follicular helper (Tfh) cell ratio. Additionally, compared with aged males, in age-matched females the greater avidity of serum IgG antibodies was found. However, in aged females IgG2a/IgG1 antibody ratio, reflecting spleen Th1/Th2 cytokine balance, was shifted towards IgG1 when compared with age-matched male mice. This shift was ascribed to a more prominent decline in the titres of functionally important IgG2a antibodies in females with aging. The study suggest that biological sex should be considered as a variable in designing strategies to manipulate with immune outcome of immunisation in aged animals, and possibly, at very long distance, humans.",
publisher = "Springer, New York",
journal = "Biogerontology",
title = "Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences",
pages = "496-475",
number = "4",
volume = "20",
doi = "10.1007/s10522-019-09811-8"
}

Arsenović-Ranin, N., Petrović, R., Živković, I., Bufan, B., Stoiljković, V.,& Leposavić, G.. (2019). Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences. in Biogerontology
Springer, New York., 20(4), 475-496.
https://doi.org/10.1007/s10522-019-09811-8

Arsenović-Ranin N, Petrović R, Živković I, Bufan B, Stoiljković V, Leposavić G. Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences. in Biogerontology. 2019;20(4):475-496.
doi:10.1007/s10522-019-09811-8 .

Arsenović-Ranin, Nevena, Petrović, Raisa, Živković, Irena, Bufan, Biljana, Stoiljković, Vera, Leposavić, Gordana, "Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences" in Biogerontology, 20, no. 4 (2019):475-496,
https://doi.org/10.1007/s10522-019-09811-8 . .

TY  - JOUR
AU  - Stevanović, Goran
AU  - Lavadinović, Lidija
AU  - Filipović-Vignjević, Svetlana
AU  - Holt, Renee
AU  - Ilić, Katarina
AU  - Scorza, Francesco Berlanda
AU  - Sparrow, Erin
AU  - Stoiljković, Vera
AU  - Torelli, Guido
AU  - Madenwald, Tamra
AU  - Socquet, Muriel
AU  - Barac, Aleksandra
AU  - Ilieva-Borisova, Yordanka
AU  - Pelemiš, Mijomir
AU  - Flores, Jorge
PY  - 2018
UR  - http://intor.torlakinstitut.com/handle/123456789/517
AB  - This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45years, were enrolled in the trial. On the day of immunization, volunteers were randomly assigned to receive either a single dose of the trivalent seasonal influenza vaccine (15g of hemagglutinin per strain) or placebo (phosphate-buffered saline). Subjects were monitored for adverse events through a clinical history and physical examination, and blood was taken for testing at screening and on day 8 to assess vaccine safety. Serum samples obtained before and 21days after immunization were tested for influenza antibody titers using hemagglutination-inhibition (HAI) and microneutralization (MN) tests. No serious adverse events were reported. Pain and tenderness at the injection site were the most commonly reported symptoms in both vaccine and placebo groups. Overall, serum HAI responses of fourfold or greater magnitude were observed to H1, H3, and B antigen in 80%, 75%, and 70% of subjects, respectively. Seroprotection rates as measured by HAI were also high (100%, 100% and 86.67%, respectively, for H1, H3 and B). Thus, Torlak's seasonal trivalent influenza vaccine was not associated with adverse events, was well-tolerated and immunogenic. It should be further evaluated in clinical trials to provide sufficient safety and immunogenicity data for licensing in Serbia.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Human Vaccines & Immunotherapeutics
T1  - Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults
EP  - 586
IS  - 3
SP  - 579
VL  - 14
DO  - 10.1080/21645515.2017.1415683
ER  - 

@article{
author = "Stevanović, Goran and Lavadinović, Lidija and Filipović-Vignjević, Svetlana and Holt, Renee and Ilić, Katarina and Scorza, Francesco Berlanda and Sparrow, Erin and Stoiljković, Vera and Torelli, Guido and Madenwald, Tamra and Socquet, Muriel and Barac, Aleksandra and Ilieva-Borisova, Yordanka and Pelemiš, Mijomir and Flores, Jorge",
year = "2018",
abstract = "This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45years, were enrolled in the trial. On the day of immunization, volunteers were randomly assigned to receive either a single dose of the trivalent seasonal influenza vaccine (15g of hemagglutinin per strain) or placebo (phosphate-buffered saline). Subjects were monitored for adverse events through a clinical history and physical examination, and blood was taken for testing at screening and on day 8 to assess vaccine safety. Serum samples obtained before and 21days after immunization were tested for influenza antibody titers using hemagglutination-inhibition (HAI) and microneutralization (MN) tests. No serious adverse events were reported. Pain and tenderness at the injection site were the most commonly reported symptoms in both vaccine and placebo groups. Overall, serum HAI responses of fourfold or greater magnitude were observed to H1, H3, and B antigen in 80%, 75%, and 70% of subjects, respectively. Seroprotection rates as measured by HAI were also high (100%, 100% and 86.67%, respectively, for H1, H3 and B). Thus, Torlak's seasonal trivalent influenza vaccine was not associated with adverse events, was well-tolerated and immunogenic. It should be further evaluated in clinical trials to provide sufficient safety and immunogenicity data for licensing in Serbia.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Human Vaccines & Immunotherapeutics",
title = "Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults",
pages = "586-579",
number = "3",
volume = "14",
doi = "10.1080/21645515.2017.1415683"
}

Stevanović, G., Lavadinović, L., Filipović-Vignjević, S., Holt, R., Ilić, K., Scorza, F. B., Sparrow, E., Stoiljković, V., Torelli, G., Madenwald, T., Socquet, M., Barac, A., Ilieva-Borisova, Y., Pelemiš, M.,& Flores, J.. (2018). Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults. in Human Vaccines & Immunotherapeutics
Taylor & Francis Inc, Philadelphia., 14(3), 579-586.
https://doi.org/10.1080/21645515.2017.1415683

Stevanović G, Lavadinović L, Filipović-Vignjević S, Holt R, Ilić K, Scorza FB, Sparrow E, Stoiljković V, Torelli G, Madenwald T, Socquet M, Barac A, Ilieva-Borisova Y, Pelemiš M, Flores J. Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults. in Human Vaccines & Immunotherapeutics. 2018;14(3):579-586.
doi:10.1080/21645515.2017.1415683 .

Stevanović, Goran, Lavadinović, Lidija, Filipović-Vignjević, Svetlana, Holt, Renee, Ilić, Katarina, Scorza, Francesco Berlanda, Sparrow, Erin, Stoiljković, Vera, Torelli, Guido, Madenwald, Tamra, Socquet, Muriel, Barac, Aleksandra, Ilieva-Borisova, Yordanka, Pelemiš, Mijomir, Flores, Jorge, "Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults" in Human Vaccines & Immunotherapeutics, 14, no. 3 (2018):579-586,
https://doi.org/10.1080/21645515.2017.1415683 . .