TY  - JOUR
AU  - Filipić, Brankica
AU  - Nikolić, Katarina
AU  - Filipić, Slavica
AU  - Jovčić, Branko
AU  - Agbaba, Danica
AU  - Antić-Stanković, Jelena
AU  - Kojić, Milan
AU  - Golić, Nataša
PY  - 2014
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/740
UR  - http://intor.torlakinstitut.com/handle/123456789/838
AB  - The CmbT substrate specificity and its role as a proton motive force-driven drug efflux pump at a molecular level were investigated in the study. In that order, 3D-quantitative structure-activity relationship (3D-QSAR) study was applied for selection of molecular determinants of multidrug recognition by CmbT. CmbT multidrug resistance protein of Lactococcus lactis contributes to extruding the structurally, chemically, and pharmacologically diverse range of substrates out of bacterial cells. This function of CmbT may result in the failure of antibiotic therapy. Homology model of CmbT protein was constructed and further opthnized. The 3D-QSAR model predictive potential was proved by use of leave-one-out cross validation Of the training set (Q(2): 0.69, R-observd(2) (vs).(Predicted) : 0.918, RMSEE: 0.193) and verification set (R-Observed vs predicted(2) : 0.704, RMSEP: 0.289). The results obtained in this study showed that high CmbT affinities to ethidium, sulbactam, and sulfathiazole could be related to the absence of significant unfavourable interactions. In contrast, the presence of specific unfavourable interaction between two hydrogen bond donor groups in bacitracin, apramycin, novobiocin, vancomycin, kanamycin, gentamycin, and tobramycin is found to be the main reason for their lower CmbT affinities. In addition, membrane position of the CmbT binding site and positive correlation between substrates lipophilicity (log D-PH so) and CmbT affinity strongly indicates that CmbT recognizes its substrates within the membrane.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of the Taiwan Institute of Chemical Engineers
T1  - Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study
EP  - 771
IS  - 3
SP  - 764
VL  - 45
DO  - 10.1016/j.jtice.2013.09.033
ER  - 

@article{
author = "Filipić, Brankica and Nikolić, Katarina and Filipić, Slavica and Jovčić, Branko and Agbaba, Danica and Antić-Stanković, Jelena and Kojić, Milan and Golić, Nataša",
year = "2014",
abstract = "The CmbT substrate specificity and its role as a proton motive force-driven drug efflux pump at a molecular level were investigated in the study. In that order, 3D-quantitative structure-activity relationship (3D-QSAR) study was applied for selection of molecular determinants of multidrug recognition by CmbT. CmbT multidrug resistance protein of Lactococcus lactis contributes to extruding the structurally, chemically, and pharmacologically diverse range of substrates out of bacterial cells. This function of CmbT may result in the failure of antibiotic therapy. Homology model of CmbT protein was constructed and further opthnized. The 3D-QSAR model predictive potential was proved by use of leave-one-out cross validation Of the training set (Q(2): 0.69, R-observd(2) (vs).(Predicted) : 0.918, RMSEE: 0.193) and verification set (R-Observed vs predicted(2) : 0.704, RMSEP: 0.289). The results obtained in this study showed that high CmbT affinities to ethidium, sulbactam, and sulfathiazole could be related to the absence of significant unfavourable interactions. In contrast, the presence of specific unfavourable interaction between two hydrogen bond donor groups in bacitracin, apramycin, novobiocin, vancomycin, kanamycin, gentamycin, and tobramycin is found to be the main reason for their lower CmbT affinities. In addition, membrane position of the CmbT binding site and positive correlation between substrates lipophilicity (log D-PH so) and CmbT affinity strongly indicates that CmbT recognizes its substrates within the membrane.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of the Taiwan Institute of Chemical Engineers",
title = "Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study",
pages = "771-764",
number = "3",
volume = "45",
doi = "10.1016/j.jtice.2013.09.033"
}

Filipić, B., Nikolić, K., Filipić, S., Jovčić, B., Agbaba, D., Antić-Stanković, J., Kojić, M.,& Golić, N.. (2014). Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study. in Journal of the Taiwan Institute of Chemical Engineers
Elsevier Science Bv, Amsterdam., 45(3), 764-771.
https://doi.org/10.1016/j.jtice.2013.09.033

Filipić B, Nikolić K, Filipić S, Jovčić B, Agbaba D, Antić-Stanković J, Kojić M, Golić N. Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study. in Journal of the Taiwan Institute of Chemical Engineers. 2014;45(3):764-771.
doi:10.1016/j.jtice.2013.09.033 .

Filipić, Brankica, Nikolić, Katarina, Filipić, Slavica, Jovčić, Branko, Agbaba, Danica, Antić-Stanković, Jelena, Kojić, Milan, Golić, Nataša, "Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study" in Journal of the Taiwan Institute of Chemical Engineers, 45, no. 3 (2014):764-771,
https://doi.org/10.1016/j.jtice.2013.09.033 . .

TY  - JOUR
AU  - Mihajlović, A.
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
AU  - Ristić, P.
AU  - Đorđević, M.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/96
AB  - Because of the ability of g-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated, For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed and validated. Rapid decreases in concentrations of 8-HQS were found in samples stored in original vials which were exposed to different temperatures and vial positions. (C) 1998 Elsevier Science B.V.
PB  - Elsevier, Amsterdam
T2  - Journal of Chromatography A
T1  - High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations
EP  - 177
IS  - 1-2
SP  - 173
VL  - 798
DO  - 10.1016/S0021-9673(97)01085-6
ER  - 

@article{
author = "Mihajlović, A. and Agbaba, Danica and Živanov-Stakić, Dobrila and Ristić, P. and Đorđević, M.",
year = "1998",
abstract = "Because of the ability of g-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated, For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed and validated. Rapid decreases in concentrations of 8-HQS were found in samples stored in original vials which were exposed to different temperatures and vial positions. (C) 1998 Elsevier Science B.V.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Chromatography A",
title = "High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations",
pages = "177-173",
number = "1-2",
volume = "798",
doi = "10.1016/S0021-9673(97)01085-6"
}

Mihajlović, A., Agbaba, D., Živanov-Stakić, D., Ristić, P.,& Đorđević, M.. (1998). High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations. in Journal of Chromatography A
Elsevier, Amsterdam., 798(1-2), 173-177.
https://doi.org/10.1016/S0021-9673(97)01085-6

Mihajlović A, Agbaba D, Živanov-Stakić D, Ristić P, Đorđević M. High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations. in Journal of Chromatography A. 1998;798(1-2):173-177.
doi:10.1016/S0021-9673(97)01085-6 .

Mihajlović, A., Agbaba, Danica, Živanov-Stakić, Dobrila, Ristić, P., Đorđević, M., "High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations" in Journal of Chromatography A, 798, no. 1-2 (1998):173-177,
https://doi.org/10.1016/S0021-9673(97)01085-6 . .

TY  - JOUR
AU  - Agbaba, Danica
AU  - Mihajlović, A.
AU  - Beljanski, P.
AU  - Živanov-Stakić, Dobrila
AU  - Vladimirov, S.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/80
AB  - TLC and HPLC methods for the determination of the preservative, 8-hydroxyquinoline sulfate in PPD-T tuberculin solution were developed. The planar chromatography method involved separation of 8-hydroxyquinoline sulfate on a TLC plate using a butyl-acetate: formic acid :2-propanol mobile phase, detection and quantitation by densitometric scanning. The HPLC method was on a LiChrosorb RP-18 column with acetonitrile-water (65:35 v/v) mobile phase, adjusted to pH 3.05 by phosphoric acid. Linearity, reproducibility and accuracy were found to be satisfactory. Under selected conditions, the limit of detection (LOD) of both methods was similar - about 25 ng.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Determination of 8-hydroxyquinoline sulfate in tuberculin solutions by planar and high performance liquid chromatography
EP  - 148
SP  - 145
VL  - 45
DO  - 10.1007/BF02505552
ER  - 

@article{
author = "Agbaba, Danica and Mihajlović, A. and Beljanski, P. and Živanov-Stakić, Dobrila and Vladimirov, S.",
year = "1997",
abstract = "TLC and HPLC methods for the determination of the preservative, 8-hydroxyquinoline sulfate in PPD-T tuberculin solution were developed. The planar chromatography method involved separation of 8-hydroxyquinoline sulfate on a TLC plate using a butyl-acetate: formic acid :2-propanol mobile phase, detection and quantitation by densitometric scanning. The HPLC method was on a LiChrosorb RP-18 column with acetonitrile-water (65:35 v/v) mobile phase, adjusted to pH 3.05 by phosphoric acid. Linearity, reproducibility and accuracy were found to be satisfactory. Under selected conditions, the limit of detection (LOD) of both methods was similar - about 25 ng.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Determination of 8-hydroxyquinoline sulfate in tuberculin solutions by planar and high performance liquid chromatography",
pages = "148-145",
volume = "45",
doi = "10.1007/BF02505552"
}

Agbaba, D., Mihajlović, A., Beljanski, P., Živanov-Stakić, D.,& Vladimirov, S.. (1997). Determination of 8-hydroxyquinoline sulfate in tuberculin solutions by planar and high performance liquid chromatography. in Chromatographia
Springer Heidelberg, Heidelberg., 45, 145-148.
https://doi.org/10.1007/BF02505552

Agbaba D, Mihajlović A, Beljanski P, Živanov-Stakić D, Vladimirov S. Determination of 8-hydroxyquinoline sulfate in tuberculin solutions by planar and high performance liquid chromatography. in Chromatographia. 1997;45:145-148.
doi:10.1007/BF02505552 .

Agbaba, Danica, Mihajlović, A., Beljanski, P., Živanov-Stakić, Dobrila, Vladimirov, S., "Determination of 8-hydroxyquinoline sulfate in tuberculin solutions by planar and high performance liquid chromatography" in Chromatographia, 45 (1997):145-148,
https://doi.org/10.1007/BF02505552 . .