TY  - JOUR
AU  - Radulović, Jelena
AU  - Mančev, Zorica
AU  - Stanojević, Stanislava
AU  - Vasiljević, T.
AU  - Kovačević-Jovanović, Vesna
AU  - Pešić, Gordana
PY  - 1996
UR  - http://intor.torlakinstitut.com/handle/123456789/63
AB  - The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors.
PB  - Elsevier, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists
EP  - 161
IS  - 2
SP  - 155
VL  - 65
DO  - 10.1016/0165-5728(96)00017-3
UR  - https://hdl.handle.net/21.15107/rcub_intor_63
ER  - 

@article{
author = "Radulović, Jelena and Mančev, Zorica and Stanojević, Stanislava and Vasiljević, T. and Kovačević-Jovanović, Vesna and Pešić, Gordana",
year = "1996",
abstract = "The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists",
pages = "161-155",
number = "2",
volume = "65",
doi = "10.1016/0165-5728(96)00017-3",
url = "https://hdl.handle.net/21.15107/rcub_intor_63"
}

Radulović, J., Mančev, Z., Stanojević, S., Vasiljević, T., Kovačević-Jovanović, V.,& Pešić, G.. (1996). Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists. in Journal of Neuroimmunology
Elsevier, Amsterdam., 65(2), 155-161.
https://doi.org/10.1016/0165-5728(96)00017-3
https://hdl.handle.net/21.15107/rcub_intor_63

Radulović J, Mančev Z, Stanojević S, Vasiljević T, Kovačević-Jovanović V, Pešić G. Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists. in Journal of Neuroimmunology. 1996;65(2):155-161.
doi:10.1016/0165-5728(96)00017-3
https://hdl.handle.net/21.15107/rcub_intor_63 .

Radulović, Jelena, Mančev, Zorica, Stanojević, Stanislava, Vasiljević, T., Kovačević-Jovanović, Vesna, Pešić, Gordana, "Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists" in Journal of Neuroimmunology, 65, no. 2 (1996):155-161,
https://doi.org/10.1016/0165-5728(96)00017-3 .,
https://hdl.handle.net/21.15107/rcub_intor_63 .

TY  - JOUR
AU  - Antić, J.
AU  - Vasiljević, T.
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Đergović, Danica
AU  - Miljević, C.
AU  - Marković, B.M.
AU  - Radulović, Jelena
PY  - 1996
UR  - http://intor.torlakinstitut.com/handle/123456789/65
AB  - It is well established that K-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the K-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icy) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icy treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 3034 markedly depend on the route of drug administration and strain susceptibility to opioids.
PB  - Elsevier, Amsterdam
T2  - Immunopharmacology
T1  - Suppression of adjuvant arthritis by kappa-opioid receptor agonist: Effect of route of administration and strain differences
EP  - 112
IS  - 2-3
SP  - 105
VL  - 34
DO  - 10.1016/0162-3109(96)00114-2
ER  - 

@article{
author = "Antić, J. and Vasiljević, T. and Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Đergović, Danica and Miljević, C. and Marković, B.M. and Radulović, Jelena",
year = "1996",
abstract = "It is well established that K-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the K-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icy) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icy treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 3034 markedly depend on the route of drug administration and strain susceptibility to opioids.",
publisher = "Elsevier, Amsterdam",
journal = "Immunopharmacology",
title = "Suppression of adjuvant arthritis by kappa-opioid receptor agonist: Effect of route of administration and strain differences",
pages = "112-105",
number = "2-3",
volume = "34",
doi = "10.1016/0162-3109(96)00114-2"
}

Antić, J., Vasiljević, T., Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Đergović, D., Miljević, C., Marković, B.M.,& Radulović, J.. (1996). Suppression of adjuvant arthritis by kappa-opioid receptor agonist: Effect of route of administration and strain differences. in Immunopharmacology
Elsevier, Amsterdam., 34(2-3), 105-112.
https://doi.org/10.1016/0162-3109(96)00114-2

Antić J, Vasiljević T, Stanojević S, Vujić V, Kovačević-Jovanović V, Đergović D, Miljević C, Marković B, Radulović J. Suppression of adjuvant arthritis by kappa-opioid receptor agonist: Effect of route of administration and strain differences. in Immunopharmacology. 1996;34(2-3):105-112.
doi:10.1016/0162-3109(96)00114-2 .

Antić, J., Vasiljević, T., Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Đergović, Danica, Miljević, C., Marković, B.M., Radulović, Jelena, "Suppression of adjuvant arthritis by kappa-opioid receptor agonist: Effect of route of administration and strain differences" in Immunopharmacology, 34, no. 2-3 (1996):105-112,
https://doi.org/10.1016/0162-3109(96)00114-2 . .

TY  - JOUR
AU  - Radulović, Jelena
AU  - Dimitrijević, Mirjana
AU  - Laban, Olgica
AU  - Stanojević, Stanislava
AU  - Vasiljević, T.
AU  - Kovačević-Jovanović, Vesna
AU  - Marković, B.M.
PY  - 1995
UR  - http://intor.torlakinstitut.com/handle/123456789/59
AB  - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.
T2  - Peptides
T1  - Effect of Met-enkephalin and opioid antagonists on rat macrophages
EP  - 1213
IS  - 7
SP  - 1209
VL  - 16
DO  - 10.1016/0196-9781(95)02003-F
ER  - 

@article{
author = "Radulović, Jelena and Dimitrijević, Mirjana and Laban, Olgica and Stanojević, Stanislava and Vasiljević, T. and Kovačević-Jovanović, Vesna and Marković, B.M.",
year = "1995",
abstract = "Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.",
journal = "Peptides",
title = "Effect of Met-enkephalin and opioid antagonists on rat macrophages",
pages = "1213-1209",
number = "7",
volume = "16",
doi = "10.1016/0196-9781(95)02003-F"
}

Radulović, J., Dimitrijević, M., Laban, O., Stanojević, S., Vasiljević, T., Kovačević-Jovanović, V.,& Marković, B.M.. (1995). Effect of Met-enkephalin and opioid antagonists on rat macrophages. in Peptides, 16(7), 1209-1213.
https://doi.org/10.1016/0196-9781(95)02003-F

Radulović J, Dimitrijević M, Laban O, Stanojević S, Vasiljević T, Kovačević-Jovanović V, Marković B. Effect of Met-enkephalin and opioid antagonists on rat macrophages. in Peptides. 1995;16(7):1209-1213.
doi:10.1016/0196-9781(95)02003-F .

Radulović, Jelena, Dimitrijević, Mirjana, Laban, Olgica, Stanojević, Stanislava, Vasiljević, T., Kovačević-Jovanović, Vesna, Marković, B.M., "Effect of Met-enkephalin and opioid antagonists on rat macrophages" in Peptides, 16, no. 7 (1995):1209-1213,
https://doi.org/10.1016/0196-9781(95)02003-F . .