TY  - CONF
AU  - Ćuruvija, Ivana
AU  - Bufan, Biljana
AU  - Đorović, Emilija
AU  - Blagojević, Veljko
AU  - Grujić-Milanović, Jelica
AU  - Marković, Milica
AU  - Djuretić, Jasmina
PY  - 2022
UR  - http://intor.torlakinstitut.com/handle/123456789/674
AB  - Aims Ageing affects N-methyl-D-aspartate receptors (NMDARs), their expression and function in neuronal and non-neuronal
cells. Contribution of NMDARs to pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been investigated
but further study is still needed. The aim of this study was to determine whether ageing affects the role of NMDARs in EAE.
Methods Memantine, a non-competitive NMDAR antagonist which limits pathological activity of NMDARs while sparing
normal synaptic activity, was administered orally from day 7 after immunization to 3- and 24-month-old female Dark Agouti
rats. The animals were sacrificed at the peak of the disease. Spinal cord mononuclear cells were analyzed by flow cytometry.
Brain tissue was collected for biochemical analysis of redox status and RT-qPCR. Results Semiprophylactic administration of
memantine ameliorated clinical disease course, with greater effect in aged rats. Memantine reduced the number, frequency,
and reactivation of CD4+ T lymphocytes and increased the relative percentage of CX3CR1-expressing microglia in spinal
cord, but to a greater extent in aged rats. Additionally, analysis of brain redox status parameters showed that memantine was
more effective in reducing superoxide anion radical, malondialdehyde and advanced oxidation protein products in aged rats
than in young ones. In accordance with previous findings, NMDAR inhibition by memantine decreased NADPH oxidase and
IL-1β expression and increased the nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression, to a greater
extent in aged rats. Conclusions The involvement of NMDARs in the pathogenesis of EAE was age-dependent, being more
pronounced in aged than in young rats.
C3  - FENS Forum Book of Abstracts, Paris
T1  - Age-Dependent Role Of Nmda Receptors In Experimental Autoimmune Encephalomyelitis
SP  - S05-250
UR  - https://hdl.handle.net/21.15107/rcub_intor_674
ER  - 

@conference{
author = "Ćuruvija, Ivana and Bufan, Biljana and Đorović, Emilija and Blagojević, Veljko and Grujić-Milanović, Jelica and Marković, Milica and Djuretić, Jasmina",
year = "2022",
abstract = "Aims Ageing affects N-methyl-D-aspartate receptors (NMDARs), their expression and function in neuronal and non-neuronal
cells. Contribution of NMDARs to pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been investigated
but further study is still needed. The aim of this study was to determine whether ageing affects the role of NMDARs in EAE.
Methods Memantine, a non-competitive NMDAR antagonist which limits pathological activity of NMDARs while sparing
normal synaptic activity, was administered orally from day 7 after immunization to 3- and 24-month-old female Dark Agouti
rats. The animals were sacrificed at the peak of the disease. Spinal cord mononuclear cells were analyzed by flow cytometry.
Brain tissue was collected for biochemical analysis of redox status and RT-qPCR. Results Semiprophylactic administration of
memantine ameliorated clinical disease course, with greater effect in aged rats. Memantine reduced the number, frequency,
and reactivation of CD4+ T lymphocytes and increased the relative percentage of CX3CR1-expressing microglia in spinal
cord, but to a greater extent in aged rats. Additionally, analysis of brain redox status parameters showed that memantine was
more effective in reducing superoxide anion radical, malondialdehyde and advanced oxidation protein products in aged rats
than in young ones. In accordance with previous findings, NMDAR inhibition by memantine decreased NADPH oxidase and
IL-1β expression and increased the nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression, to a greater
extent in aged rats. Conclusions The involvement of NMDARs in the pathogenesis of EAE was age-dependent, being more
pronounced in aged than in young rats.",
journal = "FENS Forum Book of Abstracts, Paris",
title = "Age-Dependent Role Of Nmda Receptors In Experimental Autoimmune Encephalomyelitis",
pages = "S05-250",
url = "https://hdl.handle.net/21.15107/rcub_intor_674"
}

Ćuruvija, I., Bufan, B., Đorović, E., Blagojević, V., Grujić-Milanović, J., Marković, M.,& Djuretić, J.. (2022). Age-Dependent Role Of Nmda Receptors In Experimental Autoimmune Encephalomyelitis. in FENS Forum Book of Abstracts, Paris, S05-250.
https://hdl.handle.net/21.15107/rcub_intor_674

Ćuruvija I, Bufan B, Đorović E, Blagojević V, Grujić-Milanović J, Marković M, Djuretić J. Age-Dependent Role Of Nmda Receptors In Experimental Autoimmune Encephalomyelitis. in FENS Forum Book of Abstracts, Paris. 2022;:S05-250.
https://hdl.handle.net/21.15107/rcub_intor_674 .

Ćuruvija, Ivana, Bufan, Biljana, Đorović, Emilija, Blagojević, Veljko, Grujić-Milanović, Jelica, Marković, Milica, Djuretić, Jasmina, "Age-Dependent Role Of Nmda Receptors In Experimental Autoimmune Encephalomyelitis" in FENS Forum Book of Abstracts, Paris (2022):S05-250,
https://hdl.handle.net/21.15107/rcub_intor_674 .

TY  - JOUR
AU  - Kecmanović, Miljana
AU  - Dobričić, Valerija
AU  - Dimitrijević, Rajna
AU  - Keckarević, Dušan
AU  - Savić-Pavićević, Dušanka
AU  - Keckarević-Marković, Milica
AU  - Ivković, Maja
AU  - Romac, Stanka
PY  - 2010
UR  - http://intor.torlakinstitut.com/handle/123456789/312
AB  - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population
EP  - 506
IS  - 7
SP  - 502
VL  - 120
DO  - 10.3109/00207451003765956
ER  - 

@article{
author = "Kecmanović, Miljana and Dobričić, Valerija and Dimitrijević, Rajna and Keckarević, Dušan and Savić-Pavićević, Dušanka and Keckarević-Marković, Milica and Ivković, Maja and Romac, Stanka",
year = "2010",
abstract = "Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population",
pages = "506-502",
number = "7",
volume = "120",
doi = "10.3109/00207451003765956"
}

Kecmanović, M., Dobričić, V., Dimitrijević, R., Keckarević, D., Savić-Pavićević, D., Keckarević-Marković, M., Ivković, M.,& Romac, S.. (2010). Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 120(7), 502-506.
https://doi.org/10.3109/00207451003765956

Kecmanović M, Dobričić V, Dimitrijević R, Keckarević D, Savić-Pavićević D, Keckarević-Marković M, Ivković M, Romac S. Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience. 2010;120(7):502-506.
doi:10.3109/00207451003765956 .

Kecmanović, Miljana, Dobričić, Valerija, Dimitrijević, Rajna, Keckarević, Dušan, Savić-Pavićević, Dušanka, Keckarević-Marković, Milica, Ivković, Maja, Romac, Stanka, "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):502-506,
https://doi.org/10.3109/00207451003765956 . .

TY  - JOUR
AU  - Dimitrijević, Rajna
AU  - Cadez, Ivana
AU  - Keckarević-Marković, Milica
AU  - Keckarević, Dušan
AU  - Kecmanović, Miljana
AU  - Dobričić, Valerija
AU  - Savić-Pavićević, Dušanka
AU  - Brajusković, Goran
AU  - Romac, Stanka
PY  - 2010
UR  - http://intor.torlakinstitut.com/handle/123456789/299
AB  - Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population
EP  - 501
IS  - 7
SP  - 496
VL  - 120
DO  - 10.3109/00207451003765907
ER  - 

@article{
author = "Dimitrijević, Rajna and Cadez, Ivana and Keckarević-Marković, Milica and Keckarević, Dušan and Kecmanović, Miljana and Dobričić, Valerija and Savić-Pavićević, Dušanka and Brajusković, Goran and Romac, Stanka",
year = "2010",
abstract = "Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population",
pages = "501-496",
number = "7",
volume = "120",
doi = "10.3109/00207451003765907"
}

Dimitrijević, R., Cadez, I., Keckarević-Marković, M., Keckarević, D., Kecmanović, M., Dobričić, V., Savić-Pavićević, D., Brajusković, G.,& Romac, S.. (2010). Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 120(7), 496-501.
https://doi.org/10.3109/00207451003765907

Dimitrijević R, Cadez I, Keckarević-Marković M, Keckarević D, Kecmanović M, Dobričić V, Savić-Pavićević D, Brajusković G, Romac S. Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience. 2010;120(7):496-501.
doi:10.3109/00207451003765907 .

Dimitrijević, Rajna, Cadez, Ivana, Keckarević-Marković, Milica, Keckarević, Dušan, Kecmanović, Miljana, Dobričić, Valerija, Savić-Pavićević, Dušanka, Brajusković, Goran, Romac, Stanka, "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):496-501,
https://doi.org/10.3109/00207451003765907 . .

TY  - JOUR
AU  - Janković, N.
AU  - Kemanović, M.
AU  - Dimitrijević, Rajna
AU  - Keckarević-Marković, Milica
AU  - Dobričić, Valerija
AU  - Savić-Pavićević, Dušanka
AU  - Romac, Stanka
PY  - 2008
UR  - http://intor.torlakinstitut.com/handle/123456789/251
AB  - Saitohin (STH) is located in the intron of the human gene for microtubule-associated protein tau. Q7R polymorphism has been identified in the STH gene. Some neurodegenerative disorders were found to be associated with the presence of certain STH allele. This study genotyped 37 subjects with diagnosis of Huntington's disease, but lacking mutations in HD, PRNP, JPH-3, and FTL genes for STH polymorphism. It was determined that Q allele of STH gene was over-represented in a tested group of patients (P  gt  Pt). Over-representation of Q allele in a group of patients might be considered as genetic risk factor for HD like diseases.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - HD phenocopies - Possible role of saitohin gene
EP  - 397
IS  - 3
SP  - 391
VL  - 118
DO  - 10.1080/00207450701593103
ER  - 

@article{
author = "Janković, N. and Kemanović, M. and Dimitrijević, Rajna and Keckarević-Marković, Milica and Dobričić, Valerija and Savić-Pavićević, Dušanka and Romac, Stanka",
year = "2008",
abstract = "Saitohin (STH) is located in the intron of the human gene for microtubule-associated protein tau. Q7R polymorphism has been identified in the STH gene. Some neurodegenerative disorders were found to be associated with the presence of certain STH allele. This study genotyped 37 subjects with diagnosis of Huntington's disease, but lacking mutations in HD, PRNP, JPH-3, and FTL genes for STH polymorphism. It was determined that Q allele of STH gene was over-represented in a tested group of patients (P  gt  Pt). Over-representation of Q allele in a group of patients might be considered as genetic risk factor for HD like diseases.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "HD phenocopies - Possible role of saitohin gene",
pages = "397-391",
number = "3",
volume = "118",
doi = "10.1080/00207450701593103"
}

Janković, N., Kemanović, M., Dimitrijević, R., Keckarević-Marković, M., Dobričić, V., Savić-Pavićević, D.,& Romac, S.. (2008). HD phenocopies - Possible role of saitohin gene. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 118(3), 391-397.
https://doi.org/10.1080/00207450701593103

Janković N, Kemanović M, Dimitrijević R, Keckarević-Marković M, Dobričić V, Savić-Pavićević D, Romac S. HD phenocopies - Possible role of saitohin gene. in International Journal of Neuroscience. 2008;118(3):391-397.
doi:10.1080/00207450701593103 .

Janković, N., Kemanović, M., Dimitrijević, Rajna, Keckarević-Marković, Milica, Dobričić, Valerija, Savić-Pavićević, Dušanka, Romac, Stanka, "HD phenocopies - Possible role of saitohin gene" in International Journal of Neuroscience, 118, no. 3 (2008):391-397,
https://doi.org/10.1080/00207450701593103 . .