Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
Abstract
The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
Keywords:
nucleus basalis magnocellularis / brain lesions / plaque-forming cell response / Arthus reaction / delayed hypersensitivity / antibody production / ratSource:
International Journal of Neuroscience, 1997, 89, 3-4, 165-176Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459708988472
ISSN: 0020-7454
PubMed: 9134454
WoS: A1997WW41100003
Scopus: 2-s2.0-0031080273
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TorlakTY - JOUR AU - Popović, M. AU - Jovanova-Nešić, Katica AU - Popović, N. AU - Ugrešić, Nenad AU - Kostić, V. AU - Rakić, L. PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/81 AB - The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat EP - 176 IS - 3-4 SP - 165 VL - 89 DO - 10.3109/00207459708988472 ER -
@article{ author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Ugrešić, Nenad and Kostić, V. and Rakić, L.", year = "1997", abstract = "The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat", pages = "176-165", number = "3-4", volume = "89", doi = "10.3109/00207459708988472" }
Popović, M., Jovanova-Nešić, K., Popović, N., Ugrešić, N., Kostić, V.,& Rakić, L.. (1997). Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 89(3-4), 165-176. https://doi.org/10.3109/00207459708988472
Popović M, Jovanova-Nešić K, Popović N, Ugrešić N, Kostić V, Rakić L. Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience. 1997;89(3-4):165-176. doi:10.3109/00207459708988472 .
Popović, M., Jovanova-Nešić, Katica, Popović, N., Ugrešić, Nenad, Kostić, V., Rakić, L., "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat" in International Journal of Neuroscience, 89, no. 3-4 (1997):165-176, https://doi.org/10.3109/00207459708988472 . .