Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex
Samo za registrovane korisnike
1997
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability ...of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.
Ključne reči:
Alzheimer's disease / active avoidance / spontaneous motor activity / fetal frontal cortex / transplantation / ratIzvor:
International Journal of Neuroscience, 1997, 91, 1-2, 11-+Izdavač:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459708986362
ISSN: 0020-7454
PubMed: 9394212
WoS: A1997YD95000002
Scopus: 2-s2.0-0031239356
Institucija/grupa
TorlakTY - JOUR AU - Popović, N. AU - Jovanova-Nešić, Katica AU - Popović, M. AU - Bokonjić, D. AU - Rakić, L. PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/75 AB - The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex EP - + IS - 1-2 SP - 11 VL - 91 DO - 10.3109/00207459708986362 ER -
@article{ author = "Popović, N. and Jovanova-Nešić, Katica and Popović, M. and Bokonjić, D. and Rakić, L.", year = "1997", abstract = "The effect of fetal frontal cortex transplantation on behaviour performance was examined in adult male Wistar rats with lesions of the nucleus basalis magnocellularis (NBM). Compared to intact and sham-operated controls, the rats tested ten or twenty days after bilateral electrolytic lesions of NBM exhibited the significant learning and memory impairments (acquisition and performance of two-way active avoidance) whereas spontaneous motor activity was not significantly altered. The animals which received allotransplants of fetal frontal cortex (from 18-day gestational rat fetuses) into NBM, two (''early'' transplantation -NBM-ET) or ten (''delayed'' transplantation-NBM-DT) days after lesioning, respectively, manifested the complete amelioration of noticed impairments when tested ten days after transplantation procedure. Corresponding sham-transplants groups (NBM-SET and NBM-SDT) showed only slightly improvement of acquisition but not performance of two-way active avoidance. The ability of the transplants to restore learning and memory in the NBM lesioned rats suggests that graft of fetal frontal cortex can functionally influence neuronal activity of the lesioned host brain.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex", pages = "+-11", number = "1-2", volume = "91", doi = "10.3109/00207459708986362" }
Popović, N., Jovanova-Nešić, K., Popović, M., Bokonjić, D.,& Rakić, L.. (1997). Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 91(1-2), 11-+. https://doi.org/10.3109/00207459708986362
Popović N, Jovanova-Nešić K, Popović M, Bokonjić D, Rakić L. Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex. in International Journal of Neuroscience. 1997;91(1-2):11-+. doi:10.3109/00207459708986362 .
Popović, N., Jovanova-Nešić, Katica, Popović, M., Bokonjić, D., Rakić, L., "Learning and memory in nucleus basalis magnocellularis-lesioned rats after transplantation of fetal frontal cortex" in International Journal of Neuroscience, 91, no. 1-2 (1997):11-+, https://doi.org/10.3109/00207459708986362 . .