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Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid
dc.creator | Stojanović, Marijana | |
dc.creator | Petrušić, Vladimir | |
dc.creator | Živković, Irena | |
dc.creator | Inić-Kanada, Aleksandra | |
dc.creator | Stojičević, Ivana | |
dc.creator | Marinković, Emilija | |
dc.creator | Dimitrijević, Ljiljana | |
dc.date.accessioned | 2021-02-18T10:42:02Z | |
dc.date.available | 2021-02-18T10:42:02Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0257-277X | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/395 | |
dc.description.abstract | It is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera beta 2-glycoprotein I (beta 2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-beta 2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. beta 2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and beta 2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and beta 2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after beta 2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, beta 2GPI or glutaraldehyde-treated beta 2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and autoreactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response. | en |
dc.publisher | Humana Press Inc, Totowa | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Immunologic Research | |
dc.subject | Tetanus toxoid | en |
dc.subject | beta 2-Glycoprotein I | en |
dc.subject | Molecular mimicry | en |
dc.subject | Polyclonal cell activation | en |
dc.title | Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 31 | |
dc.citation.issue | 1 | |
dc.citation.other | 56(1): 20-31 | |
dc.citation.rank | M22 | |
dc.citation.spage | 20 | |
dc.citation.volume | 56 | |
dc.identifier.doi | 10.1007/s12026-012-8343-1 | |
dc.identifier.pmid | 22875539 | |
dc.identifier.scopus | 2-s2.0-84876411640 | |
dc.identifier.wos | 000317849100003 | |
dc.type.version | publishedVersion |