Prikaz osnovnih podataka o dokumentu
Strain differences in the humoral immune response to commensal bacterial antigens in rats
dc.creator | Kovačević-Jovanović, Vesna | |
dc.creator | Miletić, Tatjana | |
dc.creator | Stanojević, Stanislava | |
dc.creator | Mitić, Katarina | |
dc.creator | Dimitrijević, Mirjana | |
dc.date.accessioned | 2021-02-18T10:41:22Z | |
dc.date.available | 2021-02-18T10:41:22Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1217-8950 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/386 | |
dc.description.abstract | We have investigated the immune response to commensal bacterial species in the two inbred rat strains: Dark Agouti (DA) and Albino Oxford (AO). The predominant Gram-negative aerobe in our rats' intestinal bacterial flora was Escherichia coli, while Proteus mirabilis was isolated only from DA rat strain. We report that sera from both DA and AO rat strains contain specific IgG against predominant intestinal flora. Intramuscular administration of commensal bacterial antigens provoked only Th1-type antibody response in AO rats while DA rats developed mixed Th1- and Th2-type antibody response to E. coli and Th1-type response to P. mirabilis antigens. Weaker antibody production to own E. coli and higher serum levels of natural IgG and IgA P. mirabilis-specific antibodies combined with higher CD3+ cells proliferation was found in AO rats. Strain difference in the pattern of antibody production and differential regulation of immune response to commensal bacteria may contribute to the marked differences in the immune reactivity of AO and DA rats. | en |
dc.publisher | Akademiai Kiado Rt, Budapest | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Acta Microbiologica et Immunologica Hungarica | |
dc.subject | commensal bacteria | en |
dc.subject | humoral immune response | en |
dc.subject | mesenteric lymph node cells | en |
dc.subject | tolerance | en |
dc.subject | rat strains | en |
dc.title | Strain differences in the humoral immune response to commensal bacterial antigens in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 288 | |
dc.citation.issue | 3 | |
dc.citation.other | 60(3): 271-288 | |
dc.citation.rank | M23 | |
dc.citation.spage | 271 | |
dc.citation.volume | 60 | |
dc.identifier.doi | 10.1556/AMicr.60.2013.3.4 | |
dc.identifier.pmid | 24060552 | |
dc.identifier.scopus | 2-s2.0-84884850671 | |
dc.identifier.wos | 000324913900004 | |
dc.type.version | publishedVersion |