NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions
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2012
Authors
Dimitrijević, MirjanaMitić, Katarina
Kuštrimović, Nataša
Vujić, Vesna
Stanojević, Stanislava
Article (Published version)
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Neuropeptide Y (NPY) suppressed clinical experimental autoimmune encephalomyelitis (EAE) and reduced numbers of CD28+, CD11b+ and CD80+ cells among spinal cord infiltrating cells at the peak of disease in Dark Agouti rat strain. Suppression of EAE was accompanied by the reduced expression of costimulatory CD80 and CD86 molecules on ED1+ macrophages and OX62+ dendritic cells in draining lymph nodes during the inductive phase of EAE. An inhibitor of dipeptidyl peptidase 4, an enzyme which terminates the action of NPY on 11 receptor subtype, did not sustain the suppressive effect of NPY on the EAE development, suggesting involvement of Y2 and Y5 receptors. (C) 2012 Elsevier B.V. All rights reserved.
Keywords:
EAE / Dipeptidyl peptidase 4 / Neuropeptide Y / RatSource:
Journal of Neuroimmunology, 2012, 245, 1-2, 23-31Publisher:
- Elsevier, Amsterdam
Funding / projects:
DOI: 10.1016/j.jneuroim.2012.01.013
ISSN: 0165-5728
PubMed: 22365383
WoS: 000303908100004
Scopus: 2-s2.0-84859644108
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TorlakTY - JOUR AU - Dimitrijević, Mirjana AU - Mitić, Katarina AU - Kuštrimović, Nataša AU - Vujić, Vesna AU - Stanojević, Stanislava PY - 2012 UR - http://intor.torlakinstitut.com/handle/123456789/357 AB - Neuropeptide Y (NPY) suppressed clinical experimental autoimmune encephalomyelitis (EAE) and reduced numbers of CD28+, CD11b+ and CD80+ cells among spinal cord infiltrating cells at the peak of disease in Dark Agouti rat strain. Suppression of EAE was accompanied by the reduced expression of costimulatory CD80 and CD86 molecules on ED1+ macrophages and OX62+ dendritic cells in draining lymph nodes during the inductive phase of EAE. An inhibitor of dipeptidyl peptidase 4, an enzyme which terminates the action of NPY on 11 receptor subtype, did not sustain the suppressive effect of NPY on the EAE development, suggesting involvement of Y2 and Y5 receptors. (C) 2012 Elsevier B.V. All rights reserved. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions EP - 31 IS - 1-2 SP - 23 VL - 245 DO - 10.1016/j.jneuroim.2012.01.013 ER -
@article{ author = "Dimitrijević, Mirjana and Mitić, Katarina and Kuštrimović, Nataša and Vujić, Vesna and Stanojević, Stanislava", year = "2012", abstract = "Neuropeptide Y (NPY) suppressed clinical experimental autoimmune encephalomyelitis (EAE) and reduced numbers of CD28+, CD11b+ and CD80+ cells among spinal cord infiltrating cells at the peak of disease in Dark Agouti rat strain. Suppression of EAE was accompanied by the reduced expression of costimulatory CD80 and CD86 molecules on ED1+ macrophages and OX62+ dendritic cells in draining lymph nodes during the inductive phase of EAE. An inhibitor of dipeptidyl peptidase 4, an enzyme which terminates the action of NPY on 11 receptor subtype, did not sustain the suppressive effect of NPY on the EAE development, suggesting involvement of Y2 and Y5 receptors. (C) 2012 Elsevier B.V. All rights reserved.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions", pages = "31-23", number = "1-2", volume = "245", doi = "10.1016/j.jneuroim.2012.01.013" }
Dimitrijević, M., Mitić, K., Kuštrimović, N., Vujić, V.,& Stanojević, S.. (2012). NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions. in Journal of Neuroimmunology Elsevier, Amsterdam., 245(1-2), 23-31. https://doi.org/10.1016/j.jneuroim.2012.01.013
Dimitrijević M, Mitić K, Kuštrimović N, Vujić V, Stanojević S. NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions. in Journal of Neuroimmunology. 2012;245(1-2):23-31. doi:10.1016/j.jneuroim.2012.01.013 .
Dimitrijević, Mirjana, Mitić, Katarina, Kuštrimović, Nataša, Vujić, Vesna, Stanojević, Stanislava, "NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions" in Journal of Neuroimmunology, 245, no. 1-2 (2012):23-31, https://doi.org/10.1016/j.jneuroim.2012.01.013 . .