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Propranolol influences EAE development by impairing antigen presenting cell migration into the draining lymph nodes
(Abstracts of the 5th European Congress of Immunology - ECI 2018 - Amsterdam, The Netherlands, 2018)
Introduction: Catecholamines are implicated in development of multiple sclerosis and EAE in Dark Agouti (DA) rats. To enlighten their β−adrenoceptor−mediated immunomodulatory action, DA rats of both sexes immunized for EAE ...
Sexual dimorphism in mechanisms controlling development of CD4+ T cell response in collagen-induced arthritis
(5th European Congress of Immunology, Septembar 2-5, Abstract Book, 2018)
Introduction: Considering sex bias in rheumatoid arthritis prevalence, influence of biological sex on the disease development in Dark Agouti rat collagen II (CII)−induced arthritis (CIA) model of the human disease was ...
Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis
(Elsevier Science Bv, Amsterdam, 2018)
The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: ...
The involvement of estrogen receptors alpha and beta in the in vitro effects of 17 beta-estradiol on secretory profile of peritoneal macrophages from naturally menopausal female and middle-aged male rats
(Pergamon-Elsevier Science Ltd, Oxford, 2018)
The systemic and extra- gonadal levels of 17 beta-estradiol (E2) change during aging, and affect the expression of estrogen receptors (ERs) in the immune cells of both females and males. The age-related cessation of ovarian ...
Rat strain differences in peritoneal immune cell response to selected gut microbiota: A crossroad between tolerance and autoimmunity?
(Pergamon-Elsevier Science Ltd, Oxford, 2018)
Aims: Some gut commensals can be protective, whereas others are implicated as necessary for development of inflammatory/autoimmune diseases. Peritoneal immune cells may play an important role in promoting auto-immunity in ...
Cooperative binding of anti-tetanus toxin monoclonal antibodies: Implications for designing an efficient biclonal preparation to prevent tetanus toxin intoxication
(Elsevier Sci Ltd, Oxford, 2018)
Oligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual ...
Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type
(Academic Press Ltd- Elsevier Science Ltd, London, 2018)
The study explored influence of biological sex on development of humoral immune response to seasonal trivalent whole inactivated virus (WIV) and split virus (SV) influenza vaccines in outbred Swiss mouse model. To this ...
Strain differences in thymic atrophy in rats immunized for EAE correlate with the clinical outcome of immunization
(Public Library Science, San Francisco, 2018)
An accumulating body of evidence suggests that development of autoimmune pathologies leads to thymic dysfunction and changes in peripheral T-cell compartment, which, in turn, perpetuate their pathogenesis. To test this ...
Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults
(Taylor & Francis Inc, Philadelphia, 2018)
This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The ...